JP6051480B1 - Aqueous fungicide composition based on povidone iodine - Google Patents
Aqueous fungicide composition based on povidone iodine Download PDFInfo
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- JP6051480B1 JP6051480B1 JP2016023122A JP2016023122A JP6051480B1 JP 6051480 B1 JP6051480 B1 JP 6051480B1 JP 2016023122 A JP2016023122 A JP 2016023122A JP 2016023122 A JP2016023122 A JP 2016023122A JP 6051480 B1 JP6051480 B1 JP 6051480B1
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 229920000153 Povidone-iodine Polymers 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 229960001621 povidone-iodine Drugs 0.000 title claims abstract description 37
- 230000000855 fungicidal effect Effects 0.000 title claims description 7
- 239000000417 fungicide Substances 0.000 title claims description 6
- 239000004088 foaming agent Substances 0.000 claims abstract description 23
- 239000003381 stabilizer Substances 0.000 claims abstract description 21
- 239000006260 foam Substances 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- -1 polyoxyethylene lauryl ether sodium sulfate Polymers 0.000 claims abstract description 15
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims abstract description 14
- 239000000645 desinfectant Substances 0.000 claims abstract description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 11
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 10
- 238000005187 foaming Methods 0.000 claims description 8
- 238000013329 compounding Methods 0.000 claims description 2
- 230000002070 germicidal effect Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 23
- 239000007864 aqueous solution Substances 0.000 abstract description 11
- 239000000243 solution Substances 0.000 abstract description 9
- 230000001590 oxidative effect Effects 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000003899 bactericide agent Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229940031957 lauric acid diethanolamide Drugs 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
【目的】 比較的安価な界面活性剤であって、ポビドンヨードの強い酸化力に対して、化学的に安定な界面活性剤を用いて、ポビドンヨードの水溶液の、持続性のある安定な気泡を発生せしめることができる殺菌剤組成物を提供する。【構成】ポビドンヨード水溶液に界面活性剤として、ジオクチルソジウムスルホサクシネート、ポリオキシエチレンラウリルエーテル硫酸ナトリウム或いはラウリル硫酸ナトリウムを配合したポビドンヨードを主成分とする殺菌剤組成物において、ポビドンヨードの濃度が５〜１０Ｗ／Ｖ％であり、起泡剤として、ポリオキシエチレンラウリルエーテル硫酸ナトリウム又はラウリル硫酸ナトリウム用い、気泡の安定化剤として、ジオクチルソジウムスルホサクシネートを用い、該起泡剤の濃度が０．５〜１０Ｗ／Ｖ％であり、該安定化剤の濃度が０．０２〜３Ｗ／Ｖ％であり、該全組成物中の該起泡剤と許該安定化剤の合計含有量が０．５〜１０Ｗ／Ｖ％であることを特徴とする、安定した気泡を生ずるポビドンヨードを主成分とする水溶液殺菌剤組成物。【選択図】なし[Purpose] A relatively inexpensive surfactant that generates a stable and stable bubble in an aqueous solution of povidone iodine using a chemically stable surfactant against the strong oxidizing power of povidone iodine. Disinfectant compositions that can be provided are provided. [Composition] In a bactericidal composition mainly composed of povidone iodine containing dioctyl sodium sulfosuccinate, polyoxyethylene lauryl ether sodium sulfate or sodium lauryl sulfate as a surfactant in an aqueous povidone iodine solution, the concentration of povidone iodine is 5 to 5 10 W / V%, polyoxyethylene lauryl ether sodium sulfate or sodium lauryl sulfate was used as the foaming agent, dioctylsodium sulfosuccinate was used as the foam stabilizer, and the concentration of the foaming agent was 0.00. 5 to 10 W / V%, the stabilizer concentration is 0.02 to 3 W / V%, and the total content of the foaming agent and the allowed stabilizer in the total composition is 0.00. An aqueous solution mainly composed of povidone iodine that produces stable bubbles, characterized by being 5 to 10 W / V% Bacterial composition. [Selection figure] None
Description
本発明は、ポピドンヨードを主成分とする水溶液殺菌剤組成物に関する。 The present invention relates to an aqueous disinfectant composition containing popidone iodine as a main component.
ポビドンヨードを主成分とする水溶液は、殺菌作用が強く、殺菌剤として、広く使用されている。そのポビドンヨード水溶液に、ジオクチルソジウムスルホサクシネート、ポリオキシエチレンラウリルエーテル硫酸ナトリウム或いはラウリル硫酸ナトリウム等のアニオン界面活性剤を配合することにより、その殺菌剤組成物の殺菌力が向上することが開示されている（特許文献１）。 An aqueous solution containing povidone iodine as a main component has a strong bactericidal action and is widely used as a bactericidal agent. It is disclosed that by adding an anionic surfactant such as dioctylsodium sulfosuccinate, sodium polyoxyethylene lauryl ether sulfate or sodium lauryl sulfate to the povidone iodine aqueous solution, the bactericidal power of the bactericidal composition is improved. (Patent Document 1).
ポビドンヨードを主成分とする殺菌剤は褐色の含ヨード水溶液であり、これを使用する際に、薬液が飛散して、衣服等に付着すると褐色の染みとなり、その洗浄に手数を要する。また手指の消毒の際、液垂れが生ずると、薬液が無駄となる。 A bactericidal agent containing povidone iodine as a main component is a brown iodine-containing aqueous solution. When this is used, the chemical solution is scattered and becomes brown stains when it adheres to clothes and the like, which requires a lot of washing. In addition, when liquid sagging occurs during finger disinfection, the chemical solution is wasted.
その解決策として、ポビドンヨードを含有する殺菌剤組成物にアンモニウム塩の硫酸エステル型界面活性剤を配合することにより、ポビドンヨードの殺菌力を増強すると共に、安定した持続性のある泡を形成することができ、殺菌剤を使用する際に、薬液を起泡式ポンプを有する容器より、薬液の気泡として吐出せしめると、薬液の飛散と液垂れを防止することができ、その使用が極めて容易となること、更にこれにラウリル酸ジエタノールアミド等の非イオン性界面活性剤を添加することにより、気泡の安定性が増すことが開示されている（特許文献２）。 As a solution to this, by adding a sulfate ester type surfactant of ammonium salt to a bactericidal composition containing povidone iodine, it is possible to enhance the bactericidal power of povidone iodine and to form a stable and sustainable foam. When using a bactericidal agent, if the chemical solution is discharged as a bubble of the chemical solution from a container having a foaming pump, the chemical solution can be prevented from scattering and dripping, and its use becomes extremely easy. Furthermore, it is disclosed that the stability of bubbles is increased by adding a nonionic surfactant such as lauric acid diethanolamide (Patent Document 2).
ポビドンヨードは強い殺菌力を有するが、一方、極めて強い酸化力を有し、その酸化力によっても、酸化・分解されない化学的安定性を有する界面活性剤でなければ、ポビドンヨードの殺菌力増強用界面活性剤及び気泡発生用の界面活性剤として使用することはできない。上記特許文献２の発明は、ポビドンヨードにより分解されることのない、化学的に安定な界面活性剤を、ポビドンヨードの殺菌力増強剤及び気泡発生剤として用いる方法を開示するが、高価な界面活性剤を使用する必要がある。 Povidone iodine has a strong bactericidal power, but on the other hand, it has a very strong oxidizing power, and if it is not a surfactant that has chemical stability that is not oxidized or decomposed by its oxidizing power, the surface activity for enhancing bactericidal power of povidone iodine It cannot be used as an agent or a surfactant for generating bubbles. The invention of Patent Document 2 discloses a method of using a chemically stable surfactant that is not decomposed by povidone iodine as a bactericidal power enhancer and a bubble generating agent for povidone iodine. Need to use.
また、上記特許文献１で用いられている界面活性剤は、ポビドンヨードに対して安定であり、殺菌力の増強の効果はあるが、充分安定した気泡を発生するこはできなかった。 Further, the surfactant used in Patent Document 1 is stable against povidone iodine and has an effect of enhancing the bactericidal power, but has not been able to generate sufficiently stable bubbles.
したがって、本発明は、比較的安価な界面活性剤であって、ポビドンヨードの強い酸化力に対して、化学的に安定な界面活性剤を用いて、ポビドンヨードの水溶液の、持続性のある安定な気泡を発生せしめることができる殺菌剤組成物を提供することを目的とする。 Therefore, the present invention is a relatively inexpensive surfactant, which uses a surfactant that is chemically stable against the strong oxidizing power of povidone iodine, and maintains a stable and stable air bubble in an aqueous solution of povidone iodine. An object of the present invention is to provide a bactericidal composition capable of generating odor.
上記目的を達成すべく、本発明者らは鋭意研究を重ねた結果、従来からポビドンヨードの殺菌力を増すために使用されている、ポビドンヨードに対して化学的に安定な界面活性剤を用い、その選択と配合の割合を工夫することにより、極めて安定した持続性のある気泡をポビドンヨード水溶液に発生せしめることができることを見出し、本発明を完成するに至った。 In order to achieve the above object, as a result of intensive studies, the present inventors have used a surface active agent that is chemically stable to povidone iodine, which has been used to increase the bactericidal power of povidone iodine. By devising the ratio of selection and blending, it was found that extremely stable and persistent bubbles can be generated in the aqueous povidone iodine solution, and the present invention has been completed.
即ち、本発明はポビドンヨード水溶液に界面活性剤として、ジオクチルソジウムスルホサクシネート、ポリオキシエチレンラウリルエーテル硫酸ナトリウム或いはラウリル硫酸ナトリウムを配合したボビドンヨードを主成分とする殺菌剤組成物において、ポビドンヨードの濃度が５〜１０Ｗ／Ｖ％であり、起泡剤として、ポリオキシエチレンラウリルエーテル硫酸ナトリウム又はラウリル硫酸ナトリウム用い、気泡の安定化剤として、ジオクチルソジウムスルホサクシネートを用い、該起泡剤の濃度が０．５〜１０Ｗ／Ｖ％であり、該安定化剤の濃度が０．０２〜３Ｗ／Ｖ％であり、該全組成物中の該起泡剤と該安定化剤の合計含有量が０．５〜１０Ｗ／Ｖ％であり、該起泡剤と該安定化剤の配合比が１：１〜５０：１であることを特徴とする、安定した気泡を生ずるポビドンヨードを主成分とする水溶液殺菌剤組成物を要旨とする。That is, the present invention relates to a bactericidal composition mainly composed of bovidone iodine containing dioctyl sodium sulfosuccinate, polyoxyethylene sodium lauryl ether sodium sulfate or sodium lauryl sulfate as a surfactant in a povidone iodine aqueous solution, and the concentration of povidone iodine is 5-10 W / V%, using polyoxyethylene lauryl ether sodium sulfate or sodium lauryl sulfate as a foaming agent, using dioctylsodium sulfosuccinate as a foam stabilizer, and the concentration of the foaming agent is 0.5 to 10 W / V%, the stabilizer concentration is 0.02 to 3 W / V%, and the total content of the foaming agent and the stabilizer in the total composition is 0. .5~10W / V% der is, the compounding ratio of the standing-foaming agent and the stabilizing agent is 1: 1 to 50: to wherein 1 der Rukoto , The gist of the aqueous disinfectant compositions based on povidone-iodine to produce a stable foam.
本発明のポビドンヨード水溶液を主成分とする殺菌剤組成物によれば、比較的安価な界面活性剤を用いて、ポビドンヨードの水溶液の殺菌剤力を増強すると共に、持続性のある安定な気泡を発生せしめることができ、殺菌剤の薬液の飛散や液垂れのない、使いやすい殺菌剤組成物を提供することができる。 According to the disinfectant composition comprising the aqueous povidone iodine solution of the present invention as a main component, a relatively inexpensive surfactant is used to enhance the disinfectant power of the aqueous solution of povidone iodine and to generate stable and stable bubbles. Thus, it is possible to provide an easy-to-use bactericidal composition that is free from splashing and dripping of the bactericide.
本発明の殺菌剤組成物の水溶液中のポビドンヨードの含有量は５〜１０Ｗ／Ｖ％が好ましく用いられる。 The content of povidone iodine in the aqueous solution of the fungicide composition of the present invention is preferably 5 to 10 W / V%.
本発明の殺菌剤組成物に用いられる界面活性剤としては、起泡剤として、ポリオキシエチレンラウリルエーテル硫酸ナトリウム又はラウリル硫酸ナトリウムが用いられ、気泡の安定化剤としてジオクチルソジウムスルホサクシネートが用いられる。
これらの界面活性剤はポビドンヨード水溶液の殺菌力を増強するための界面活性剤としても作用する。As the surfactant used in the disinfectant composition of the present invention, polyoxyethylene lauryl ether sodium sulfate or sodium lauryl sulfate is used as a foaming agent, and dioctyl sodium sulfosuccinate is used as a foam stabilizer. It is done.
These surfactants also act as surfactants for enhancing the bactericidal power of povidone iodine aqueous solution.
本発明の殺菌剤組成物中の起泡剤の濃度は、０．５〜１０Ｗ／Ｖ％が用いられ、好ましくは１〜８Ｗ／Ｖ％、更に好ましくは１〜５Ｗ／Ｖ％が用いられる。 The concentration of the foaming agent in the fungicide composition of the present invention is 0.5 to 10 W / V%, preferably 1 to 8 W / V%, more preferably 1 to 5 W / V%.
本発明の殺菌剤組成物中の安定化剤の濃度は、０．０２〜３Ｗ／Ｖ％が用いられ、好ましくは０．１〜２．５Ｗ／Ｖ％、更に好ましくは０．５〜２Ｗ／Ｖ％が用いられる。 The concentration of the stabilizer in the fungicide composition of the present invention is 0.02 to 3 W / V%, preferably 0.1 to 2.5 W / V%, more preferably 0.5 to 2 W / V. V% is used.
上記起泡剤と気泡の安定化剤の配合重量比は、１：１〜５０：１が用いられ、１：１〜２５：１が好ましく用いられ、１：１〜５：１が更に好ましく用いられる。重量比が５０：１を超えると、殺菌剤組成物の気泡の安定性が損われる。The blending weight ratio of the foaming agent and the foam stabilizer is 1: 1 to 50: 1, preferably 1 : 1 to 25 : 1, and more preferably 1: 1 to 5: 1. It is done. When the weight ratio exceeds 50: 1, the stability of the air bubbles of the disinfectant composition is impaired.
本発明の殺菌剤組成物中の起泡剤と気泡の安定化剤の配合量は、両者の合計含有量が、０．５〜１０Ｗ／Ｖ％となるように配合され、１〜６Ｗ／Ｖ％が更に好ましい。合計含有量が０．５Ｗ／Ｖ％未満では、殺菌剤組成物の殺菌力が低下する。 The blending amount of the foaming agent and the foam stabilizer in the fungicide composition of the present invention is blended so that the total content of both is 0.5 to 10 W / V%, and 1 to 6 W / V % Is more preferable. When the total content is less than 0.5 W / V%, the bactericidal power of the bactericidal composition is lowered.
本発明の殺菌剤組成物中には、ポビドンヨード水溶液を主成分とする殺菌剤組成物に通常用いられる、公知のｐＨ調整剤、粘度調整剤、溶剤、香料その他の添加剤を必要に応じて配合することができる。 In the bactericidal composition of the present invention, known pH adjusting agents, viscosity adjusting agents, solvents, fragrances and other additives usually used in bactericidal compositions mainly composed of povidone iodine aqueous solution are blended as necessary. can do.
本発明の殺菌剤組成物に用いられる容器は、液状物を収容して、ポンプのレバーを押し下げることにより、内容液を泡状に吐出する公知のメッシュ又は多孔質フィルターを備えた起泡ポンプ式容器が用いられる。 The container used for the disinfectant composition of the present invention is a foaming pump type equipped with a known mesh or porous filter that contains liquid material and discharges the liquid in foam form by pushing down the lever of the pump. A container is used.
以下に実施例により、更に本発明を具体的に、詳細に説明するが、本発明はこれらの実施例に限定されるものではない。 The present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples.
〔実施例１〕
ポビドンヨード７．５Ｗ／Ｖ％、ポリオキシエチレンラウリルエーテル硫酸ナトリウム０．５Ｗ／Ｖ％、ジオクチルソジウムスルホサクシネート０．５Ｗ／Ｖ％、その他の添加物を表１に示すとおり配合してなるポピドンヨードを主成分とする水溶液殺菌剤組成物を調製し、その殺菌剤組成物について、起泡力、気泡の安定度および液垂れ時間を次の方法により測定した。その結果を表１に示す。[Example 1]
Povidone iodine 7.5 W / V%, polyoxyethylene lauryl ether sodium sulfate 0.5 W / V%, dioctylsodium sulfosuccinate 0.5 W / V%, and other additives as shown in Table 1 An aqueous disinfectant composition containing as a main component was prepared, and the foaming power, bubble stability and dripping time of the disinfectant composition were measured by the following methods. The results are shown in Table 1.
ここで、起泡力及び気泡の安定度は、ＪＩＳ Ｋ ３３６２ ８．５の起泡力及び泡の安定度測定法に準じて、以下の方法により測定した。
即ち、下部にガラスコックを有する内側断面積２０ｃｍ２のガラス管の下部に、５０ｍｌの試料液をガラス管の内面を潤しながら泡の生じないように流し込み、立設したそのガラス管の下部の液面の上方９００ｍｍの高さより、２００ｍｌの試料液を、３０秒間かけて、下部の液面の中心に滴下して、液面上に生じた泡の高さ（ｍｍ）を測定して起泡力とし、その５分後の泡の高さ（ｍｍ）を測定し、最初の泡の高さに対する割合（％）を泡の安定度とした。この操作を数回行い、その測定値の平均値を求めた。すべての測定は２５℃で行った。殺菌剤組成物を使い易くするためには、安定度は５０％以上が望ましい。Here, the foaming force and the stability of bubbles were measured by the following methods according to the foaming force and foam stability measurement method of JIS K 3362 8.5.
That is, 50 ml of sample liquid was poured into the lower part of a glass tube having an inner cross-sectional area of 20 cm 2 having a glass cock at the lower part so as not to generate bubbles while moistening the inner surface of the glass tube. From the height of 900 mm above the surface, 200 ml of sample liquid is dropped on the center of the lower liquid surface over 30 seconds, and the foam height is measured by measuring the height (mm) of the bubble generated on the liquid surface. The foam height (mm) after 5 minutes was measured, and the ratio (%) to the initial foam height was defined as the foam stability. This operation was performed several times, and the average value of the measured values was obtained. All measurements were performed at 25 ° C. In order to facilitate the use of the disinfectant composition, the stability is desirably 50% or more.
液垂れ試験は、試料を多孔質フィルターを備えた起泡ポンプ式容器に充填し、そのポンプを手で１回押し下げ、吐出した約１ｇの泡を、日本薬局方ふるい番号１８号（８５０μｍ）の篩上に載置し、篩上の泡が壊れて、液滴が最初に滴下するまでの時間を測定し、泡の液垂れ時間とした。殺菌剤組成物の使用の際の使い易さを高めるためには、上記方法で測定した液垂れ時間が５分以上が望ましい。 In the dripping test, the sample was filled into a foaming pump type container equipped with a porous filter, the pump was pushed down once by hand, and about 1 g of the discharged foam was passed through the Japanese Pharmacopoeia Sieve No. 18 (850 μm). It was placed on the sieve, the time until the foam on the sieve broke and the liquid droplets dropped for the first time was measured, and was defined as the foam dripping time. In order to improve the ease of use when using the bactericide composition, the dripping time measured by the above method is preferably 5 minutes or more.
更に、試料を多孔質フィルターを備えた起泡ポンプ式容器に充填し、そのポンプを１回押し下げて、吐出した泡を観察し、表１に、○：均一で滑らかな泡、△：泡にはなるが、不均一な泡、×：泡にならない、として観察結果を記載した。 Furthermore, the sample was filled into a foaming pump type container equipped with a porous filter, the pump was pushed down once, and the discharged foam was observed. In Table 1, ○: uniform and smooth foam, Δ: foam Although observed, the observation results are described as non-uniform bubbles, x: no bubbles.
〔実施例２〜６〕
実施例１において、起泡剤、ポリオキシエチレンラウリルエーテル硫酸ナトリウムと、安定化剤、ジオクチルソジウムスルホサクシネートの配合量を変えて試験を行い、同様にその殺菌剤組成物について、起泡力、気泡の安定度および液垂れ時間を測定し、生じた泡を観察した結果を、実施例２〜６として表１に示す。[Examples 2 to 6]
In Example 1, the test was performed by changing the blending amount of the foaming agent, sodium polyoxyethylene lauryl ether sulfate, the stabilizer, and dioctylsodium sulfosuccinate. Table 1 shows the results of measuring the stability of the bubbles and the dripping time and observing the resulting bubbles as Examples 2 to 6.
〔比較例１〕
実施例１において、起泡剤、ポリオキシエチレンラウリルエーテル硫酸ナトリウムの配合量を０．５Ｗ／Ｖ％として、本発明の範囲外とした場合の試験結果を、比較例１として表１に示す。[Comparative Example 1]
In Example 1, Table 1 shows the test results as Comparative Example 1 when the blending amount of the foaming agent and sodium polyoxyethylene lauryl ether sulfate is 0.5 W / V% and out of the scope of the present invention.
〔比較例２〕
実施例１において、起泡剤、ポリオキシエチレンラウリルエーテル硫酸ナトリウムのみを配合し、安定化剤、ジオクチルソジウムスルホサクシネートを配合しないものについて、同様に試験をした結果を比較例２として、表２に示す。[Comparative Example 2]
In Example 1, a foaming agent and polyoxyethylene lauryl ether sodium sulfate alone were blended, and a stabilizer and dioctyl sodium sulfosuccinate were not blended. It is shown in 2.
〔比較例３〕
実施例１において、起泡剤として、ポリオキシエチレンラウリルエーテル硫酸ナトリウムの代わりに、ラウリル硫酸ナトリウムを用い、安定化剤、ジオクチルソジウムスルホサクシネートを配合しないものについて、同様に試験をした結果を、比較例３として、表２に示す。[Comparative Example 3]
In Example 1, as a foaming agent, instead of polyoxyethylene lauryl ether sodium sulfate, sodium lauryl sulfate was used, and a stabilizer and dioctyl sodium sulfosuccinate were not blended. As Comparative Example 3, it is shown in Table 2.
〔比較例４〕
実施例１において、起泡剤、ポリオキシエチレンラウリルエーテル硫酸ナトリウムを配合せず、安定化剤、ジオクチルソジウムスルホサクシネートのみを配合したものをについて、同様に試験をした結果を比較例４として表２に示す。[Comparative Example 4]
In Example 1, a foaming agent and polyoxyethylene lauryl ether sodium sulfate were not blended, and only a stabilizer and dioctyl sodium sulfosuccinate were blended. It shows in Table 2.
〔実施例７〜１３〕
実施例１において、起泡剤としてラウリル硫酸ナトリウムを用い、起泡剤と安定化剤の配合量を変えて、同様に試験をした結果を、実施例７〜１３として、表３に示す。[Examples 7 to 13]
In Example 1, sodium lauryl sulfate was used as the foaming agent, and the results of the same test were performed with the blending amounts of the foaming agent and the stabilizer varied, and Examples 7 to 13 are shown in Table 3.
〔比較例５及び６〕
実施例７において、起泡剤、ラウリル硫酸ナトリウムと、安定化剤、ジオクチルソジウムスルホサクシネートの配合比を変えて、本発明の範囲外とした場合の試験結果を、比較例５及び６として、表４に示す。[Comparative Examples 5 and 6]
In Example 7, the test results when the blending ratio of the foaming agent, sodium lauryl sulfate, the stabilizer, and dioctyl sodium sulfosuccinate were changed to be out of the scope of the present invention were shown as Comparative Examples 5 and 6. Table 4 shows.
ポピドンヨードを主成分とする殺菌剤組成物は殺菌剤として広く使用されており、本発明により、比較的安価な界面活性剤を用いて、使いやすい殺菌剤組成物を得ることができ、産業上広く利用することができる。 A bactericidal composition based on popidone iodine is widely used as a bactericidal agent, and according to the present invention, a bactericidal composition that is easy to use can be obtained using a relatively inexpensive surfactant. Can be used.
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| JPH01153644A (en) * | 1987-12-10 | 1989-06-15 | Meiji Seika Kaisha Ltd | Germicidal composition |
| CN101032470A (en) * | 2007-04-21 | 2007-09-12 | 郑起平 | Povidone-iodine bubble agent and preparing method |
| JP2009132694A (en) * | 2007-10-31 | 2009-06-18 | Meiji Seika Kaisha Ltd | Foam stabilizer composition |
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| JPH01153644A (en) * | 1987-12-10 | 1989-06-15 | Meiji Seika Kaisha Ltd | Germicidal composition |
| CN101032470A (en) * | 2007-04-21 | 2007-09-12 | 郑起平 | Povidone-iodine bubble agent and preparing method |
| JP2009132694A (en) * | 2007-10-31 | 2009-06-18 | Meiji Seika Kaisha Ltd | Foam stabilizer composition |
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