JP5829400B2 - 骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物 - Google Patents

骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物 Download PDF

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JP5829400B2
JP5829400B2 JP2010543624A JP2010543624A JP5829400B2 JP 5829400 B2 JP5829400 B2 JP 5829400B2 JP 2010543624 A JP2010543624 A JP 2010543624A JP 2010543624 A JP2010543624 A JP 2010543624A JP 5829400 B2 JP5829400 B2 JP 5829400B2
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Prior art keywords
bone
erythropoietin
fibronectin
use according
compound
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JP2010543624A
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English (en)
Japanese (ja)
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JP2011510066A5 (https=
JP2011510066A (ja
Inventor
サヘル ハメド，
サヘル ハメド，
Original Assignee
レメドー バイオメッド リミテッド
レメドー バイオメッド リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
JP2010543624A 2008-01-24 2009-01-22 骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物 Active JP5829400B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US663308P 2008-01-24 2008-01-24
US61/006,633 2008-01-24
PCT/IL2009/000087 WO2009093240A2 (en) 2008-01-24 2009-01-22 Erythropoietin and fibronectin compositions for bone regeneration

Publications (3)

Publication Number Publication Date
JP2011510066A JP2011510066A (ja) 2011-03-31
JP2011510066A5 JP2011510066A5 (https=) 2012-02-16
JP5829400B2 true JP5829400B2 (ja) 2015-12-09

Family

ID=40901507

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010543624A Active JP5829400B2 (ja) 2008-01-24 2009-01-22 骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物

Country Status (4)

Country Link
US (2) US20100310626A1 (https=)
EP (1) EP2268301B1 (https=)
JP (1) JP5829400B2 (https=)
WO (1) WO2009093240A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5869219B2 (ja) 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物
EP2674166A1 (en) * 2012-06-15 2013-12-18 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Use of erythropoietin (EPO) for the local treatment of cancer treatment-associated osteo-necrosis of the jaw
TWI466693B (zh) * 2012-10-12 2015-01-01 Univ Nat Taiwan 用於製備礦化促進膜之組成物及具有該膜之植體及其製法
US20150306185A1 (en) * 2012-11-02 2015-10-29 University Of Rochester Heparanase and its uses related to exostoses
RU2541181C1 (ru) * 2013-09-23 2015-02-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ коррекции микроциркуляции в костной ткани при экспериментальном остеопорозе и переломах на его фоне рекомбинантным эритропоэтином
US20230181677A1 (en) * 2016-08-26 2023-06-15 Sewon Biotechnology Inc. Polypeptide for promoting bone regeneration or bone formation and its use
EP4340865A4 (en) * 2021-05-18 2025-04-02 Attias, Eyal USE OF ERYTHROPOIETIN (EPO) OR ERYTHROPOIESIS STIMULATING AGENT (ESA) FOR THE TREATMENT OF OSTEOMYELITIS, BONE INFECTION AND BONE INFLAMMATION
WO2023081691A1 (en) * 2021-11-04 2023-05-11 Contrafect Corporation Method of treating and preventing bone and joint infections

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2106A (en) * 1841-05-29 Tailob s measuke
AT385658B (de) * 1985-03-28 1988-05-10 Serotherapeutisches Inst Wien Verfahren zur herstellung einer fuer die anwendung beim menschen geeigneten fibronektinloesung
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
EP0673384A4 (en) * 1992-12-10 1996-10-09 Univ Minnesota POLYPEPTIDES USEFUL IN TREATING INFLAMMABLE DISEASES.
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
AU5390699A (en) * 1998-07-24 2000-02-14 Pharmacal Biotechnologies, Inc. Osseous tissue reconstruction system and method
GB0012209D0 (en) * 2000-05-19 2000-07-12 Novartis Ag Organic compounds
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) * 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US6913762B2 (en) * 2001-04-25 2005-07-05 Mayo Foundation For Medical Education And Research Stent having non-woven framework containing cells
US20040265268A1 (en) * 2001-08-18 2004-12-30 Deepak Jain Compositions and methods for skin rejuvenation and repair
ES2302845T3 (es) * 2001-10-19 2008-08-01 Zymogenetics, Inc. Factor de crecimiento dimerizado y materiales y metodos para producirlo.
US7622299B2 (en) * 2002-02-22 2009-11-24 University Of Washington Bioengineered tissue substitutes
WO2004103410A1 (en) * 2002-06-06 2004-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods compositions and articles of manufacture for modulating bone growth
JPWO2003103703A1 (ja) * 2002-06-06 2005-10-06 中外製薬株式会社 骨代謝疾患治療剤
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
DE10303584A1 (de) * 2003-01-30 2004-08-12 Stauss, Robert, Dr. Verwendung von Erythropoietin (EPO) als ein Beschichtungsmaterial auf medizinischen Implantaten
US20050148512A1 (en) * 2003-11-10 2005-07-07 Angiotech International Ag Medical implants and fibrosis-inducing agents
EP1550715A1 (de) * 2003-12-30 2005-07-06 Bionethos Holding Gmbh Verfahren zur Regenation von Gewebe
AU2004309083B2 (en) * 2003-12-30 2010-11-11 Augustinus Bader Tissue regeneration method
DE102004063927A1 (de) * 2004-01-23 2005-12-15 Epoplus Gmbh Co.Kg Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20070003906A1 (en) * 2005-06-30 2007-01-04 Alza Corporation Intraosseous Drug Delivery Portal, Injector, and System
WO2008006187A2 (en) * 2006-07-12 2008-01-17 Legeev, Yury V. Protein complexes for prevention and treatment of diseases with angiogenesis disorders
BRPI0812718A2 (pt) * 2007-06-19 2014-12-23 Baxter Int Métodos para modificar a liberação de uma proteína do fator de crescimento derivado de plaqueta, para modificar a liberação de um fator de crescimento derivado de plaqueta, para a liberação de uma proteína do fator de crescimento derivado de plaqueta e para tratar um paciente que sobre de um distúrbio ou doença, kit, e, uso de um selante de fibrina

Also Published As

Publication number Publication date
WO2009093240A2 (en) 2009-07-30
EP2268301B1 (en) 2020-02-26
US20240307491A1 (en) 2024-09-19
US20100310626A1 (en) 2010-12-09
WO2009093240A3 (en) 2009-11-12
EP2268301A2 (en) 2011-01-05
JP2011510066A (ja) 2011-03-31

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