JP6028025B2 - オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定 - Google Patents

オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定 Download PDF

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JP6028025B2
JP6028025B2 JP2014518468A JP2014518468A JP6028025B2 JP 6028025 B2 JP6028025 B2 JP 6028025B2 JP 2014518468 A JP2014518468 A JP 2014518468A JP 2014518468 A JP2014518468 A JP 2014518468A JP 6028025 B2 JP6028025 B2 JP 6028025B2
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ミハエル・ヨセフス・テレジア・ファン・エイジク
ルネ・コルネリス・ヨセフス・ホガース
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キージーン・エン・フェー
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2014518468A 2011-07-08 2012-07-09 オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定 Active JP6028025B2 (ja)

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US201161505787P 2011-07-08 2011-07-08
US61/505,787 2011-07-08
PCT/NL2012/050493 WO2013009175A1 (en) 2011-07-08 2012-07-09 Sequence based genotyping based on oligonucleotide ligation assays

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JP2014520525A JP2014520525A (ja) 2014-08-25
JP2014520525A5 JP2014520525A5 (OSRAM) 2015-08-27
JP6028025B2 true JP6028025B2 (ja) 2016-11-16

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US (4) US9777322B2 (OSRAM)
EP (2) EP2980226A1 (OSRAM)
JP (1) JP6028025B2 (OSRAM)
AU (1) AU2012281242B2 (OSRAM)
CA (1) CA2840929C (OSRAM)
DK (1) DK2729580T3 (OSRAM)
ES (1) ES2556580T3 (OSRAM)
WO (1) WO2013009175A1 (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US9777322B2 (en) * 2011-07-08 2017-10-03 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
WO2013192292A1 (en) * 2012-06-21 2013-12-27 Justin Lamb Massively-parallel multiplex locus-specific nucleic acid sequence analysis
JP6234463B2 (ja) * 2012-09-10 2017-11-22 ジーンスカイ ダイアグノスティクス(スーツォウ) インコーポレーテッドGenesky Diagnostics (Suzhou) Inc. 核酸の多重分析の方法
US9270344B2 (en) * 2013-02-01 2016-02-23 Creating Revolutions, LLC Combination process interaction
CN105074007A (zh) * 2013-03-12 2015-11-18 考希尔股份有限公司 用于产前遗传分析的系统和方法
JP6088710B2 (ja) 2013-08-19 2017-03-01 シンギュラー・バイオ・インコーポレイテッド 単分子検出アッセイおよびその使用
JP6442534B2 (ja) * 2014-06-02 2018-12-19 ベース4 イノベーション リミテッド ヌクレオチド多型の検出方法
JP6793112B2 (ja) * 2014-08-01 2020-12-02 アリオサ ダイアグノスティックス インコーポレイテッドAriosa Diagnostics,Inc. 胎児コピー数変異の統計的尤度を提供するアッセイ方法および胎児染色体異数性の尤度決定のためのアッセイ方法
CN104372093B (zh) * 2014-11-10 2016-09-21 博奥生物集团有限公司 一种基于高通量测序的snp检测方法
WO2016134191A1 (en) * 2015-02-18 2016-08-25 Singular Bio, Inc. Assays for single molecule detection and use thereof
GB2536446B (en) * 2015-03-17 2020-06-03 Salisbury Nhs Found Trust PCR method
US10844428B2 (en) * 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
CN106435744B (zh) 2015-08-13 2022-02-01 生捷科技控股公司 使用y-接头和消失限制位点的文库构建
ES2911421T3 (es) 2015-12-08 2022-05-19 Twinstrand Biosciences Inc Adaptadores, métodos y composiciones mejorados para secuenciación dúplex
WO2018127408A1 (en) * 2017-01-05 2018-07-12 Tervisetehnoloogiate Arenduskeskus As Quantifying dna sequences
US10844429B2 (en) 2017-01-18 2020-11-24 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
US11739367B2 (en) 2017-11-08 2023-08-29 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
EP3768853A4 (en) * 2018-03-23 2021-04-28 Board Of Regents The University Of Texas System EFFICIENT SEQUENCING OF DSDNA WITH EXTREMELY LOW ERROR RATE
JP7491576B2 (ja) 2018-06-12 2024-05-28 キージーン ナムローゼ フェンノートシャップ 核酸増幅法
AU2019300172A1 (en) 2018-07-12 2021-01-28 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
JP7602464B2 (ja) * 2019-01-04 2024-12-18 ウィリアム マーシュ ライス ユニバーシティ 多重コピー数変異検出および対立遺伝子比定量化のための定量的アンプリコン配列決定
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
CA3153533A1 (en) * 2019-09-09 2021-03-18 Sherlock Biosciences, Inc. System
WO2021048291A1 (en) * 2019-09-12 2021-03-18 Glaxosmithkline Intellectual Property Development Limited Method for screening libraries
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
US20230348962A1 (en) * 2021-11-04 2023-11-02 Florida State University Research Foundation, Inc. Using Hairpin Formation To Identify DNA and RNA Sequences Having A Target Nucleic Acid Sequence
CN118006735B (zh) * 2023-05-30 2025-07-04 深圳赛陆医疗科技有限公司 一种snp芯片及其制备方法和应用

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
DE68926504T2 (de) 1988-07-20 1996-09-12 David Segev Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
EP0439182B1 (en) 1990-01-26 1996-04-24 Abbott Laboratories Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
RU2182176C2 (ru) 1991-09-24 2002-05-10 Кейгене Н.В. Способ селективной амплификации, олигонуклеотид и набор для селективной амплификации
US5470705A (en) 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
AU684279B2 (en) 1993-04-12 1997-12-11 Northwestern University Method of forming oligonucleotides
US5692223A (en) 1993-10-22 1997-11-25 Minolta Co., Ltd. Remotely-controlled flash photographing system
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US20070269799A9 (en) 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5876924A (en) 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
WO1996015271A1 (en) 1994-11-16 1996-05-23 Abbott Laboratories Multiplex ligations-dependent amplification
SE506908C2 (sv) 1995-09-08 1998-03-02 Ulf Landegren Inst F Medicinsk Medicinsk användning av padlockprober
EP0912761A4 (en) 1996-05-29 2004-06-09 Cornell Res Foundation Inc DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION
US6312892B1 (en) 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
ATE236997T1 (de) 1998-07-21 2003-04-15 Keygene Nv Verbesserte primer zur aflp amplifizierung
ATE309390T1 (de) 1998-07-30 2005-11-15 Solexa Ltd Matrizen von biomolekülen und ihre verwendung in sequenzierung
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
EP1131153A1 (en) 1998-11-06 2001-09-12 Solexa Ltd. A method for reproducing molecular arrays
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
US20020086289A1 (en) 1999-06-15 2002-07-04 Don Straus Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
US6156178A (en) 1999-07-13 2000-12-05 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
EP1130113A1 (en) 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
AU2001265121A1 (en) 2000-05-30 2001-12-11 Applera Corporation Methods for detecting target nucleic acids using coupled ligation and amplification
AU2002231934A1 (en) 2001-01-30 2002-08-12 Solexa Ltd. Arrayed polynucleotides and their use in genome analysis
CA2453207A1 (en) 2001-07-06 2003-01-16 454 Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
GB0119719D0 (en) 2001-08-13 2001-10-03 Solexa Ltd DNA sequence analysis
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
EP1319718A1 (en) 2001-12-14 2003-06-18 Keygene N.V. High throughput analysis and detection of multiple target sequences
DE10162904B4 (de) 2001-12-20 2006-05-11 Jeyes Deutschland Gmbh Vorrichtung zur Abgabe eines flüssigen Wirkstoffs in ein Spülwasser
US20060088826A1 (en) * 2001-12-28 2006-04-27 Van Eijk Michael Josephus Ther Discrimination and detection of target nucleotide sequences using mass spectrometry
EP3438116B1 (en) 2002-08-23 2021-02-17 Illumina Cambridge Limited Labelled nucleotides
JP2006509040A (ja) 2002-08-23 2006-03-16 ソレックサ リミテッド 修飾されたヌクレオチド
EP1567669B1 (en) 2002-12-02 2010-03-24 Illumina Cambridge Limited Determination of methylation of nucleic acid sequences
EP1594980B2 (en) 2003-01-29 2017-08-16 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
GB0304371D0 (en) 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
EP1633888B1 (en) 2003-06-17 2009-03-25 Keygene N.V. Means and method for the detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs
GB0320059D0 (en) 2003-08-27 2003-10-01 Solexa Ltd A method of sequencing
WO2005026389A2 (en) 2003-08-29 2005-03-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ligation-based method of analysis of single nucleotide polymorphisms on genomic dna
DK1664345T3 (da) 2003-09-02 2015-06-22 Keygene Nv OLA-baserede fremgangsmåder til detektion af target-nukleinsyresekvenser
EP1602733A1 (en) 2004-06-02 2005-12-07 Keygene N.V. Detection of target nucleotide sequences using an asymmetric oligonucleotide ligation assay
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
GB0400584D0 (en) 2004-01-12 2004-02-11 Solexa Ltd Nucleic acid chacterisation
GB0400974D0 (en) 2004-01-16 2004-02-18 Solexa Ltd Multiple inexact matching
GB0402895D0 (en) 2004-02-10 2004-03-17 Solexa Ltd Arrayed polynucleotides
US20060211000A1 (en) * 2005-03-21 2006-09-21 Sorge Joseph A Methods, compositions, and kits for detection of microRNA
EP1910537A1 (en) 2005-06-06 2008-04-16 454 Life Sciences Corporation Paired end sequencing
EP2363504A1 (en) * 2005-12-22 2011-09-07 Keygene N.V. Method for high-throughtput AFLP-based polymorphism detection
WO2007101075A2 (en) * 2006-02-22 2007-09-07 Applera Corporation Double-ligation method for haplotype and large-scale polymorphism detection
JP5237126B2 (ja) 2006-03-01 2013-07-17 キージーン ナムローゼ フェンノートシャップ ライゲーションアッセイを用いてハイスループットシークエンスに基づき遺伝子関連配列を検出する方法
EP2677309B9 (en) 2006-12-14 2014-11-19 Life Technologies Corporation Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
EP2307577B1 (en) 2008-06-25 2015-06-03 Life Technologies Corporation Methods for measuring analytes using large scale fet arrays
CN102203597A (zh) 2008-06-26 2011-09-28 生命技术公司 使用fet阵列检测分子相互作用的方法和装置
US20100035252A1 (en) 2008-08-08 2010-02-11 Ion Torrent Systems Incorporated Methods for sequencing individual nucleic acids under tension
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
EP2342552B1 (en) 2008-10-22 2022-09-14 Life Technologies Corporation Floating gate chemical field effect transistor array with bilayer gate dielectric
WO2010126614A2 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2435461B1 (en) 2009-05-29 2017-08-09 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20120077191A1 (en) 2010-08-11 2012-03-29 Celula, Inc. Genotyping dna
AU2012255121B2 (en) 2011-05-17 2017-03-09 Dxterity Diagnostics Incorporated Methods and compositions for detecting target nucleic acids
US9777322B2 (en) * 2011-07-08 2017-10-03 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays

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WO2013009175A1 (en) 2013-01-17
US10988807B2 (en) 2021-04-27
US9777322B2 (en) 2017-10-03
US20200071757A1 (en) 2020-03-05
US11873529B2 (en) 2024-01-16
JP2014520525A (ja) 2014-08-25
US20140221217A1 (en) 2014-08-07
EP2729580B1 (en) 2015-09-16
CA2840929C (en) 2020-03-24
US20210207213A1 (en) 2021-07-08
EP2980226A1 (en) 2016-02-03
AU2012281242B2 (en) 2016-12-22
US10422001B2 (en) 2019-09-24
ES2556580T3 (es) 2016-01-19
DK2729580T3 (en) 2015-12-14
US20180023135A1 (en) 2018-01-25
AU2012281242A1 (en) 2014-02-27
CA2840929A1 (en) 2013-01-17
EP2729580A1 (en) 2014-05-14

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