JP5922678B2 - 免疫学的検定試験のためのシステム - Google Patents
免疫学的検定試験のためのシステム Download PDFInfo
- Publication number
- JP5922678B2 JP5922678B2 JP2013548586A JP2013548586A JP5922678B2 JP 5922678 B2 JP5922678 B2 JP 5922678B2 JP 2013548586 A JP2013548586 A JP 2013548586A JP 2013548586 A JP2013548586 A JP 2013548586A JP 5922678 B2 JP5922678 B2 JP 5922678B2
- Authority
- JP
- Japan
- Prior art keywords
- probe
- well
- cartridge
- reagent
- rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000003018 immunoassay Methods 0.000 title claims description 26
- 238000012360 testing method Methods 0.000 title claims description 8
- 239000000523 sample Substances 0.000 claims description 297
- 239000003153 chemical reaction reagent Substances 0.000 claims description 75
- 238000009739 binding Methods 0.000 claims description 50
- 230000027455 binding Effects 0.000 claims description 49
- 239000012491 analyte Substances 0.000 claims description 45
- 238000005259 measurement Methods 0.000 claims description 36
- 239000000872 buffer Substances 0.000 claims description 30
- 108010090804 Streptavidin Proteins 0.000 claims description 23
- 238000005406 washing Methods 0.000 claims description 17
- 239000007864 aqueous solution Substances 0.000 claims description 15
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 12
- 239000004033 plastic Substances 0.000 claims description 10
- 229920003023 plastic Polymers 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000000919 ceramic Substances 0.000 claims description 2
- 239000013013 elastic material Substances 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 239000013307 optical fiber Substances 0.000 claims description 2
- 238000003825 pressing Methods 0.000 description 88
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 40
- 239000011616 biotin Substances 0.000 description 20
- 229960002685 biotin Drugs 0.000 description 20
- 235000020958 biotin Nutrition 0.000 description 20
- 238000000034 method Methods 0.000 description 19
- 238000003556 assay Methods 0.000 description 11
- 238000001514 detection method Methods 0.000 description 11
- 239000007850 fluorescent dye Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 239000000427 antigen Substances 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 7
- 239000012131 assay buffer Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 5
- 239000002981 blocking agent Substances 0.000 description 5
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 5
- 239000012488 sample solution Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 108090001008 Avidin Proteins 0.000 description 4
- 238000009007 Diagnostic Kit Methods 0.000 description 4
- 229920001213 Polysorbate 20 Polymers 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
- 229920001917 Ficoll Polymers 0.000 description 3
- 125000005228 aryl sulfonate group Chemical group 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 3
- ZPZDIFSPRVHGIF-UHFFFAOYSA-N 3-aminopropylsilicon Chemical compound NCCC[Si] ZPZDIFSPRVHGIF-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000007413 biotinylation Methods 0.000 description 2
- 230000006287 biotinylation Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003303 ruthenium Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- ATYCFNRXENKXSE-MHPIHPPYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[6-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)NCCCCCC(=O)NCCCCCC(=O)ON1C(=O)CCC1=O ATYCFNRXENKXSE-MHPIHPPYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108050001427 Avidin/streptavidin Proteins 0.000 description 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- -1 amino, carboxyl Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001615 biotins Chemical class 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 108010011505 fluorescein-avidin Proteins 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- YAYGSLOSTXKUBW-UHFFFAOYSA-N ruthenium(2+) Chemical compound [Ru+2] YAYGSLOSTXKUBW-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430963P | 2011-01-08 | 2011-01-08 | |
| US61/430,963 | 2011-01-08 | ||
| PCT/US2012/020532 WO2012094625A2 (en) | 2011-01-08 | 2012-01-06 | Systems for immunoassay tests |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081275A Division JP6279649B2 (ja) | 2011-01-08 | 2016-04-14 | 免疫学的検定試験のためのシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501933A JP2014501933A (ja) | 2014-01-23 |
| JP2014501933A5 JP2014501933A5 (enExample) | 2015-02-26 |
| JP5922678B2 true JP5922678B2 (ja) | 2016-05-24 |
Family
ID=46457990
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548586A Active JP5922678B2 (ja) | 2011-01-08 | 2012-01-06 | 免疫学的検定試験のためのシステム |
| JP2016081275A Active JP6279649B2 (ja) | 2011-01-08 | 2016-04-14 | 免疫学的検定試験のためのシステム |
| JP2018004219A Pending JP2018054637A (ja) | 2011-01-08 | 2018-01-15 | 免疫学的検定試験のためのシステム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081275A Active JP6279649B2 (ja) | 2011-01-08 | 2016-04-14 | 免疫学的検定試験のためのシステム |
| JP2018004219A Pending JP2018054637A (ja) | 2011-01-08 | 2018-01-15 | 免疫学的検定試験のためのシステム |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8753574B2 (enExample) |
| EP (1) | EP2661624B1 (enExample) |
| JP (3) | JP5922678B2 (enExample) |
| CN (3) | CN103430024B (enExample) |
| WO (1) | WO2012094625A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018054637A (ja) * | 2011-01-08 | 2018-04-05 | アクセス メディカル システムズ,リミティド | 免疫学的検定試験のためのシステム |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9804179B2 (en) | 2011-01-08 | 2017-10-31 | Access Medical Systems, Ltd. | Systems for immunoassay tests |
| US9052315B2 (en) | 2012-05-09 | 2015-06-09 | Advanced Animal Diagnostics, Inc. | Rapid detection of analytes in liquid samples |
| US10359614B2 (en) | 2012-07-03 | 2019-07-23 | Advanced Animal Diagnostics, Inc. | Diagnostic apparatus |
| EP2743694A1 (en) * | 2012-12-14 | 2014-06-18 | Numares GmbH | Method for supplementing a sample with specific information and sample tube system |
| FR3000218A1 (fr) | 2012-12-26 | 2014-06-27 | Biomerieux Sa | Barrette d'analyse comprenant des moyens pour fixer un cone a ladite barrette |
| AU2013202778A1 (en) * | 2013-03-14 | 2014-10-02 | Gen-Probe Incorporated | Systems, methods, and apparatuses for performing automated reagent-based assays |
| US9797893B2 (en) | 2013-05-09 | 2017-10-24 | Advanced Animal Diagnostics, Inc. | Rapid detection of analytes in liquid samples |
| WO2015054113A1 (en) | 2013-10-07 | 2015-04-16 | Access Medical Systems, Ltd. | Cartridge assembly tray for immunoassay tests |
| US10639626B2 (en) | 2013-11-07 | 2020-05-05 | Biotix, Inc. | Multiple tube devices and methods of manufacture and use |
| GB201322081D0 (en) * | 2013-12-13 | 2014-01-29 | Ge Healthcare Bio Sciences Ab | Circular extractor |
| KR101588816B1 (ko) * | 2014-04-10 | 2016-01-26 | (주)마이크로디지탈 | 진단용 디텍션 웰 및 이를 갖는 진단용 카트리지 |
| EP3233281B1 (en) | 2014-12-15 | 2019-07-10 | Randox Laboratories Ltd. | Biochip storage well and method for sealing it |
| US9835640B2 (en) | 2015-02-13 | 2017-12-05 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
| WO2016172800A1 (en) | 2015-04-28 | 2016-11-03 | Aterica Inc. | Portable organic molecular sensing device and related systems and methods |
| JP6810055B2 (ja) * | 2015-05-11 | 2021-01-06 | アクセス メディカル システムズ,リミティド | イムノアッセイにおける試験プローブおよび試薬の再利用方法 |
| CN105334318A (zh) * | 2015-11-28 | 2016-02-17 | 宁波美康生物科技股份有限公司 | 一种便捷式c反应蛋白检测试剂盒 |
| CN108779458B (zh) * | 2015-12-04 | 2022-07-15 | 技术合伙公司 | 试样制备系统和筒座 |
| CN110036276A (zh) * | 2016-10-11 | 2019-07-19 | 万迈医疗仪器有限公司 | 使用干涉仪的生物分子光学传感器 |
| US11529628B2 (en) * | 2017-04-28 | 2022-12-20 | Ezdia Tech Inc. | Automated immunoassay device and method using large magnetic particle complex |
| CA3070762A1 (en) * | 2017-07-21 | 2019-01-24 | Helena Laboratories Corporation | System and method for depositing antisera in immunofixation electrophoresis |
| WO2019050976A1 (en) | 2017-09-06 | 2019-03-14 | Access Medical Systems, Ltd. | FERROMAGNETIC ROTORS FOR STIRRING A LIQUID IN A MICROCAVITY |
| WO2020254472A1 (en) * | 2019-06-21 | 2020-12-24 | Diesse Diagnostica Senese S.P.A. | System for single-use immunochemical tests |
| JP7512370B2 (ja) * | 2019-07-26 | 2024-07-08 | アクセス・メディカル・システムズ,リミテッド | 生化学試験用の干渉センサ |
| CN114245873B (zh) * | 2019-07-30 | 2025-05-09 | 匹思灵公司 | 同时分析多种生物标志物的设备和同时分析多种生物标志物的方法 |
| CN110404594B (zh) * | 2019-07-31 | 2024-06-04 | 深圳麦科田生物医疗技术股份有限公司 | 样本分析试剂盒 |
| CN110549088B (zh) * | 2019-09-01 | 2024-06-25 | 浙江联宜电机有限公司 | 台阶销上料机构 |
| USD925760S1 (en) * | 2019-09-17 | 2021-07-20 | Access Medical Systems, Ltd. | Interferometric probe for biochemical testing |
| USD975312S1 (en) | 2020-02-14 | 2023-01-10 | Beckman Coulter, Inc. | Reagent cartridge |
| CN112539720A (zh) * | 2020-12-23 | 2021-03-23 | 北京宝隆特设备检测有限公司 | 一种高效的超声波测厚仪及其使用方法 |
| WO2023090446A1 (ja) * | 2021-11-22 | 2023-05-25 | 国立大学法人東京大学 | 検体分析装置、検体分析方法 |
| WO2024259688A1 (zh) * | 2023-06-21 | 2024-12-26 | 深圳迈瑞生物医疗电子股份有限公司 | 样本分析仪、试剂盒、样本分析仪的控制方法 |
| CN117533661B (zh) * | 2023-12-28 | 2025-11-11 | 长沙迈迪克智能科技有限公司 | 用于血液储存管理系统的血框取送装置及血液储存管理系统 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1499989A (en) * | 1923-04-20 | 1924-07-01 | Lehmann Franz | Vise for use with machine tools |
| US2754708A (en) * | 1953-08-25 | 1956-07-17 | Multiple Die Vise Co Inc | Vise for irregularly shaped objects |
| US2882771A (en) * | 1956-06-22 | 1959-04-21 | Ronald R Blazek | Work-holding device having plungers actuated by hydraulic fluid composed of a fusible alloy |
| US4447546A (en) | 1982-08-23 | 1984-05-08 | Myron J. Block | Fluorescent immunoassay employing optical fiber in capillary tube |
| JPS59175976A (ja) * | 1983-03-23 | 1984-10-05 | 三菱電機株式会社 | ロボツトのハンド装置 |
| US4752564A (en) * | 1983-07-12 | 1988-06-21 | Phillips Petroleum Company | Fermentation method and apparatus |
| US4572564A (en) * | 1984-07-12 | 1986-02-25 | General Electric Company | Adaptive gripping device |
| US4631815A (en) * | 1985-12-18 | 1986-12-30 | Amp Incorporated | Pick-up head |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5011207A (en) * | 1987-08-03 | 1991-04-30 | Stevens S Scott | Robotic end effector for grasping objects |
| US4891321A (en) * | 1987-10-21 | 1990-01-02 | Hubscher Thomas T | Apparatus for performing determinations of immune reactants in biological fluids |
| JPH03117587U (enExample) * | 1990-03-14 | 1991-12-04 | ||
| CA2050121C (en) * | 1991-03-04 | 2005-04-19 | Glen A. Carey | Automated analyzer |
| US6498037B1 (en) * | 1991-03-04 | 2002-12-24 | Bayer Corporation | Method of handling reagents in a random access protocol |
| FI930440A0 (fi) * | 1993-02-01 | 1993-02-01 | Labsystems Oy | Bestaemningsfoerfarande |
| US5650334A (en) | 1995-08-31 | 1997-07-22 | First Medical, Inc. | Fluorescent labelling compositions and methods for their use |
| US5884906A (en) * | 1995-10-16 | 1999-03-23 | Morse; Loren | Hydraulically compensating jaw for holding multiple work pieces |
| EP1291654B1 (en) | 2000-04-28 | 2006-11-22 | Mitsubishi Kagaku Iatron, Inc. | Automatic measuring cartridge and measuring method using it |
| US6345816B1 (en) * | 2000-05-11 | 2002-02-12 | Snap Jaws Manufacturing Co. | Hydraulic vise jaws |
| US6464939B1 (en) * | 2000-07-06 | 2002-10-15 | Varian, Inc. | Saliva testing and confirmation device |
| CN2473613Y (zh) * | 2001-04-26 | 2002-01-23 | 雷刚平 | 粪便采集盛放器 |
| HUP0303809A3 (en) * | 2001-05-09 | 2011-05-30 | Axis Shield Asa | Assay system |
| JP2004205268A (ja) * | 2002-12-24 | 2004-07-22 | Canon Inc | 蛍光免疫測定方法及び蛍光免疫測定装置 |
| EP1650570B1 (en) * | 2003-07-17 | 2021-05-26 | LSI Medience Corporation | Apparatus for use in measuring a component contained in a sample comprising a measuring device and a cartridge |
| TWM246495U (en) * | 2003-10-31 | 2004-10-11 | Hon Hai Prec Ind Co Ltd | Automatic apparatus for assembling bearig to motor |
| GB0503836D0 (en) * | 2005-02-24 | 2005-04-06 | Axis Shield Asa | Method |
| US8075850B2 (en) * | 2006-01-13 | 2011-12-13 | The Bode Technology Group, Inc. | Touch evidence collection apparatus and method |
| CA2738317C (en) * | 2008-09-24 | 2020-01-14 | Straus Holdings Inc. | Imaging analyzer for testing analytes |
| EP2404162B1 (en) | 2009-03-03 | 2017-12-27 | Access Medical System Co., Ltd. | Detection system and method for high sensitivity fluorescent assays |
| CN103430024B (zh) * | 2011-01-08 | 2016-06-29 | 万迈医疗仪器有限公司 | 用于免疫分析检测的系统 |
| WO2012145270A2 (en) | 2011-04-20 | 2012-10-26 | Access Medical Systems, Ltd. | Luminescent polymer cyclic amplification |
| CN102358988B (zh) * | 2011-11-14 | 2013-06-12 | 宁波慈星股份有限公司 | 沉降三角控制装置 |
| US9568431B2 (en) * | 2012-04-16 | 2017-02-14 | Access Medical Systems, Ltd. | Luminescent immunoassays for quantitating analytes having a wide concentration range |
| US8534728B1 (en) * | 2012-11-19 | 2013-09-17 | Harris Corporation | Adaptive robotic gripper |
| CN103753242A (zh) * | 2013-11-25 | 2014-04-30 | 重庆舰帏机械有限公司 | 曲轴夹具 |
-
2012
- 2012-01-06 CN CN201280004844.2A patent/CN103430024B/zh active Active
- 2012-01-06 CN CN201610350276.1A patent/CN106018782A/zh active Pending
- 2012-01-06 EP EP12731911.9A patent/EP2661624B1/en active Active
- 2012-01-06 JP JP2013548586A patent/JP5922678B2/ja active Active
- 2012-01-06 CN CN202010094963.8A patent/CN111505265A/zh active Pending
- 2012-01-06 WO PCT/US2012/020532 patent/WO2012094625A2/en not_active Ceased
-
2013
- 2013-07-05 US US13/936,047 patent/US8753574B2/en active Active
-
2014
- 2014-06-10 US US14/301,228 patent/US9468926B2/en active Active
-
2016
- 2016-04-14 JP JP2016081275A patent/JP6279649B2/ja active Active
-
2018
- 2018-01-15 JP JP2018004219A patent/JP2018054637A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018054637A (ja) * | 2011-01-08 | 2018-04-05 | アクセス メディカル システムズ,リミティド | 免疫学的検定試験のためのシステム |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103430024A (zh) | 2013-12-04 |
| JP2014501933A (ja) | 2014-01-23 |
| US20130295591A1 (en) | 2013-11-07 |
| US8753574B2 (en) | 2014-06-17 |
| EP2661624B1 (en) | 2017-08-02 |
| WO2012094625A3 (en) | 2013-01-17 |
| US9468926B2 (en) | 2016-10-18 |
| JP2016166882A (ja) | 2016-09-15 |
| CN103430024B (zh) | 2016-06-29 |
| US20140295578A1 (en) | 2014-10-02 |
| CN111505265A (zh) | 2020-08-07 |
| JP6279649B2 (ja) | 2018-02-14 |
| EP2661624A4 (en) | 2014-05-28 |
| CN106018782A (zh) | 2016-10-12 |
| WO2012094625A2 (en) | 2012-07-12 |
| EP2661624A2 (en) | 2013-11-13 |
| JP2018054637A (ja) | 2018-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6279649B2 (ja) | 免疫学的検定試験のためのシステム | |
| US11879901B2 (en) | Cartridges for immunoassay tests and methods of using the same | |
| US12153061B2 (en) | Cartridge assembly tray for immunoassay tests | |
| JP6810055B2 (ja) | イムノアッセイにおける試験プローブおよび試薬の再利用方法 | |
| CA2745442C (en) | Test element having combined control and calibration zone | |
| EP2631007A1 (en) | Device for parallelization and performance increase in microarray-immunoassays with solid, non-porous capture-zone | |
| US10809251B2 (en) | Immunoassay with enhanced sensitivity | |
| US8501496B2 (en) | Immunoassay cuvettes | |
| RU2710262C1 (ru) | Способ проведения биологического микроанализа |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150106 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150106 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150928 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20151110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160209 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160315 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160414 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5922678 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |