JP5794297B2 - Ｇｐｒ１１９アゴニストとしてのピリダジノン - Google Patents
Ｇｐｒ１１９アゴニストとしてのピリダジノン Download PDFInfo
- Publication number
- JP5794297B2 JP5794297B2 JP2013508516A JP2013508516A JP5794297B2 JP 5794297 B2 JP5794297 B2 JP 5794297B2 JP 2013508516 A JP2013508516 A JP 2013508516A JP 2013508516 A JP2013508516 A JP 2013508516A JP 5794297 B2 JP5794297 B2 JP 5794297B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- phenyl
- methyl
- benzoxazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *c1nc(ccc(*)c2)c2[o]1 Chemical compound *c1nc(ccc(*)c2)c2[o]1 0.000 description 5
- KNLOYUUHCARONP-UHFFFAOYSA-N CC(C)C(C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O Chemical compound CC(C)C(C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O KNLOYUUHCARONP-UHFFFAOYSA-N 0.000 description 1
- XNOMDPLPGJNDBQ-UHFFFAOYSA-N CC(C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O Chemical compound CC(C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O XNOMDPLPGJNDBQ-UHFFFAOYSA-N 0.000 description 1
- UEMXBBIEHRYMTE-UHFFFAOYSA-N CC(CC(c(cc1)cc2c1nc(-c1ccc[s]1)[o]2)=NN1)C1=O Chemical compound CC(CC(c(cc1)cc2c1nc(-c1ccc[s]1)[o]2)=NN1)C1=O UEMXBBIEHRYMTE-UHFFFAOYSA-N 0.000 description 1
- RDRKKVPBQYFGSU-UHFFFAOYSA-N CCC(C(c(cc1)cc2c1nc(-c1ccccc1)[o]2)=NN1)OC1=O Chemical compound CCC(C(c(cc1)cc2c1nc(-c1ccccc1)[o]2)=NN1)OC1=O RDRKKVPBQYFGSU-UHFFFAOYSA-N 0.000 description 1
- UVYLSNWVYKMAQJ-UHFFFAOYSA-N CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OCC(CC2)CCN2S(C)(=O)=O)[o]3)=NNC1=O Chemical compound CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OCC(CC2)CCN2S(C)(=O)=O)[o]3)=NNC1=O UVYLSNWVYKMAQJ-UHFFFAOYSA-N 0.000 description 1
- QKGMWKSZGSDLOM-UHFFFAOYSA-N CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OCCOC)[o]3)=NNC1=O Chemical compound CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OCCOC)[o]3)=NNC1=O QKGMWKSZGSDLOM-UHFFFAOYSA-N 0.000 description 1
- BHWCYYVRWYIONW-ZYZRXSCRSA-N CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OC[C@H](CCC2)N2C(C)C)[o]3)=NNC1=O Chemical compound CCC(C1)C(c(cc2)cc3c2nc(-c(cc2)ccc2OC[C@H](CCC2)N2C(C)C)[o]3)=NNC1=O BHWCYYVRWYIONW-ZYZRXSCRSA-N 0.000 description 1
- XNOMDPLPGJNDBQ-NSHDSACASA-N C[C@@H](C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O Chemical compound C[C@@H](C1)C(c(cc2)cc3c2nc(-c2ccccc2)[o]3)=NNC1=O XNOMDPLPGJNDBQ-NSHDSACASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162364.3 | 2010-05-07 | ||
| EP10162364 | 2010-05-07 | ||
| PCT/EP2011/057285 WO2011138427A2 (en) | 2010-05-07 | 2011-05-06 | Pyridazinones as gpr119 agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525472A JP2013525472A (ja) | 2013-06-20 |
| JP2013525472A5 JP2013525472A5 (enExample) | 2014-06-26 |
| JP5794297B2 true JP5794297B2 (ja) | 2015-10-14 |
Family
ID=42711866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508516A Active JP5794297B2 (ja) | 2010-05-07 | 2011-05-06 | Ｇｐｒ１１９アゴニストとしてのピリダジノン |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8772323B2 (enExample) |
| EP (1) | EP2566864B1 (enExample) |
| JP (1) | JP5794297B2 (enExample) |
| WO (1) | WO2011138427A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201200046A1 (ru) | 2009-06-24 | 2012-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения, фармацевтическая композиция и связанные с ними способы |
| JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
| US8772323B2 (en) * | 2010-05-07 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists |
| UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
| AU2012208530A1 (en) | 2011-01-21 | 2013-07-11 | Boehringer Ingelheim International Gmbh | Fused dihydrofurans as GPR119 modulators for the treatment of diabetes, obesity and related disorders |
| JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ１１９モジュレーターとしてのｎ−シクロプロピル−ｎ−ピペリジニルベンズアミド |
| EA031618B1 (ru) | 2011-06-09 | 2019-01-31 | Ризен Фармасьютикалз Са | Соединения-модуляторы gpr-119 |
| US8921398B2 (en) | 2011-06-09 | 2014-12-30 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof |
| WO2013186109A1 (en) * | 2012-06-12 | 2013-12-19 | Boehringer Ingelheim International Gmbh | 2,3-dihydro-furo[2,3-c]pyridin-2-yl-piperidine derivatives, pharmaceutical compositions containing them and uses thereof |
| CA2878625A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| TWI652014B (zh) | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
| WO2016004513A1 (en) * | 2014-07-11 | 2016-01-14 | Simon Fraser University | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods |
| US10919875B2 (en) | 2015-06-18 | 2021-02-16 | 89Bio Ltd | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| ES2821049T3 (es) | 2015-06-18 | 2021-04-23 | 89Bio Ltd | Derivados de piperidina 1,4 sustituidos |
| CA3015934A1 (en) | 2016-04-01 | 2017-10-05 | Basf Se | Bicyclic compounds |
| WO2018086703A1 (en) | 2016-11-11 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dihydropyridazinones substituted with phenylureas |
| US11897867B2 (en) | 2017-08-04 | 2024-02-13 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer |
| JOP20200024A1 (ar) | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| CN107857720A (zh) * | 2017-10-26 | 2018-03-30 | 中山大学 | 一种西洛多辛手性中间体的制备方法 |
| CA3089754A1 (en) | 2018-01-31 | 2019-08-08 | Bayer Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
| EP3917915A1 (en) | 2019-02-01 | 2021-12-08 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2h)-one compounds for the treatment of hyperproliferative diseases |
| WO2021013693A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
| BR112022017039A2 (pt) | 2020-02-28 | 2022-11-16 | Kallyope Inc | Agonistas de gpr40 |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3511110A1 (de) | 1985-03-27 | 1986-10-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| WO2007003961A2 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
| JP2008063265A (ja) * | 2006-09-06 | 2008-03-21 | Kyorin Pharmaceut Co Ltd | ピリダジノン誘導体及びそれらを有効成分とするｐｄｅ阻害剤 |
| EP2058308A1 (fr) | 2007-11-12 | 2009-05-13 | Merck Sante | Dérivés de benzimidazoledihydrothiadiazinone comme inhibiteurs de fructose-1,6-biphosphatase et compositions pharmaceutiques les contenant. |
| US8153813B2 (en) * | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| US8772323B2 (en) * | 2010-05-07 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists |
-
2011
- 2011-05-06 US US13/696,094 patent/US8772323B2/en active Active
- 2011-05-06 JP JP2013508516A patent/JP5794297B2/ja active Active
- 2011-05-06 EP EP11718989.4A patent/EP2566864B1/en active Active
- 2011-05-06 WO PCT/EP2011/057285 patent/WO2011138427A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2566864A2 (en) | 2013-03-13 |
| WO2011138427A2 (en) | 2011-11-10 |
| US8772323B2 (en) | 2014-07-08 |
| WO2011138427A3 (en) | 2012-03-08 |
| US20130172323A1 (en) | 2013-07-04 |
| EP2566864B1 (en) | 2014-09-03 |
| JP2013525472A (ja) | 2013-06-20 |
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