JP5764822B2 - がんの治療および診断の標的遺伝子としてのｐｒｍｔ１ - Google Patents

がんの治療および診断の標的遺伝子としてのｐｒｍｔ１ Download PDF

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JP5764822B2
JP5764822B2 JP2011509332A JP2011509332A JP5764822B2 JP 5764822 B2 JP5764822 B2 JP 5764822B2 JP 2011509332 A JP2011509332 A JP 2011509332A JP 2011509332 A JP2011509332 A JP 2011509332A JP 5764822 B2 JP5764822 B2 JP 5764822B2
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cancer
prmt1
double
gene
stranded molecule
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JP2012501164A (ja
JP2012501164A5 (enExample
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中村　祐輔
祐輔 中村
隆二 浜本
隆二 浜本
亮 富樫
亮 富樫
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Oncotherapy Science Inc
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    • C12Y201/01125—Histone-arginine N-methyltransferase (2.1.1.125)
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JP2011509332A 2008-08-27 2009-08-25 がんの治療および診断の標的遺伝子としてのｐｒｍｔ１ Expired - Fee Related JP5764822B2 (ja)

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Application Number Priority Date Filing Date Title
US19041608P 2008-08-27 2008-08-27
US61/190,416 2008-08-27
PCT/JP2009/004091 WO2010023877A1 (en) 2008-08-27 2009-08-25 Prmt1 for target genes of cancer therapy and diagnosis

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JP2012501164A JP2012501164A (ja) 2012-01-19
JP2012501164A5 JP2012501164A5 (enExample) 2012-10-11
JP5764822B2 true JP5764822B2 (ja) 2015-08-19

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US (1) US8512944B2 (enExample)
EP (1) EP2329044B1 (enExample)
JP (1) JP5764822B2 (enExample)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970135B1 (en) 2013-03-14 2018-07-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
DK2970132T3 (da) 2013-03-14 2020-12-21 Epizyme Inc Argininmethyltransferaseinhibitorer og anvendelser deraf
EP2970220A2 (en) 2013-03-14 2016-01-20 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153090A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Pyrazole derivatives asprmt1 inhibitors and uses thereof
WO2014153172A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
EP2970181B1 (en) 2013-03-14 2017-06-07 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
JP2016514164A (ja) 2013-03-14 2016-05-19 エピザイム，インコーポレイティド アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
EP3363434A1 (en) 2013-03-14 2018-08-22 Epizyme Inc Arginine methyltransferase inhibitors and uses thereof
WO2016149299A1 (en) * 2015-03-16 2016-09-22 Epinova Therapeutics Corp. Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation
CN109709333B (zh) * 2018-08-01 2021-09-24 东南大学 H4k20、h3k9及h3k36三甲基化量检测试剂在食管癌预后评估中的应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5922687A (en) 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US6294378B1 (en) 1996-07-26 2001-09-25 Sloan-Kettering Institute For Cancer Research Method and reagents for genetic immunization
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CN1331326A (zh) 2000-06-30 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人精氨酸甲基转移酶(hrmt)32.12和编码这种多肽的多核苷酸
CN1339592A (zh) 2000-08-21 2002-03-13 上海博德基因开发有限公司 一种新的多肽——蛋白质精氨酸n－甲基转移酶－1(prmt1)11.44和编码这种多肽的多核苷酸
EP1320587A2 (en) 2000-08-24 2003-06-25 Millenium Pharmaceuticals, Inc. 46863, a human methyltransferase and uses thereof
CA2467936C (en) 2001-11-21 2013-11-05 Mitsubishi Chemical Corporation Method of inhibiting gene expression
AU2003207708A1 (en) 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes
WO2003074736A1 (en) * 2002-03-04 2003-09-12 Institute Of Gene And Brain Science Diagnostics and remedies for malignant brain tumor
ATE513843T1 (de) 2002-09-25 2011-07-15 Univ Massachusetts Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna
WO2004098634A2 (en) * 2003-04-30 2004-11-18 Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health Protein arginine n-methyltransferase 2 (prmt-2)
WO2005044976A2 (en) 2003-06-20 2005-05-19 Isis Pharmaceuticals, Inc. Oligomeric compounds for use in gene modulation
US20050136437A1 (en) 2003-08-25 2005-06-23 Nastech Pharmaceutical Company Inc. Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
WO2005045037A2 (en) 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2005060722A2 (en) 2003-12-18 2005-07-07 President And Fellows Of Hardvard College Modulation of immune system function by modulation of polypeptide arginine methyltransferases
WO2006021817A2 (en) 2004-08-23 2006-03-02 Sylentis S.A.U. Treatment of eye disorders characterized by an elevated introacular pressure by sirnas
JP4908402B2 (ja) * 2004-09-24 2012-04-04 オンコセラピー・サイエンス株式会社 ＵＲＬＣ８のｔＲＮＡ−ジヒドロウリジンシンターゼ活性によって非小細胞肺癌を診断する方法
US7939254B2 (en) 2005-02-28 2011-05-10 Oncotherapy Science, Inc. Breast cancer related gene ZNFN3A1
JP2008535491A (ja) * 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 癌に関連した遺伝子（ＰＴＰε）
US20100119445A1 (en) * 2005-07-21 2010-05-13 N.V. Organon Plexin d1 as a target for tumor diagnosis and therapy
EP1920056A1 (en) 2005-07-25 2008-05-14 Oncotherapy Science, Inc. Compositions and methods for treating breast cancer
US7714014B2 (en) 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules
JP5014780B2 (ja) * 2006-12-28 2012-08-29 株式会社先端生命科学研究所 メチル化ヘテロジニアス・ヌクレア・リボヌクレオプロテインの免疫学的分析方法及びその利用
EP2137158A4 (en) 2007-02-28 2012-04-18 Methylgene Inc LOW-MOLECULAR INHIBITORS OF PROTEINARGININE METHYLTRANSFERASES (PRMTS)
EP2221053A1 (de) 2009-02-20 2010-08-25 Albert-Ludwigs-Universität Freiburg Pharmazeutische Zusammensetzung enthaltend Hemmstoffe der Proteinmethyltransferase I und deren Verwendung zur Behandlung von Tumorerkrankungen

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EP2329044A1 (en) 2011-06-08
JP2012501164A (ja) 2012-01-19
EP2329044A4 (en) 2011-11-02
WO2010023877A1 (en) 2010-03-04
EP2329044B1 (en) 2016-05-18
US8512944B2 (en) 2013-08-20
US20110160293A1 (en) 2011-06-30

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