JP5837622B2 - 多胎妊娠の分子検査 - Google Patents
多胎妊娠の分子検査 Download PDFInfo
- Publication number
- JP5837622B2 JP5837622B2 JP2013554948A JP2013554948A JP5837622B2 JP 5837622 B2 JP5837622 B2 JP 5837622B2 JP 2013554948 A JP2013554948 A JP 2013554948A JP 2013554948 A JP2013554948 A JP 2013554948A JP 5837622 B2 JP5837622 B2 JP 5837622B2
- Authority
- JP
- Japan
- Prior art keywords
- allele
- locus
- fetuses
- fetal
- loci
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/40—Population genetics; Linkage disequilibrium
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Data Mining & Analysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioethics (AREA)
- Databases & Information Systems (AREA)
- Artificial Intelligence (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Software Systems (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446256P | 2011-02-24 | 2011-02-24 | |
| US61/446,256 | 2011-02-24 | ||
| PCT/IB2012/000344 WO2013041921A1 (en) | 2011-02-24 | 2012-02-24 | Molecular testing of multiple pregnancies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015217329A Division JP6068598B2 (ja) | 2011-02-24 | 2015-11-05 | 多胎妊娠の分子検査 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507158A JP2014507158A (ja) | 2014-03-27 |
| JP2014507158A5 JP2014507158A5 (https=) | 2014-05-08 |
| JP5837622B2 true JP5837622B2 (ja) | 2015-12-24 |
Family
ID=47753591
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554948A Active JP5837622B2 (ja) | 2011-02-24 | 2012-02-24 | 多胎妊娠の分子検査 |
| JP2015217329A Active JP6068598B2 (ja) | 2011-02-24 | 2015-11-05 | 多胎妊娠の分子検査 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015217329A Active JP6068598B2 (ja) | 2011-02-24 | 2015-11-05 | 多胎妊娠の分子検査 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10900080B2 (https=) |
| EP (5) | EP2860265B1 (https=) |
| JP (2) | JP5837622B2 (https=) |
| CN (2) | CN106011237B (https=) |
| AU (1) | AU2012311262C1 (https=) |
| CA (3) | CA2827873C (https=) |
| TW (1) | TWI611186B (https=) |
| WO (1) | WO2013041921A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3783110T (lt) | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012088456A2 (en) | 2010-12-22 | 2012-06-28 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| EP2860265B1 (en) | 2011-02-24 | 2016-10-26 | The Chinese University of Hong Kong | Determining fetal DNA percentage for twins |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN104053787A (zh) * | 2012-05-23 | 2014-09-17 | 深圳华大基因医学有限公司 | 鉴定双胞胎类型的方法和系统 |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| TWI489305B (zh) * | 2012-11-21 | 2015-06-21 | Bgi Diagnosis Co Ltd | 對胎兒遺傳異常的無創性檢測 |
| JP6525894B2 (ja) | 2013-02-28 | 2019-06-05 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 超並列rna配列決定による母体血漿のトランスクリプトーム解析 |
| TWI637058B (zh) * | 2013-03-15 | 2018-10-01 | 香港中文大學 | 測定多胞胎妊娠之胎兒基因組 |
| HUE042654T2 (hu) | 2013-06-21 | 2019-07-29 | Sequenom Inc | Eljárás genetikai variációk nem-invazív megállapítására |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| EP4063517B1 (en) | 2015-07-20 | 2026-01-07 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in cell-free dna mixtures of maternal and fetal dna |
| EP3518974A4 (en) | 2016-09-29 | 2020-05-27 | Myriad Women's Health, Inc. | NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION |
| JP7370862B2 (ja) | 2017-03-17 | 2023-10-30 | セクエノム, インコーポレイテッド | 遺伝子モザイク症のための方法およびプロセス |
| WO2018223057A1 (en) * | 2017-06-02 | 2018-12-06 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies |
| EP3631008B1 (en) * | 2017-06-02 | 2025-12-03 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
| WO2018223053A1 (en) | 2017-06-02 | 2018-12-06 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
| IL271147B2 (en) | 2017-06-20 | 2025-04-01 | Illumina Inc | Accurate computational methods for decomposing mixtures of DNA from donors with unknown genotypes |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN112634986B (zh) * | 2019-09-24 | 2024-07-26 | 厦门赛尔吉亚医学检验所有限公司 | 一种基于孕妇外周血对双胞胎合子性质的无创鉴定方法 |
| KR102162831B1 (ko) | 2019-12-26 | 2020-10-08 | 주식회사 마크로젠 | 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치 |
| JP7121440B1 (ja) * | 2020-12-16 | 2022-08-18 | 株式会社seeDNA | 多型座位の信号の信頼性値の算出方法 |
| CN114214425B (zh) * | 2020-12-23 | 2024-01-19 | 上海亿康医学检验所有限公司 | 一种鉴定核酸样本的亲本倾向性的方法或装置 |
| CN113981062B (zh) * | 2021-10-14 | 2024-02-20 | 武汉蓝沙医学检验实验室有限公司 | 以非生父和母亲dna评估胎儿dna浓度的方法及应用 |
| WO2023120783A1 (ko) * | 2021-12-24 | 2023-06-29 | 주식회사 마크로젠 | 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치 |
| CN116052766B (zh) * | 2023-01-09 | 2026-01-02 | 北京交通大学 | 一种染色体纯合区域的检测方法、系统及电子设备 |
| CN120412715B (zh) * | 2025-03-17 | 2025-11-28 | 上海蓝沙生物科技有限公司 | 一种通过多态性位点连锁区域块评估孕期母本游离血液中胎儿DNA浓度(cffDNA)的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6013449A (en) | 1997-11-26 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
| EP1368369A4 (en) | 2000-11-15 | 2006-02-22 | Hoffmann La Roche | METHOD AND REAGENTS FOR IDENTIFYING RARE FOETAL CELLS IN THE MATERIAL CIRCUIT |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| WO2003031646A1 (en) * | 2001-10-12 | 2003-04-17 | The University Of Queensland | Multiple genetic marker selection and amplification |
| US6977162B2 (en) * | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| ATE382101T1 (de) * | 2004-07-01 | 2008-01-15 | Integragen Sa | Einen transkriptionsfaktor kodierendes humanes prädispositionsgen für autismus sowie dessen verwendungen |
| US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
| WO2007147074A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
| LT2557517T (lt) * | 2007-07-23 | 2023-01-10 | The Chinese University Of Hong Kong | Nukleino rūgščių sekos disbalanso nustatymas |
| JP2010043063A (ja) * | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| CA2748030A1 (en) * | 2008-12-22 | 2010-07-01 | Arnold R. Oliphant | Methods and genotyping panels for detecting alleles, genomes, and transcriptomes |
| LT3783110T (lt) | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US20110312503A1 (en) * | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| US10316362B2 (en) * | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| AU2011358564B9 (en) * | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| EP2860265B1 (en) | 2011-02-24 | 2016-10-26 | The Chinese University of Hong Kong | Determining fetal DNA percentage for twins |
| CN103797129B (zh) | 2011-04-12 | 2016-08-17 | 维里纳塔健康公司 | 使用多态计数来解析基因组分数 |
| AU2011365507A1 (en) * | 2011-04-14 | 2013-05-02 | Verinata Health, Inc. | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
| ES2886508T3 (es) * | 2011-10-06 | 2021-12-20 | Sequenom Inc | Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas |
| TWI637058B (zh) | 2013-03-15 | 2018-10-01 | 香港中文大學 | 測定多胞胎妊娠之胎兒基因組 |
-
2012
- 2012-02-24 EP EP14193704.5A patent/EP2860265B1/en active Active
- 2012-02-24 JP JP2013554948A patent/JP5837622B2/ja active Active
- 2012-02-24 US US13/405,073 patent/US10900080B2/en active Active
- 2012-02-24 AU AU2012311262A patent/AU2012311262C1/en active Active
- 2012-02-24 CA CA2827873A patent/CA2827873C/en active Active
- 2012-02-24 WO PCT/IB2012/000344 patent/WO2013041921A1/en not_active Ceased
- 2012-02-24 EP EP18213644.0A patent/EP3489368B1/en active Active
- 2012-02-24 CA CA3252077A patent/CA3252077A1/en active Pending
- 2012-02-24 EP EP12834099.9A patent/EP2678451B1/en active Active
- 2012-02-24 EP EP13187208.7A patent/EP2682887A2/en not_active Withdrawn
- 2012-02-24 TW TW101106446A patent/TWI611186B/zh active
- 2012-02-24 CA CA3160848A patent/CA3160848C/en active Active
- 2012-02-24 EP EP17161168.4A patent/EP3202921B1/en active Active
- 2012-02-24 CN CN201610340015.1A patent/CN106011237B/zh active Active
- 2012-02-24 CN CN201280016005.2A patent/CN103492589B/zh active Active
-
2015
- 2015-11-05 JP JP2015217329A patent/JP6068598B2/ja active Active
-
2020
- 2020-12-15 US US17/122,397 patent/US20210095340A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA3160848A1 (en) | 2013-03-28 |
| EP2682887A2 (en) | 2014-01-08 |
| JP6068598B2 (ja) | 2017-01-25 |
| EP2678451A1 (en) | 2014-01-01 |
| JP2014507158A (ja) | 2014-03-27 |
| WO2013041921A1 (en) | 2013-03-28 |
| US20130059733A1 (en) | 2013-03-07 |
| CN103492589A (zh) | 2014-01-01 |
| EP3202921A1 (en) | 2017-08-09 |
| EP3202921B1 (en) | 2019-02-13 |
| CA2827873A1 (en) | 2013-03-28 |
| AU2012311262C1 (en) | 2017-06-29 |
| EP2860265A1 (en) | 2015-04-15 |
| CN106011237A (zh) | 2016-10-12 |
| CN106011237B (zh) | 2019-12-13 |
| JP2016034282A (ja) | 2016-03-17 |
| EP2678451A4 (en) | 2014-10-22 |
| TWI611186B (zh) | 2018-01-11 |
| CN103492589B (zh) | 2016-06-15 |
| EP2860265B1 (en) | 2016-10-26 |
| US10900080B2 (en) | 2021-01-26 |
| CA3160848C (en) | 2025-07-08 |
| US20210095340A1 (en) | 2021-04-01 |
| AU2012311262A1 (en) | 2013-05-02 |
| CA3252077A1 (en) | 2025-03-20 |
| EP3489368A1 (en) | 2019-05-29 |
| AU2012311262B2 (en) | 2014-10-09 |
| EP2678451B1 (en) | 2017-04-26 |
| CA2827873C (en) | 2022-08-16 |
| HK1203567A1 (en) | 2015-10-30 |
| TW201243326A (en) | 2012-11-01 |
| EP3489368B1 (en) | 2020-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6068598B2 (ja) | 多胎妊娠の分子検査 | |
| US20220282332A1 (en) | Size-based genomic analysis | |
| TWI458976B (zh) | 由母體之生物樣本分析胎兒之基因體 | |
| CA2823618C (en) | Noninvasive prenatal genotyping of fetal sex chromosomes | |
| US20140256559A1 (en) | Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing | |
| EP3666902A1 (en) | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing | |
| HK40002656A (en) | Molecular testing of multiple pregnancies | |
| HK40002656B (en) | Molecular testing of multiple pregnancies | |
| HK1194163A (en) | Determining fetal dna percentage for twins | |
| HK1203567B (en) | Determining fetal dna percentage for twins | |
| HK1192765A (en) | Molecular testing of multiple pregnancies | |
| HK1192765B (en) | Molecular testing of multiple pregnancies | |
| HK40113543A (en) | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing | |
| AU2015200462B2 (en) | Size-based genomic analysis | |
| HK40032387A (en) | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing | |
| BR122020014914B1 (pt) | Métodos para identificar uma mutação de novo no genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávida, e, meio legível por computador não transitório |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140218 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140218 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150421 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150717 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150904 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151006 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20151105 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5837622 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |