JP6009302B2 - Fine hole forming device, fine needle tip and tip holder - Google Patents

Description

  The present invention relates to a micropore forming apparatus, a microneedle chip, and a chip holder, and more particularly to a micropore forming apparatus, a microneedle chip, and a chip holder that form micropores in a subject's skin using the microneedle chip.

  Conventionally, a fine hole forming apparatus including a fine needle tip and a tip holder is known (see, for example, Patent Document 1).

  Patent Document 1 discloses a micropore forming apparatus including a microneedle chip and a chip holder that detachably holds the microneedle chip. In this fine hole forming device, the fine needle chip is mounted on the chip holder by fitting the chip container into the opening of the chip holder while the fine needle chip is housed in the chip container. After use, the fine needle chip is removed from the chip holder and returned to the chip container by fitting the chip container into the opening of the chip holder with the fine needle chip mounted on the chip holder. The fine needle tip and the tip holder are disposable and are discarded after use. In the micropore forming apparatus according to Patent Document 1, the user touches the microneedle chip by configuring so that the microneedle chip can be attached to and detached from the chip holder using the chip container. It is possible to attach and detach the fine needle tip. Thereby, in the said patent document 1, the contamination of the fine needle | hook accompanying the contact at the time of attachment or detachment is prevented.

JP 2007-236844 A

  However, in the above-mentioned Patent Document 1, since the chip container is used not only for attaching but also removing the fine needle chip, the user can use the chip container for removal after attaching the fine needle chip to the chip holder. It is necessary to keep it. Since it is easier to use disposable parts quickly, it is desirable to be able to remove the fine needle tip more easily without preparing a separate member (chip container). .

  The present invention has been made to solve the above-described problems, and one object of the present invention is to more easily remove the fine needle tip without using a separate member for removal. It is to provide a possible fine hole forming device, fine needle tip and tip holder.

  In order to achieve the above object, a micropore forming apparatus according to a first aspect of the present invention is a micropore forming apparatus for forming micropores in a subject's skin, comprising a columnar chip body and a tip of a chip body. A plurality of microneedles provided on the chip body, a microneedle chip including a protruding portion protruding from a side surface of the chip body, and a chip holder for detachably holding the microneedle chip. A chip holding portion that has a slit-like guide portion that guides the protruding portion of the fine needle chip to the mating position, engages with the protruding portion at the engaging position, and holds the fine needle tip; And an engagement release unit that releases the engagement between the fine needle tip and the tip holding unit by moving from the engagement position in contact with the protrusion.

  In the micropore forming apparatus according to the first aspect of the present invention, as described above, the microneedle chip is provided with the protruding portion protruding from the side surface of the chip body, and is provided to be movable with respect to the chip holding portion. By simply moving the disengagement part by moving the disengagement part by providing the disengagement part on the chip holder to disengage the fine needle chip and the chip holding part by moving from the engagement position in contact with Is moved in a direction to release the engagement with the tip holding portion, so that the fine needle tip can be easily removed. Accordingly, the user can remove the fine needle tip in a non-contact manner without separately using a member for removal, and can more easily attach and detach the fine needle tip.

  In the micropore forming apparatus according to the first aspect, preferably, the protruding portion has a length that protrudes outside the slit-shaped guide portion, and the disengagement portion includes the slit-shaped portion of the protruding portion. The protruding portion is configured to move in contact with a portion protruding outside the guide portion.

  In the micropore forming apparatus according to the first aspect, preferably, the guide portion guides the protruding portion from the entrance position of the first rotation angle to the engagement position of the second rotation angle different from the first rotation angle. The fine needle tip is configured to rotate around the central axis of the tip body with the movement of the protruding portion from the entrance position to the engaging position when mounted on the tip holding portion. . With this configuration, when the protruding portion is guided between the inlet position and the engaging position as the fine needle tip is attached / detached, the fine needle tip is relatively moved around the central axis with respect to the tip holding portion. It is necessary to rotate. As a result, for example, even when the engagement between the protruding portion and the tip holding portion is released due to an impact or the like, the fine needle tip becomes difficult to fall off, and the fine needle tip is prevented from dropping against the user's will. Can be suppressed.

  In this case, preferably, the guide portion is connected to the first slit portion extending from the entrance position of the first rotation angle and the first slit portion, and from the first rotation angle to the engagement position of the second rotation angle. And a second slit portion that guides the protrusion so as to rotate. If comprised in this way, a protrusion part can be engaged with a chip | tip holding | maintenance part by rotating a fine needle chip | tip from a 1st rotation angle to a 2nd rotation angle at the terminal end of a 1st slit part. As a result, the fine needle tip can be effectively prevented from falling off against the user's will, and when the fine needle tip is mounted, the protrusion is moved to the end of the first slit portion and then fine. It can be easily mounted simply by twisting (turning) the needle tip.

  In the fine hole forming device according to the first aspect, preferably, the chip holding part further includes a cylindrical part capable of inserting the chip body of the fine needle chip and guiding the insertion of the chip body, and having a slit shape. The guide portion is formed on the peripheral wall of the cylindrical portion, and is configured to guide the movement of the protruding portion when the chip body is inserted into the cylindrical portion. The protruding portion of the fine needle tip is held by the fine needle tip. It has a length that protrudes to the outside of the cylindrical portion through the slit-shaped guide portion while being held by the portion. If comprised in this way, since not only a protrusion part but the chip body inserted in the cylinder part will be guided by the cylinder part, the fine needle chip can be securely attached in the correct posture without being inclined and attached. Can be installed. Even in this case, since the protruding portion protrudes to the outside of the cylindrical portion, the engaging releasing portion is brought into contact with the portion of the protruding portion protruding outward from the cylindrical portion so that the protruding portion can be easily engaged and disengaged. The engagement can be released.

  In the micropore forming apparatus according to the first aspect, preferably, the tip holding unit is configured to move in a predetermined direction so that the microneedles of the microneedle tip collide with the skin of the subject, and the disengagement unit Is configured to move in a direction different from the predetermined direction in which the tip holding portion moves to release the engagement between the fine needle tip and the tip holding portion. If comprised in this way, since the movement direction of a chip | tip holding | maintenance part and the movement direction of an engagement release part can be varied, an engagement release part is moved accidentally at the time of use of a micropore formation apparatus, or a fine needle It is possible to prevent an erroneous operation of moving the chip holding part by mistake when removing the chip.

  In this case, it is preferable that the disengagement unit is configured to rotate about the axis center in a predetermined direction in which the tip holding unit moves to release the engagement between the fine needle tip and the tip holding unit. . If comprised in this way, a misoperation will be prevented more reliably by making the movement (turning) direction of a disengagement part into the rotation direction in the surface orthogonal to the movement direction (predetermined direction) of a chip | tip holding | maintenance part. can do. Further, when the movement direction of the engagement release portion coincides with the movement direction of the tip holding portion, or when the movement direction of the engagement release portion is a linear direction orthogonal to the movement direction of the tip holding portion, The device becomes larger by the amount of linear stroke. On the other hand, by configuring the disengagement unit so as to rotate about the center of the axis in the predetermined direction in which the chip holding unit moves, it is possible to prevent the apparatus from becoming large even in a configuration in which the disengagement unit is provided. can do.

  In the fine hole forming device according to the first aspect, preferably, the disengagement portion is urged in a direction from the entrance position side toward the engagement position side and is moved to the entrance position side against the urging force. Thus, the engagement between the fine needle tip and the tip holding portion is released. If constituted in this way, unless the user intentionally moves the disengagement part to the entrance position side, the disengagement part does not release the engagement between the fine needle tip and the tip holding part. It is possible to prevent the fine needle tip from dropping from the tip holder due to accidental movement of the disengagement portion.

  In the micropore forming apparatus according to the first aspect, preferably, the chip holder further includes a housing having an opening at a tip and housing the chip holding portion therein, and the microneedle chip has an opening of the housing. The chip holding part is configured to move to a position where the disengagement part and the protruding part do not come into contact with each other when the opening of the housing faces upward. With this configuration, when the opening is upward, the disengagement part cannot release the engagement between the fine needle tip (protruding part) and the tip holding part. It is possible to prevent the needle tip from jumping out toward the upper user (user's face).

  In the microscopic hole forming apparatus according to the first aspect, preferably, the chip holding unit is configured to be able to move in a predetermined direction so that the microneedle of the microneedle chip collides with the skin of the subject. An urging unit that applies an urging force to the chip holding unit in a predetermined direction, and holds the chip holding unit in a state where the urging force of the urging unit is accumulated, and releases the chip holding unit to move in a predetermined direction. A release mechanism, and the disengagement part does not come into contact with the protrusion when the tip holding part is held by the release mechanism, and can come into contact with the protrusion when the tip holding part is released from the release mechanism. It is configured. If comprised in this way, a micropore can be easily formed in a test subject's skin by anyone irrespective of a user's operation technique only by releasing a release mechanism by making a fine needle point at a test subject's skin. In addition, by disposing the disengagement portion so that it does not come into contact with the protruding portion when the tip holding portion is held by the release mechanism, the tip holding portion is also provided in the configuration in which the biasing portion and the release mechanism are provided. It is possible to prevent the engagement between the fine needle tip and the tip holding portion from being accidentally released without being released while being held by the release mechanism.

  In the micropore forming device according to the first aspect, preferably, the protruding portion has a columnar shape extending from the side surface of the chip body and has a flat surface portion, and the engagement releasing portion is used when releasing the engagement. It has a flat contact surface in surface contact with the flat surface portion of the protrusion. According to this structure, when the engagement between the fine needle tip and the tip holding portion is released, the protrusion can be moved by bringing the engagement release portion and the protrusion into surface contact with each other. Unlike the case of line contact, it is possible to suppress stress concentration on the contact portion between the disengagement portion and the protruding portion, and as a result, it is possible to suppress the occurrence of breakage and deformation of components.

  According to a second aspect of the present invention, there is provided a microneedle chip of a micropore forming apparatus, which includes a chip holder and a microneedle chip that is detachably attached to the chip holder, and is used to form micropores in the skin of a subject. And a columnar chip body, a plurality of fine needles provided at the tip of the chip body, and a protruding part protruding from the side surface of the chip body, the protruding part being a chip holding part provided in the chip holder It is guided along the slit-shaped guide provided from the entrance position to the engagement position, and is configured to engage with the chip holding section at the engagement position, and is arranged at the engagement position of the chip holding section. In the state, a portion of the protruding portion that protrudes outside the slit-shaped guide portion is configured to contact the engagement release portion.

  In the microneedle chip according to the second aspect of the present invention, as described above, the protrusion protruding from the side surface of the chip body is provided on the microneedle chip, and is protruded in a state of being disposed at the engagement position of the chip holding portion. By configuring the protrusion so that the portion of the portion that protrudes outside the slit-shaped guide portion contacts the disengagement portion, the disengagement portion is simply moved and brought into contact with the protrusion. Is moved in a direction to release the engagement with the tip holding portion, so that the fine needle tip can be easily removed. Accordingly, the user can remove the fine needle tip in a non-contact manner without separately using a member for removal, and can more easily attach and detach the fine needle tip.

  In the fine needle tip according to the second aspect, preferably, the protruding portion has a columnar shape extending from the side surface of the tip body, and includes a flat surface portion that is in surface contact with the disengagement portion. According to this structure, when the engagement between the fine needle tip and the tip holding portion is released, the protrusion can be moved by bringing the engagement release portion and the protrusion into surface contact with each other. Unlike the case of line contact, it is possible to suppress stress concentration on the contact portion between the disengagement portion and the protruding portion, and as a result, it is possible to suppress the occurrence of breakage and deformation of components.

  In the microneedle chip according to the second aspect, preferably, a plurality of protrusions are provided corresponding to a plurality of guide parts provided in the chip holding part. If comprised in this way, since the several point (several protrusion part) of a fine needle chip | tip will be each guided to an engagement position by a some guide part, it will suppress that it is attached in the state which the fine needle chip | tip inclined. It is possible to attach the fine needle tip to the tip holder in a correct posture easily and reliably.

  The fine needle chip according to the second aspect preferably further includes a cap that is detachably attached to the fine needle chip and covers a plurality of fine needles at the tip of the chip body. If comprised in this way, since a fine needle chip | tip can be mounted | worn with a chip | tip holder with a cap mounted | worn, a user can mount | wear with a fine needle chip | tip, without touching a fine needle. As a result, it is possible to reliably prevent the fine needles from being contaminated due to the contact during attachment / detachment.

  In this case, the cap preferably has a flat grip portion extending in the longitudinal direction of the columnar chip body. If comprised in this way, a user can hold | grip the flat holding part of a cap with a finger | toe, and can mount | wear with a fine needle chip | tip to a chip holder. As a result, workability at the time of mounting the fine needle tip is improved, and it is not necessary to touch the fine needle tip itself at the time of mounting, so that contamination of not only the fine needle but also the entire fine needle tip can be reduced as much as possible. In addition, when the fine needle tip is small, the fine needle tip is difficult to grasp, and the present invention is particularly effective when the size of the fine needle tip is small.

  In the configuration in which the fine needle tip includes a cap, preferably, the protrusion is guided from the first rotation angle entrance position to the engagement position of the second rotation angle different from the first rotation angle, and the protrusion The columnar chip body is configured to rotate around the central axis with the movement of the cap, and the chip body engages with the cap so as not to rotate relative to the cap about the central axis of the chip body. The unit is further provided. If comprised in this way, in the structure which rotates a fine needle chip | tip and is mounted | worn with a chip | tip holder, it can prevent that a fine needle chip | tip rotates idly with respect to a cap (only a cap rotates). The fine needle tip can be easily rotated and attached to the tip holder.

  A third aspect of the present invention includes a tip holder and a tip holder for a micropore forming device that is used to form micropores in the skin of a subject, including a tip holder and a fine needle tip that is detachably attached to the tip holder. In the configuration in which the microneedle chip includes a columnar chip body, a plurality of microneedles provided at the tip of the chip body, and a protrusion protruding from the side surface of the chip body, the chip holder has an entrance position. A chip-shaped guide portion that guides the protruding portion of the fine needle chip from the first position to the engaging position, engages with the protruding portion at the engaging position, and holds the fine needle chip; A disengagement portion that is provided so as to be movable, and that disengages the fine needle tip from the tip holding portion by moving the protrusion from the engagement position in contact with the protrusion. As a feature .

  In the chip holder according to the third aspect of the present invention, as described above, the microneedle chip is provided so as to be movable with respect to the chip holding part, and moves from the engaging position by contacting the projecting part. By providing the chip holder with an engagement release portion that releases the engagement between the tip holding portion and the tip holding portion, the protrusion is moved in the direction to release the engagement with the tip holding portion simply by moving the engagement release portion. Therefore, the fine needle tip can be easily removed. Accordingly, the user can remove the fine needle tip in a non-contact manner without separately using a member for removal, and can more easily attach and detach the fine needle tip.

  According to the present invention, it is possible to provide a fine hole forming device, a fine needle chip, and a chip holder that can remove a fine needle chip more easily without using a separate member for removal.

It is the perspective view which showed the external appearance of the micropore formation apparatus by one Embodiment of this invention. It is a disassembled perspective view for demonstrating the chip | tip holder of the micropore formation apparatus shown in FIG. It is the perspective view which showed the fine needle chip | tip of the micropore formation apparatus shown in FIG. It is a front view of the fine needle chip | tip shown in FIG. FIG. 4 is a side view of the fine needle tip shown in FIG. 3. FIG. 4 is a perspective view illustrating a state where a cap is attached to the fine needle chip illustrated in FIG. 3. It is a typical fragmentary sectional view for demonstrating the internal structure of the chip holder shown in FIG. It is a typical perspective view for demonstrating the structure of the chip | tip holding | maintenance part of the chip holder shown in FIG. FIG. 3 is an exploded perspective view showing an engagement release portion of the chip holder shown in FIG. 2. FIG. 8 is an enlarged cross-sectional view taken along line 500-500 in FIG. 7 in a state where the fine needle chip is held by the chip holding unit. It is a schematic diagram for demonstrating the position of the chip | tip holding | maintenance part of the state which made the opening of the chip | tip holder downward. It is a schematic diagram for demonstrating the position of the chip | tip holding | maintenance part of the state which made the opening of the chip | tip holder upward. It is a typical perspective view for demonstrating the attachment or detachment operation | movement to the chip holder of a fine needle chip | tip. It is the typical perspective view which showed the state by which the protrusion part of the fine needle chip | tip was arrange | positioned in the engagement position. It is a schematic diagram for demonstrating the chip | tip holding | maintenance part by the 1st modification of this embodiment. It is a schematic diagram for demonstrating the chip | tip holding | maintenance part by the 2nd modification of this embodiment.

  DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments embodying the present invention will be described below with reference to the drawings.

  First, with reference to FIGS. 1-12, the whole structure of the micropore formation apparatus 1 by one Embodiment of this invention is demonstrated.

  As shown in FIG. 1, a micropore forming apparatus 1 according to an embodiment of the present invention includes a microneedle chip 2 and a chip holder 3 that detachably holds the microneedle chip 2. The micropore forming device 1 attaches a sterilized microneedle tip 2 and causes the microneedles 21 of the microneedle tip 2 to collide with the skin of a living body (for example, the skin of a human body), thereby causing the skin of the living body to be touched. It is an apparatus for forming bodily fluid extraction holes (micropores). Specifically, the micropore forming apparatus 1 forms a plurality of fine extraction holes that penetrate the skin and reach the dermis but do not reach the subcutaneous tissue, and exude interstitial fluid from the extraction holes. Device. A body fluid (interstitial fluid) exuded from the extraction hole formed by the micropore forming device 1 is collected and analyzed by a blood sugar level analyzer (not shown), thereby calculating a blood sugar level, and the diabetic patient himself It is possible to monitor and manage blood glucose levels.

  The microneedle chip 2 includes a columnar chip body 20, a plurality of microneedles 21 provided on the tip surface (lower end surface) of the chip body 20, and a pair of projecting portions 22 that project from the side surface of the chip body 20. . The protruding portion 22 is formed so as to protrude laterally from a position on the base (other end) side of the chip body 20. For the convenience of explanation, the side on which the fine needle 21 is arranged with respect to the chip body 20 is referred to as the distal end side, and the side opposite to the fine needle 21 (the protruding portion 22 side) is referred to as the root side.

  As shown in FIG. 2, the chip holder 3 includes a housing 30, a chip holding part 40 that detachably holds the fine needle chip 2, and an engagement that releases the engagement between the fine needle chip 2 and the chip holding part 40. The mating release unit 50, the spring member 60, and the release mechanism 70 are mainly provided. Further, the tip holding portion 40 is formed with a pair of slit-like guide portions 41 for guiding the protruding portion 22 of the fine needle tip 2 from the entrance position P1 (see FIG. 8) to the engagement position P2 (see FIG. 8). ing. The tip holding portion 40 holds the fine needle tip 2 by engaging with the protruding portion 22 of the fine needle tip 2 at the engagement position P2. The disengagement part 50 is provided so as to be movable with respect to the chip holding part 40, and comes into contact with the protrusion part 22 located at the engagement position P2 to move the protrusion part 22 from the engagement position P2. The engagement between the chip 2 and the chip holding part 40 is released. The spring member 60 is an example of the “biasing portion” in the present invention.

  First, the configuration of the fine needle tip 2 according to an embodiment of the present invention will be described in detail with reference to FIGS. 3 to 6 and FIG.

  As shown in FIGS. 3 to 5, the chip body 20 of the fine needle chip 2 includes a columnar columnar portion 23 and a needle member 24 fixedly attached to the distal end side of the columnar portion 23. The columnar part 23 is a cylindrical resin member in which a pair of protruding parts 22 are integrally formed. The pair of projecting portions 22 project linearly with a projecting length L from the side surface of the columnar portion 23 in the opposite direction (lateral direction) across the central axis CA1 in the longitudinal direction of the columnar portion 23. The protrusion length L is set to a predetermined length that can contact the engagement release portion 50 in a state where the protrusion length L is disposed at the engagement position P <b> 2 of the chip holding portion 40. The protruding portion 22 is formed in an oval (rounded rectangular) columnar shape having a pair of flat surface portions 22a (left and right side surfaces) and arcuate portions 22b (upper and lower side surfaces) formed on the side surfaces when viewed from the protruding direction. Has been. The flat surface portion 22a is flat so as to come into surface contact with a later-described convex portion 54 (contact surface 54a) (see FIG. 8) of the disengagement portion 50 when the engagement with the chip holding portion 40 is released. It is formed in a shape.

  The needle member 24 is a resin member in which a plurality of fine needles 21 are formed on the tip side surface. The needle member 24 is fixedly attached to the columnar portion 23 by fitting the tip portion of the columnar portion 23 into a recess (not shown) formed on the root side. In use, the needle member 24 and the columnar portion 23 are not separated, and the chip body 20 composed of the needle member 24 and the columnar portion 23 is handled as one member. The plurality of fine needles 21 are densely arranged on the tip side surface of the needle member 24. A pair of engaging blades 24 a that protrude in a flange shape toward the outside are integrally formed on the outer peripheral surface on the base side of the needle member 24. The engaging blade 24 a protrudes in the opposite direction across the central axis CA <b> 1 of the columnar portion 23, as with the protruding portion 22. The columnar part 23 and the needle member 24 are aligned so that the rotational position around the central axis CA1 of the pair of engaging blades 24a coincides with the rotational position around the central axis CA1 of the pair of protruding parts 22 And are fixed to each other. The engaging blade 24a is an example of the “cap engaging portion” in the present invention.

  As shown in FIG. 6, the microneedle chip 2 is provided so as to be detachable from the microneedle chip 2 and includes a resin cap 25 that covers the plurality of microneedles 21 at the tip. The cap 25 is formed so as to completely cover the tip side surface (fine needle 21) of the needle member 24 and the outer peripheral surface (side surface) of the needle member 24. For this reason, the cap 25 is formed with a pair of engagement recesses 25a into which the pair of engagement blades 24a are fitted. Thus, the engagement blade 24a is engaged with the cap 25 so that the fine needle tip 2 (the needle member 24 and the columnar portion 23) does not rotate relative to the cap 25 around the central axis CA1.

  A flat grip portion 26 extending in the longitudinal direction (tip direction) of the columnar portion 23 is formed on the distal end side of the cap 25. The gripping portion 26 is provided for gripping the gripping portion 26 and performing attachment work when the fine needle chip 2 is mounted on the chip holder 3. A convex portion 26 a for preventing slipping is formed on the distal end side of the grip portion 26. The flat surface (gripping surface 26b) of the gripping portion 26 corresponds to the pair of protrusions 22 and the pair of engagement blades 24a in the rotation position, and the pair of protrusions 22 and the pair of engagement blades 24a are connected to each other. The passing plane and the gripping surface 26b are substantially parallel. This is because, as will be described later, when the fine needle tip 2 is attached to the tip holder 3, the fine needle tip 2 is rotated around the central axis CA 1, so that the user performs the attaching operation while holding the grip portion 26. It was made easy.

  Next, with reference to FIG. 2 and FIGS. 7-12, the structure of the chip holder 3 by one Embodiment of this invention is demonstrated in detail. For convenience of explanation, in the tip holder 3, the side on which the fine needle tip 2 in the longitudinal direction (Z direction) is attached (the direction in which the fine needle 21 faces) is referred to as the distal end side (arrow Z1 direction side). The side opposite to the side on which 2 is mounted is referred to as the back side (arrow Z2 direction side).

  As shown in FIG. 2, the housing 30 includes an outer case 31 and an inner case 32. The outer case 31 has a cylindrical shape and accommodates the inner case 32 in a state in which the outer case 31 can slide in the longitudinal direction Z with respect to the inner case 32. The inner case 32 is configured so as to form a cylindrical shape by combining two members divided in half, and the chip holding portion 40, the spring member 60, and the release mechanism 70 are accommodated therein. Further, an engagement release portion 50 is attached to the opening 32 a on the distal end side of the inner case 32.

  As shown in FIGS. 2 and 7, the chip holding portion 40 is a resin member provided so as to be movable along the longitudinal direction Z inside the inner case 32. The chip holding part 40 protrudes laterally on the upper end side, a cylindrical part 42 disposed on the distal end side (Z1 direction side), a pair of first protrusions 43 projecting laterally at the central portion in the longitudinal direction Z. A pair of second protrusions 44 are integrally included. As shown in FIG. 8, the cylindrical part 42 can insert the chip body 20 (columnar columnar part 23) of the fine needle chip 2 and guide the insertion of the chip body 20. The cylindrical portion 23) is formed in a cylindrical shape having an inner diameter corresponding to the outer diameter. A guide portion 41 and an engaging portion 45 that engages with the protruding portion 22 at the engaging position P2 are integrally formed on the peripheral wall of the cylindrical portion 42.

  A pair of guide portions 41 and engaging portions 45 are provided corresponding to the pair of projecting portions 22. The guide portion 41 is configured to guide the protruding portion 22 from the entrance position P1 arranged at the entrance angle θ1 around the central axis CA2 to the engagement position P2 arranged at the engagement angle θ2 different from the entrance angle θ1. Has been. Specifically, the guide portion 41 is connected to the first slit portion 41a that linearly extends in the Z2 direction from the distal end side entrance position P1 toward the back side, and the first slit portion 41a, and is engaged from the entrance angle θ1. And a second slit portion 41b that guides the protrusion 22 so as to rotate to the engagement position P2 of the angle θ2. The first slit portion 41a is formed linearly in the Z2 direction, and the second slit portion 41b is formed to extend in the circumferential direction by an angular difference between the entrance angle θ1 and the engagement angle θ2. For this reason, when the fine needle tip 2 is attached to the tip holding portion 40, the angle between the entrance angle θ1 and the engagement angle θ2 with the movement of the protruding portion 22 from the entrance position P1 to the engagement position P2. It rotates around the central axis CA1 (CA2) by the difference. The central axis CA2 of the cylindrical portion 42 and the central axis CA1 of the chip body 20 (columnar portion 23) coincide with each other in a state where the columnar portion 23 is inserted into the cylindrical portion 42. The angle difference between the entrance angle θ1 and the engagement angle θ2 is a predetermined angle of less than 90 degrees. The entrance angle θ1 and the engagement angle θ2 are examples of the “first rotation angle” and the “second rotation angle” in the present invention, respectively.

  The engaging part 45 is a pair of arc-shaped parts formed so as to sandwich and engage the arc-shaped part 22b (upper and lower surfaces of the projecting part 22) of the projecting part 22. The engaging piece 45a that engages with the upper surface side of the protruding portion 22 functions as a resin spring, and is pushed and expanded toward the back side (Z2 direction) when the protruding portion 22 moves to the engaging position P2. When the protruding portion 22 is disposed at the engaging position P2, the engaging piece 45a is restored and returned to the original position, whereby the protruding portion 22 is engaged with the chip holding portion 40 (engaging portion 45) at the engaging position P2. Combined.

  As shown in FIG. 9, the disengagement portion 50 is formed in an annular shape so as to surround the periphery of the opening 32 a (see FIG. 2) at the distal end portion of the inner case 32, and is attached to the distal end portion of the inner case 32. . Unlike the movement direction (Z direction) of the chip holding unit 40, the disengagement unit 50 is configured to be rotatable about the central axis CA2 (R1 and R2 directions). The engagement release unit 50 includes an annular release member 51, an annular torsion spring 52, and an annular wheel 53 attached to the release member 51. A cylindrical cover 33 (see FIG. 2) for defining the position of the skin (contact surface) with respect to the fine needle chip 2 exposed from the opening 32a (position in the Z direction) is attached to the tip side of the wheel 53. It has been.

  As shown in FIGS. 2 and 9, the release member 51 is attached to the distal end portion of the inner case 32 so as to be rotatable around the central axis in the longitudinal direction Z. The release member 51 integrally includes a pair of peripheral portions 51a, a pair of attachment projections 51b, and a pair of engagement projections 51c that protrude toward the distal end side. The pair of peripheral portions 51a are formed on the inner peripheral side of the annular release member 51, and each have a convex portion 54 that protrudes toward the inside in the radial direction. The convex portion 54 has a flat contact surface 54a, and a portion of the flat surface portion 22a of the protruding portion 22 disposed at the engagement position P2 that protrudes outside the slit-shaped guide portion 41 and the contact surface 54a are provided. It is formed so that surface contact is possible. As shown in FIG. 10, the release member 51 is rotated in the arrow R1 direction from the engagement position P2 side to the entrance position P1 side, whereby the contact surface 54a of the convex portion 54 becomes the flat surface portion 22a of the protrusion portion 22. And the protrusion 22 is moved from the engagement position P2.

  The pair of attachment protrusions 51b are disposed on the same inner peripheral side as the peripheral portion 51a. Further, the pair of engagement protrusions 51 c are arranged on the outer peripheral side of the release member 51. The inner peripheral side circumferential portion 51a and the mounting projection 51b protrude from the inner side of the inner case 32 to the distal end side, and the outer peripheral side engagement projection 51c is an arc-shaped notch 32b formed in the inner case 32 (see FIG. 10) to the front end side. For this reason, the release member 51 can rotate until the engagement protrusion 51c contacts the inner case 32 at the end of the notch 32b.

  The torsion spring 52 is provided so as to bias the release member 51 in the direction of the arrow R2 from the inlet position P1 side to the engagement position P2 side. Specifically, as shown in FIG. 10, the torsion spring 52 has one end 52a engaged with the R1 direction side surface of the engaging protrusion 51c (one of the pair of engaging protrusions 51c), and the other end 52 b is fixed to a locking portion 32 c formed integrally with the inner case 32. Thereby, the torsion spring 52 urges the engaging protrusion 51c in the R2 direction. The engagement protrusion 51c is positioned at the end of the notch 32b on the R2 direction side by the urging force of the torsion spring 52.

  As shown in FIG. 9, the wheel 53 is disposed on the distal end side with respect to the release member 51 and is provided so as to surround and cover the release member 51 and the torsion spring 52. On the inner peripheral side of the wheel 53, a mounting hook 53a and an engaging projection 53b are integrally formed. As shown in FIG. 10, the wheel 53 is attached to the release member 51 by engaging the attachment hook 53 a with the attachment protrusion 51 b of the release member 51. The engagement convex portion 53b is disposed in the vicinity of the engagement protrusion 51c of the release member 51 on the R2 direction side. Accordingly, when the user rotates the wheel 53 in the R1 direction, the attachment hook 53a and the engagement convex portion 53b rotate the release member 51 in the R1 direction.

  As shown in FIGS. 2 and 7, the spring member 60 and the release mechanism 70 are disposed in the inner case 32 on the back side (Z2 direction side) in the longitudinal direction Z with respect to the chip holding portion 40. The spring member 60 is a compression coil spring, and is attached to a support member 61 fixed in the inner case 32. The spring member 60 applies a biasing force to the chip holding unit 40 in the injection direction Z1 toward the opening 32a of the housing 30. Further, the release mechanism 70 holds the tip holding portion 40 in a state where the urging force of the spring member 60 is accumulated, and releases the tip holding portion 40 to move it in the injection direction (tip side) Z1. The release mechanism 70 engages with the tip holding portion 40 and engages with the tip holding portion 40 at a compressed position P3 (see FIG. 7) where the spring member 60 is compressed, and a movable hook 71 that moves to the back side (Z2 direction). A stopper member 72 for holding the chip holding part 40, and a release button 73 for releasing the chip holding part 40 by releasing the engagement between the stopper member 72 and the chip holding part 40. .

  The movable hook 71 has a pair of engagement pieces 71 a that can be engaged with the pair of first protrusions 43 of the chip holding portion 40, and is configured to be movable in the longitudinal direction Z within the inner case 32. The movable hook 71 is fixed to the outer case 31 by a screw member through a slit 32d formed in the inner case 32 so as to extend in the longitudinal direction. Therefore, the movable hook 71 moves in the Z2 direction in the inner case 32 as the outer case 31 is slid in the Z2 direction with respect to the inner case 32. At this time, the pair of engaging pieces 71a are engaged with the pair of first protrusions 43 from the distal end side to move the chip holding portion 40 in the Z2 direction.

  The stopper member 72 integrally includes a pair of engagement hooks 72a that can be engaged with the pair of second protrusions 44 of the chip holding portion 40, a pair of rotating shaft portions 72b, and a pair of contact pieces 72c. ing. The stopper member 72 is supported by the bearing of the inner case 32 so as to be rotatable about the rotation shaft portion 72b. The stopper member 72 is urged in a direction opposite to the R3 direction around the rotation shaft portion 72b by a spring (not shown). When the tip holding portion 40 is moved in the Z2 direction, the stopper member 72 is moved outward (R3 direction) by the inclined surface 72d (see FIG. 7) of the engaging hook 72a being pushed away by contacting the second protrusion 44. Is rotated. When the tip holding part 40 reaches the compression position P3, the stopper member 72 is rotated in the direction opposite to the R3 direction by the urging force of a spring (not shown) and returns to the state shown in FIG. When the stopper member 72 returns, the engagement hook 72a engages with the second protrusion 44, and the tip holding portion 40 is held at the compression position P3 in a state where the spring member 60 is compressed.

  The release button 73 is disposed at the inner end of the inner case 32 (the Z2 direction side). The release button 73 includes a button portion 73a that is exposed to the outside from the back end of the housing 30 (the inner case 32 and the outer case 31), and a protruding piece 73b that protrudes toward the distal end side (Z1 direction). The release button 73 moves to the distal end side when the button portion 73 a is pushed, and the protruding piece 73 b presses the contact piece 72 c of the stopper member 72. As a result, the release button 73 rotates the stopper member 72 in the R3 direction to release the engagement between the chip holding portion 40 and the stopper member 72, and releases (releases) the chip holding portion 40 held at the compression position P3. )

  A buffer member 34 is provided at a predetermined position on the front end side in the inner case 32. When the tip holding part 40 released from the compression position P3 moves in the Z1 direction, the buffer member 34 contacts the slide piece 46 of the tip holding part 40 and receives the impact. For this reason, the buffer member 34 defines the position when the chip holding part 40 moves to the most distal end side.

  Here, as shown in FIG. 7, in the state where the buffer member 34 and the chip holding unit 40 are in contact, the inner side end of the chip holding unit 40 and the tip of the spring member 60 have a predetermined length in the longitudinal direction Z. They are separated by a gap CL. Therefore, when the tip (opening 32a) of the chip holder 3 is directed downward, the chip holding part 40 is held in contact with the buffer member 34, and when the tip (opening 32a) of the chip holder 3 is directed upward, the chip is held. The holding part 40 moves to the back side (Z2 direction) by the distance CL and is held in contact with the spring member 60. As a result, as shown in FIG. 11, in the state where the tip (opening 32a) of the chip holder 3 is directed downward, the position in the longitudinal direction Z of the protrusion 22 of the fine needle chip 2 held by the chip holder 40 is The protrusions 22 and the protrusions 54 can be brought into contact with each other so as to coincide with the position in the longitudinal direction Z of the protrusions 54 of the disengagement part 50. On the other hand, as shown in FIG. 12, when the tip (opening 32a side) of the tip holder 3 is directed upward, the tip holding portion 40 moves in the Z2 direction by the distance CL, so that the position of the protruding portion 22 in the longitudinal direction Z However, it moves to a position where it does not come into contact with the convex portion 54 of the disengagement portion 50, and the protruding portion 22 and the convex portion 54 cannot be contacted. In this way, in a state where the tip (opening 32a side) of the chip holder 3 is directed upward, the chip is so arranged that the engagement releasing part 50 cannot release the engagement between the fine needle chip 2 and the chip holding part 40. A holder 3 is configured.

  In the state where the tip holding portion 40 is held by the release mechanism 70, the tip holding portion 40 enters the compression position P3 (see FIG. 7) inside (inner side) of the inner case 32. The convex portion 54 and the protruding portion 22 of the fine needle chip 2 cannot be contacted. For this reason, in a state in which the tip holding unit 40 is held by the release mechanism 70, the engagement release unit 50 is configured so that the engagement between the fine needle tip 2 and the tip holding unit 40 cannot be released. Therefore, in this embodiment, the engagement release part 50 is fine only in a state where the chip holding part 40 is released (released) and the tip of the chip holder 3 (opening 32a side) is directed downward. The engagement between the needle tip 2 and the tip holding portion 40 can be released.

  Next, with reference to FIG. 8, FIG. 13, and FIG. 14, the mounting operation of the fine needle tip 2 to the tip holder 3 of the fine hole forming device 1 according to one embodiment of the present invention will be described.

  As shown in FIG. 8, the fine needle tip 2 is attached to the tip holder 3 with the cap 25 attached to the fine needle tip 2. First, the user grasps the grasping portion 26 of the cap 25 and inserts the columnar portion 23 into the cylindrical portion 42 of the chip holding portion 40 from the opening 32a side. At this time, the rotation angle of the protruding portion 22 is made to coincide with the entrance angle θ1 (inlet position P1) of the guide portion 41. When the fine needle tip 2 is moved in the Z2 direction with respect to the tip holder 3, the protruding portion 22 is guided in the Z2 direction by the first slit portion 41a of the guide portion 41 as shown in FIG. When the protrusion 22 reaches the terminal end (Z2 direction side end) of the first slit portion 41a, the user rotates the fine needle tip 2 from the entrance angle θ1 to the engagement angle θ2 by twisting the cap 25. Let Thereby, the protrusion part 22 is guided to the 2nd slit part 41b, and is moved toward the engagement position P2. At this time, when the protruding portion 22 moves while pushing and expanding the engaging piece 45a of the engaging portion 45 in the Z2 direction, and the protruding portion 22 is disposed at the engaging position P2, as shown in FIG. And the chip holding part 40 (engagement part 45) engage. Thereafter, when the user pulls the cap 25 in the Z1 direction, the cap 25 is removed from the fine needle chip 2, and the fine needle 21 is exposed. Thus, the mounting of the fine needle chip 2 on the chip holder 3 is completed.

  Next, with reference to FIG. 13 and FIG. 14, the removal operation | movement of the microneedle chip | tip 2 from the chip | tip holder 3 of the micropore formation apparatus 1 by one Embodiment of this invention is demonstrated.

  As described above, the disengagement of the fine needle tip 2 can be performed only with the tip holding portion 40 released (released) and with the tip (opening 32a side) of the tip holder 3 facing downward. It is. In this state, as shown in FIG. 14, the user applies a force larger than the biasing force of the torsion spring 52 to rotate the wheel 53 of the disengagement unit 50 in the R1 direction. As the wheel 53 rotates, the release member 51 also rotates, and the convex portion 54 rotates from the engagement position P2 (engagement angle θ2) toward the entrance position P1 (inlet angle θ1). As a result, the contact surface 54a of the convex portion 54 comes into contact with the flat surface portion 22a of the protruding portion 22, and the protruding portion 22 is moved along the second slit portion 41b in the R1 direction, which is opposite to the direction of mounting. At this time, the protrusion 22 moves while pushing and expanding the engagement piece 45a of the engagement portion 45 in the Z2 direction, and the protrusion 22 is detached from the engagement portion 45, whereby the protrusion 22 and the chip holding portion 40 (engagement). The engagement with the joint portion 45) is released. As the engagement is released, the projecting portion 22 vigorously rotates in the R1 direction, abuts against the inclined surface 41c of the guide portion 41, changes the moving direction from the R1 direction to the Z1 direction, and the entrance position by the action of gravity. Leave P1. Thus, the removal of the fine needle tip 2 from the tip holder 3 is completed.

  Next, with reference to FIG. 7, the operation | movement at the time of use of the micropore formation apparatus 1 by one Embodiment of this invention (at the time of micropore formation) is demonstrated.

  After attaching the fine needle chip 2 to the chip holder 3, the user holds the chip holding unit 40 on the release mechanism 70 as shown in FIG. 7. Specifically, the user slides the outer case 31 in the Z2 direction with respect to the inner case 32, thereby moving the movable hook 71 in the Z2 direction and compressing the spring member 60 while moving the tip holding unit 40 in the Z2 direction. Move to. When the second protrusion 44 of the chip holding part 40 pushes the inclined surface 72d of the stopper member 72 and reaches the compression position P3, the engagement hook 72a engages with the second protrusion 44, and the chip holding part 40 is moved to the stopper member 72. Retained. Thereby, the operation preparation of the fine hole forming apparatus 1 is completed, and the user returns the outer case 31 to the original position (movement limit in the Z1 direction).

  Thereafter, the user places the chip holder 3 so as to press the tip of the cylindrical cover 33 against the skin, and pushes the release button 73. The release button 73 rotates the stopper member 72 in the R3 direction to release the engagement between the engagement hook 72a and the second protrusion 44. As a result, the tip holding portion 40 held by the stopper member 72 is released (released), and the tip holding portion 40 is moved from the compression position P3 toward the opening 32a by the urging force of the compressed spring member 60 in the Z1 direction. Moved (injected). As a result, the microneedle tip 2 held at the tip of the tip holding part 40 jumps out of the opening 32a, and the microneedle 21 at the tip collides with the skin, thereby forming a micropore in the skin. As described above, the formation of fine holes by the fine hole forming apparatus 1 is performed.

  As described above, the formed micropore (extraction hole) penetrates the skin and reaches the dermis but does not reach the subcutaneous tissue. Since body fluid (interstitial fluid) exudes from the extraction hole, the interstitial fluid is extracted and supplied to an analyzer (not shown) for analysis.

  In the present embodiment, as described above, the fine needle chip 2 is provided with the protruding portion 22 protruding from the side surface of the chip body 20 with the protruding length L, and is provided so as to be movable with respect to the chip holding portion 40. Contact between the protruding portion 22 protruding at the protruding length and a portion protruding outside the guide portion 41 and moving the protruding portion 22 from the engaging position P2 makes it possible to engage the fine needle tip 2 with the tip holding portion 40. The chip holder 3 is provided with an engagement release portion 50 for releasing the engagement. Thereby, since the protrusion 22 is moved in the direction (R1 direction) for releasing the engagement with the tip holding portion 40 only by moving the engagement release portion 50, the fine needle tip 2 is easily removed. be able to. As a result, the user can remove the fine needle tip 2 in a non-contact manner without separately using a member for removal, and can attach and detach the fine needle tip 2 more easily.

  In the present embodiment, as described above, the guide portion 41 is configured to guide the protruding portion 22 from the entrance position P1 having the entrance angle θ1 to the engagement position P2 having the engagement angle θ2 different from the entrance angle θ1. The fine needle tip 2 is configured to rotate around the central axis CA1 of the tip body 20 with the movement of the protruding portion 22 from the inlet position P1 to the engaging position P2 when mounted on the tip holding portion 40. With this configuration, even when the engagement between the protruding portion 22 and the tip holding portion 40 is released due to an impact or the like, for example, the fine needle tip 2 is difficult to drop off, and the fine needle tip 2 is fine against the will of the user. It is possible to suppress the needle tip 2 from falling off.

  In the present embodiment, as described above, the first slit portion 41a extending from the entrance position P1 at the entrance angle θ1 and the protrusion 22 so as to rotate from the entrance angle θ1 to the engagement position P2 at the engagement angle θ2. The guide portion 41 is provided with a second slit portion 41b for guiding the above. With this configuration, the fine needle tip 2 can be effectively prevented from falling off against the user's will, and when the fine needle tip 2 is mounted, the protrusion 22 is provided with the first slit portion 41a. It can be easily attached to the chip holding part 40 simply by twisting (turning) the fine needle chip 2 after moving to the end of the chip.

  In the present embodiment, as described above, the tip main body 20 of the fine needle tip 2 can be inserted, and the cylindrical portion 42 that guides the insertion of the tip main body 20 is provided in the tip holding portion 40, and the fine needle tip 2 is provided. The protruding portion 22 is formed to have a predetermined protruding length L that protrudes to the outside of the cylindrical portion 42 via the guide portion 41 in a state where the fine needle tip 2 is held by the tip holding portion 40. If comprised in this way, since the chip | tip main body 20 is guided by the cylinder part 42, the fine needle chip | tip 2 can be reliably mounted | worn with a correct attitude | position. Also in this case, since the protruding portion 22 protrudes to the outside of the cylindrical portion 42, the engagement releasing portion 50 is brought into contact with the portion of the protruding portion 22 protruding to the outer side of the cylindrical portion 42 so that the protruding portion can be easily formed. Can be disengaged by moving in the disengagement direction (R1 direction).

  In the present embodiment, as described above, the tip holding unit 40 moves the disengagement unit 50 in a direction different from the predetermined direction in which the tip holding unit 40 moves, so that the fine needle tip 2 and the tip holding unit are moved. 40 is configured to be disengaged from 40. With this configuration, it is possible to prevent an erroneous operation such that the disengagement unit 50 is erroneously moved when the fine hole forming apparatus 1 is used or the tip holding unit 40 is erroneously moved when the fine needle tip 2 is removed. it can.

  Further, in the present embodiment, as described above, the disengagement unit 50 is rotated around the axis center in the predetermined direction in which the chip holding unit 40 moves, and the engagement between the fine needle chip 2 and the chip holding unit 40 is achieved. Configure to cancel the match. If comprised in this way, a misoperation will be made more reliable by making the moving direction (R1 direction) of the engagement releasing part 50 into the rotation direction in the surface orthogonal to the moving direction (Z direction) of the chip | tip holding | maintenance part 40. Can be prevented. Further, for example, unlike the case where the disengagement unit 50 moves in the linear direction, it is not necessary to ensure a large stroke amount of the disengagement unit 50. Therefore, even in the configuration in which the disengagement unit 50 is provided, the apparatus (chip holder 3) Can be prevented from increasing in size.

  In the present embodiment, as described above, the disengagement unit 50 is urged in the R2 direction from the inlet position P1 side toward the engagement position P2 side, and is moved to the inlet position P1 side against the urging force. Thus, the disengagement unit 50 is configured to disengage the fine needle tip 2 from the tip holding unit 40. With this configuration, in order to release the engagement between the fine needle tip 2 and the tip holding portion 40, the user needs to intentionally move the engagement release portion 50 to the entrance position P1 side. It is possible to prevent the fine needle tip 2 from dropping from the tip holder 3 due to the accidental movement of the disengaging part 50.

  Further, in the present embodiment, as described above, the chip holding unit 40 is located at a position where the engagement releasing unit 50 and the protruding unit 22 do not come into contact with each other when the opening 32a of the chip holder 3 (housing 30) faces upward. Is configured to move. With this configuration, when the opening 32a is in the upward direction, the engagement release unit 50 cannot release the engagement between the fine needle tip 2 and the tip holding unit 40. Can be prevented from jumping out toward the user (user's face).

  In the present embodiment, as described above, the protrusion 22 and the disengagement unit 50 do not come into contact with each other when the tip holding unit 40 is held by the release mechanism 70, and the tip holding unit 40 is released from the release mechanism 70. In the released state, the tip holder 3 is configured so that the protrusion 22 and the disengagement part 50 can come into contact with each other. If comprised in this way, a micropore can be easily formed in a test subject's skin only by canceling | releasing the release mechanism 70 irrespective of a user's operation technique. Further, when the tip holding part 40 is held by the release mechanism 70, the protrusion 22 and the disengagement part 50 do not come into contact with each other, so that the tip holding part 40 is held by the release mechanism 70 and is not released. It is possible to prevent erroneous engagement between the fine needle tip 2 and the tip holding portion 40.

  In the present embodiment, as described above, the protrusion 22 is provided with the flat surface portion 22a, and the engagement release portion 50 is in flat contact with the flat surface portion 22a of the protrusion 22 when the engagement is released. The contact surface 54a is provided. If comprised in this way, since the engagement release part 50 and the protrusion part 22 can be surface-contacted and the protrusion part 22 can be moved, unlike the case of point contact or line contact, the engagement release part 50 and protrusion The stress concentration on the contact portion with the portion 22 can be suppressed, and as a result, the occurrence of breakage and deformation of the component can be suppressed.

  In the present embodiment, as described above, a pair of protruding portions 22 are provided corresponding to the pair of guide portions 41 provided in the chip holding portion 40. If comprised in this way, since the several point (a pair of protrusion part 22) of the fine needle chip | tip 2 is each guided to the engagement position P2 by the several (a pair of) guide part 41, it is easy and reliably in a correct attitude | position. The fine needle tip 2 can be attached to the tip holder 3.

  In the present embodiment, the cap 25 that covers the plurality of fine needles 21 is provided as described above. With this configuration, the fine needle chip 2 can be attached to the chip holder 3 without touching the fine needle 21 while the cap 25 is attached. As a result, it is possible to prevent the fine needles 21 from being contaminated due to contact during attachment / detachment.

  In the present embodiment, as described above, the cap 25 is provided with the flat grip portion 26 extending in the longitudinal direction of the columnar chip body 20. With this configuration, workability when mounting the fine needle tip 2 is improved, and it is not necessary to touch the fine needle tip 2 itself during mounting, so that not only the fine needle 21 but also the entire fine needle tip 2 is contaminated. Can be reduced as much as possible. In addition, by providing the engagement blade 24 a on the fine needle tip 2, it is possible to prevent the fine needle tip 2 from spinning around the cap 25.

  The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is shown not by the above description of the embodiments but by the scope of claims for patent, and further includes all modifications within the meaning and scope equivalent to the scope of claims for patent.

  For example, in the said embodiment, although the example of the fine needle chip | tip provided with a pair of protrusion part was shown, this invention is not limited to this. The number of protrusions may be one or three or more.

  Moreover, in the said embodiment, although the chip | tip main body of the fine needle chip | tip was comprised with 2 members, a columnar part and a needle member, this invention is not limited to this. In the present invention, the chip body may be constituted by a single member. For example, the columnar portion and the needle member may be integrally formed, or the fine needle may be directly formed at the tip of the columnar portion without providing the needle member.

  Moreover, in the said embodiment, although the example which provided the cap in the fine needle chip | tip was shown, this invention is not limited to this. In the present invention, it is not necessary to provide a cap.

  Moreover, although the example which provided the engagement blade | wing in the fine needle chip | tip so that the fine needle chip | tip did not rotate relatively with respect to a cap was shown in the said embodiment, this invention is not limited to this. In the present invention, it is not necessary to provide the engagement blade on the fine needle tip. For example, the protrusion may engage with the cap to prevent relative rotation of the fine needle tip with respect to the cap. Further, for example, the needle member may be formed in a prismatic shape, and the cap may be engaged with the corner portion of the needle member.

  In the above embodiment, the example in which the rotation positions around the central axis of the protruding portion of the fine needle chip, the engaging blade, and the holding surface of the holding portion of the cap are shown. Not limited. The projecting portion, the engaging blade, and the gripping surface of the gripping portion of the cap may have different rotational positions.

  Moreover, in the said embodiment, the example which comprised so that a fine needle chip | tip and the chip | tip holding | maintenance part might be engaged by rotating the fine needle chip | tip around the central axis CA1 from the entrance angle (theta) 1 to the engagement angle (theta) 2 was shown. However, the present invention is not limited to this. As in the first modified example shown in FIG. 15, the fine needle tip and the tip holding portion may be engaged by moving linearly without rotating the fine needle tip. As shown in FIG. 15A, in the chip holding unit 140 in the first modified example, a linear slit-shaped guide unit 141 is configured by a pair of guide pieces 142. An engaging portion 145 that protrudes inward from the guide piece 142 is formed in front of the engaging position P2 at the end portion in the Z2 direction of the guide portion 141. When the protruding portion 22 is moved from the entrance position P1 to the engaging position P2, the protruding portion 22 deforms the engaging portion 145, and the protruding portion 22 is disposed at the engaging position P2. The portion 140 (the restored engaging portion 145) is engaged. As shown in FIG. 15B, the disengagement unit 150 moves the protrusion 22 by moving the disengagement unit 150 arranged on the Z2 direction side of the engagement position P2 to the tip side (Z1 direction). It is made to detach | leave from the engagement position P2, and engagement with the protrusion part 22 and the chip | tip holding | maintenance part 140 (engagement part 145) is cancelled | released.

  As in the first modification, only the slit-shaped guide portion may be provided without providing the cylindrical portion in the chip holding portion.

  Moreover, in the said embodiment, the protrusion part 22 of a fine needle chip | tip has the length which protrudes on the outer side of the slit-shaped guide part 41 of the chip | tip holding | maintenance part 40, and the convex part 54 of the engagement releasing part 50 is Although the structure which moves the protrusion part 22 by contacting the part protruded to the outer side of the guide part 41 was shown, this invention is not limited to this. As another form, the protrusion 22 has such a length that it does not protrude outside the guide part 41, and the protrusion 54 enters the slit of the guide part 41 and comes into contact with the protrusion 54. Also good. When this form is adopted, since the vertical movement of the chip holding part 40 is restricted when the convex part 54 always enters the slit, the disengagement part protrudes to the inside of the housing only in an arbitrary case. It is necessary to.

  Moreover, in the said embodiment, although the example comprised so that a fine needle chip | tip and a chip | tip holding | maintenance part might engage by rotating a fine needle chip | tip around a central axis was shown, this invention is limited to this. Absent. As in the second modification shown in FIG. 16, the fine needle tip may be rotated in the vertical direction (around the horizontal axis). As shown in FIG. 16A, the chip holder 240 in the second modified example includes a first slit portion 241a that is inclined obliquely, and a second that extends in an arc shape from the first slit portion 241a to the engagement position P2. A guide portion 241 having a slit portion 241b is provided. After the protrusion 22 is inserted obliquely along the first slit portion 241a from the entrance position P1, the protrusion 22 is turned by rotating the fine needle tip 2 in the vertical direction (Ra direction) around the base end. It moves to the engagement position P2 along the second slit portion 241b. In addition, illustration of the engaging part is abbreviate | omitted in FIG. As shown in FIG. 16B, the disengagement part 250 moves the protrusion 22 to the engagement position by moving the disengagement part 250 arranged on the extension line in the Ra direction in the reverse direction (Rb direction). It is made to detach | leave from P2, and engagement with the protrusion part 22 and the chip | tip holding | maintenance part 240 is cancelled | released.

  Moreover, in the said embodiment, although the example which comprised the slit-shaped guide part by the 1st slit part and the 2nd slit part was shown, this invention is not limited to this. In the present invention, the guide portion may be constituted by three or more slit portions.

  Moreover, in the said embodiment, when the opening of a chip | tip holder (housing | casing) is upward, opening is upward by comprising so that a chip | tip holding | maintenance part may move to the position where an engagement release part and a protrusion part do not contact. In this state, the example in which the engagement between the tip holding portion and the fine needle tip cannot be released has been shown, but the present invention is not limited to this. In the present invention, the tip holder may be configured so that the engagement between the tip holding portion and the fine needle tip can be released even when the opening is upward.

DESCRIPTION OF SYMBOLS 1 Micro hole formation apparatus 2 Micro needle chip 3 Chip holder 20 Chip main body 21 Micro needle 22 Protruding part 22a Flat surface part 24a Engagement blade (cap engaging part)
25 Cap 26 Grasping part 30 Housing 32a Opening 40, 140, 240 Tip holding part 41, 141, 241 Guide part 41a, 241a First slit part 41b, 241b Second slit part 42 Tube part 50, 150, 250 Disengagement Part 54a contact surface 60 spring member (biasing part)
70 Release mechanism L Projection length P1 Entrance position P2 Engagement position θ1 Entrance angle (first rotation angle)
θ2 engagement angle (second rotation angle)

Claims (18)

A micropore forming apparatus for forming micropores in a subject's skin,
Columnar chip body, a plurality of micro-needles provided at a distal end of the tip body, and a including fine fine needle chip a protruding portion that protrudes from a side surface of the chip body,
A chip holder that detachably holds the fine needle chip;
The tip holder is
A chip holder that has a slit-shaped guide portion that guides the protruding portion of the fine needle tip from the entrance position to the engaging position, and that can hold the fine needle tip by engaging with the protruding portion at the engaging position. And
Engagement release portion that is movably provided with respect to the tip holding portion and releases the engagement between the fine needle tip and the tip holding portion by moving from the engagement position in contact with the protrusion. And a micropore forming apparatus. The protruding portion has a length that protrudes to the outside of the slit-shaped guide portion,
The micro-hole forming apparatus according to claim 1, wherein the disengagement portion contacts the portion of the protrusion that protrudes outside the slit-shaped guide portion and moves the protrusion. The guide portion is configured to guide the protrusion from the entrance position at a first rotation angle to the engagement position at a second rotation angle different from the first rotation angle,
The fine needle tip is configured to rotate around the central axis of the tip body as the projection moves from the entrance position to the engagement position when mounted on the tip holding portion. The micropore forming apparatus according to claim 1 or 2.   The guide portion is connected to the first slit portion extending from the entrance position of the first rotation angle, and the engagement position of the second rotation angle from the first rotation angle. The fine hole forming apparatus according to claim 3, further comprising: a second slit portion that guides the protrusion so as to rotate to the right. The chip holding part further includes a cylindrical part capable of inserting the chip body of the fine needle chip and guiding the insertion of the chip body,
The slit-shaped guide part is formed on the peripheral wall of the cylindrical part, and is configured to guide the movement of the protruding part accompanying the insertion of the chip body into the cylindrical part,
The protruding portion of the fine needle tip has a length that protrudes to the outside of the cylindrical portion through the slit-shaped guide portion in a state where the fine needle tip is held by the tip holding portion. Item 5. The micropore forming apparatus according to any one of Items 1 to 4. The tip holding part is configured to be able to move in a predetermined direction and collide the fine needle of the fine needle tip with the skin of a subject,
The engagement disengaging portion is configured to move in a direction different from the predetermined direction in which the tip holding portion moves to release the engagement between the fine needle tip and the tip holding portion. The micropore forming apparatus according to any one of 1 to 5.   The disengagement part is configured to rotate about an axis center in the predetermined direction in which the tip holding part moves, and to disengage the fine needle chip from the tip holding part. The micropore forming apparatus according to claim 6.   The disengagement portion is urged in a direction from the inlet position side toward the engagement position side, and is moved to the inlet position side against the urging force, whereby the fine needle tip and the tip holding portion are The micropore forming apparatus according to any one of claims 1 to 7, wherein the micropore forming apparatus is configured to release engagement with a portion. The chip holder further includes a housing having an opening at a tip and accommodating the chip holding portion therein,
The fine needle chip is held in the chip holding part through the opening of the housing,
The chip holding portion is configured to move to a position where the disengagement portion and the protruding portion do not contact with each other when the opening of the housing is facing upward. The micropore forming apparatus according to item 1. The tip holding part is configured to be able to move in a predetermined direction and collide the fine needle of the fine needle tip with the skin of a subject,
The tip holder holds the tip holding portion in a state where the biasing portion for applying a biasing force to the tip holding portion in the predetermined direction and the biasing force of the biasing portion are accumulated. And a release mechanism that releases the part and moves it in the predetermined direction,
The disengagement part does not come into contact with the protruding part when the tip holding part is held by the release mechanism, and can come into contact with the protruding part when the tip holding part is released from the release mechanism. The micropore forming apparatus according to any one of claims 1 to 9, which is configured. The protrusion has a columnar shape extending from the side surface of the chip body and a flat surface portion.
The micro-hole forming apparatus according to claim 1, wherein the disengagement unit has a flat contact surface that comes into surface contact with the flat surface portion of the protrusion when releasing the engagement. . A microneedle tip of a micropore forming device, which comprises a tip holder and a microneedle tip that is detachably attached to the tip holder, and is used to form micropores in the skin of a subject,
A columnar chip body;
A plurality of fine needles provided at the tip of the chip body;
A protruding portion protruding from the side surface of the chip body,
The protruding portion is guided from the entrance position to the engaging position along a slit-shaped guide portion provided in the chip holding portion provided in the chip holder, and is engaged with the chip holding portion at the engaging position. A fine needle tip that is configured and configured so that the protruding portion comes into contact with an engagement release portion provided in the tip holder in a state of being arranged at the engagement position of the tip holding portion.   The fine needle chip according to claim 12, wherein the protrusion has a columnar shape extending from a side surface of the chip body, and includes a flat surface portion in surface contact with the engagement release portion.   The fine needle chip according to claim 12 or 13, wherein a plurality of the projecting portions are provided corresponding to the plurality of guide portions provided in the chip holding portion.   The microneedle chip according to any one of claims 12 to 14, further comprising a cap that is detachably provided on the microneedle chip and covers the plurality of microneedles at a tip of the chip body.   The fine needle chip according to claim 15, wherein the cap has a flat grip portion extending in a longitudinal direction of the columnar chip body. The protrusion is guided from the entrance position at a first rotation angle to the engagement position at a second rotation angle different from the first rotation angle,
The columnar chip body is configured to rotate around the central axis as the protrusion moves.
The fine needle chip according to claim 15 or 16, further comprising a cap engaging portion that engages with the cap so as not to rotate relative to the cap around a central axis of the chip main body. A chip holder of a micropore forming device comprising a chip holder and a microneedle tip that is detachably attached to the chip holder, and is used to form micropores in the skin of a subject,
In the configuration in which the microneedle chip includes a columnar chip body, a plurality of microneedles provided at the tip of the chip body, and a protruding portion protruding from a side surface of the chip body,
The tip holder is
A chip holder that has a slit-shaped guide portion that guides the protruding portion of the fine needle tip from the entrance position to the engaging position, and that can hold the fine needle tip by engaging with the protruding portion at the engaging position. And
It is provided so as to be movable with respect to the tip holding portion, and the engagement between the fine needle tip and the tip holding portion is released by contacting the protruding portion and moving the protruding portion from the engaging position. A tip holder comprising: a disengagement unit;

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