JP6058532B2 - エンドセリン−1産生抑制用組成物、及び細胞増殖促進用組成物 - Google Patents
エンドセリン−1産生抑制用組成物、及び細胞増殖促進用組成物 Download PDFInfo
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- JP6058532B2 JP6058532B2 JP2013512433A JP2013512433A JP6058532B2 JP 6058532 B2 JP6058532 B2 JP 6058532B2 JP 2013512433 A JP2013512433 A JP 2013512433A JP 2013512433 A JP2013512433 A JP 2013512433A JP 6058532 B2 JP6058532 B2 JP 6058532B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
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JP2011099839 | 2011-04-27 | ||
JP2011099839 | 2011-04-27 | ||
PCT/JP2012/061235 WO2012147861A1 (fr) | 2011-04-27 | 2012-04-26 | Composition pour inhibition de la production d'endosérine-1 et composition pour promotion de la prolifération cellulaire |
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JPWO2012147861A1 JPWO2012147861A1 (ja) | 2014-07-28 |
JP6058532B2 true JP6058532B2 (ja) | 2017-01-11 |
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JP2013512433A Active JP6058532B2 (ja) | 2011-04-27 | 2012-04-26 | エンドセリン−1産生抑制用組成物、及び細胞増殖促進用組成物 |
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JP (1) | JP6058532B2 (fr) |
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KR20150049417A (ko) * | 2013-10-30 | 2015-05-08 | 주식회사 엘지생활건강 | 하르파고사이드를 포함하는 피부 재생, 주름 개선, 항산화, 항염증 및 피부 미백용 조성물 |
JP6508876B2 (ja) * | 2014-02-25 | 2019-05-08 | 株式会社ノエビア | 皮膚外用剤 |
JP6403487B2 (ja) * | 2014-08-12 | 2018-10-10 | ロート製薬株式会社 | 外用剤 |
KR102356451B1 (ko) * | 2014-08-13 | 2022-01-26 | 주식회사 엘지생활건강 | 샨즈히시드 메틸에스터 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백, 탄력, 주름개선, 또는 보습용 화장료 또는 약학 조성물 |
JP2016088882A (ja) * | 2014-11-04 | 2016-05-23 | ロート製薬株式会社 | 外用剤 |
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JP2016204307A (ja) * | 2015-04-22 | 2016-12-08 | ロート製薬株式会社 | 皮膚外用組成物、着色抑制剤および着色抑制方法 |
EP3338761A1 (fr) * | 2016-12-20 | 2018-06-27 | DSM IP Assets B.V. | Compositions cosmétiques |
FR3062794B1 (fr) * | 2017-02-14 | 2021-11-26 | Sokhna Racky Ba | Procede de traitement cosmetique ternaire destine au sevrage progressif des peaux ayant subit une depigmentation volontaire tout en prevenant et corrigeant les signes du vieillissement. |
WO2022136067A1 (fr) * | 2020-12-23 | 2022-06-30 | Workforce Biologics Ltd | Formulation comprenant du p-menthane-3,8-diol |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003514839A (ja) * | 1999-11-26 | 2003-04-22 | エルブイエムエイチ レシェルシェ | アジュガトルケスタニカ抽出物およびその化粧品用途 |
US20050271608A1 (en) * | 2004-06-05 | 2005-12-08 | Gupta Shyam K | Skin whitening compositions based on hydroxyaryl alkyl ketones and their isosteric derivatives |
JP2005343803A (ja) * | 2004-06-01 | 2005-12-15 | Ichimaru Pharcos Co Ltd | 美白剤 |
US20060074108A1 (en) * | 2004-10-04 | 2006-04-06 | Bioderm Research | Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition |
JP2009209063A (ja) * | 2008-03-03 | 2009-09-17 | Univ Kinki | 皮膚外用剤または皮膚化粧料 |
WO2010030000A1 (fr) * | 2008-09-12 | 2010-03-18 | 学校法人 日本大学 | Agent de blanchiment de la peau et préparation cutanée externe pour le blanchiment de la peau |
-
2012
- 2012-04-26 JP JP2013512433A patent/JP6058532B2/ja active Active
- 2012-04-26 WO PCT/JP2012/061235 patent/WO2012147861A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003514839A (ja) * | 1999-11-26 | 2003-04-22 | エルブイエムエイチ レシェルシェ | アジュガトルケスタニカ抽出物およびその化粧品用途 |
JP2005343803A (ja) * | 2004-06-01 | 2005-12-15 | Ichimaru Pharcos Co Ltd | 美白剤 |
US20050271608A1 (en) * | 2004-06-05 | 2005-12-08 | Gupta Shyam K | Skin whitening compositions based on hydroxyaryl alkyl ketones and their isosteric derivatives |
US20060074108A1 (en) * | 2004-10-04 | 2006-04-06 | Bioderm Research | Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition |
JP2009209063A (ja) * | 2008-03-03 | 2009-09-17 | Univ Kinki | 皮膚外用剤または皮膚化粧料 |
WO2010030000A1 (fr) * | 2008-09-12 | 2010-03-18 | 学校法人 日本大学 | Agent de blanchiment de la peau et préparation cutanée externe pour le blanchiment de la peau |
Non-Patent Citations (6)
Title |
---|
JPN6012037812; 沢辺昭義 他: '美に挑む!植物性化粧品原料' Foods & Food Ingredients J. Jpn. Vol.213, No.10, 2008, p.897-909 * |
JPN6012037813; 正木仁: 'チロシナーゼ活性測定法および美白効果評価法' FRAGRANCE JOURNAL 臨時増刊,No.18, 2003, p.35-41 * |
JPN6012037814; 八谷輝: 'エンドセリンとSCFからみたシミの生成メカニズム研究' FRAGRANCE JOURNAL 臨時増刊,No.18, 2003, p.9-15 * |
JPN6012037815; LI, Y. et al.: 'Improvement in the Turnover Rate of the Stratum Corneum in False Aged Model Rats by the Administrati' Biol. Pharm. Bull. Vol.22, No.6, 1999, p.582-585 * |
JPN6012037816; HOUGHTON, P. J. et al.: 'Buddleja and Wound Healing' SOFW-Journal Vol.123, No.1, 1997, p.40-43 * |
JPN6012037817; HO, J. N.: 'Protective Effects of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Oxidative Stress i' Biol. Pharm. Bull. Vol.28, No.7, 2005, p.1244-1248 * |
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