JP5839361B2 - 再活性化を予防する結核ｔｂワクチン - Google Patents

再活性化を予防する結核ｔｂワクチン Download PDF

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JP5839361B2
JP5839361B2 JP2012506340A JP2012506340A JP5839361B2 JP 5839361 B2 JP5839361 B2 JP 5839361B2 JP 2012506340 A JP2012506340 A JP 2012506340A JP 2012506340 A JP2012506340 A JP 2012506340A JP 5839361 B2 JP5839361 B2 JP 5839361B2
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vaccine
composition
infection
polypeptide
immunogenic
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JP2012524733A5 (https=
JP2012524733A (ja
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ディートリッヒ，ジェス
アンデルセン，ペーター
ルンドベリ，カリーナ，ヴィンギスボ
ホアン，チュク，ティー，キム，タン
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スタテンス セールム インスティトゥート
スタテンス セールム インスティトゥート
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2012506340A 2009-04-24 2010-04-23 再活性化を予防する結核ｔｂワクチン Expired - Fee Related JP5839361B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200900539 2009-04-24
DKPA200900539 2009-04-24
PCT/DK2010/000054 WO2010121618A1 (en) 2009-04-24 2010-04-23 A tuberculosis tb vaccine to prevent reactivation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015127000A Division JP6215260B2 (ja) 2009-04-24 2015-06-24 再活性化を予防する結核ｔｂワクチン

Publications (3)

Publication Number Publication Date
JP2012524733A JP2012524733A (ja) 2012-10-18
JP2012524733A5 JP2012524733A5 (https=) 2013-06-06
JP5839361B2 true JP5839361B2 (ja) 2016-01-06

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JP2012506340A Expired - Fee Related JP5839361B2 (ja) 2009-04-24 2010-04-23 再活性化を予防する結核ｔｂワクチン
JP2015127000A Active JP6215260B2 (ja) 2009-04-24 2015-06-24 再活性化を予防する結核ｔｂワクチン

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US (2) US9074001B2 (https=)
EP (1) EP2421557B1 (https=)
JP (2) JP5839361B2 (https=)
KR (2) KR20170072366A (https=)
CN (2) CN102413837B (https=)
AU (1) AU2010238943B9 (https=)
BR (1) BRPI1006452A2 (https=)
CA (1) CA2759583C (https=)
DK (1) DK2421557T3 (https=)
ES (1) ES2714383T3 (https=)
HK (1) HK1204549A1 (https=)
IL (1) IL215591A (https=)
MX (2) MX2011011186A (https=)
PL (1) PL2421557T3 (https=)
TR (1) TR201903223T4 (https=)
WO (1) WO2010121618A1 (https=)
ZA (1) ZA201108564B (https=)

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PT2315773T (pt) * 2008-07-25 2016-11-23 Glaxosmithkline Biologicals Sa Polipéptidos, polinucleótidos e composições para utilização no tratamento de tuberculose latente
HUE037121T2 (hu) 2008-07-25 2018-08-28 Glaxosmithkline Biologicals Sa Új készítmények és eljárások
MX2011000982A (es) 2008-07-25 2011-03-02 Glaxosmithkline Biolog Sa La proteina de tuberculosis rv2386c, composiciones y usos de la misma.
GB0906215D0 (en) 2009-04-09 2009-05-20 Lalvani Ajit Diagnostic test
SI2528621T1 (sl) 2010-01-27 2017-01-31 Glaxosmithkline Biologicals S.A., Modificirani tuberkolozni antigeni
EP2661253B1 (en) * 2011-01-04 2017-04-19 Archivel Farma, SL Liposome formulation suitable for treating or preventing tuberculosis
ES2670493T3 (es) 2012-01-12 2018-05-30 Archivel Farma, S.L. Vacuna de MTB-C contra respuestas alérgicas
JP6470179B2 (ja) * 2012-10-23 2019-02-13 スタテンス セールム インスティトゥート 結核菌（ｍ．ｔｕｂｅｒｃｕｌｏｓｉｓ）ワクチン
CA2898131A1 (en) * 2013-03-15 2014-09-18 The Trustees Of The Univeristy Of Pennsylvania Synthetic immunogens for prophylaxis or treatment of tuberculosis
LT3084442T (lt) * 2013-12-16 2021-07-12 Statens Serum Institut Diagnostiniai reagentai, skirti pagerintai in vivo arba in vito ląstelių medijuojamai imunologinei tuberkuliozės diagnozei
EP3092000A1 (en) * 2014-01-09 2016-11-16 Transgene SA Fusion of heterooligomeric mycobacterial antigens
WO2015161853A1 (en) * 2014-04-24 2015-10-29 Statens Serum Institut New m.tuberculosis vaccines
CN104151433A (zh) * 2014-08-11 2014-11-19 兰州大学 一种结核分枝杆菌融合蛋白及其制备方法和应用
CN104225591A (zh) * 2014-09-15 2014-12-24 兰州大学 一种免疫佐剂及含有该免疫佐剂的疫苗
KR20190009308A (ko) * 2016-05-21 2019-01-28 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) 2차 결핵 및 비결핵성 마이코박테리아 감염을 치료하기 위한 조성물 및 방법
WO2019210282A2 (en) * 2018-04-26 2019-10-31 Children's National Medical Center Mycobacterial antigen compositions and methods of use
CN110423279B (zh) * 2019-06-20 2021-07-27 扩增生物科技(北京)有限公司 结核分枝杆菌重组融合蛋白eecc及其制备方法和应用
CN115598041B (zh) * 2021-07-07 2025-08-19 中国科学院微生物研究所 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用
KR102577332B1 (ko) * 2021-12-29 2023-09-11 재단법인 오송첨단의료산업진흥재단 항원성 및 안정성이 개선된 항원을 포함하는 잠복결핵 진단용 조성물
KR20250082868A (ko) 2023-11-30 2025-06-09 서울대학교산학협력단 분비형 코리스메이트 뮤테이즈 (Rv1885c)가 약화된 Mycobacterium bovis BCG 균주, 이를 포함하는 백신용 조성물 및 이의 용도
CN117777259B (zh) * 2024-02-23 2024-06-07 上海科新生物技术股份有限公司 检测结核感染的抗原组合物、试剂盒及其应用
CN120192426B (zh) * 2025-03-04 2025-11-11 江西澄实生物科技有限公司 一种预防沙门氏菌感染的疫苗及其应用

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Also Published As

Publication number Publication date
JP6215260B2 (ja) 2017-10-18
ES2714383T3 (es) 2019-05-28
US20150093407A1 (en) 2015-04-02
CN104107425A (zh) 2014-10-22
CN104107425B (zh) 2018-07-17
HK1166018A1 (zh) 2012-10-19
IL215591A0 (en) 2011-12-29
EP2421557B1 (en) 2018-12-05
JP2015199771A (ja) 2015-11-12
US20120039925A1 (en) 2012-02-16
WO2010121618A1 (en) 2010-10-28
AU2010238943A1 (en) 2011-11-03
HK1204549A1 (en) 2015-11-27
PL2421557T3 (pl) 2019-07-31
ZA201108564B (en) 2018-11-28
EP2421557A1 (en) 2012-02-29
CA2759583A1 (en) 2010-10-28
BRPI1006452A2 (pt) 2016-12-27
IL215591A (en) 2016-03-31
US9074001B2 (en) 2015-07-07
MX370744B (es) 2019-12-20
CN102413837A (zh) 2012-04-11
CN102413837B (zh) 2015-11-25
CA2759583C (en) 2020-06-16
JP2012524733A (ja) 2012-10-18
TR201903223T4 (tr) 2019-03-21
KR20120014176A (ko) 2012-02-16
EP2421557A4 (en) 2013-03-13
KR20170072366A (ko) 2017-06-26
AU2010238943B2 (en) 2015-09-17
AU2010238943A9 (en) 2015-10-15
AU2010238943B9 (en) 2015-10-15
MX2011011186A (es) 2012-02-13
US10519202B2 (en) 2019-12-31
DK2421557T3 (en) 2019-03-25

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