JP5804671B2 - Shampoo for head lice control - Google Patents

Description

The present invention relates to a method for controlling head lice, more specifically to a method for controlling head lice without using insecticidal components such as pyrethroids.

There are three types of lice parasitic on humans: head lice, body lice, and white lice. Among them, head lice infest the head and lay eggs on the hair. Eggs change around 0.5 mm in about a week, and the larval stage is about 1-2 weeks. It is known that adults have a lifespan of about one month and lay about 200 eggs during this period. After World War II, it was said that it was almost extinct in Japan. However, as exchanges with foreign countries flourished, it was brought into Japan and is spreading again. The only insecticidal component that has received regulatory registration in Japan as a lice control agent for human bodies is currently pyrethroid-based Smithlin, and Smithin shampoo is widely used as a control agent.
Several patents have been filed regarding the composition. For example, Patent Document 1 (Patent No. 3274223) discloses amine oxide, polyoxyethylene polyoxypropylene block polymer, polyoxyethylene sorbitan fatty acid ester and / or Alternatively, a shampoo composition containing polyoxyethylene alkyl phenyl ether and Smithlin is disclosed.

On the other hand, although it is limited recently, it has been reported that lice exhibiting resistance to Smithlin have appeared. Then, the development of the lice control agent based on a physical effect | action using the medicinal component which shows a novel effect | action without mix | blending the conventional insecticidal component is also sought. For example, Patent Document 2 describes a composition containing a fatty acid ester as a medicinal ingredient, and Patent Document 3 describes a composition containing a terpene. It has not been done and cannot be said to be effective enough.

Japanese Patent No. 3274223 Special table 2005-529896 Special table 2002-501007

The present invention pays attention to the liquid property of the shampoo composition during shampooing, and can provide a practical lice control effect without using an insecticidal component such as a pyrethroid, and a head lice control method with excellent usability. It is something to be offered.

The present invention has been found that the following constitution has an excellent effect for achieving the above-mentioned object.
(1) Surfactant containing polyoxyethylene sorbitan fatty acid ester, general formula
(R ₁ represents an alkyl group having 8 to 16 carbon atoms, R ₂ and R ₃ represent an alkyl group having 1 to 2 carbon atoms or a hydroxyethyl group, and R ₂ and R ₃ may be the same or different. The foam specific gravity is 0.05 to 0.2, and the defoaming degree after 2 minutes is 30% or less in the defoaming test by the Ross Miles method. A shampoo composition, which does not contain a pyrethroid insecticidal component, and is used so as to suffocate the head lice by leaving it in a foam state for 15 minutes or more after shampooing by discharging the composition. A head lice shampoo.
(2) The shampoo for controlling head lice as described in (1), wherein the shampoo cap is used to leave the foam for 15 minutes or longer .

The head lice extermination method of the present invention has a practical lice extermination effect by a simple method without using an insecticidal component such as a pyrethroid, and there is no fear of causing drug resistance, so its practicality is extremely high. high.

Examples of the surfactant used in the present invention include, but are not limited to, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene alkylphenyl ether. In particular, polyoxyethylene sorbitan fatty acid ester having an HLB of 10 or more is preferable. For example, polyoxyethylene (hereinafter abbreviated as POE) (20) sorbitan monolaurate, POE (20) sorbitan monopalmitate, POE ( 20) Sorbitan monostearate, POE (20) sorbitan monooleate, POE (22) sorbitan monoisostearate and the like.
Examples of the polyoxyethylene glycerin fatty acid ester include POE (15) glycerin monostearate, POE (18) glycerin monooleate, POE (20) glycerin tristearate, and the like. Polyoxyethylene alkylphenyl ether Examples thereof include POE (7.5) nonyl phenyl ether, POE (15) nonyl phenyl ether, POE (30) octyl phenyl ether, and the like.
The amount of these surfactants to be added is usually 1.0 to 15% by weight, preferably 2.0 to 10% by weight, based on the total amount of the shampoo composition.

As the foaming agent used in the present invention, those corresponding to amphoteric surfactants are good, among which general formula




(R ₁ represents an alkyl group having 8 to 16 carbon atoms, R ₂ and R ₃ represent an alkyl group having 1 to 2 carbon atoms or a hydroxyethyl group, and R ₂ and R ₃ may be the same or different. The amine oxide represented by this is preferable. For example, alkyldimethylamine oxide such as lauryldimethylamine oxide and myristyldimethylamine oxide, alkyldiethylamine oxide such as lauryldiethylamine oxide, laurylmethylethylamine oxide, lauryldihydroxyethylamine oxide, etc., preferably lauryldimethylamine oxide and the like. Examples thereof include alkyldimethylamine oxide.
The blending amount of the foaming agent is usually in the range of 1.0 to 10% by weight of the total amount of the shampoo composition, but from the viewpoint of irritation and physical stability, it is 1.5 to 4.0% by weight. Is preferred.

In the present invention, a thickener is preferably blended in order to adjust the viscosity of the shampoo composition. As such a thickening agent, a polyoxyethylene polyoxypropylene block polymer that is easy to use and contains 4 to 200 units of ethylene oxide and 5 to 100 units of propylene oxide is particularly effective. For example, polyoxyethylene (160) polyoxypropylene (30) block polymer, polyoxyethylene (20) polyoxypropylene (20) block polymer, polyoxyethylene (120) polyoxypropylene (40) block polymer and the like can be mentioned. .
The blending amount of the block polymer is usually in the range of 1.0 to 40% by weight of the total amount of the shampoo composition, and may be appropriately adjusted in consideration of the viscosity of the shampoo composition.

In the shampoo composition of the present invention, in addition to the above components, various additives such as preservatives, bactericides, buffers, pH, etc., as long as they do not interfere with the purpose of the present invention, including purified water. A regulator, an antioxidant, a fragrance, a pigment, a foaming stabilizer, a chelating agent, a conditioning agent and the like can be blended.
As the antioxidant, sodium edetate and / or dibutylhydroxytoluene are particularly effective, and the pH of the shampoo composition is preferably adjusted to near neutral, for example, 4 to 8 using a pH adjuster.

In the present invention, it is essential that the foam specific gravity of the foam to be discharged is 0.05 to 0.2, and the defoaming degree after 2 minutes is 30% or less in the defoaming test by the Ross Miles method.
If the foam specific gravity is less than 0.05, the foam is too light and the effect of wrapping the lice is insufficient. On the other hand, if it exceeds 0.2, the foam is not suitable for reaching the root of the hair.
On the other hand, if the defoaming degree exceeds 30%, the time until the trapped lice are wrapped and killed by suffocation is insufficient, and the lice cannot be completely removed.
As disclosed in the present invention, the technical idea of applying foam specific gravity and defoaming degree to a lice control agent is completely novel. For example, Patent Document 1 does not suggest or teach, and Patent Document 2 and Patent Document No. 3, the emphasis is on the efficacy of fatty acid esters and terpenes as medicinal ingredients, and no mention is made of the liquidity of the foam.

In the present invention, the shampoo composition is housed in a foam discharge container, but the discharged foam is very practical because it is adjusted to a foam state in which the head can be easily treated for the palm. Such a foam discharge container may be of any type as long as a certain amount of shampoo composition is mixed with a certain amount of air and discharged as a foam state from the container at the time of use. Specifically, for example, a squeeze foamer used by pressing the torso of a soft container with fingers, a pump former used by pressing the head of a cap equipped with a pump mechanism with fingers, and the like. The pump former is easy to use.
The mixture obtained by mixing the shampoo composition in the container with air is usually discharged in a foam form from the container outlet by passing through the porous film. Examples of the porous film include a net, a sponge, and a baked product. Examples include union. From the viewpoint of usability, a thin net is preferable, and the mesh is preferably about 30 to 300 mesh. If it is less than 30 mesh, the pores are too large and foaming is worsened. On the other hand, if it exceeds 300 mesh, the shampoo composition tends to be clogged, which is not preferable. Examples of such a net material include nylon and polyester, and one or a plurality of such materials are provided.

When the shampoo composition of the present invention thus obtained is used and the discharged foam is treated on the hair of the head for the palm, for example, the shampoo composition reaches the root of the hair. And it is possible to let the head lice suffocate and die by leaving this bubble state for 15 minutes or more. If the head is covered with a shampoo cap after shampooing, it is more effective because a good foam state can be reliably maintained.
Of course, the head lice extermination method of the present invention can be similarly applied to body lice and white lice.

Next, the head lice extermination method of the present invention will be described in more detail based on specific examples and test examples.

POE (20) sorbitan monooleate (5.0 g), lauryldimethylamine oxide (2.4 g), and POE (160) POP (30) block polymer (20.0 g) and purified water were mixed and stirred in an appropriate amount, and then adjusted to pH 6 with hydrochloric acid. . Next, 0.001 g of sodium edetate and a small amount of perfume were added and stirred, and the remaining amount of purified water was added to obtain 100 g of a shampoo composition. 50 g of this shampoo composition was accommodated in a foam discharge container and applied to the present invention. In the foam state, the foam specific gravity was 0.09 and the defoaming degree was 14%.

About 10 g of the foam discharged from the foam discharge container was taken in the palm of the hand, treated on head hair in which head lice infestation was observed, covered with a shampoo cap, and left for about 30 minutes. The foam of this shampoo fully reached the base of the hair, and after leaving it for about 20 minutes, washing with water and examining the head, the head lice were completely suffocated to death.

Various shampoo compositions shown in Table 1 were prepared according to Example 1, and contained in the foam discharge container used in Example 1, and the following tests were conducted. In addition, 20.0 weight% of POE (160) POP (30) block polymer which is a thickener was mix | blended as another component of a shampoo composition.
Lice control effect A 2 × 2 cm piece of brushed woolen cloth was placed in a 100 mL polyethylene cup, and 10 adults of about 8 years old were released after head lice emerged. 50 mL of foam or liquid discharged from the test shampoo was applied onto a piece of wool cloth and left for 5 to 60 minutes. Thereafter, the wool cloth pieces were thoroughly washed with tap water in a polyethylene cup for 1 minute. Next, the test insect was removed from the wool cloth piece and transferred to a 100 mL polyethylene cup with filter paper on the bottom. Thereafter, the specimen was placed in a thermostatic chamber at 30 ° C. and observed for life and death one day later to determine the death rate. In addition, tap water was used instead of the sample shampoo as an untreated zone.
(2) Usability test When the hair of the head was treated by discharging about 10 g from the shampoo, the usability such as whether or not it was easy to wash the hair by spreading the ejected material was evaluated. The results are indicated by ○ (easy to use and can be felt that the discharged material has reached the root of the hair), Δ, × (not easy to handle by the method of washing hair for the palm).

As a result of the test, a shampoo composition having a foam specific gravity of 0.05 to 0.2 and an antifoaming degree after 2 minutes of 30% or less in the defoaming test by the Ross Miles method was used, and the foam state was 15 minutes. According to the head lice extermination method of the present invention which is left as described above, both the lice extermination effect and the feeling of use are excellent and practical. From the evaluation of Examples 1 to 5, it was confirmed that polyoxyethylene sorbitan fatty acid ester is preferable as the surfactant, and alkyldimethylamine oxide is preferable as the foaming agent.
On the other hand, when no foaming agent is contained as in Comparative Example 1 or when the foam specific gravity is less than 0.05 (Comparative Example 2), the effect of removing lice is inferior. When the specific gravity exceeded 0.2, there was a problem in terms of usability. Further, as is clear from Comparative Examples 4 to 5, in order to obtain a sufficient lice control effect, it was necessary to leave the foam state for 15 minutes or longer.

The head lice extermination method of the present invention may be used not only for lice extermination for human bodies but also for pets and other pest extermination purposes.

Claims (2)

Surfactant containing polyoxyethylene sorbitan fatty acid ester, general formula
(R ₁ represents an alkyl group having 8 to 16 carbon atoms, R ₂ and R ₃ represent an alkyl group having 1 to 2 carbon atoms or a hydroxyethyl group, and R ₂ and R ₃ may be the same or different. The foam specific gravity is 0.05 to 0.2, and the defoaming degree after 2 minutes is 30% or less in the defoaming test by the Ross Miles method. The composition does not contain a pyrethroid insecticidal component, and is used for letting the head lice suffocate and die after shampooing it and leaving it in a foam state for 15 minutes or more. Disinfecting shampoo. Head lice shampoo disinfection according to claim 1, characterized by being used as leaving the foam state over 15 minutes using a shampoo cap.