JP6022140B2 - Aerosol composition - Google Patents

Description

  The present invention relates to aerosol compositions. More specifically, a specific amount of an oil-soluble active ingredient is dissolved in an oil phase containing a specific amount of a lipophilic liquefied gas, forming an aqueous phase and an emulsion. The present invention relates to an aerosol composition capable of adhering to water and maximizing the effect of an active ingredient.

  Conventional aerosol compositions for use on the human body, particularly skin, include sprays, foams, gels, creams, and the like using a liquefied gas such as liquefied petroleum gas or a compressed gas such as nitrogen gas. In these aerosol compositions, active ingredients are blended depending on the purpose, but even if many active ingredients are blended, the effect of the active ingredients is often not proportional to the blending amount.

  For example, Patent Documents 1 and 2 disclose spray-type sunscreen cosmetics that absorb ultraviolet rays to prevent sunburn.

Japanese Patent No. 2627750 JP 2004-224706 A

  However, in the case of the aerosol compositions described in Patent Documents 1 and 2, the SPF value is used as an index of the sunscreen effect, but the SPF value does not increase even if a large amount of UV absorber is added to increase the SPF value. There is a problem that it does not increase in proportion to the amount of blending.

  The present invention has been made in view of the above problems, and the present invention dissolves a specific amount of an oil-soluble active ingredient in an oil phase containing a specific amount of a lipophilic liquefied gas to form an emulsion with an aqueous phase. Accordingly, it is an object of the present invention to provide an aerosol composition that can be applied to a human body with less scattering and allow an active ingredient to be uniformly attached, and exhibiting the effect of the active ingredient to the maximum.

The aerosol composition of the present invention is an aerosol composition for a human body, in which an oil phase containing a lipophilic liquefied gas and an active ingredient and an aqueous phase form an emulsion,
The active ingredient is contained in an aerosol composition in an amount of 1 to 10% by weight,
The lipophilic liquefied gas is an aerosol composition for human body containing 35 to 85% by weight in an aerosol composition.

  The ratio between the active ingredient and the lipophilic liquefied gas is preferably active ingredient / lipophilic liquefied gas (weight ratio) = 1/5 to 1/30.

  The oil-based solvent is preferably contained in an amount of 0.1 to 10% by weight in the aerosol composition.

  The active ingredient is preferably an ultraviolet absorber.

  It is preferred that the aerosol composition is a water-in-oil emulsion.

  The blending amount of the oil phase is preferably 40 to 90% by weight in the aerosol composition, and the blending amount of the aqueous phase is preferably 10 to 60% by weight in the aerosol composition.

  According to the aerosol composition of the present invention, it is possible to provide an aerosol composition capable of uniformly adhering an active ingredient with little scattering when applied to a human body and maximizing the effect of the active ingredient. .

  The aerosol composition of the present invention is an aerosol composition for a human body in which an oil phase containing a lipophilic liquefied gas and an active ingredient and an aqueous phase form an emulsion, and the active ingredient is an aerosol composition. It is contained in 1 to 10% by weight, and the lipophilic liquefied gas is contained in the aerosol composition in an amount of 35 to 85% by weight.

  In the aerosol container, the lipophilic liquefied gas dissolves an active ingredient dissolved in the oil phase (hereinafter referred to as an oil-soluble active ingredient), becomes the main component of the oil phase, and forms an emulsion with the water phase. When the aerosol composition is discharged from the aerosol container to the outside, the oleophilic liquefied gas begins to vaporize, but dissolves together with the oil-soluble active ingredient in the oil phase, and further forms an aqueous phase and an emulsion, so that the entire amount is simultaneously discharged. Even after application on the skin, a part of the liquefied gas remains in the discharge, and the oil-soluble active ingredient dissolved in the oil phase spreads on the skin by the driving force of the liquefied gas. And adheres uniformly.

  Examples of the lipophilic liquefied gas include liquefied gases having a water solubility of 1% by weight or less, such as liquefied petroleum gas which is propane, normal butane, isobutane and a mixture thereof.

  The blending amount of the lipophilic liquefied gas is 35 to 85% by weight, preferably 40 to 80% by weight in the aerosol composition. When the blending amount of the oleophilic liquefied gas is less than 35% by weight, the oil-soluble active ingredient is difficult to adhere uniformly and the effect tends to be insufficient. Tends to decrease, and the effect of the active ingredient tends to be insufficient.

  The oil-soluble active ingredient is effective to adhere to the human body, particularly the skin, for example, ethyl hexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, dimethoxybenzylidene dioxo UV absorption of octyl imidazolidine propionate, hexyl diethylaminohydroxybenzoylbenzoate, t-butylmethoxydibenzoylmethane, ethylhexyltriazone, octocrine, oxybenzone, hydroxybenzophenonesulfonic acid, sodium dihydroxybenzophenonesulfonate, dihydroxybenzophenone, paraaminobenzoic acid, etc. , Pest repellents such as N, N-diethyl-m-toluamide (diet), antioxidants such as α-tocopherol and dibutylhydroxytoluene Vitamins such as retinol and dl-α-tocopherol, anti-inflammatory agents such as glycyrrhetinic acid, antifungal agents such as miconazole nitrate, sulconazole nitrate, clotrimazole, anti-inflammatory analgesics such as methyl salicylate, indomethacin, felbinac, ketoprofen, Solvents such as l-menthol and camphor, lauryl methacrylate, geranyl crotolate, acetophenone myristate, benzyl acetate, benzyl propionate, methyl phenylacetate, etc., dissolved in oily solvents or lipophilic liquefied gases What to do.

  The blending amount of the oil-soluble active ingredient is preferably 1 to 10% by weight, more preferably 2 to 8% by weight in the aerosol composition. When the amount of the oil-soluble active ingredient is less than 1% by weight, the amount adhering to the skin is small, and the effect of the active ingredient tends to be insufficient, and when it is more than 10% by weight, it is difficult to apply uniformly. The effect on the blending amount becomes insufficient.

  The oil-based solvent is a solvent of the oil-soluble active ingredient, and is used for the purpose of increasing safety by improving the pressure of the oleophilic liquefied gas with increasing temperature, for example, improving the feeling of use, for example, isopropyl myristate , Isopropyl palmitate, cetyl isooctanoate, octyl hydroxystearate, ethylhexylxyl hydroxystearate, methylpentanediol dineopentanoate, diethylpentanediol dineopentanoate, neopentyl glycol di-2-ethylhexanoate, dicapric acid Neopentyl glycol, propylene glycol dilaurate, ethylene glycol distearate, diethylene glycol dilaurate, diethylene glycol distearate, diethylene glycol diisostearate, dioleic acid Ethylene glycol, triethylene glycol dilaurate, triethylene glycol distearate, triethylene glycol diisostearate, triethylene glycol dioleate, propylene glycol monostearate, propylene glycol monooleate, ethylene glycol monostearate, tri-2-ethyl Glyceryl xanthate, tri (caprylic / capric acid) glycerin, ethylhexyl methoxycinnamate, isononyl isononanoate, isotridecyl isononanoate, diethoxyethyl succinate, diisostearyl malate, methyl polysiloxane, cyclopentasiloxane, Cyclopexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecameti Silicone oil such as cyclohexasiloxane, methylcyclopolysiloxane, tetrahydrotetramethylcyclotetrasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, hydrocarbons such as normal pentane, isopentane, Oils such as camellia oil, corn oil, olive oil, castor oil, safflower oil, jojoba oil, coconut oil, higher fatty acids such as oleic acid, and higher alcohols such as oleyl alcohol and isostearyl alcohol.

  Like the aerosol composition of the present invention, when the aerosol composition forms an emulsion containing a liquefied gas, the pressure of the aerosol composition tends to increase because it is easily affected by the pressure increase of the liquefied gas accompanying a temperature rise, Silicon oil, hydrocarbons, especially methylpolysiloxanes having a viscosity of 20 cs or less, cyclopentasiloxane, excellent in solubility with lipophilic liquefied gas, and can suppress an increase in pressure of the aerosol composition even when the temperature is increased, It is preferable to use volatile silicones such as cyclohexasiloxane and volatile hydrocarbons such as normal pentane and isopentane.

  In addition, as an oil-soluble active ingredient, an ester structure such as ethyl hexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, octyl dimethoxybenzylidene dioxoimidazolidine propionate, hexyl diethylaminohydroxybenzoylbenzoate, etc. In the case of using an ultraviolet absorber having an organic solvent, it is preferable to use an ester oil as an oily solvent or to contain an ester oil, particularly dineopentane, from the viewpoint of excellent solubility of the ultraviolet absorber and adhesion to the skin and an effect easily obtained. Methylpentanediol, diethylpentanediol dineopentanoate, neopentyl glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, propylene glycol dilaurate, distearies It is preferable to use a fatty acid and a dihydric alcohol diesters such as ethylene glycol.

  When blending the oily solvent, the blending amount is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight in the aerosol composition. If the amount of the oily solvent is less than 0.1% by weight, the effect of the oily solvent tends to be insufficient, and if it is more than 10% by weight, the concentration of the active ingredient when attached to the human body is reduced, The effect of the active ingredient becomes insufficient.

  The blending ratio of the oil-soluble active ingredient and the lipophilic liquefied gas is preferably 0.02 to 0.2, and more preferably 0.025 to 0.18. When the blending ratio is larger than 0.2, there are many active ingredients, or the amount of liquefied gas decreases, so that the active ingredients are difficult to adhere uniformly, and the effect of the active ingredients cannot be sufficiently obtained. When the blending ratio is less than 0.02, the active ingredient is small or the amount of liquefied gas increases, the adhesion rate of the active ingredient is small, and the effect of the active ingredient cannot be sufficiently obtained.

  In order to form an emulsion with the aqueous phase, a lipophilic surfactant can be added to the oil phase. Examples of the lipophilic surfactant include silicone surfactants such as polyoxyethylene / methylpolysiloxane copolymer, polyoxyethylene / polyoxypropylene / methylpolysiloxane copolymer, glycerin fatty acid ester, poly ( Nonionic interfaces such as di-tri-tetra-hexa-penta-deca) glycerin fatty acid esters, fatty acid ester-based nonionic surfactants such as sorbitan fatty acid esters, etc., with an HLB of 1-10, preferably 2-9 An activator is mentioned. In particular, PEG-10 dimethicone, PEG-12 dimethicone, PEG / PPG-19 / 19 dimethicone, PEG / PPG-20 / 20 dimethicone, PEG / PPG-30 / 10 because of the high effect of the lipophilic surfactant. Dimethicone, silicone surfactants such as alkyl PEG / PPG-18 / 18 methicone, diglyceryl fatty acid esters such as diglyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, sorbitan sesquioleate, monolauric acid Sorbitan fatty acid esters such as sorbitan are preferred.

  The blending amount of the lipophilic surfactant is preferably 0.05 to 10% by weight, more preferably 0.1 to 8% by weight in the aerosol composition. If the amount of the lipophilic surfactant is less than 0.01% by weight, it tends to be difficult to form an emulsion, and if it is more than 10% by weight, it tends to remain on the skin and inhibits the effect of the active ingredient. It becomes easy to do.

  The oil phase is prepared by preparing an oily stock solution by mixing an oil-soluble active ingredient alone or an oil-soluble active ingredient with an oily solvent and / or a lipophilic surfactant and dissolving it in a lipophilic liquefied gas in an aerosol container. Prepared.

  The blending amount of the oil phase is preferably 40 to 90% by weight, more preferably 45 to 85% by weight in the aerosol composition. When the blending amount of the oil phase is less than 40% by weight, adhesion of the oil-soluble active ingredient is easily inhibited by the aqueous phase, and when it is more than 90% by weight, the stability of the emulsion is likely to be lowered, and the oil-soluble active ingredient is reduced. It becomes difficult to adhere uniformly.

  Since the aqueous phase forms an emulsion with the oil phase described above in the aerosol container, the total amount of the lipophilic liquefied gas is not vaporized simultaneously when the aerosol composition is discharged from the aerosol container to the outside. The discharge itself is cooled by the heat of vaporization. Thereby, the vaporization of the remaining lipophilic liquefied gas is delayed and the vaporization time is adjusted. As a result, the remaining oil phase is easily spread on the skin by the vapor pressure of the oleophilic liquefied gas and the volume expansion upon vaporization. Further, the aqueous phase is separated from the remaining oil phase, and the oil phase is spread on the lipophilic skin surface to uniformly adhere the oil-soluble active ingredient. Moreover, the average particle diameter of the sprayed particle | grains (henceforth spray particle diameter) can be 10-70 micrometers, and can suppress the scattering on spraying objects, such as an arm and a back, and can make an adhesion rate high. Furthermore, it has the effect of suppressing the flammability of the aerosol composition and increasing the safety.

  The water phase can be blended with water with a hydrophilic surfactant, a water-soluble polymer, a water-soluble active ingredient, alcohols, and the like.

  The water may be used alone or as a main solvent for an aqueous phase such as a hydrophilic surfactant, and examples thereof include purified water and ion exchange water. The amount of the water is preferably 8 to 60% by weight, more preferably 10 to 55% by weight in the aerosol composition. When the amount of water is less than 8% by weight, it is difficult to obtain a stable emulsion, and the oil-soluble active ingredient is difficult to adhere uniformly. When the amount is more than 60% by weight, the oil phase is prevented from uniformly adhering to the skin surface, and the effect of the oil-soluble active ingredient tends to be lowered.

  The hydrophilic surfactant is used for the purpose of forming an emulsion with an oil phase. Examples of the hydrophilic surfactant include polyoxyethylene sorbitan fatty acid esters such as mono coconut oil fatty acid POE sorbitan, monostearic acid POE sorbitan, monooleic acid POE sorbitan, POE · POP cetyl ether, POE · POP decyl tetradecyl ether. Polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene glycerin fatty acid esters such as POE glyceryl monostearate, polyoxyethylene lanolin alcohols such as POE lanolin alcohol, polyoxyethylene hydrogenated castor oil such as POE hydrogenated castor oil, POE Cetyl ether, POE stearyl ether, POE oleyl ether, POE lauryl ether, POE behenyl ether, POE octyldedec Ethers, polyoxyethylene alkyl ethers such as POE isocetyl ether, POE isostearyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monostearate, hexaglyceryl monolaurate, hexaglyceryl monomyristate, pentaglyceryl monolaurate, monomyristic acid Pentaglyceryl, pentaglyceryl monooleate, pentaglyceryl monostearate, decaglyceryl monolaurate, decaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monoisostearate, decaglyceryl monooleate, decaglyceryl monolinoleate, etc. Polyoxyethylene such as polyglycerol fatty acid ester, POE glyceryl monooleate Polyoxyethylene sorbitan fatty acid ester such as lysine fatty acid ester, POE sorbitan monopalmitate, POE sorbitan monostearate, POE sorbitan monoisostearate, POE sorbitan monooleate, POE sorbitol monolaurate, POE sorbitol tetrastearate, tetraoleic acid Examples thereof include polyoxyethylene sorbite fatty acid esters such as POE sorbite; HLB such as 10-18, preferably 11-17. When the HLB is smaller than 10, it tends to be difficult to form an emulsion, and when the HLB is larger than 18, it is easy to foam and the active ingredient is difficult to adhere uniformly.

  The blending amount of the hydrophilic surfactant is preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight in the aerosol composition. If the amount of the hydrophilic surfactant is less than 0.01% by weight, it tends to be difficult to form an emulsion, and if it is more than 5% by weight, it tends to remain on the skin and inhibits the effect of the active ingredient. It becomes easy to do.

  The water-soluble polymer is used for the purpose of increasing the viscosity of the aqueous phase and emulsifying it with the oil phase.

  Examples of the water-soluble polymer include celluloses such as hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, nitrulose cellulose, methyl cellulose, ethyl cellulose, gums such as xanthan gum, gellan gum, carrageenan, guar gum, dextrin, pectin, starch, gelatin , Gelatin hydrolyzate, sodium alginate, modified potato starch, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, (acrylates / stearonic acid-20 steareth-20) copolymer, acrylic esters such as (acrylates / cetaconic acid ceteth-20) copolymer, etc. Can be given.

  The blending amount of the water-soluble polymer is preferably 0.01 to 3% by weight, more preferably 0.05 to 2% by weight in the aerosol composition. When the blending amount of the water-soluble polymer is less than 0.01% by weight, it is difficult to obtain the above-mentioned effect. When the blending amount is more than 3% by weight, the viscosity of the aqueous phase becomes too high and the emulsion is difficult to mix with the liquefied gas. Formation becomes difficult.

  In addition, when using an associative polymer such as a carboxyvinyl polymer, an (acrelate / itaconate steareth-20) copolymer, and an (acrelate / itaconate ceteth-20) copolymer, a pH adjuster that adjusts the pH of the aqueous phase should be used. Is preferred. Examples of the pH adjusting agent include triethanolamine, diisopropanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1, 3-propanediol and other organic alkalis, sodium hydroxide, Examples include inorganic alkalis such as potassium hydroxide and ammonium hydroxide. By adjusting the pH of the aqueous phase to 6 to 9 using these pH adjusters, the association of hydrophobic groups of the association polymer is promoted, The viscosity can be increased.

  The water-soluble active ingredient can be used for the purpose of assisting the effect of the oil-soluble active ingredient or obtaining an effect different from that of the oil-soluble active ingredient.

  Examples of the water-soluble active ingredient include ethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, collagen, xylitol, sorbitol, hyaluronic acid, caronic acid, sodium lactate, dl-pyrrolidone carboxylate, keratin, and casein. , Moisturizers such as lecithin, urea, paraoxybenzoic acid ester, sodium benzoate, potassium sorbate, phenoxyethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride, photosensitizer, parachlormetacresol, etc .; lauric acid Deodorants such as methacrylate, methyl benzoate, methyl phenylacetate, geranyl crotolate, acetophenone myristate, benzyl acetate, benzyl propionate, glycine, alanine, Singh, serine, tryptophan, cystine, cysteine, methionine, aspartic acid, glutamic acid, amino acids such as arginine, calcium pantothenate, magnesium ascorbyl phosphate, vitamins such as sodium ascorbate, etc. perfumes and the like.

  The compounding amount of the water-soluble active ingredient is preferably 0.005 to 5% by weight, more preferably 0.01 to 3% by weight in the aerosol composition. When the blending amount is less than 0.005% by weight, it is difficult to obtain the effect of the water-soluble active ingredient, and when it is more than 5% by weight, the effect of the oil-soluble active ingredient may be inhibited.

  The alcohols are used as solvents such as active ingredients that are difficult to dissolve in water and surfactants, for the purpose of making it easier to obtain the effects of oil-soluble active ingredients by adjusting the drying of the aqueous phase. And monohydric alcohols having 2 to 3 carbon atoms such as isopropyl alcohol, and 2 to 3 carbon alcohols having 3 to 5 carbon atoms such as propylene glycol, 1,3-butylene glycol and glycerin.

  The blending amount of the alcohols is preferably 0.1 to 12% by weight, more preferably 0.5 to 10% by weight in the aerosol composition. When the blending amount is less than 0.1% by weight, it is difficult to obtain the effect of alcohols. When the blending amount is more than 12% by weight, the stability of the emulsion tends to be lowered, and the effect of the oil-soluble active ingredient is sufficiently obtained. It becomes difficult.

  The aqueous phase can be prepared by blending a surfactant, a water-soluble polymer, a water-soluble active ingredient, etc. with alcohols or water. The amount of the aqueous phase is preferably 10 to 60% by weight, more preferably 15 to 55% by weight in the aerosol composition. When the blending amount of the aqueous phase is less than 10% by weight, it is difficult to obtain a stable emulsion, and the oil-soluble active ingredient is difficult to adhere uniformly. When the amount is more than 60% by weight, the oil phase is prevented from uniformly adhering to the skin surface, and the effect of the oil-soluble active ingredient tends to be lowered.

  Furthermore, the aerosol composition of this invention can mix | blend powder other than the said oil phase and water phase. The powder is dispersed in the aerosol composition, improves the stability of the emulsion, acts as an ultraviolet scattering agent that scatters ultraviolet rays when applied to the skin, and adheres to the skin for a long time by repelling water and sweat. It has effects such as preventing sunburn for a long time and reducing stickiness to improve the feeling of use.

  Examples of the powder include zinc oxide, titanium oxide, talc, sericite, silica, plate polymers such as (polyethylene terephthalate / polymethyl methacrylate) laminate, extender pigments (mica, kaolin, calcium carbonate, aluminum oxide, etc.) , Coloring pigments (eg, bengara, yellow iron oxide, black iron oxide, ultramarine blue, carbon black), polymer powders such as polyethylene powder, polymethyl methacrylate, and nylon powder. In addition, when using the aerosol product of this invention as an object for sunscreen, it is preferable to mix | blend zinc oxide, a titanium oxide, and a plate-like polymer from the point with a high ultraviolet-ray scattering effect. In particular, it is difficult to uniformly apply a plate-like polymer having a layered structure because of its shape, but it is spread on the skin by the driving force of the liquefied gas and is easily applied uniformly, and the scattering effect becomes extremely high.

  The blending amount of the powder is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight in the aerosol composition. When the blending amount is less than 0.1% by weight, the effect of scattering ultraviolet rays is weak and the sun protection effect is insufficient. On the other hand, if the amount is more than 10% by weight, the powder concentration becomes too high and the valve tends to be clogged, and the powder adhering to the discharge passage such as spout during use is dried and discharged as a lump when used next time. , Easy to use.

  The aerosol composition of the present invention fills a container with an aqueous phase and an oil-soluble active ingredient or an oily stock solution, attaches an aerosol valve to the container, further fills a liquefied gas to form an oil phase, and forms an aqueous phase and an emulsion. It can be adjusted by doing. Note that the aqueous phase and the oil-soluble active ingredient or oily stock solution may be preliminarily emulsified and then filled with the liquefied gas. When powder is blended, it may be filled in a container in advance. If the powder is hydrophilic, it is filled in an aqueous phase, and if it is lipophilic, it is dispersed in an oil-soluble active ingredient or oily stock solution. You can also

  When the aerosol composition thus obtained is discharged from the aerosol container, the lipophilic liquefied gas is vaporized to become an aqueous phase and an oil-soluble active ingredient or oily stock solution, and the oil-soluble active ingredient or oily stock solution is a propellant for liquefied gas. Separation of force and aqueous phase facilitates diffusion to the skin surface, making it easier to obtain the effect of an oil-soluble active ingredient.

Example 1
An aluminum pressure vessel was filled with powder, aqueous phase, and oily stock solution having the composition shown in Table 1. An aerosol valve was attached to the container, liquefied petroleum gas was filled from the valve, and an aqueous phase and an oil phase (oily concentrate and liquefied petroleum gas) were emulsified to produce an aerosol product for sunscreen.

Example 2
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 2 was used.

Example 3
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 3 was used.

Comparative Example 1
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 4 was used.

Comparative Example 2
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 5 was used.

Example 4
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 6 was used.

Example 5
An aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 7 was used.

Comparative Example 3
An oil-in-water foam aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 8 was used.

Comparative Example 4
A one-part spray aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 9 was used.

Reference Example 6
A water-in-oil spray aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 10 was used.

Reference Example 7
A water-in-oil spray aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 11 was used.

Reference Example 8
A water-in-oil spray aerosol product for sunscreen was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 12 was used.

Test evaluation Sunscreen effect of aerosol products The components other than the liquefied gas were discharged onto the arm so that the amount of the components was 0.5 g, and the discharged material was spread. The applied part and the part where nothing was applied were irradiated with ultraviolet rays. Irradiation to the part where nothing was applied was stopped, and the time when the applied part was tanned to the same degree as the part where the applied part was not applied was compared based on the degree of tanning and the irradiation time. The test was conducted by five people, and the results are average values.

2. Sunscreen effect of undiluted solution The measurement was performed in the same manner as the sunscreen effect of aerosol except that 0.5 g of undiluted solution was spread on the arm.

  In Examples 1 to 3, in which the lipophilic liquefied gas is contained in an aerosol composition in an amount of 35 to 85% by weight, the time required for tanning is longer than when an equal amount of the stock solution is applied, and the sunscreening effect is high. It can be seen that the active ingredient can be uniformly applied to the skin. On the other hand, in Comparative Example 1 with a small amount of lipophilic liquefied gas of 30% by weight and Comparative Example 2 with a large amount of lipophilic liquefied gas of 90% by weight, the time required for tanning is different as compared with the case where an equal amount of the stock solution is applied. It can be seen that the active ingredient is not evenly applied to the skin.

  In Example 4 including a plate-like polymer having a layered structure, the time required for tanning is longer than that in Example 1 not including a plate-like polymer, and the plate-like polymer adheres evenly and the sun protection effect is enhanced. I understand that. In Example 5 using a diester of a fatty acid and a dihydric alcohol as an oily solvent, the time required for tanning is long, and it can be seen that the active ingredient can be uniformly applied to the skin.

In Reference Examples 6 to 8 which form a water-in-oil emulsion, the time required for tanning is about twice as long as when an equal amount of the stock solution is applied, and the sunscreening effect is particularly high. It can be seen that it is uniformly applied to the skin. In addition, the stock solutions of Reference Examples 6 to 8 were easy to separate and could not be applied uniformly.

  Comparative Example 3 in which an oil-in-water emulsion is formed with a low lipophilic liquefied gas content of 10% by weight and Comparative Example 4 in which an aerosol composition forms a homogeneous phase without adding water are compared with the case where an equal amount of the stock solution is applied. As a result, the time required for tanning remains unchanged or shortened, indicating that the active ingredient cannot be uniformly applied to the skin. In particular, since Comparative Example 4 had a small spray particle size, the amount of scattering was large, and the effect of sun protection was reduced by using aerosol.

In all Examples , Reference Examples and Comparative Examples, 10% by weight of ethylhexyl methoxycinnamate was blended in the stock solution as a lipophilic active ingredient.

Reference Example 9
A water-in-oil spray aerosol product for repelling pests was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 14 was used.

Reference Example 10
A water-in-oil spray aerosol product for skin care was produced in the same manner as in Example 1 except that the aerosol composition having the composition shown in Table 15 was used.

  As described above, according to the aerosol composition of the present invention, it is possible to provide an aerosol composition in which the active ingredient uniformly adheres when applied to the human body and the effect of the active ingredient can be exhibited to the maximum.

Claims (6)

An oil phase containing a lipophilic liquefied gas, an ultraviolet absorber, and an oily solvent, and an aqueous phase containing water, a hydrophilic surfactant, celluloses, and a monohydric alcohol having 2 to 3 carbon atoms An aerosol composition for the human body formed by forming
It also contains powder,
The ultraviolet absorber is contained in the aerosol composition in an amount of 1 to 10% by weight,
The lipophilic liquefied gas is contained in the aerosol composition in an amount of 35 to 80% by weight,
An aerosol composition for a human body comprising 0.1 to 12% by weight of the monohydric alcohol having 2 to 3 carbon atoms in the aerosol composition. Wherein the ultraviolet absorber, the ratio between the lipophilic liquefied gas, ultraviolet absorber / lipophilic liquefied gas (weight ratio) = 0.02 to 0.2 and is claim 1 for human body aerosol composition.   The aerosol composition for a human body according to claim 1 or 2, wherein the content of the oily solvent is 0.1 to 10% by weight in the aerosol composition.   The aerosol composition for human body according to any one of claims 1 to 3, wherein the oily solvent is silicone oil.   The aerosol composition for human body according to any one of claims 1 to 4, wherein the cellulose is hydroxyethyl cellulose.   The amount of the oil phase is 40 to 85% by weight in the aerosol composition, the amount of the aqueous phase is 10 to 55% by weight in the aerosol composition, and the amount of the powder is 0.00 in the aerosol composition. The aerosol composition according to any one of claims 1 to 5, which is 1 to 10% by weight.