JP5781941B2 - ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド - Google Patents
ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56938—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
- G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
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- Molecular Biology (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09150888.7 | 2009-01-19 | ||
| EP09150888A EP2208787A1 (en) | 2009-01-19 | 2009-01-19 | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| PCT/EP2010/050453 WO2010081875A1 (en) | 2009-01-19 | 2010-01-15 | A recombinant alpha-hemolysin polypeptide of staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504301A JP2013504301A (ja) | 2013-02-07 |
| JP2013504301A5 JP2013504301A5 (OSRAM) | 2013-03-21 |
| JP5781941B2 true JP5781941B2 (ja) | 2015-09-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545744A Expired - Fee Related JP5781941B2 (ja) | 2009-01-19 | 2010-01-15 | ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8545853B2 (OSRAM) |
| EP (2) | EP2208787A1 (OSRAM) |
| JP (1) | JP5781941B2 (OSRAM) |
| AU (1) | AU2010205645B2 (OSRAM) |
| CA (1) | CA2749862C (OSRAM) |
| ES (1) | ES2483720T3 (OSRAM) |
| WO (1) | WO2010081875A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| HRP20182017T4 (hr) * | 2011-02-08 | 2021-08-20 | Medimmune, Llc | Protutijela koja specifično vežu alfa toksin koji stvara staphylococcus aureus i postupci uporabe |
| JP2014507142A (ja) | 2011-02-08 | 2014-03-27 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | α溶血素オリゴペプチドを含む免疫原性組成物 |
| US10766932B2 (en) | 2011-05-11 | 2020-09-08 | The Children's Medical Center Corporation | Multiple antigen presenting immunogenic composition, and methods and uses thereof |
| WO2012178093A1 (en) | 2011-06-24 | 2012-12-27 | Electronic Biosciences Inc. | High contrast signal to noise ratio device components |
| CN102977214B (zh) * | 2012-09-29 | 2014-03-12 | 重庆原伦生物科技有限公司 | 用于耐甲氧西林金黄色葡萄球菌（mrsa）疫苗的重组蛋白hf2及制备方法和应用 |
| WO2014100481A2 (en) | 2012-12-20 | 2014-06-26 | Electornic Biosciences Inc. | Modified alpha hemolysin polypeptides and methods of use |
| JP6494527B2 (ja) | 2013-02-07 | 2019-04-03 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌のコロニー形成および／または疾患からの保護を提供するタンパク質抗原 |
| CN112521464A (zh) * | 2014-03-26 | 2021-03-19 | 葛兰素史密丝克莱恩生物有限公司 | 突变型葡萄球菌抗原 |
| CA2962241A1 (en) * | 2014-09-29 | 2016-04-07 | Fujifilm Corporation | Antibody-binding polypeptide, antibody-binding fusion polypeptide, and adsorption material |
| CN105641689B (zh) * | 2016-01-21 | 2024-09-10 | 浙江海隆生物科技股份有限公司 | 一种奶牛金黄色葡萄球菌β-溶血素亚单位疫苗的制备方法及应用 |
| EP3487872A1 (en) | 2016-07-22 | 2019-05-29 | Evaxion Biotech ApS | Chimeric proteins for inducing immunity towards infection with s. aureus |
| CA3061709A1 (en) | 2017-03-28 | 2018-10-04 | The Children's Medical Center Corporation | A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| BR112019027387A8 (pt) | 2017-06-23 | 2022-12-06 | Univ Maryland | Composições imunogênicas |
| CA3107463A1 (en) | 2018-07-24 | 2020-01-30 | Medimmune, Llc | Antibody directed against s. aureus clumping factor a (clfa) |
| JP2021535921A (ja) | 2018-09-12 | 2021-12-23 | アフィニバックス、インコーポレイテッド | 多価肺炎球菌ワクチン |
| TWI852943B (zh) | 2018-09-12 | 2024-08-21 | 美商兒童醫療中心公司 | 肺炎鏈球菌融合蛋白疫苗 |
| TW202035443A (zh) | 2018-10-09 | 2020-10-01 | 美商麥迪紐有限責任公司 | 抗金黃色葡萄球菌抗體的組合 |
| IL311239A (en) | 2021-09-09 | 2024-05-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
| WO2024168197A2 (en) * | 2023-02-08 | 2024-08-15 | The Regents Of The University Of California | Membrane translocation compositions and methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU8586298A (en) * | 1997-07-25 | 1999-02-16 | University Of Massachusetts | Designed protein pores as components for biosensors |
| DK1121135T3 (da) | 1998-09-14 | 2009-03-23 | Nabi Biopharmaceuticals | Præparater af beta-glucaner og specifikke immunglobuliner |
| US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| EP1322747A4 (en) * | 2000-09-15 | 2004-12-29 | Univ Connecticut Health Ct | IMPROVED FORMULATIONS USING THERMAL SHOCK / STRESS PEPTIDE-PROTEIN COMPLEXES |
| GB0107661D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| CA2489030A1 (en) * | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals S.A. | Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria |
| RU2402347C2 (ru) * | 2004-09-22 | 2010-10-27 | ГлаксоСмитКлайн Байолоджикалз с.а. | Иммуногенная композиция |
| WO2007145689A1 (en) | 2006-06-12 | 2007-12-21 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
-
2009
- 2009-01-19 EP EP09150888A patent/EP2208787A1/en not_active Withdrawn
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2010
- 2010-01-15 CA CA2749862A patent/CA2749862C/en not_active Expired - Fee Related
- 2010-01-15 WO PCT/EP2010/050453 patent/WO2010081875A1/en not_active Ceased
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- 2010-01-15 AU AU2010205645A patent/AU2010205645B2/en not_active Ceased
- 2010-01-15 US US13/143,795 patent/US8545853B2/en not_active Expired - Fee Related
- 2010-01-15 JP JP2011545744A patent/JP5781941B2/ja not_active Expired - Fee Related
- 2010-01-15 EP EP10700742.9A patent/EP2382316B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010205645A1 (en) | 2011-07-14 |
| ES2483720T3 (es) | 2014-08-07 |
| AU2010205645B2 (en) | 2014-09-04 |
| WO2010081875A1 (en) | 2010-07-22 |
| CA2749862C (en) | 2015-02-24 |
| EP2382316A1 (en) | 2011-11-02 |
| CA2749862A1 (en) | 2010-07-22 |
| US8545853B2 (en) | 2013-10-01 |
| US20120014983A1 (en) | 2012-01-19 |
| EP2382316B1 (en) | 2014-04-23 |
| JP2013504301A (ja) | 2013-02-07 |
| EP2208787A1 (en) | 2010-07-21 |
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