JP5759673B2 - 組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法 - Google Patents

組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法 Download PDF

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JP5759673B2
JP5759673B2 JP2009554750A JP2009554750A JP5759673B2 JP 5759673 B2 JP5759673 B2 JP 5759673B2 JP 2009554750 A JP2009554750 A JP 2009554750A JP 2009554750 A JP2009554750 A JP 2009554750A JP 5759673 B2 JP5759673 B2 JP 5759673B2
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JP2010521973A (ja
JP2010521973A5 (enExample
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シャンクリン，ジョン
ニュエン，タム
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ブルックヘブン サイエンス アソシエイツ，エルエルシー
ブルックヘブン サイエンス アソシエイツ，エルエルシー
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009554750A 2007-03-21 2008-03-20 組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法 Active JP5759673B2 (ja)

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US89621207P 2007-03-21 2007-03-21
US60/896,212 2007-03-21
PCT/US2008/057704 WO2008116094A2 (en) 2007-03-21 2008-03-20 Combined hairpin-antisense compositions and methods for modulating expression

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JP2010521973A JP2010521973A (ja) 2010-07-01
JP2010521973A5 JP2010521973A5 (enExample) 2011-05-06
JP5759673B2 true JP5759673B2 (ja) 2015-08-05

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US (2) US8796442B2 (enExample)
EP (1) EP2129680B1 (enExample)
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AR (3) AR066194A1 (enExample)
AU (1) AU2008228814B2 (enExample)
BR (1) BRPI0809130A8 (enExample)
CA (1) CA2681323A1 (enExample)
DK (1) DK2129680T3 (enExample)
ES (1) ES2538217T3 (enExample)
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PL (1) PL2129680T3 (enExample)
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AR098140A2 (es) 2016-05-04
AU2008228814B2 (en) 2014-03-06
JP2010521973A (ja) 2010-07-01
DK2129680T3 (en) 2015-08-10
AU2008228814A1 (en) 2008-09-25
US20140342453A1 (en) 2014-11-20
US20080311658A1 (en) 2008-12-18
PT2129680E (pt) 2015-08-28
EP2129680B1 (en) 2015-05-06
US8796442B2 (en) 2014-08-05
HUE027018T2 (en) 2016-08-29
US9193972B2 (en) 2015-11-24
EP2129680A2 (en) 2009-12-09
EP2129680A4 (en) 2010-10-20
ES2538217T3 (es) 2015-06-18
WO2008116094A2 (en) 2008-09-25
AR080722A2 (es) 2012-05-02
CA2681323A1 (en) 2008-09-25
AR066194A1 (es) 2009-08-05
WO2008116094A3 (en) 2008-11-20
BRPI0809130A8 (pt) 2021-11-03
PL2129680T3 (pl) 2015-10-30
BRPI0809130A2 (pt) 2014-08-26

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