JP5781943B2 - 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 - Google Patents

炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 Download PDF

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JP5781943B2
JP5781943B2 JP2011546451A JP2011546451A JP5781943B2 JP 5781943 B2 JP5781943 B2 JP 5781943B2 JP 2011546451 A JP2011546451 A JP 2011546451A JP 2011546451 A JP2011546451 A JP 2011546451A JP 5781943 B2 JP5781943 B2 JP 5781943B2
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substituted
alkyl
fluoro
phenyl
cycloalkyl
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JP2012515724A (ja
JP2012515724A5 (enExample
Inventor
ラジンダー シング，
ラジンダー シング，
リ，フイ
ザオ，ハオラン
コルリ，ラオ
ツォ，キン
ラムファル，ジョン
グー，シーハイ
バルデス，カルロス
チャン，ジン
シュタウファー，エミリー
ダンクトン，マシュー
アルバレス，サルバドール
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ライジェル ファーマシューティカルズ， インコーポレイテッド
ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2011546451A 2009-01-21 2010-01-21 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 Expired - Fee Related JP5781943B2 (ja)

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US14627309P 2009-01-21 2009-01-21
US61/146,273 2009-01-21
US26416509P 2009-11-24 2009-11-24
US61/264,165 2009-11-24
PCT/US2010/021662 WO2010090875A1 (en) 2009-01-21 2010-01-21 Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases

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JP2015018931A Division JP2015110629A (ja) 2009-01-21 2015-02-03 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体

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JP2012515724A JP2012515724A (ja) 2012-07-12
JP2012515724A5 JP2012515724A5 (enExample) 2013-03-07
JP5781943B2 true JP5781943B2 (ja) 2015-09-24

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JP2011546451A Expired - Fee Related JP5781943B2 (ja) 2009-01-21 2010-01-21 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体
JP2015018931A Withdrawn JP2015110629A (ja) 2009-01-21 2015-02-03 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体

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US (2) US8377924B2 (enExample)
EP (1) EP2389373B1 (enExample)
JP (2) JP5781943B2 (enExample)
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ES (1) ES2635504T3 (enExample)
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TW201609671A (zh) 2013-12-20 2016-03-16 標誌製藥公司 經取代之二胺基嘧啶基化合物、其組合物及使用其之治療方法
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JP6903577B2 (ja) 2014-12-16 2021-07-14 シグナル ファーマシューティカルズ，エルエルシー 皮膚におけるｃ−Ｊｕｎ Ｎ末端キナーゼの阻害の測定方法
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