JP5882791B2 - Kakkonto liquid composition - Google Patents

Description

  The present invention relates to an internal liquid composition containing kakkonto extract. More specifically, the present invention relates to a solution composition for internal use of Kakkonto which improves the unpleasant taste such as bitterness and astringency and a peculiar unpleasant odor possessed by Kakkonto extract and makes it easy to take.

  Kakkonto is a Chinese herbal medicine used for the treatment or prevention of a wide range of diseases including cold medicine, but it has a strong bitter taste and astringency, and also has a unique herbal odor and paralysis of some tongues. There is also a feeling. In particular, in the case of liquid preparations, there is a problem that these unpleasant flavors are exhibited even if the amount of Kakkonto is very small.

  Conventionally, in order to mask the bitter taste of pharmaceuticals and improve unpleasant odors, studies have been made on the blending of sweeteners and fragrances, etc., but masking of bitterness and flavor at present is not sufficient, especially It was difficult for women and children to take.

  Currently, there are 50 items of Kakkonto solution (excluding syrup) (see Non-Patent Document 1, for example) currently on the market in Japan, and the addition status of sweeteners and fragrances is shown in Table 1. None of them have been improved to the extent that they are still delicious. Therefore, treatment by improving the patient's compliance, such as discontinuing the patient's original use, exhaling while the child is taking, not taking the necessary amount, delaying the recovery of the disease, and worsening the disease. In order to improve the effect, further improvement of bitterness and flavor is strongly desired.

  Until now, what blended sucrose, D-sorbitol, and the fragrance | flavor with the self-contained Kakkonto extract containing liquid agent is disclosed (patent document 1). In addition, the addition of polyhydric alcohol has a masking effect on liquids for internal use containing ingredients with unpleasant tastes such as herbal medicines, sucrose, fructose, glucose, erythritol, trehalose, maltitol, xylitol, honey, licorice , Saccharin, aspartame, stevia extract, sucralose, acesulfame K, glycyrrhizic acid, and other sweeteners are added to enhance the bitter taste masking effect (see Patent Document 2).

  However, so far, (1) one or more selected from the group consisting of sucrose, honey and isomerized sugar, and (2) one selected from the group consisting of sucralose, stevia and thaumatin Or 2 or more types and (3) Kakkonto solution containing 1 type or 2 types or more of fragrances selected from the group consisting of fruit-based fragrance, ginger fragrance, and pepper fragrance is not known. There was no suggestion that a kekkonto solution with a very good feeling of use would be realized when these were blended in specific amounts.

JP 2001-288101 A JP 2002-363105 A

Japan Pharmaceutical Collection General Medicine 2010-11 Jiho 2009, 1024-1039

  A bitter taste that can be taken deliciously with an oral liquid containing kakkonto extract that has an unpleasant taste such as bitterness and a unique unpleasant odor, and that does not cause vomiting due to the taste and odor of the internal liquid even if it is taken by a child It is a problem to provide a kakkonto liquid composition with improved taste and taste such as odor.

  In order to solve the above-mentioned problems, the present inventors have intensively studied for many years about Kakkonto-containing liquid agents. Among them, in order to mask the unpleasant taste peculiar to Kakkonto and unique unpleasant odor during the beginning of drinking, during drinking, and after drinking, a sweet ingredient with a fast masking action and a sweet ingredient with a moderate masking action time, Furthermore, it has been found that it is only necessary to combine a sweetening component that has a slow onset of masking action but is persistent.

  However, it became clear that masking against the unpleasant odor of Kakkonto extract was also indispensable, and as a result of repeated studies, the feeling of taking was extremely good only when the fleur, ginger and pepper flavors were added. The present inventors have found that kakkonto liquid can be realized and have completed the present invention.

That is, the present invention provides the following (1) to (3).
(1): Kakkonto liquid composition containing (a) to (c).
(A) 0.1 to 10 w / v% of one or more selected from the group consisting of sucrose, honey, and isomerized sugar
(B) One selected from the group consisting of sucralose 0.005-0.05 w / v%, stevia 0.005-0.05 w / v%, and thaumatin 0.0001-0.005 w / v% Or two or more sweeteners (c) one or more flavors selected from the group consisting of a fruit flavor, ginger flavor, and pepper flavor (2): a fruit flavor is lemon, orange The composition according to (1), which is one or more selected from orange, yuzu, kumquat, karin, apple, peach, lychee, and mango.
(3): The composition according to (1) or (2), wherein the sugar content is 2 to 20.

  ADVANTAGE OF THE INVENTION According to this invention, even if it uses a Kakkonto internal use liquid containing unpleasant tastes, such as bitter taste, and a peculiar unpleasant odor, it can be taken deliciously and the Kakkonto liquid composition which is easy to take even in children is obtained.

  Hereinafter, the present invention will be described in more detail.

The Kakkonto extract composition of the present invention is a Kakkonto extract-containing solution,
(A) 0.1 to 10 w / v% of one or more selected from the group consisting of sucrose, honey, and isomerized sugar
(B) Sucralose 0.005-0.05 w / v%, Stevia 0.005-0.05 w / v%,
And one or two or more sweeteners selected from the group consisting of thaumatin 0.0001 to 0.005 w / v%. (C) selected from the group consisting of fruit-based fragrance, ginger fragrance, and red pepper fragrance. The above-mentioned (a) to (c) may be contained.

  The “Kakkonto extract” in the present invention includes the main ingredient, kakon (Kakkon), maou (mao), taisou (daiso), keihi (cinnamon), peonies (glaze), licorice (licorice), ginger (ginger) ) And is commercially available as dried kakkonto extract.

  Although it does not specifically limit as content of the Kakkonto extract in this invention, 50-96 w / v% of the whole prescription can be added, and 70-92 w / v% is preferable.

  The component (a) in the present invention means one or more selected from the group consisting of sucrose, honey, and isomerized sugar, but contains both components of sucrose and isomerized sugar. Is preferred.

  Here, the isomerized sugar means a liquid sugar mainly composed of glucose and fructose, and includes glucose fructose liquid sugar, fructose glucose liquid sugar, high fructose liquid sugar, and sugar mixed isomerized liquid sugar. High fructose liquid sugar is preferred. Although the sweetener which is (a) component can use together 1 type, or 2 or more types, the compounding quantity of the whole sweetener is 0.1-10.0 w / with respect to the internal use liquid composition whole quantity. v% is preferred.

  In addition to the sweetener of the above component (a), sugars such as fructose, glucose, maltose and the like may be used as long as the taste improving effect such as bitterness of the composition of the present invention is not inhibited. Sweet sweeteners may be added, and sugar sweeteners such as maltitol, xylitol, erythritol, sorbitol, mannitol, and high-intensity sweeteners such as aspartame, acesulfame potassium, saccharin, etc. You may mix | blend.

  The component (b) in the present invention comprises sucralose 0.005 to 0.05 w / v%, stevia 0.005 to 0.05 w / v%, and thaumatin 0.0001 to 0.005 w / v%. Means one or more sweeteners selected from the group, sucralose 0.005-0.05 w / v%, stevia 0.005-0.05 w / v%, and thaumatin 0.0001-0 Those containing two or more selected from the group consisting of 0.005 w / v% are preferred, and those containing all three are more preferred. Here, stevia (or stevia extract), sucralose and thaumatin are easily commercially available. For example, sucralose and thaumatin can be purchased from San-Ei Gen FFI Co., Ltd.

  (C) component in this invention means the 1 type (s) or 2 or more types selected from the group which consists of a fruit-type fragrance | flavor, a ginger fragrance | flavor, and a red pepper fragrance | flavor. Here, the fruit flavor is not particularly limited as long as it is a fruit, but lemon, tangerine, orange, yuzu, kumquat, karin, apple, peach, litchi and mango are preferable.

  As a ginger fragrance | flavor or a chili pepper fragrance | flavor, fragrance | flavors, such as an extract extracted from ginger and a pepper, and a capsaicin combination extract, are preferable. As the component (c) in the present invention, it may be blended with only one of the above, or two or more may be blended. In terms of surface. As a fruit-type fragrance | flavor, 1 type (s) or 2 or more types selected from the group which consists of lemon, orange, and mango are especially preferable.

  The composition of the present invention contains the above-mentioned (a) to (c), which improves the unpleasant taste such as bitterness at the time of taking which is a problem, relaxes the taste such as a unique unpleasant odor, and is delicious. A kakkonto liquid composition that can be taken and can be easily taken even by children can be provided.

  The sugar content of the composition of the present invention is preferably in the range of 2-20.

  The composition of the present invention includes the necessary components (a) to (c) and enhances the sourness by adding an acid, thereby enhancing the refreshing feeling and making it easier to take. It can also be improved. Here, as the acid to be added, for example, an organic acid such as acetic acid, citric acid, malic acid, tartaric acid, ascorbic acid, or phosphoric acid is preferably used.

  The other compounding components of the composition of the present invention are not particularly limited and may be appropriately selected depending on the purpose. For example, preservatives, preservatives, flavoring agents, cooling agents, surfactants, Examples include solubilizers, emulsifiers, solvents, buffers, suspending agents, thickeners, colorants, stabilizers, solubilizers, etc. These may be used alone or in combination of two or more. You may use together.

  The composition of this invention can be manufactured by the well-known method generally known as a manufacturing method of a liquid agent.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated further more concretely, it is not limited to an Example at all.

  Table 2 shows formulations of Examples (Examples 1 to 3) and Comparative Examples (Comparative Examples 1 to 5).

[Test example] Sensory test using Kakkonto solution Each of Kakkonto solution shown in Table 2 by 4 panelists: 1) Pre-taste, 2) Aftertaste, 3) Smell, 4) Total feeling of use Was subjected to sensory evaluation according to the following evaluation criteria. The results are shown in Table 3.

<Evaluation criteria>
5: Very easy to drink 4: Easy to drink 3: Slightly easy to drink 2: Difficult to drink 1: Very difficult to drink (equivalent to or less than conventional kakkonto combination liquid)

[Evaluation results]
As shown in Table 3, the oral liquids of Examples 1 to 3 all have an uncomfortable taste such as the bitter taste of Kakkonto and a unique unpleasant odor, and are compared with conventional Kakkonto. Then, it was something that could be taken dramatically and deliciously.

  In Comparative Example 1, the total amount of sucrose, honey, and isomerized sugar is as small as 0.01 w / v%, so that the effect of improving the bitter taste that appears quickly is insufficient. In Comparative Example 2, sucrose, honey, isomerized sugar The total amount of 15.0 w / v% was too much, so that the sweetness that was expressed quickly became too strong and the sweetness was so bad that the feeling of administration was poor.

  In Comparative Example 3, the total amount of sucralose, stevia, and thaumatin is as small as 0.00043 w / v%, so the effect of improving the bitterness that appears slowly is insufficient, and in Comparative Example 4, the sum of sucralose, stevia, and thaumatin is 0. Since the amount was too high at .403 w / v%, the sweetness that was developed slowly became too strong, and the sweetness was inferior and the feeling of taking was poor.

  In Comparative Example 5, a milk-based fragrance is blended, but the compatibility with the odor component of Kakkonto extract is poor and the masking effect is insufficient, resulting in an unpleasant odor than Kakkonto extract alone and poor feeling of administration. became.

  An unpleasant taste such as a bitter taste at the time of taking and a taste such as a peculiar unpleasant odor can be alleviated to provide a kakkonto liquid composition that can be taken deliciously and can be easily taken even by children.

Claims (3)

Kakkonto liquid composition containing (a) to ( d ).
(A) 0.1 to 10 w / v% of one or two selected from the group consisting of sucrose and isomerized sugar
(B) One or two sweeteners selected from the group consisting of 0.005 to 0.05 w / v% stevia and 0.0001 to 0.005 w / v% thaumatin ( c ) Sucralose 005 to 0.05 w / v%
( D ) 1 type, or 2 or more types of fragrance | flavors selected from the group which consists of a fruit-type fragrance | flavor, a ginger fragrance | flavor, and a red pepper fragrance | flavor.   The composition according to claim 1, wherein the fruit flavor is one or more selected from lemon, mandarin orange, orange, yuzu, kumquat, karin, apple, peach, lychee, and mango.   The composition of Claim 1 or 2 whose sugar content is 2-20.