JP5801543B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition containing a fluoride ion supplying compound.

  The main component of the tooth is hydroxyapatite, and in the mouth, the elution (decalcification) of phosphate ions and calcium ions and the crystallization (remineralization) to calcium phosphate and hydroxyapatite are usually in an equilibrium state. Dental caries promotes decalcification by causing bacteria such as Streptococcus mutans to decompose sucrose and produce organic acids, lowering pH, and eluting tooth calcium and the like It will go on. In the initial stages of caries, enamel produces subsurface demineralized lesions of the teeth called white spots. Here, it is known that fluorine ions can prevent the occurrence of caries and eliminate such vitiligo by promoting crystallization of calcium ions and phosphate ions, that is, remineralization.

  On the other hand, sugar alcohols such as xylitol are known to be non-fermentative and to inhibit the growth of caries-causing bacteria, and Patent Document 1 reports an oral composition containing xylitol and a fluorine compound in a specific ratio. ing. As a technique for promoting remineralization with a fluorine compound, Patent Document 2 describes an oral composition containing a sugar alcohol such as xylitol, sodium fluoride, and magnesium ions, and Patent Document 3 discloses paratinite. The composition for oral cavity containing a fluorine compound is described, The result that the amount of remineralization is so high that there is much content of a paratinite is shown.

JP-A-3-48613 Japanese Patent Application Laid-Open No. 11-12143 Japanese Patent Laid-Open No. 2000-247852

In order to incorporate fluoride ions into the tooth enamel and promote remineralization, it is conceivable to increase the fluoride ion concentration, but in terms of solubility and safety of fluoride ions, a large amount of dentifrice composition can be used. It is difficult to contain, and it is desirable to efficiently incorporate a small amount of fluorine ions into the enamel. On the other hand, the dentifrice compositions of Patent Documents 2 and 3 describe that a combination of a fluoride ion supply compound and a sugar alcohol prevents caries due to both the effects of remineralization and the suppression of caries-causing bacteria growth. As a result of examination by the inventors, the amount of fluorine ions taken into the tooth enamel was not always high.
Therefore, an object of the present invention is to provide a dentifrice composition having an improved remineralization effect with improved fluoride ion incorporation into the tooth enamel.

Therefore, the present inventor conducted various studies on the cause of insufficient improvement in the amount of fluorine ion taken into the tooth enamel despite the combined use of a fluorine ion supply compound and a sugar alcohol. It has been found that if the amount of water is too much relative to the amount of sugar alcohol, the amount of fluoride ions taken into the tooth enamel is not sufficiently improved even though a sufficient amount of sugar alcohol is dissolved. On the other hand, even when the amount of water was too small, the amount of fluorine ions taken into the tooth enamel was not sufficiently improved.
As a result of further investigation, a combination of a fluorine ion supply compound and a sugar alcohol having low solubility in water, and adjusting the water content to a certain range, the amount of fluoride ions taken into the tooth enamel is significantly increased. It has been found that a dentifrice composition that is improved and has an excellent tooth remineralization effect can be obtained.

That is, the present invention includes the following components (A), (B) and (C):
(A) 0.002 to 5% by mass of fluorine ion supply compound in terms of fluorine,
(B) 30 to 65% by mass of a sugar alcohol that dissolves 5 to 30 g with respect to 100 g of an aqueous solution at 20 ° C.,
(C) Water 10-25% by mass
And a dentifrice composition in which the mass ratio (B / C) of component (B) to component (C) is greater than 1 and 6 or less.

  If the dentifrice composition of this invention is used, the fluorine ion of a fluorine ion supply compound will be taken in in an enamel efficiently, and the remineralization of an enamel will improve.

The dentifrice composition of the present invention contains a fluoride ion supply compound (A). The fluorine ion supply compound may be either an inorganic compound or an organic compound. Specifically, sodium fluoride, potassium fluoride, tin fluoride, sodium fluoride siliconate, sodium monofluorophosphate, ammonium fluoride, aluminum fluoride, silver fluoride, hexylamine hydrofluoride, fluoride Examples thereof include decanolamine hydride and octadecenylamine hydrofluoride, and sodium fluoride and sodium monofluorophosphate are preferred from the viewpoint of high fluorine ion uptake into tooth enamel. These fluorine ion supply compounds can be blended in the dentifrice composition of the present invention in one kind or in combination of two or more kinds.
Fluorine ion supply compound (A) is contained in an amount of 0.002 to 5% by mass in terms of fluorine ions with respect to the composition from the viewpoint of ensuring a sufficient amount of fluorine ions taken into the tooth enamel and safety. More preferably, the content is 0.01 to 1% by mass, and further preferably 0.05 to 1% by mass.

  The dentifrice composition of this invention contains the sugar alcohol (B) which melt | dissolves 5-30g with respect to 100g of aqueous solution in 20 degreeC. Examples of the sugar alcohol (B) dissolved in 5 to 30 g with respect to 100 g of the aqueous solution at 20 ° C. used in the present invention include mannitol, α-D-glucopyranosyl-1,6-sorbitol, α-D-glucopyranosyl-1,6- Examples include mannitol, α-D-glucopyranosyl-1,6-sorbitol and paratinite which is a mixture of α-D-glucopyranosyl-1,6-mannitol.

  Mannitol is a kind of hexitol and is a sugar alcohol of mannose. Industrially, it is produced by electrolytic reduction of corn starch sugar and high-pressure reduction of sucrose. The mannitol used in the present invention may be at least one selected from D-mannitol, L-mannitol, and D, L-mannitol, and is not particularly limited. Easy and preferred. The solubility of mannitol is 18 g per 100 g of aqueous solution at 20 ° C.

  Palatinite is a disaccharide sugar alcohol and is an equimolar mixture of α-D-glucopyranosyl-1,6-mannitol and its isomer α-D-glucopyranosyl-1,6-sorbitol. Palatinite is obtained by using sucrose as a raw material, converting sucrose to palatinose with a glycosyltransferase and then hydrogenating it. Palatinit is a trade name of Mitsui Sugar Co., Ltd. and Suducker AG Co. (Japanese name: South German Sugar Co., Ltd.), and there is another name of reduced palatinose or isomalt. The solubility of palatinit is 28 g per 100 g of aqueous solution at 20 ° C.

These sugar alcohols (B) can be used alone or in combination of two or more. Moreover, sugar alcohol (B) may mix | blend any of powder and a granular form.
These sugar alcohols (B) are contained in the dentifrice composition of the present invention in an amount of 30 to 65% by mass, more preferably 30 to 60% by mass, especially 30 It is preferable to contain -55 mass%.

  The content of water (C) in the dentifrice composition of the present invention is important from the viewpoint of the effect of improving the amount of fluoride ions taken into the tooth enamel, and is preferably 10 to 25% by mass, more preferably 10 to 20% by mass. By containing 10 to 25% by mass of water (C), the composition has a structural viscosity due to the presence of the undissolved sugar alcohol (B), and the fluorine ion supplying compound dissolved in the contained water (C). It is thought that liquidity can be secured. Further, since the amount of sugar alcohol (B) dissolved in water is small, the concentration of the fluoride ion supply in water (C) can be increased, and the high concentration fluoride ion supply flows and contacts the teeth. I think that. Thus, the dentifrice composition of the present invention can increase the amount of fluoride ions taken into the tooth enamel. In addition, the water (C) includes, for example, water contained in components such as sorbitol liquid in addition to the purified water blended.

  In the dentifrice composition of the present invention, the mass ratio (B / C) of sugar alcohol (B) to water (C) is greater than 1 and 6 or less, and the amount of sugar alcohol (B) is greater than water (C). In many cases, the dentifrice composition contains a sugar alcohol (B) that is contained beyond the saturated dissolution state and is in an undissolved state. From the viewpoint of ensuring the fluidity of the fluorine ion supply compound (A) dissolved in water (C) while making the composition have structural viscosity by allowing the undissolved sugar alcohol (B) to exist, the sugar alcohol ( The mass ratio (B / C) of B) to water (C) is more preferably 1.2 to 3, and particularly preferably 1.5 to 3.

The dentifrice composition of the present invention contains the sugar alcohol (B) having the above-mentioned certain solubility, but may further contain another sugar alcohol (E) having a solubility of more than 30 g with respect to 100 g of an aqueous solution at 20 ° C. . As other sugar alcohols (E), the sugar alcohol (E1) having a solubility in 100 g of an aqueous solution at 20 ° C. higher than 30 g but not higher than 50 g, sugar alcohol (E2) higher than 50 g and not higher than 70 g, and sugar alcohol (E3 higher than 70 g) ) Can be contained. The other sugar alcohol (E) is preferably the sugar alcohol (E1) from the viewpoint of the amount of fluorine taken into the tooth enamel.
When other sugar alcohol (E) is contained, the mass ratio (E / C) to water (C) contained in the dentifrice composition is preferably less than 1, preferably 0.75 or less, and further 5 or less is preferable.

  When the other sugar alcohol (E1) is contained, the mass ratio (E1 / B) to the sugar alcohol (B) is preferably 1 or less, more preferably 0.8 or less, and further preferably 0.5 or less. When the sugar alcohol (E2) is contained, the mass ratio (E2 / B) to the sugar alcohol (B) is preferably 0.2 or less, more preferably 0.18 or less, and further preferably 0.17 or less. When the sugar alcohol (E3) is contained, the mass ratio (E3 / B) to the sugar alcohol (B) is preferably 0.1 or less, and more preferably 0.05 or less.

  Examples of the sugar alcohol (E1) include erythritol having a solubility of 36 g in an aqueous solution at 20 ° C., and glyceritol having a solubility in an aqueous solution of 100 g at 20 ° C., 60 g of maltitol, and the like. Examples of the sugar alcohol (E3) include sorbitol having a solubility of 72 g in 100 g of an aqueous solution at 20 ° C.

Moreover, it is preferable that the dentifrice composition of this invention contains a binder (D). Examples of the binder (D) include sodium carboxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, xanthan gum, carrageenan, sodium alginate, hydroxypropyl cellulose, guar gum, sodium chondroitin sulfate and the like. These can use 1 type (s) or 2 or more types.
Usually, the binder (D) is blended for gelation of a gel-like dentifrice, or for paste-like dentifrice and for dentifrice, but in the present invention, fluoride ions in water (C). From the viewpoint of securing the fluidity of the present invention, it is preferably 0.1% by mass or more and 1.2% by mass or less, more preferably 1.0% by mass or less, and more preferably 1.0% by mass in the dentifrice composition of the present invention. %, More preferably less than 0.8% by mass.

  The dentifrice composition of the present invention includes a foaming agent, a foaming aid, an abrasive, a wetting agent, a thickening agent, a gelling agent, a sweetening agent, a preservative within the range that does not impair the effects of the present invention in addition to the above components , Fungicides, medicinal components, pigments, dyes, fragrances and the like can be appropriately contained. Further, the dentifrice composition of the present invention is prepared in a dosage form such as a gel or a paste, and can be used as a toothpaste or a gel dentifrice.

  The dentifrice composition of the present invention preferably has a viscosity of 500 to 10,000 dPa · s at 20 ° C., more preferably 1000 to 7000 dP · s. By ensuring the viscosity of 10,000 dPa · s or less, the fluidity of the fluoride ion supply compound (A) in the contained water (C) is ensured while the structural viscosity of the composition is given by the undissolved sugar alcohol. Can do. The viscosity of the dentifrice composition is packed in a container for viscosity measurement and stored in a thermostat at 20 ° C. for 24 hours, and then a rotor H7 (rotation speed) of 2.5 rpm using a helipath type viscometer (B type viscometer). Measurement can be performed under conditions of 1 minute.

  In the dentifrice composition of the present invention, the rate of decrease in viscosity (20 ° C.) when 25% by mass of water is added is 10% or less with respect to the viscosity of the stock solution before adding water (20 ° C.). Preferably, it is further preferably 1 to 10%, more preferably 3 to 8%, particularly preferably 3 to 7%. In the dentifrice composition of the present invention, the composition has a structural viscosity with sugar alcohol in an undissolved state, and therefore the rate of decrease in viscosity due to the addition of water is large. In a preferred embodiment, according to the dilution model with saliva during tooth brushing operation, which is diluted with 25% water by mass, the viscosity of the composition is reduced to 10% or less, so fluorine ions in water (C) Can be applied to teeth with high concentration and fluidity. From this point, the viscosity (20 ° C.) when 25% by mass of water is added is the viscosity measured within 1 hour after adding water.

  In the following examples,% means mass%.

Test example 1
Each component of the sample containing the fluorine ion supply compound shown in Table 1 and its content were mixed to prepare dentifrice compositions of Examples 1-4 and Comparative Examples 1-5. Comparative Example 6 is a fluorine solution in which a fluorine feed is dissolved in water. The pH was neutral (6-8).

100 mg of each sample of the toothpaste compositions of Examples 1 to 6, Comparative Examples 1 to 6, and the fluorine solution of Comparative Example 7 was applied to HAP pellets (APP-100 HOYA) 10 mm × 10 mm × 2 mm for 3 minutes, and ion-exchanged water. The dentifrice composition was removed and the pellets were dried. Extraction of fluoride ions from the dried pellets with 1N hydrochloric acid for 30 seconds, using a fluorine ion electrode (ionplus-Fluoride (ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (ORION)) The amount of fluorine adsorbed on the HAP pellet was quantified.
Viscosity was measured for samples and samples diluted with 25% purified water. The measurement conditions were stored for 1 hour in a thermostat at 20 ° C., and then measured with a B-type viscometer using a rotor H7 (rotational speed) of 2.5 rpm for 1 minute. However, after dilution, a sample having a viscosity of 500 dPa · s or less was measured under the same conditions using a rotor H2.

As shown in Table 1, the amount of fluorine uptake of the dentifrice compositions of Examples 1-6 containing 5-30 g of sugar alcohol (B) dissolved in 100 g of aqueous solution at 20 ° C. more than water (C) is fluorine. The result was higher than that of Comparative Example 6 of the solution. Moreover, the amount of fluorine uptake of the dentifrice composition of the present invention is the content of sugar alcohol (B) rather than water (C), Comparative Example 1 containing 40 g of xylitol (solubility is 66 g with respect to 100 g of aqueous solution at 20 ° C.). Comparative Examples 2, 4, and 5 having a small amount, Comparative Example 3 that does not contain any sugar alcohol (B), and Comparative Example 6 in which the content of sugar alcohol (B) exceeds 6 times that of water (C) Higher results were obtained than the dentifrice composition.
Moreover, the dentifrice composition of Examples 1-6 has more sugar alcohol (B) which dissolves 5-30g with respect to 100g of aqueous solution in 20 degreeC than water (C) (sugar alcohol (B) / water (C). Is greater than 1), and the content of the binder is 1% or less. Therefore, the viscosity (P2) at 20 ° C. obtained by diluting the dentifrice compositions of Examples 1 to 6 with 25% water is reduced to 10% or less with respect to the viscosity (P1) at 20 ° C. before dilution, and is not dissolved. It can be determined that the structural viscosity of the composition due to the sugar alcohol in the state is reduced by dilution. On the other hand, since the dentifrice compositions of Comparative Examples 1 to 4 are made viscous by the binder, the viscosity reduction after dilution was 10% or more.

Claims (1)

The following components (A), (B) , (C) and (D) :
(A) 0.002 to 5% by mass of fluorine ion supply compound in terms of fluorine,
(B) 30 to 65% by mass of one or more sugar alcohols selected from mannitol, α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol,
(C) Water 10-25% by mass
(D) Binder 0.1-1.0% by mass
Containing the mass ratio of component (B) and the component (C) (B / C) is are three der from greater than 1, a viscosity (20 ° C.) is 500~10000dPa · s, 25 weight by weight ratio A dentifrice composition in which the rate of decrease in viscosity when diluted by adding% water is 10% or less of the viscosity before dilution .