JP5806514B2 - Automatic analyzer - Google Patents

Description

  Embodiments described herein relate generally to an automatic analyzer that analyzes a component contained in a liquid such as a test sample collected from a subject.

  The automatic analyzer is intended for biochemical test items and immunological test items, and generates analytical data expressed by the concentration and enzyme activity of each test item by measuring the color change caused by the reaction between the sample and the reagent. To do. Moreover, the analysis data represented by a density | concentration is produced | generated by measuring using the ion selective electrode which detects each electrolyte, such as sodium ion, potassium ion, and chlorine ion contained in a biochemical test item.

  In measurement using an ion-selective electrode, each electrolyte is measured by supplying a sample and a diluting solution for diluting the sample into the container, and guiding the mixed solution of the sample and the diluting solution from the container to the ion-selective electrode. An electrolyte measurement unit is known. In this electrolyte measurement unit, the sample is supplied into the container by the sample dispensing probe moved above the container. Moreover, a dilution liquid is supplied by the dilution nozzle arrange | positioned in the container. The mixed solution composed of the supplied sample and the diluted solution is mixed in the container by a stirrer or the like and then guided from the container to the ion selective electrode.

JP-A 63-132170

  However, as the sample used for analysis becomes smaller, the amount of the liquid mixture decreases, and the capacity of the container needs to be reduced. For this reason, there exists a problem which a stirring bar cannot contact a dilution nozzle and a sample dispensing probe, and cannot stir a liquid mixture.

  The embodiment has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can easily mix a liquid mixture.

In order to achieve the above object, an automatic analyzer according to an embodiment stores a plurality of supplied liquids, a container having a mouth at a lower end portion through which the plurality of liquids flow out, and a mixed liquid composed of the plurality of liquids a measurement unit that measures one end connected to the port, a first flow path communicating before Symbol vessel, the opening neighborhood in the first flow path to one end of the connected first of One end is connected to the second flow path that communicates with the inside of the container via the flow path, the other end is connected to one end of the measurement unit, and the other end of the measurement unit. A third flow channel communicating with the second flow channel via the measurement unit, a first terminal connected to the other end of the first flow channel, and the other end of the third flow channel. A second terminal connected to the third terminal, and a third terminal, and either the first terminal or the second terminal and the third end A three-way switching valve that closes between the other terminal and the third terminal when opened between, and a fourth flow path having one end connected to the third terminal, When communicating with the fourth flow path, and opening between the first flow path and the fourth flow path by opening between the first terminal and the third terminal, The mixed liquid stored in the container is caused to flow out from the mouth and flow from one end of the first flow path to the other end, and then flow toward the one end of the first flow path. And when the space between the third channel and the fourth channel is opened by the opening between the second terminal and the third terminal. , the mixture which has flowed into the container, the first flow path by flowing out of the outlet, the connecting portion and the and the this first flow path the second flow path first Via the flow path, characterized in that a pump for flowing the measurement portion.

The figure which shows the structure of the automatic analyzer which concerns on embodiment. The perspective view which shows the structure of the analysis part which concerns on embodiment. The block diagram which shows an example of a structure of the electrolyte measurement unit which concerns on embodiment. The figure which shows the structure of the container which concerns on embodiment, a dilution liquid supply part, and a calibration liquid supply part. The figure which shows an example of a structure of the tube which concerns on embodiment, and a three-way switching valve. The figure which shows the distribution channel of the calibration liquid supplied in the container which concerns on embodiment. The figure which shows the distribution channel of the calibration liquid supplied in the container which concerns on embodiment. The figure which shows the distribution channel of the liquid mixture which consists of the diluent and sample which were supplied in the container which concerns on embodiment. The figure which shows the distribution channel of the liquid mixture which consists of the diluent and sample which were supplied in the container which concerns on embodiment. The figure which shows the distribution channel of the liquid mixture which consists of the diluent and sample which were supplied in the container which concerns on embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

  FIG. 1 is a block diagram illustrating a configuration of an automatic analyzer according to the embodiment. The automatic analyzer 100 includes an analysis unit 24 that measures a standard sample and a test sample, and each test item based on standard data and test data generated by the measurement of the standard sample and the test sample by the analysis unit 24. Data processing unit 30 for generating calibration data and analysis data, output unit 50 for outputting calibration data and analysis data generated by the data processing unit 30, input of analysis parameters for each inspection item, and various command signals And a system control unit 54 that controls the analysis unit 24, the data processing unit 30, and the output unit 50 in an integrated manner.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 24. The analysis unit 24 rotates a sample container 17 that stores each sample such as a standard sample and a test sample, a sample disk 5 that holds the sample container 17, and a plurality of reaction containers 3 arranged on the circumference. The reaction disk 4 that can be held, a sample dispensing probe 16 that performs dispensing to suck and discharge each sample in the sample container 17 held on the sample disk 5 into the reaction container 3, and the sample dispensing probe 16 And a sample dispensing arm 10 that supports the pivotable and vertically movable.

  In addition, a reagent container 6 that accommodates a first reagent and a two reagent system of the first reagent that react with the components of the test item included in each sample, a reagent container 1 that stores the reagent container 6, and a reagent container 1 A reagent rack 1a that holds the stored reagent container 6 so as to be rotatable, and a part that is sucked into the reaction container 3 from which the first reagent in the reagent container 6 held in the reagent rack 1a is sucked and discharged. A first reagent dispensing probe 14 for performing the injection is provided. Moreover, the 1st reagent dispensing arm 8 which supports the 1st reagent dispensing probe 14 so that rotation and a vertical movement are possible is provided.

  In addition, a reagent container 7 that stores a second reagent that forms a pair with the first reagent of the two-reagent system, a reagent container 2 that stores the reagent container 7, and a reagent container 7 stored in the reagent container 2 are rotated. A reagent rack 2a that can be held, and a second reagent part that performs dispensing to suck the second reagent in the reagent container 7 held in the reagent rack 2a and discharge it into the reaction container 3 from which the first reagent has been discharged. An injection probe 15 and a second reagent dispensing arm 9 that supports the second reagent dispensing probe 15 so as to be rotatable and vertically movable are provided.

  In addition, in order to measure each sample, photometry for measuring the components of each test item contained in the mixed solution of each sample and the first reagent in the reaction vessel 3 or the mixed solution of each sample and the first and second reagents. A unit 13; an electrolyte measurement unit 22 for measuring each electrolyte such as sodium ion, potassium ion, and chlorine ion, which are components of electrolyte items included in each sample discharged by the sample dispensing probe 16, and a photometric unit 13 And a reaction container cleaning unit 12 that cleans the inside of the reaction container 3 that contains the liquid mixture measured by the above.

  And the photometry unit 13 irradiates light to the reaction container 3 which rotates, and detects the light which permeate | transmitted the liquid mixture containing a standard sample and a test sample. Then, standard data and test data are generated based on the detected light, and the generated standard data and test data are output to the data processing unit 30. The electrolyte measurement unit 22 measures standard samples and test samples to generate standard data and test data, and outputs the generated standard data and test data to the data processing unit 30.

  The data processing unit 30 shown in FIG. 1 includes a calculation unit 31 that generates calibration data and analysis data based on standard data and test data output from the photometry unit 13 and the electrolyte measurement unit 22 of the analysis unit 24, And a data storage unit 32 for storing calibration data and analysis data generated by the calculation unit 31.

  The calculation unit 31 generates calibration data based on the standard data of each inspection item generated by the analysis unit 24. Further, based on calibration data in which test data for each test item generated by the analysis unit 24 is generated in advance, analysis data represented by an activity value, a concentration value, or the like is generated. The generated calibration data and analysis data are stored in the data storage unit 32 and output to the output unit 50.

  The output unit 50 includes a printing unit 51 that prints out calibration data and analysis data output from the data processing unit 30, and a display unit 52 that displays the output. The printing unit 51 includes a printer and prints and outputs calibration data, analysis data, and the like output from the data processing unit 30 on printer paper according to a preset format. The display unit 52 includes a monitor such as a CRT or a liquid crystal panel, displays an analysis parameter setting screen for setting analysis parameters of each inspection item, calibration data output from the data processing unit 30, analysis data, and the like. Is displayed.

  The operation unit 53 includes input devices such as a keyboard, a mouse, a button, and a touch key panel. The operation unit 53 sets analysis parameters for each examination item, inputs subject information such as a subject ID and a subject name of the subject, and examines the subject. Various inputs such as selection of inspection items to be analyzed for each sample are performed.

  The system control unit 54 includes a CPU and a storage circuit, and stores input information such as command signals input from the operation unit 53, analysis parameters of each test item, sample information, and test items selected for each test sample. To do. Based on the input information, control of the entire system is performed such as control for causing each unit of the analysis unit 24 to perform measurement operation in a predetermined sequence of a fixed cycle, control for creating a calibration curve, and generation and output of analysis data.

Next, the configuration of the electrolyte measurement unit 22 in the analysis unit 24 will be described.
FIG. 3 is a block diagram showing an example of the configuration of the electrolyte measurement unit 22. The electrolyte measurement unit 22 includes a container 61 for storing the standard sample and the test sample supplied by the sample dispensing probe 16, and a diluent supply for supplying a diluent for diluting each sample into the container 61. And a calibration solution supply unit 63 for supplying calibration solution for calibrating the measurement result of the mixed solution of each sample and the diluent into the container 61.

  Further, the electrolyte measurement unit 22 includes a pump 64 configured by, for example, a cylinder and a plunger that causes each liquid of the mixed liquid and the calibration liquid to flow out from the container 61, a measurement unit 60 that measures each liquid that flows out from the container 61, and a measurement. The drainage tank 65 from which the liquids that are no longer needed are discharged, the tube 66 in which a flow path is formed until each liquid in the container 61 is discharged to the drainage tank 65, and the tube 66 And three-way switching valves 67 and 68 such as a three-way solenoid valve.

  FIG. 4 is a diagram showing the configuration of the container 61, the diluent supply unit 62, and the calibration solution supply unit 63. This container 61 has an opening 611 to which each sample, diluent and calibration liquid are supplied at the upper end, and an opening 612 through which each liquid supplied to the center of the lower end flows. And the liquid mixture of each sample supplied with the sample dispensing probe 16 and the diluent supplied by the diluent supply part 62 is stored. Further, the calibration liquid supplied from the calibration liquid supply unit 63 is stored.

  The diluent supply unit 62 includes a nozzle 621 disposed in a container 61 that discharges the diluent, a tube 622 having one end connected to the nozzle 621, and a first terminal connected to the other end of the tube 622. A three-way switching valve 623 and a tube 624 having one end connected to the second terminal of the three-way switching valve 623 are provided. Also, a diluent container 625 for storing a diluent in which the other end of the tube 624 is disposed, a tube 626 having one end connected to the third terminal of the three-way switching valve 623, and connected to the other end of the tube 626 The pump 627 is provided.

  When the three-way valve switching valve 623 opens the second terminal and the third terminal and closes the first terminal, the diluent in the diluent container 625 is sucked by the suction operation of the pump 627. Next, when the three-way valve switching valve 623 opens between the first terminal and the third terminal and closes the second terminal, the diluent is supplied into the container 61 by the discharge operation of the pump 627. At this time, each sample is supplied into the container 61 by the sample dispensing probe 16.

  The calibration liquid supply unit 63 includes a nozzle 631 disposed in the container 61 that discharges the calibration liquid, a tube 632 having one end connected to the nozzle 631, and a first terminal connected to the other end of the tube 632. A three-way switching valve 633 and a tube 634 having one end connected to the second terminal of the three-way switching valve 633 are provided. In addition, a calibration solution container 635 for storing a calibration solution in which the other end portion of the tube 634 is disposed, and a tube 636 whose one end portion is connected to the third terminal of the three-way switching valve 633 are provided. Moreover, the pump 637 comprised with the cylinder and plunger connected to the other end part of the tube 636 is provided.

  When the three-way valve switching valve 633 opens the second terminal and the third terminal and closes the first terminal, the calibration liquid in the calibration liquid container 635 is sucked by the suction operation of the pump 637. Next, when the three-way switching valve 633 opens between the first terminal and the third terminal and closes the second terminal, the calibration liquid is supplied into the container 61 by the discharge operation of the pump 637.

  3 includes an ion sensor unit 601 that detects a plurality of electrolytes contained in each liquid, and standard data and test data based on detection signals of each electrolyte detected by the ion sensor unit 601. And a signal processing unit 602 for generating.

  The ion sensor unit 601 is disposed between the container 61 and the pump 64 and has a through hole into which each liquid guided from the container 61 through the tube 66 flows. And each ion-selective electrode which selectively detects each electrolyte contained in each liquid flowing into the through-hole and shows a potential according to the concentration, and a reference electrode which shows a potential serving as a reference for each ion-selective electrode It has. Then, a detection signal as a potential difference between each ion selective electrode and the reference electrode is output to the signal processing unit 602.

  FIG. 5 is a view showing an example of the configuration of the tube 66 and the three-way switching valves 67 and 68. The tube 66 includes first to sixth tubes 661 to 666. The first tube 661 has one end connected to the opening 612 of the container 61 and the other end connected to the first terminal of the three-way switching valve 67. In the first tube 661, a first flow path 661a communicating with the container 61 is formed.

  The second tube 662 has one end joined to the first tube 661 and the other end connected to one end of the ion sensor unit 601 in the measurement unit 60. The second tube 662 communicates with the first flow path 661 a in the vicinity of the container 61, and a second flow path that guides each liquid of the calibration liquid and the mixed liquid in the container 61 to the ion sensor unit 601. 662a is formed.

  The third tube 663 has one end connected to the other end of the ion sensor unit 601 and the other end connected to the second terminal of the three-way switching valve 67. The third tube 663 is formed with a third flow path 663a through which each liquid measured by the ion sensor unit 601 flows.

  The fourth tube 664 has one end connected to the third terminal of the three-way switching valve 67 and the other end connected to the first terminal of the three-way switching valve 68. Then, the fourth flow channel 664a into which each liquid flowing out from the first flow channel 661a of the first tube 661 and the third flow channel 663a of the third tube 663 flows into the fourth tube 664. Is formed.

  The fifth tube 665 has one end connected to the second terminal of the three-way switching valve 68 and the other end connected to the pump 64. And in the 5th tube 665, the 5th flow path 665a into which each liquid which flowed out from the 4th flow path 664a of the 4th tube 664 flows in is formed.

  The sixth tube 666 has one end connected to the third terminal of the three-way switching valve 68 and the other end arranged in the drainage tank 65. In the sixth tube 666, a sixth channel 666a for guiding each liquid flowing out from the fifth channel 665a of the fifth tube 665 to the drainage tank 65 is formed.

  The three-way switching valve 67 switches between the first flow path 661a and the fourth flow path 664a or the third flow path 663a and the fourth flow path 664a so that they can communicate with each other. When the first flow path 661a and the fourth flow path 664a communicate with each other, the mixed liquid flows out of the container 61 by the suction operation of moving the plunger of the pump 64 in the arrow L1 direction. Flow 661a. Further, the mixed liquid that has flowed through the first flow path 661a flows into the container 61 by the discharge operation of moving the plunger of the pump 64 in the direction of the arrow L2 opposite to the L1 direction. Further, when the third flow path 663a and the fourth flow path 664a communicate with each other, each liquid flows out of the container 61 by the suction operation of the pump 64, and one end portion of the first flow path 661a and the second flow path 661a. It flows into the ion sensor unit 601 through the flow path 662a.

  The three-way switching valve 68 switches between the fourth flow path 664a and the fifth flow path 665a or the fifth flow path 665a and the sixth flow path 666a so that they can communicate with each other. When the fourth flow path 664 a and the fifth flow path 665 a are communicated with each other, each liquid flows out of the container 61 by the suction operation of the pump 64, and the outflowed mixed liquid flows into the container 61 by the discharge operation of the pump 64. Is flowed into. Further, when the fifth flow path 665a and the sixth flow path 666a are communicated with each other, the liquid in the cylinder of the pump 64 and the fifth and sixth flow paths 665a, 666a is discharged by the discharge operation of the pump 64. It is discharged into the liquid tank 65.

  Hereinafter, an example of the operation of the electrolyte measurement unit 22 will be described with reference to FIGS. 1 to 10. 6 and 7 are diagrams showing a flow path of the calibration liquid supplied into the container 61. FIG. FIG. 8 to FIG. 10 are diagrams showing the flow paths of the mixed liquid composed of the diluent and each sample supplied into the container 61.

  By opening the first and third terminals and closing the second terminal of the three-way switching valve 67, the first flow path 661a and the fourth flow path 664a are opened, and the third flow path 663a and the fourth flow path are opened. The space between the paths 664a is closed. Further, when the first and second terminals of the three-way switching valve 68 are opened and the third terminal is closed, the space between the fourth channel 664a and the fifth channel 665a is opened, and the fifth channel 665a and the sixth channel 665a are opened. The channel 666a is closed. One end of the first channel 661a between the opening 612 of the container 61 and one end of the second channel 662a is filled with air, and the second and third channels 662a and 663a and the ion sensor unit 601 are filled with air. The inside is filled with, for example, a calibration solution.

  The container 61 stores the calibration liquid supplied from the calibration liquid supply unit 63 as shown in FIG. Then, as shown in FIG. 6B, by the suction operation of moving the plunger of the pump 64 in the L1 direction, a part of the calibration liquid flows out from the container 61 and slightly exceeds one end of the first flow path 661a. Stop at the position.

  As described above, the first flow path 661 a communicating with the inside of the container 61 and the second flow path 662 a communicating with the first flow path 661 a and guiding each liquid in the container 61 to the ion sensor unit 601 are provided. By allowing the calibration liquid in the container 61 to flow out to a position including one end of the first flow path 661a, the space between the container 61 and the second flow path 662a can be filled with the calibration liquid. Further, by connecting the second channel 662a to the first channel 661a in the vicinity of the container 61, the space between the container 61 and the second channel 662a can be filled with a small amount of calibration liquid.

  After a part of the calibration liquid stops in the first flow path 661a, the third flow path 663a and the fourth flow path are opened by opening the second and third terminals of the three-way switching valve 67 and closing the first terminal. The space between 664a is opened, and the space between the first channel 661a and the fourth channel 664a is closed. Then, when a suction operation is performed to move the plunger of the pump 64 further in the L1 direction from the position of FIG. 6B, most of the calibration liquid flows out from the container 61 as shown in FIG. It flows through one end of the first channel 661a, the second channel 662a, and the ion sensor unit 601, and stops in the middle of the third channel 663a.

  In this manner, after the space between the container 61 and the second flow path 662a is filled with the calibration liquid, the calibration liquid in the container 61 is caused to flow into the ion sensor unit 601, thereby allowing the ion sensor unit 601 to use the calibration liquid that does not contain air. Can fill in. Thereby, the detection abnormality by mixing of the air into the ion sensor unit 601 can be prevented.

  After the calibration liquid stops in the third flow path 663a, the first and third terminals of the three-way switching valve 67 are opened and the second terminal is closed, so that the first flow path 661a and the fourth flow path 664a are separated. The third channel 663a and the fourth channel 664a are closed. Then, when a suction operation for moving the plunger of the pump 64 further in the L1 direction from the position of FIG. 7A is performed, as shown in FIG. 7B, the bottom of the container 61 and the first flow path 661a. The calibration liquid remaining at one end of the liquid flows and stops at a position away from one end of the first flow path 661a. Thereby, the container 61 and the one end part of the 1st flow path 661a become empty.

  As described above, when the calibration liquid in the container 61 is caused to flow into the ion sensor unit 601, the calibration liquid is left in one end portion of the first flow path 661a, and in the container 61 and one end section of the first flow path 661a. By allowing the remaining calibration liquid to flow to a position away from one end of the first channel 661a, the inside of the container 61 and one end of the first channel 661a can be filled with air. Thereby, the contamination by the liquid remaining in the container 61 of the liquid to be supplied next or in the first flow path 661a can be reduced.

  After the calibration liquid stops at a position away from one end of the first flow path 661a, the signal processing unit 602 generates calibration data based on the detection signal detected by the ion sensor unit 601, and the generated calibration data Is output to the calculation unit 31 of the data processing unit 30.

  After being detected by the ion sensor unit 601, the second and third terminals of the three-way switching valve 68 are opened and the first terminal is closed, whereby the fifth channel 665a and the sixth channel 666a are opened. The fourth channel 664a and the fifth channel 665a are closed. Then, the discharge operation of moving the plunger of the pump 64 in the L2 direction from the position of FIG. 7B to the position of FIG. 6A results in the cylinder of the pump 64 and the fifth and sixth flow paths 665a, 666a. These liquids are discharged to the drainage tank 65.

  After being discharged into the drainage tank 65, the first and second terminals of the three-way switching valve 68 are opened and the third terminal is closed, so that the fourth channel 664a and the fifth channel 665a are opened. The space between the fifth channel 665a and the sixth channel 666a is closed. And the container 61 stores the liquid mixture which consists of the dilution liquid supplied from the dilution liquid supply part 62, and the test sample supplied from the sample dispensing probe 16, as shown to Fig.8 (a).

  After the diluent and the test sample are supplied into the container 61, when a suction operation is performed in which the plunger of the pump 64 is moved in the L1 direction from the position shown in FIG. 8A, as shown in FIG. 8B. Most of the liquid mixture flows out of the container 61, flows through the first flow path 661a, and stops halfway.

  After the mixed liquid stops in the first flow path 661a, a discharge operation is performed in which the plunger of the pump 64 is moved in the L2 direction from the position shown in FIG. 8B to the position shown in FIG. 8A. As shown to a), the liquid mixture which flowed out from the container 61 flows through the 1st flow path 661a, and flows in in the container 61. FIG.

  Thus, by providing the first flow path 661a separately from the second flow path 662a that guides each liquid to the ion sensor unit 601, the mixed liquid flows out of the container 61 and flows through the first flow path 661a. Then, the mixed solution can be mixed by flowing into the container 61. Thereby, a liquid mixture can be easily mixed with a simple structure, without enlarging the capacity | capacitance of the container 61. FIG.

After the mixed liquid flows into the container 61, a part of the mixed liquid flows out from the container 61 as shown in FIG. 9B by the suction operation of moving the plunger of the pump 64 in the L1 direction. Stops at a position beyond one end of the flow path 661a.

  Thus, the container 61 and the second flow path are filled with the calibration liquid in the second flow path 662a by causing the mixed liquid in the container 61 to flow out to a position including one end of the first flow path 661a. The space between 662a can be filled with the liquid mixture. In addition, by connecting the second channel 662a to the first channel 661a in the vicinity of the container 61, the space between the container 61 and the second channel 662a can be filled with a small amount of liquid mixture.

  After a part of the mixed liquid stops in the first flow path 661a, the third flow path 663a and the fourth flow path are opened by opening the second and third terminals of the three-way switching valve 67 and closing the first terminal. The space between 664a is opened, and the space between the first channel 661a and the fourth channel 664a is closed. Then, when a suction operation is performed to move the plunger of the pump 64 further in the L1 direction from the position of FIG. 9B, most of the liquid mixture flows out of the container 61 as shown in FIG. It flows through one end of the first channel 661a, the second channel 662a, and the ion sensor unit 601, and stops in the middle of the third channel 663a.

  In this manner, after the space between the container 61 and the second flow path 662a is filled with the mixed liquid, the mixed liquid in the container 61 is caused to flow into the ion sensor unit 601, whereby the ion sensor unit 601 is mixed with the mixed liquid not containing air. Can fill in. Thereby, the detection abnormality by mixing of the air into the ion sensor unit 601 can be prevented.

  After the mixed liquid stops in the third flow path 663a, the first and third terminals of the three-way switching valve 67 are opened and the second terminal is closed, so that the first flow path 661a and the fourth flow path 664a are separated. The third channel 663a and the fourth channel 664a are closed. Then, when a suction operation for moving the plunger of the pump 64 further in the L1 direction from the position of FIG. 10A is performed, as shown in FIG. 10B, the bottom of the container 61 and the first flow path 661a. The liquid mixture remaining at one end of the first fluid flows and stops at a position away from one end of the first flow path 661a. Thereby, the container 61 and the one end part of the 1st flow path 661a become empty.

  As described above, when the mixed liquid in the container 61 is caused to flow into the ion sensor unit 601, the mixed liquid remains in one end portion of the first flow path 661a, and in the container 61 and one end portion of the first flow path 661a. By flowing the remaining mixed liquid to a position away from one end of the first channel 661a, the second channel 662a is filled with the liquid, and the inside of the container 61 and one end of the first channel 661a are air-filled. Can be filled with. Thereby, the contamination by the liquid remaining in the container 61 of the liquid to be supplied next or in the first flow path 661a can be reduced.

  After the liquid mixture stops in the first flow path 661a, the signal processing unit 602 generates test data based on the detection signal detected by the ion sensor unit 601, and sends the generated test data to the calculation unit 31. Output.

  After being detected by the ion sensor unit 601, the second and third terminals of the three-way switching valve 68 are opened and the first terminal is closed, whereby the fifth channel 665a and the sixth channel 666a are opened. The fourth channel 664a and the fifth channel 665a are closed. The plunger of the pump 64 moves in the L2 direction from the position shown in FIG. 10B to the position shown in FIG. 9A, and the fifth and sixth flow paths 665a and 666a are formed in the cylinder of the pump 64. These liquids are discharged to the drainage tank 65.

  The calculation unit 31 reads calibration data of each electrolyte item from the data storage unit 32 and generates analysis data based on the read calibration data and the calibration data and test data output from the signal processing unit 602. The generated analysis data is printed out and displayed on the output unit 50.

  In addition, the 2nd pump comprised similarly to the 7th tube and the pump 64 is provided, and the other end part of the 3rd tube 663 is connected to the 1st terminal of the three-way selector valve 68. Further, the other end of the fourth tube 664 is connected to the second pump. One end of the seventh tube is connected to the second terminal of the three-way switching valve 67, and the other end of the seventh tube is disposed in the drainage tank 65. Then, the liquid mixture may be caused to flow out of the container 61 by the second pump and flow into the container 61 after flowing through the first flow path 661a.

  According to the embodiment described above, the first flow path 661a communicating with the container 61 and the second flow that communicates with the first flow path 661a and guides each liquid in the container 61 to the ion sensor unit 601. A path 662a is provided.

  When each liquid in the container 61 flows into the ion sensor unit 601, each liquid remains at one end of the first flow path 661a, and remains in the container 61 and at one end of the first flow path 661a. By causing each liquid to flow to a position away from one end of the first channel 661a, the inside of the container 61 and one end of the first channel 661a can be filled with air. Thereby, the contamination by the liquid remaining in the container 61 of the liquid to be supplied next or in the first flow path 661a can be reduced.

  Next, by letting each liquid in the container 61 flow out to a position including the one end of the first flow path 661a, the container 61 and the second flow path are filled with the liquid that has previously flowed into the second flow path 662a. The space between 662a can be filled with each liquid. Then, by allowing each liquid in the container 61 to flow into the ion sensor unit 601 later, the inside of the ion sensor unit 601 can be filled with each liquid not containing air. Thereby, the detection abnormality by mixing of the air into the ion sensor unit 601 can be prevented.

  In addition, the mixed solution can be mixed by flowing the supplied diluted solution and sample mixed solution out of the container 61, flowing the first channel 661a, and then flowing into the container 61. Thereby, a liquid mixture can be easily mixed with a simple structure, without enlarging the capacity | capacitance of the container 61. FIG.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalents thereof.

22 Electrolyte measurement unit 60 Measurement unit 61 Container 62 Diluent supply unit 63 Calibration solution supply unit 64 Pump 65 Drain tank 66 Tubes 67 and 68 Three-way switching valve 601 Ion sensor unit 602 Signal processing unit 661 First tube 661a First tube Channel 662 Second tube 662a Second channel 663 Third tube 663a Third channel 664 Fourth tube 664a Fourth channel 665 Fifth tube 665a Fifth channel 666 Sixth Tube 666a Sixth flow path

Claims (8)

A container for storing a plurality of supplied liquids, and having a mouth at a lower end of the plurality of liquids,
A measuring unit for measuring a mixed liquid composed of the plurality of liquids;
One end connected to the port, a first flow path communicating before Symbol vessel,
One end is connected to the first flow channel in the vicinity of the mouth and communicates with the container through the first flow channel, and the other end is connected to one end portion of the measurement unit. A second flow path in communication;
A third flow path having one end connected to the other end of the measurement section and communicating with the second flow path via the measurement section;
A first terminal connected to the other end of the first flow path; a second terminal connected to the other end of the third flow path; and a third terminal; Or a three-way switching valve that closes between the other terminal and the third terminal when opening between either one of the second terminals and the third terminal;
A fourth flow path having one end connected to the third terminal;
When communicating with the fourth flow path, and opening between the first flow path and the fourth flow path by opening between the first terminal and the third terminal, The mixed liquid stored in the container is caused to flow out from the mouth and flow from one end of the first flow path to the other end, and then flow toward the one end of the first flow path. And when the space between the third channel and the fourth channel is opened by the opening between the second terminal and the third terminal. The mixed liquid that has flowed into the container is caused to flow out of the mouth, and the first flow path, a connection portion between the first flow path and the second flow path, and the second flow path are provided. An automatic analyzer comprising: a pump that flows into the measurement unit via the pump. When the space between the first flow path and the fourth flow path is open , the pump causes a part of the mixed liquid that has flowed into the container to flow out from the mouth, and After flowing from one end of the flow path to the other end and stopping at a position exceeding the connection portion of the first flow path, the gap between the third flow path and the fourth flow path is When open, most of the liquid mixture in the container flows out of the mouth and flows into the measurement unit via the first channel, the connection unit, and the second channel. The automatic analyzer according to claim 1, wherein: When the space between the third flow path and the fourth flow path is open , the pump causes most of the mixed liquid in the container to flow out of the mouth, and the first flow The container when the space between the first channel and the fourth channel is opened after flowing into the measurement unit via the channel, the connection unit, and the second channel. The mixed liquid remaining in the outlet is caused to flow out from the mouth, flow from one end to the other end of the first flow path, and stopped at a position away from between the mouth and the connecting portion. The automatic analyzer according to claim 1 or 2.   In the second flow path and the measurement unit, the pump causes the mixed liquid to flow out from the mouth and flow from one end to the other end of the first flow path, and the first flow path. 4. The liquid according to claim 1, wherein the liquid is filled with a liquid different from the liquid mixture when flowing in the direction of one end of the flow path and flowing into the container from the mouth. The automatic analyzer described. When the pump is filled with a liquid different from the mixed liquid in the second flow path and the measurement unit, and the space between the first flow path and the fourth flow path is open , the container The mixed liquid stored inside is flowed from one end of the first flow path to the other end after flowing out from the mouth, and then flowed toward the one end of the first flow path. A part of the mixed liquid that has flowed into the container through the mouth and flowed out from the mouth to flow from one end to the other end of the first flow path; After stopping at a position exceeding the connection portion of the flow path, when the space between the third flow path and the fourth flow path is opened, most of the mixed liquid in the container is Flowing out from the mouth, flowing into the measurement unit via the first flow path, the connection part and the second flow path, After flowing the mixture to the measurement portion, when between the fourth flow path and the first flow path is opened, the liquid mixture remaining in the container, the mouth of the container 2. The automatic analyzer according to claim 1, wherein the automatic analyzer is caused to flow out from one end of the first flow path toward the other end and stop at a position away from between the mouth and the connecting portion. . The liquid different from the mixed liquid is a calibration liquid for calibrating the result measured by the measurement unit,
6. The automatic analyzer according to claim 4, further comprising a calculation unit that generates analysis data based on the measurement result of the mixed solution and the calibration solution measured by the measurement unit. A fifth flow path having one end connected to the pump;
A sixth flow path having one end connected to the drainage tank;
A first terminal connected to the other end of the fourth flow path, a second terminal connected to the other end of the fifth flow path, and a second terminal connected to the other end of the sixth flow path. 3 terminal, and when the space between either the fourth channel or the sixth channel and the fifth channel is open, the other channel and the and a three-way valve that is closed between the fifth channel,
The pump communicates with the fourth flow path through the fifth flow path when the fourth flow path and the fifth flow path are open. The automatic analyzer according to any one of claims 1 to 6 . The measurement unit includes a through-hole into which the mixed solution flows through the second flow path and an ion-selective electrode that selectively detects an electrolyte contained in the mixed solution that has flowed into the through-hole. The automatic analyzer according to any one of claims 1 to 7 , characterized in that:

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