JP6058641B2 - 射出成形および吹込成形によりポリマー体内補綴物を製造するための方法およびシステム - Google Patents
射出成形および吹込成形によりポリマー体内補綴物を製造するための方法およびシステム Download PDFInfo
- Publication number
- JP6058641B2 JP6058641B2 JP2014512076A JP2014512076A JP6058641B2 JP 6058641 B2 JP6058641 B2 JP 6058641B2 JP 2014512076 A JP2014512076 A JP 2014512076A JP 2014512076 A JP2014512076 A JP 2014512076A JP 6058641 B2 JP6058641 B2 JP 6058641B2
- Authority
- JP
- Japan
- Prior art keywords
- mold
- tube
- stock tube
- stock
- cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 48
- 229920000642 polymer Polymers 0.000 title claims description 22
- 238000001746 injection moulding Methods 0.000 title claims description 15
- 238000010102 injection blow moulding Methods 0.000 title description 2
- 239000002243 precursor Substances 0.000 claims description 45
- 230000002093 peripheral effect Effects 0.000 claims description 29
- 239000002861 polymer material Substances 0.000 claims description 21
- 230000009477 glass transition Effects 0.000 claims description 2
- 241000700159 Rattus Species 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 description 57
- 239000007924 injection Substances 0.000 description 57
- 239000000758 substrate Substances 0.000 description 25
- 239000000463 material Substances 0.000 description 17
- 239000002952 polymeric resin Substances 0.000 description 14
- 229920003002 synthetic resin Polymers 0.000 description 14
- 239000012530 fluid Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 238000001125 extrusion Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000000071 blow moulding Methods 0.000 description 5
- 229920001432 poly(L-lactide) Polymers 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000001131 transforming effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000004660 morphological change Effects 0.000 description 2
- 229920001434 poly(D-lactide) Polymers 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- RBMHUYBJIYNRLY-UHFFFAOYSA-N 2-[(1-carboxy-1-hydroxyethyl)-hydroxyphosphoryl]-2-hydroxypropanoic acid Chemical compound OC(=O)C(O)(C)P(O)(=O)C(C)(O)C(O)=O RBMHUYBJIYNRLY-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 230000007847 structural defect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
- B29C49/06—Injection blow-moulding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
- B29C2049/023—Combined blow-moulding and manufacture of the preform or the parison using inherent heat of the preform, i.e. 1 step blow moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2067/00—Use of polyesters or derivatives thereof, as moulding material
- B29K2067/04—Polyesters derived from hydroxycarboxylic acids
- B29K2067/043—PGA, i.e. polyglycolic acid or polyglycolide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2067/00—Use of polyesters or derivatives thereof, as moulding material
- B29K2067/04—Polyesters derived from hydroxycarboxylic acids
- B29K2067/046—PLA, i.e. polylactic acid or polylactide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7532—Artificial members, protheses
Landscapes
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/114,941 US8747728B2 (en) | 2011-05-24 | 2011-05-24 | Method and system for manufacturing a polymer endoprosthesis by injection molding and blow molding |
| US13/114,941 | 2011-05-24 | ||
| PCT/US2012/039164 WO2012162402A1 (en) | 2011-05-24 | 2012-05-23 | Method and system for manufacturing a polymer endoprosthesis by injection molding and blow molding |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518793A JP2014518793A (ja) | 2014-08-07 |
| JP2014518793A5 JP2014518793A5 (enExample) | 2015-07-09 |
| JP6058641B2 true JP6058641B2 (ja) | 2017-01-11 |
Family
ID=46201849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512076A Expired - Fee Related JP6058641B2 (ja) | 2011-05-24 | 2012-05-23 | 射出成形および吹込成形によりポリマー体内補綴物を製造するための方法およびシステム |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8747728B2 (enExample) |
| EP (1) | EP2714369B1 (enExample) |
| JP (1) | JP6058641B2 (enExample) |
| CN (1) | CN103619562B (enExample) |
| WO (1) | WO2012162402A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
| US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
| US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
| US20140107761A1 (en) | 2004-07-26 | 2014-04-17 | Abbott Cardiovascular Systems Inc. | Biodegradable stent with enhanced fracture toughness |
| US8002817B2 (en) * | 2007-05-04 | 2011-08-23 | Abbott Cardiovascular Systems Inc. | Stents with high radial strength and methods of manufacturing same |
| US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
| US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
| US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
| US9078740B2 (en) | 2013-01-21 | 2015-07-14 | Howmedica Osteonics Corp. | Instrumentation and method for positioning and securing a graft |
| EP4558208A1 (de) | 2022-07-22 | 2025-05-28 | BVS - Best Vascular Solutions GmbH | Ballonkathetervorrichtunq zur atraumatischen aufdehnung von hohlorganen sowie ein verfahren zur herstellung einer solchen ballonkathetervorrichtung |
| DE102022122630A1 (de) * | 2022-07-22 | 2024-01-25 | Bvs - Best Vascular Solutions Gmbh | Ballonkathetervorrichtung zur atraumatischen Behandlung von Hohlorganen sowie ein Verfahren zur Herstellung einer solchen Ballonkathetervorrichtung |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE844214C (de) | 1949-12-07 | 1952-07-17 | Basf Ag | Verfahren zur Herstellung von Hohlkoerpern |
| BE531868A (enExample) * | 1953-09-21 | 1900-01-01 | ||
| US3002225A (en) | 1958-04-26 | 1961-10-03 | Ankerwerk Gebr Goller | Apparatus for forming hollow plastic articles having an open neck portion by injection molding |
| FR76005E (fr) * | 1959-07-06 | 1961-09-08 | Perfectionnements aux presses à injection en matières plastiques | |
| NL257286A (enExample) * | 1959-11-03 | 1900-01-01 | ||
| US3492387A (en) * | 1961-10-13 | 1970-01-27 | Plastic Ammunition Products In | Plastic article making |
| US3170971A (en) * | 1962-06-22 | 1965-02-23 | Owens Illinois Glass Co | Method for making hollow plastic articles |
| US3390431A (en) * | 1963-09-10 | 1968-07-02 | Emery I. Valyi | Apparatus for molding articles |
| DE2143262A1 (de) | 1971-08-28 | 1973-03-01 | Dynamit Nobel Ag | Verfahren und vorrichtung zur herstellung von doppelwandigen hohlkoerpern aus thermoplasten |
| US4342184A (en) * | 1972-09-29 | 1982-08-03 | Eck William F Van | Method of manufacture of hypodermic syringe |
| US4155974A (en) * | 1975-12-17 | 1979-05-22 | Valyi Emery I | Method for making oriented hollow plastic articles |
| AU537385B2 (en) * | 1979-07-19 | 1984-06-21 | Yoshino Kogyosho Co., Ltd. | Moulding elongated parison with integral plug |
| US5674242A (en) * | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
| CN1153102A (zh) * | 1995-09-29 | 1997-07-02 | 株式会社青木固研究所 | 注射拉伸吹塑成型方法 |
| JPH0994872A (ja) * | 1995-09-29 | 1997-04-08 | Aokiko Kenkyusho:Kk | 射出延伸吹込成形方法 |
| US6682690B2 (en) * | 2001-02-01 | 2004-01-27 | Schmalbach-Lubreca Ag | Core rod positioning method |
| US20060020330A1 (en) | 2004-07-26 | 2006-01-26 | Bin Huang | Method of fabricating an implantable medical device with biaxially oriented polymers |
| US8501079B2 (en) * | 2009-09-14 | 2013-08-06 | Abbott Cardiovascular Systems Inc. | Controlling crystalline morphology of a bioabsorbable stent |
| US20110066222A1 (en) | 2009-09-11 | 2011-03-17 | Yunbing Wang | Polymeric Stent and Method of Making Same |
| US8043553B1 (en) * | 2004-09-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article |
| US7622070B2 (en) | 2005-06-20 | 2009-11-24 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing an implantable polymeric medical device |
| US7476245B2 (en) | 2005-08-16 | 2009-01-13 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| US20070290412A1 (en) * | 2006-06-19 | 2007-12-20 | John Capek | Fabricating a stent with selected properties in the radial and axial directions |
| US20080001330A1 (en) | 2006-06-28 | 2008-01-03 | Bin Huang | Fabricating polymer stents with injection molding |
| GB0701210D0 (en) | 2007-01-23 | 2007-02-28 | Leafgreen Ltd | Moulding apparatus and method |
| US8002817B2 (en) | 2007-05-04 | 2011-08-23 | Abbott Cardiovascular Systems Inc. | Stents with high radial strength and methods of manufacturing same |
| US7766953B2 (en) * | 2007-05-16 | 2010-08-03 | Med Institute, Inc. | Deployment system for an expandable stent |
| US7666342B2 (en) | 2007-06-29 | 2010-02-23 | Abbott Cardiovascular Systems Inc. | Method of manufacturing a stent from a polymer tube |
| US8337739B2 (en) * | 2008-08-12 | 2012-12-25 | Abbott Cardiovascular Systems Inc. | Improving fracture toughness of medical devices with a stereocomplex nucleating agent |
-
2011
- 2011-05-24 US US13/114,941 patent/US8747728B2/en not_active Expired - Fee Related
-
2012
- 2012-05-23 JP JP2014512076A patent/JP6058641B2/ja not_active Expired - Fee Related
- 2012-05-23 EP EP12725238.5A patent/EP2714369B1/en not_active Not-in-force
- 2012-05-23 CN CN201280031685.5A patent/CN103619562B/zh active Active
- 2012-05-23 WO PCT/US2012/039164 patent/WO2012162402A1/en not_active Ceased
-
2014
- 2014-05-02 US US14/268,396 patent/US20140239558A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014518793A (ja) | 2014-08-07 |
| EP2714369B1 (en) | 2017-11-22 |
| US8747728B2 (en) | 2014-06-10 |
| WO2012162402A1 (en) | 2012-11-29 |
| CN103619562A (zh) | 2014-03-05 |
| CN103619562B (zh) | 2016-08-31 |
| US20120299226A1 (en) | 2012-11-29 |
| US20140239558A1 (en) | 2014-08-28 |
| EP2714369A1 (en) | 2014-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6058641B2 (ja) | 射出成形および吹込成形によりポリマー体内補綴物を製造するための方法およびシステム | |
| US7875233B2 (en) | Method of fabricating a biaxially oriented implantable medical device | |
| US9522503B2 (en) | Methods of treatment with stents with enhanced fracture toughness | |
| US9211682B2 (en) | Controlling crystalline morphology of a bioabsorbable stent | |
| EP1773566B1 (en) | Method of fabricating an implantable medical device with biaxially oriented polymers | |
| EP2429601B1 (en) | Fabricating an implantable medical device from an amorphous or very low crystallinity polymer construct | |
| US8394317B2 (en) | Method of improving fracture toughness of implantable medical devices through annealing | |
| CN103732189B (zh) | 制造具有用于增强再内皮化的具沟槽腔表面的生物可吸收且耐久的支架的方法 | |
| US20110169197A1 (en) | Fabricating Polymer Stents with Injection Molding | |
| WO2007149457A1 (en) | Fabricating a stent with selected properties in the radial and axial directions | |
| CN103476365A (zh) | 用于制造压溃可恢复聚合物支架的方法 | |
| CN105188618A (zh) | 具有增强的轴向疲劳特性的聚合物支架 | |
| AU2014307027B2 (en) | Bioresorbable scaffold for treatment of bifurcation lesion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20141222 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20150105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150518 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150518 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20160129 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160216 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20161108 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20161207 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6058641 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |