JP2011510066A5 - - Google Patents

Info

Publication number

JP2011510066A5

JP2011510066A5 JP2010543624A JP2010543624A JP2011510066A5 JP 2011510066 A5 JP2011510066 A5 JP 2011510066A5 JP 2010543624 A JP2010543624 A JP 2010543624A JP 2010543624 A JP2010543624 A JP 2010543624A JP 2011510066 A5 JP2011510066 A5 JP 2011510066A5

Authority

JP

Japan

Prior art keywords

use according

group

compound

bone

effective amount

Prior art date

2009-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 6
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 6
• 102000003951 Erythropoietin Human genes 0.000 claims 4
• 108090000394 Erythropoietin Proteins 0.000 claims 4
• 102100037362 Fibronectin Human genes 0.000 claims 4
• 108010067306 Fibronectins Proteins 0.000 claims 4
• 229940112869 bone morphogenetic protein Drugs 0.000 claims 4
• 229940105423 erythropoietin Drugs 0.000 claims 4
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
• 238000007910 systemic administration Methods 0.000 claims 4
• 210000000988 bone and bone Anatomy 0.000 claims 3
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
• -1 bisphosphonate compound Chemical class 0.000 claims 2
• 230000010478 bone regeneration Effects 0.000 claims 2
• 230000007547 defect Effects 0.000 claims 2
• 229940126864 fibroblast growth factor Drugs 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 238000002513 implantation Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims 1
• VNTJGCYVIRTGMZ-PXGLAOGESA-N 2-[[2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s,3r)-2-[[(2s)-2-[[2-[[(2s)-5-amino-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoyl]amino]acety Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)N)CC(C)C)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)NCC(O)=O)C1=CC=C(O)C=C1 VNTJGCYVIRTGMZ-PXGLAOGESA-N 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 208000020084 Bone disease Diseases 0.000 claims 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
• 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
• 102000055006 Calcitonin Human genes 0.000 claims 1
• 108060001064 Calcitonin Proteins 0.000 claims 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
• 108010051696 Growth Hormone Proteins 0.000 claims 1
• 102000018997 Growth Hormone Human genes 0.000 claims 1
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
• 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 1
• 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 1
• 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims 1
• 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 1
• 101800003595 Osteogenic growth peptide Proteins 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 108090000445 Parathyroid hormone Proteins 0.000 claims 1
• 102000003982 Parathyroid hormone Human genes 0.000 claims 1
• 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims 1
• 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
• 230000000123 anti-resoprtive effect Effects 0.000 claims 1
• 229960004015 calcitonin Drugs 0.000 claims 1
• 229910052791 calcium Inorganic materials 0.000 claims 1
• 239000011575 calcium Substances 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000002316 cosmetic surgery Methods 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 229940011871 estrogen Drugs 0.000 claims 1
• 239000000262 estrogen Substances 0.000 claims 1
• 239000000122 growth hormone Substances 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 108700007229 noggin Proteins 0.000 claims 1
• 102000045246 noggin Human genes 0.000 claims 1
• 230000000399 orthopedic effect Effects 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 230000000010 osteolytic effect Effects 0.000 claims 1
• 239000000199 parathyroid hormone Substances 0.000 claims 1
• 229960001319 parathyroid hormone Drugs 0.000 claims 1
• 208000028169 periodontal disease Diseases 0.000 claims 1
• 230000003239 periodontal effect Effects 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 238000011200 topical administration Methods 0.000 claims 1