JP5732118B2 - Vesicle composition - Google Patents

Description

  The present invention relates to a vesicle composition, a method for producing the same, and use thereof.

  In recent years, the use of perms, hair colors, bleaches, and the like has become common, but hair damage due to these chemical treatments has also become a problem. Conventionally, hair cosmetics such as rinses, conditioners and treatments have been used to improve the feel of hair after shampooing, but further performance improvements are desired from the viewpoint of reducing hair damage. Yes.

  Patent Document 1 discloses a hair cosmetic that can repair or inhibit chemical treatment, dryer drying, hair damage / fatigue destruction caused by daily hair care behavior, and can impart good flexibility and a supple feel from the time of wet to the time of drying. Is disclosed. In Patent Document 1, as a specific embodiment that can solve such a problem, a specific branched fatty acid or a salt thereof, a specific tertiary amine or a salt thereof, and a specific aromatic alcohol as necessary. Containing hair cosmetics are disclosed.

  Patent Document 2 discloses a hair cosmetic that has biodegradability, is environmentally friendly, and can stably contain long-chain alcohols, oils, and the like. It is described that such hair cosmetics are excellent in flexibility and smoothness when wet. Patent Document 2 discloses a hair cosmetic containing a specific tertiary amine, a linear or branched fatty acid, an inorganic acid or an organic acid as a specific embodiment that can solve such a problem. Has been.

  Patent Document 3 discloses a hair treatment composition comprising a multilayer vesicle dispersion stabilized with cholesterol, a basic amino acid, a fatty acid and a nonionic active agent for the purpose of repairing and preventing hair damage, and a multilayer vesicle. Hair treatment compositions such as shampoos and conditioners containing the dispersion are disclosed. This treatment composition is described as specifically promoting the penetration of some hair active substances into hair fibers.

On the other hand, a phase inversion emulsification method and a liquid crystal emulsification method are known as one of methods for producing an emulsified composition. The phase inversion emulsification method is a method of emulsifying while adding an aqueous phase to an oil phase. The liquid crystal emulsification method is a method of emulsifying while adding an aqueous phase to the liquid crystal phase. For example, in Non-Patent Document 1, emulsification is performed while adding an aqueous phase to the oil phase, and a fine emulsion having an average particle size of 1 μm or less is formed by utilizing the fact that the oil-water interface tension is remarkably reduced near the phase inversion point. Yes.
Further, for example, Patent Document 4 discloses a method for producing an oil-in-water emulsion containing a quaternary ammonium salt, which has good fragrance long-lasting and diffusibility and good stability over time.

JP 2008-297218 A JP 2002-114648 A JP 2002-516831 A JP 2008-094980 A

Optimization of Nano-emulsion Preparation by Low-Energy Methods in an Ionic Surfactant System, Langmuir 2006, 22, 8326-8332

  The techniques described in Patent Documents 1 and 2 describe hair cosmetics in which specific tertiary amines and linear or branched fatty acids are combined, but nothing is mentioned about forming a vesicle structure. Therefore, the techniques described in Patent Documents 1 and 2 are insufficient from the viewpoints of suppression of stickiness during rinsing and suppression of stickiness after drying.

  In the technique described in Patent Literature 3, cholesterol is mixed as an essential component to form multilayer vesicles. In other words, a vesicle structure is formed by the presence of specific lipids such as sterols, but even if the usual treatment agent components are used, it is smooth when rinsing, suppresses luster, and is smooth after drying. It was insufficient from the viewpoint of suppressing stickiness.

  Furthermore, phase inversion emulsification as described in Non-Patent Document 1 and Patent Document 4 is generally performed for stabilization of the emulsion, but no mention is made of forming a vesicle structure. Furthermore, emulsions have problems in terms of slickness during rinsing and stickiness after drying, and there is room for improvement.

  The present inventors have obtained a vesicle having a relatively large average particle size in water by combining a linear fatty acid in addition to a specific tertiary amine and a specific branched fatty acid and further using a specific organic acid. Found that it can be configured.

Furthermore, the present inventors have obtained a hair cosmetic composition using a composition in which vesicles occupy a large volume as described above, which is smooth when rinsed, does not become slippery, smooth after drying, and suppresses stickiness. I found out that
Such vesicle compositions are specifically formed from components (A), (B), (C), (D) and water, and include certain tertiary amines and certain branched fatty acids and linear chains. The present invention was completed by finding that it can be produced from fatty acids and specific organic acids and shows a sufficient volume ratio of vesicles.

That is, according to the vesicle composition of the present invention, a vesicle composition in which a continuous phase formed from the components (A), (B), (C), (D) and water shown below is an aqueous phase, Vesicle composition containing vesicles having a mass ratio of component (A) to component (B) of (A) / (B) = 70/30 to 40/60 and an average particle diameter of 5 to 500 μm :
(A) Linear fatty acid having 14 to 24 carbon atoms (B) Branched fatty acid having 14 to 24 carbon atoms and represented by general formula (1)

〔式（１）中、ａ、ｂ、ｃの総和は、ａ＋ｂ＋ｃ＝１１〜２１であり、ｂは１である分岐の飽和脂肪酸。〕
（Ｃ）第３級アミン化合物
（Ｄ）炭素数１〜８の有機酸
が提供される。

[In formula (1), the sum of a, b, and c is a + b + c = 11-21, and b is a branched saturated fatty acid of 1. ]
(C) Tertiary amine compound (D) An organic acid having 1 to 8 carbon atoms is provided.

  According to the vesicle composition of the present invention, it is possible to obtain a hair cosmetic product that is smooth during rinsing, suppresses slimy, is smooth after drying, and suppresses stickiness.

In the vesicle composition of the present invention, the continuous phase formed from the following components (A), (B), (C), (D) and water is an aqueous phase. Hereinafter, each component will be specifically described.
(A) C14-24 linear fatty acid (B) C14-24 branched fatty acid having a predetermined structure (C) Tertiary amine compound (D) C1-8 organic acid

First, the component (A) will be described.
The component (A) used in the present invention is a linear fatty acid having 14 to 24 carbon atoms. It may be saturated or unsaturated, and saturated fatty acid is particularly preferable. From the viewpoint of forming vesicles, the carbon number is preferably 14 or more, particularly 16 or more, and preferably 22 or less, particularly 20 or less. Among these, stearic acid having 18 carbon atoms is preferable from the viewpoint of excellent smoothness during rinsing.

  The content of the component (A) is preferably 0.5% by mass or more and 1% by mass or more, and preferably 5% by mass or less and 3% by mass or less in the vesicle composition.

  The component (B) used in the present invention is a branched fatty acid having 14 to 24 carbon atoms, and is a branched fatty acid represented by the general formula (1).

〔式（１）中、ａ、ｂ、ｃの総和は、ａ＋ｂ＋ｃ＝１１〜２１であり、ｂは１である分岐の飽和脂肪酸。〕

[In formula (1), the sum of a, b, and c is a + b + c = 11-21, and b is a branched saturated fatty acid of 1. ]

  Such branched fatty acids include 14-methylpentadecanoic acid, 15-methylhexadecanoic acid, 16-methylheptadecanoic acid, 17-methyloctadecanoic acid, 18-methylnonadecanoic acid, 19-methyleicosanoic acid, 20-methylheneico. Examples include sanic acid, 14-methylhexadecanoic acid, 15-methylheptadecanoic acid, 16-methyloctadecanoic acid, 17-methylnonadecanoic acid, 18-methyleicosanoic acid, and 19-methylheneicosanoic acid. “Cosmetics Raw Material Standards Second Edition Comment I (1984) Yakuji Nippo” In the branched fatty acid described in 87 (C) isostearic acid, the methyl group is a side chain and the position is not specified, but the unsaturated side chain fatty acid by-produced when synthesizing dimer acid from oleic acid Is a C18 side chain fatty acid obtained by hydrogenation. Specifically, isostearic acid EX [made by higher alcohol industry] is mentioned.

  From the viewpoint of excellent smoothness at the time of rinsing, a + b + c is preferably 13 (carbon number 16) or more, and 19 (carbon number 22) or less, particularly 17 (carbon number 20) or less. Of these, isostearic acid having one of 15 methyl branches is preferred for a + b + c, from the viewpoint of a feeling of use that does not cause slickness during rinsing.

Two or more kinds of the branched fatty acids of component (B) may be used in combination.
The content of the component (B) is preferably 0.2% by mass or more and 0.5% by mass or more, and preferably 4% by mass or less and 2% by mass or less in the vesicle composition.

  Moreover, the mass ratio of a component (A) and a component (B) can be (A) / (B) = 70 / 30-40 / 60. Furthermore, the particle size of the vesicle is as large as 5 μm or more, and 60/40 to 50/50 is preferable from the viewpoints of smoothness at the time of rinsing, suppression of stickiness, smoothness after drying, and suppression of stickiness.

  From the viewpoint of forming vesicles, component (A) and component (B) preferably have a freezing point of 40 ° C. or higher when they are mixed, smooth during rinsing, not sticky, smooth after drying, and suppress stickiness From the viewpoint, it is preferable to combine with a composition of 55 ° C. or lower. In particular, it is preferable to combine in such a composition that the freezing point is 45 ° C. or more and 52 ° C. or less.

  In addition, the component (A) and the component (B) are compounds having the same total carbon number from the viewpoint that the particle size of the vesicle is as large as 5 μm or more, smooth at the time of rinsing, non-smooth, smooth after drying, and suppressing stickiness. Are preferably combined. Specifically, a combination of linear stearic acid and 16-methylheptadecanoic acid is preferable, and linear stearic acid and isostearic acid (isostearic acid EX) may be combined.

  Examples of the component (C) used in the present invention include tertiary amine compounds represented by the general formula (2).

〔上記一般式（２）中、Ｒ^１１は総炭素数８〜３５の−ＯＣＯ−若しくは−ＣＯＯ−で表される官能基で分断又は−ＯＨで置換されていてもよい直鎖若しくは分岐鎖のアルキル基、アルケニル基、又は脂肪族アシルオキシ（ポリエトキシ）エチル基を示し、Ｒ^１２は炭素数１〜２２のアルキル基、若しくはヒドロキシアルキル基、又は合計付加モル数１０以下のポリオキシエチレン基を示し、２個のＲ^１２は同一でも異なってもよい。〕

[In the above general formula (2), R ¹¹ is a linear or branched chain which may be divided by a functional group represented by —OCO— or —COO— having a total carbon number of 8 to 35 or substituted with —OH. An alkyl group, an alkenyl group, or an aliphatic acyloxy (polyethoxy) ethyl group, R ¹² represents an alkyl group having 1 to 22 carbon atoms, or a hydroxyalkyl group, or a polyoxyethylene group having a total number of added moles of 10 or less; Two R ¹² may be the same or different. ]

  The tertiary amine compound of component (C) preferably includes one or more of the following tertiary amine compounds (i) to (iii).

(I) Hydroxy ether alkylamine For example, the compound represented by the following general formula (3) is mentioned.

〔一般式（３）中、Ｒ^１７は、炭素数６〜２４の直鎖又は分岐鎖のアルキル基又はアルケニル基を示し、Ｒ^１８及びＲ^１９は、同一又は相異なって炭素数１〜６のアルキル基又は−（ＡＯ）_ｆＨ（Ａは炭素数２〜４のアルキレン基、ｆは１〜６の数を示し、ｆ個のＡは同一でも異なってもよく、その配列は任意である）を示す。ｅは１〜５の数を示す。〕

[In General Formula (3), R ¹⁷ represents a linear or branched alkyl group or alkenyl group having 6 to 24 carbon atoms, and R ¹⁸ and R ¹⁹ are the same or different and have 1 to 6 carbon atoms. An alkyl group or — (AO) _f H (A represents an alkylene group having 2 to 4 carbon atoms, f represents a number of 1 to 6, and f A may be the same or different, and the arrangement thereof is arbitrary) Indicates. e shows the number of 1-5. ]

  Specific examples include hexadecyloxy (2-hydroxypropyl) dimethylamine and octadecyloxy (2-hydroxypropyl) dimethylamine.

(Ii) Etheramine Examples include compounds represented by the following general formula (4).

〔上記一般式（４）中、Ｒ^２０は、炭素数６〜２４の直鎖又は分岐鎖のアルキル基又はアルケニル基を示し、Ｒ^２１及びＲ^２２は、同一又は相異なって炭素数１〜６のアルキル基又は−（ＡＯ）_ｇＨ（Ａは炭素数２〜４のアルキレン基を示し、ｇは１〜６の数を示し、ｇ個のＡは同一でも異なってもよく、その配列は任意である）を示す。〕

[In the general formula (4), R ²⁰ represents a linear or branched alkyl group or alkenyl group having 6 to 24 carbon atoms, and R ²¹ and R ²² are the same or different and have 1 to 6 carbon atoms. Alkyl group or-(AO) _g H (A represents an alkylene group having 2 to 4 carbon atoms, g represents a number of 1 to 6, g A may be the same or different, and the arrangement thereof is arbitrary. Is). ]

  Specific examples include N, N-dimethyl-3-hexadecyloxypropylamine and N, N-dimethyl-3-octadecyloxypropylamine.

(Iii) Alkylamidoamines Examples include compounds represented by the following general formula (5).

〔上記一般式（５）中、Ｒ^２３は炭素数１１〜２３の脂肪族炭化水素基を示し、Ｒ^２４は同一又は異なって、水素原子又は炭素数１〜４のアルキル基を示し、ｎは２〜４の数を示す。〕

[In the general formula (5), R ²³ represents an aliphatic hydrocarbon group having 11 to ²³ carbon atoms, R ²⁴ is the same or different and represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and n represents Numbers from 2 to 4 are shown. ]

  Specific examples include N- (3- (dimethylamino) propyl) docosanamide and N- (3- (dimethylamino) propyl) stearamide.

As a preferable cationic surfactant selected from the above tertiary amine compounds, (ii) ether amine or (iii) alkylamidoamine is preferable from the viewpoint of smoothness during coating and rinsing.
Among them, (ii) ether amine is particularly preferable, and N, N-dimethyl-3-hexadecyloxypropylamine and N, N-dimethyl-3-octadecyloxypropylamine are particularly preferable. Among them, N, N-dimethyl- 3-octadecyloxypropylamine is preferred.

  The cationic surfactant selected from the tertiary amine of component (C) may be used alone or in combination of two or more. In view of smoothness during rinsing and imparting smoothness after drying, the content of component (C) is preferably 0.5 to 15% by mass in the vesicle composition. Furthermore, 1 to 10% by mass, particularly 3 to 6% by mass is preferable.

Component (D) used in the present invention is an organic acid having 1 to 8 carbon atoms.
Specifically, monocarboxylic acids such as acetic acid, propionic acid and caprylic acid; dicarboxylic acids such as malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid and fumaric acid; glycolic acid, lactic acid, hydroxyacrylic acid and glycerin Hydroxycarboxylic acids such as acid, malic acid, tartaric acid and citric acid; aromatic carboxylic acids such as benzoic acid, salicylic acid and phthalic acid; acidic amino acids such as glutamic acid and aspartic acid. Of these, hydroxycarboxylic acids and acidic amino acids are preferred. As the hydroxycarboxylic acid, glycolic acid, citric acid, lactic acid, and malic acid are particularly preferable, and among them, glycolic acid and lactic acid are preferable. As the acidic amino acid, glutamic acid is particularly preferable.
The content of the component (D) is preferably 0.05% by mass or more and 0.1% by mass or more, and preferably 4% by mass or less and 2% by mass or less in the vesicle composition.

  The hair cosmetic composition of the present invention contains water. As the water, purified water is preferably used. The content of water is not particularly limited, and can be appropriately adjusted according to the purpose of use.

  As a combination of the component (A), the component (B), the component (C), and the component (D), the above-described compounds can be appropriately combined. The combination is not particularly limited. For example, as a combination of component (A), component (B), component (C), and component (D), component (A) is linear stearic acid, and component (B) is It is preferably isostearic acid (isostearic acid EX), component (C) is (ii) ether amine or (iii) alkylamidoamine, and component (D) is a combination of glycolic acid or lactic acid.

  Vesicles are formed by component (A), component (B), component (C), component (D) and water, and in particular, multilayer lamellar vesicles (so-called onion vesicles) composed of several double membranes are dispersed in water. The resulting vesicle composition is likely to be formed. In addition, the vesicle generally refers to a vesicle having an inner layer that is hollow or an aqueous phase, but the multilayer lamella vesicle formed here includes those having a structure in which part or all of the inner layer is an oil phase. In the present application, “vesicles” include multilayer lamella vesicles.

  From the viewpoint of increasing the vesicle volume concentration in the vesicle dispersion, the molar ratio of fatty acid (component (A) + component (B)) to organic acid (component (D)) ((A) + (B)) / (D) is 5/5 or more, preferably 7/3 or more, and 9/1 or less, preferably 8/2.

  In addition, from the viewpoint of efficiently contributing the component (A), the component (B), the component (C), and the component (D) to vesicle formation, the acid equivalent of (A) + (B) + (D) and ( The ratio of C) to the base equivalent is 0.25 or more, preferably 0.5 or more, preferably 0.6 or more, and 4 or less, preferably 2 or less, more preferably 1.8 or less. .

  Furthermore, from the viewpoint of storage stability and handling properties of the vesicle dispersion, the total amount of the component (A), the component (B), the component (C) and the component (D) in the vesicle dispersion is 1 to 20% by mass. Preferably, it is 1 to 15% by mass.

The vesicle composition of the present invention preferably takes the form of a vesicle dispersion (premix). This vesicle dispersion can be obtained, for example, through the following steps.
That is,
(I) a step of dissolving an oil phase containing the component (A), the component (B), the component (C), and the component (D) at a temperature equal to or higher than the melting point of the oil phase;
(Ii) mixing the resulting oil phase while adding an aqueous phase;
Can be suitably manufactured. According to such a procedure, a vesicle composition in which the continuous phase is an aqueous phase is obtained.

In step (i), the oil phase needs to be dissolved from the viewpoint of stable production. For this reason, it is preferable to melt | dissolve at the temperature more than melting | fusing point of an oil phase, and also melt | dissolve at the temperature higher 5 degreeC or more than the melting | fusing point of an oil phase, and it is preferable to melt | dissolve especially 10 degreeC or more higher than the melting point of an oil phase.
The oil phase is preferably in a uniformly mixed state. Therefore, in this step, it is preferable to dissolve the oil phase while mixing. The mixing method is not particularly limited, but it is preferable to mix by, for example, stirring.

  In step (ii), the temperature at the time of dropping the aqueous phase can be appropriately determined by the oil phase temperature, the temperature of the dropping water phase, and heating or cooling in a mixing device. Here, purified water such as ion-exchanged water or distilled water is used for the “aqueous phase”, but a polyhydric alcohol which is a component (E) described later that dissolves in water, such as glycerin or dipropylene glycol, is contained. You can also Further, from the viewpoint of efficiently producing vesicles, it is preferable that the oil phase temperature and the temperature of the dropped water phase be equal to or higher than the phase transition temperature of the vesicle to be formed.

  The volume concentration of vesicles in the vesicle dispersion can be adjusted by the dropping speed of the aqueous phase to the oil phase and the stirring speed when dropping the aqueous phase, and the particle size of the vesicle can be adjusted by the stirring speed (shearing speed) after the start of dropping of the aqueous phase. It is. The optimum value of the dropping speed of the aqueous phase to the oil phase and the stirring speed at the time of dropping varies depending on the formulation of the vesicle composition, the component ratio, the size and shape of the mixing tank, but the viscosity rises most during the dropping of the aqueous phase Conditions that allow uniform mixing in the state are preferred. As the aqueous phase is further dropped, the viscosity of the vesicle dispersion decreases and the vesicle volume concentration decreases. The amount of the aqueous phase to be dropped can be appropriately adjusted in consideration of the storage stability and handling properties of the vesicle dispersion.

  Although the dropping speed of the water phase to the oil phase can be appropriately selected as described above, it is desirable to drop over 10 minutes or more for the purpose of increasing the volume concentration of the vesicle in the vesicle dispersion. Although the dropping speed is not particularly limited, for example, when the total amount of the water phase to be dropped is 600 g, it is preferably dropped at 5 to 20 g / min.

In addition, from the viewpoint of the stability of the vesicle composition, it is a method for producing a vesicle composition comprising a step of (iii) cooling to a temperature lower than or equal to the phase transition temperature of the vesicle immediately after the completion of the aqueous phase dropping after the step (ii). Is preferred.

In addition, the average particle diameter when the vesicle is spherical is 5 μm or more, preferably 7 μm or more, more preferably 10 μm or more, and 500 μm or less, preferably 300 μm from the viewpoint of further improving the feeling of familiarity when applying hair. Hereinafter, it is more preferably 200 μm or less, and particularly preferably 50 μm or less. Here, the average particle size is a particle size distribution measuring device used in the measurement of the vesicle volume concentration, for example, Multisizer ^TM 4 manufactured by Beckman Coulter, Inc. or CDA-1000X manufactured by Sysmex Corporation, or a laser diffraction particle size distribution. Using a measurement device such as SALD2100 manufactured by Shimadzu Corporation or LA-920 manufactured by Horiba, Ltd., the intensity distribution of the scattered light obtained by irradiating the vesicle moving in the flow cell in the circulation system with laser light is measured. The average particle size can be measured by the volume distribution obtained by converting from the intensity distribution. The measurement is desirably performed at room temperature (15 to 30 ° C.).

The vesicle composition of the present invention may further contain (E) a polyhydric alcohol.
Specific examples of the component (E) include propylene glycol, dipropylene glycol, 1,3-propanediol, glycerin, 1,3-butylene glycol, isopentyldiol, sorbitol and the like. In particular, propylene glycol and dipropylene glycol are preferable.

  Here, in addition to the specific combination of the component (A), the component (B), the component (C), and the component (D), the component (E) may be added, and in particular, propylene as the component (E). It is preferable to combine with glycol or dipropylene glycol.

  The content of the component (E) is preferably 0.5 to 60% by mass, more preferably 1 to 50% by mass with respect to the entire vesicle composition, from the viewpoint of storage stability of the vesicle composition. 2-20 mass% is especially preferable.

  In the addition of the component (E), in the step (i), the oil phase containing the component (A), the component (B), the component (C) and the component (D) is heated to a temperature equal to or higher than the melting point of the oil phase. After being dissolved in (1), component (E) can be added to the oil phase. Alternatively, in the step (i), the oil phase containing the component (A), the component (B), the component (C), the component (D), and the component (E) is solidified at a temperature equal to or higher than the melting point of the oil phase. You may obtain the oil phase dissolved until the thing disappeared. After the step (i), the vesicle dispersion having a high vesicle volume concentration and high storage stability can be obtained by passing through the step (ii) of adding and mixing the aqueous phase to the obtained oil phase. . Further, from the viewpoint of storage stability of the vesicle, it is preferable to pass through a step (iii) of quickly cooling to a temperature lower than the phase transition temperature of the vesicle after completion of dropping of the aqueous phase.

Moreover, an arbitrary component can be put in the oil phase in the range which does not inhibit manufacture of the vesicle of this invention. Examples of the optional component include various extracts and antioxidants, but are not limited thereto. The optional component that can be added to the oil phase is 1% by mass or less of the total oil phase from the viewpoint of producing a stable vesicle composition.
Arbitrary components can be added to the aqueous phase as long as the production of the vesicle of the present invention is not inhibited. Examples of optional components that can be added include various extracts and preservatives, but are not limited thereto. The optional component that can be added to the aqueous phase is 0.1% by mass or less of the entire aqueous phase from the viewpoint of producing a stable vesicle composition.

  The higher alcohol is not a vesicle during emulsification, and it tends to take a lamellar lamellar structure. Therefore, it is preferably 2% by mass or less in the vesicle composition, particularly preferably 1% by mass or less, and more preferably 0.5% by mass or less. It is preferable that it is not contained or substantially not contained in the vesicle composition.

  When producing a vesicle composition, an aqueous phase is dropped into an oil phase in a shear mixed state. The mixing apparatus is not particularly limited as long as shear mixing can be performed. However, when the viscosity becomes high during the addition of the aqueous phase, an apparatus capable of mixing a high-viscosity product, for example, ADI homomixer manufactured by Primemix Co., Ltd. K. A combination mix, a vacuum emulsification stirrer manufactured by Mizuho Industry Co., Ltd., a Max blend stirrer manufactured by Sumitomo Heavy Industries, Ltd., a supermix stirrer manufactured by Satake Chemical Machinery Co., Ltd., and the like are preferable. Although it does not specifically limit about stirring speed, For example, it is preferable to stir at 50-100 rpm.

Although there is no confirmation, in the vesicle obtained by such a production method of the present invention, the structure on the hair surface can be suitably changed by easily changing the structure from the vesicle to a film shape when applied to the hair. It is considered possible.
Moreover, the conventional vesicle structure is comprised by interposing specific lipids, such as sterols and phospholipids, as described, for example in Japanese translations of PCT publication No. 2002-516831. In contrast, the present invention can form a vesicle composition without containing sterols or phospholipids. That is, it can be said that the vesicle structure can be constituted by components conventionally used in hair cosmetics such as rinses and conditioners. Accordingly, the present invention provides a novel pharmaceutical formulation in the art.

The hair cosmetic composition of the present invention contains the aforementioned vesicle composition.
As a content of the vesicle composition in the hair cosmetic composition, it provides flexibility, smoothness, moist feeling, and the like. Therefore, the total amount of the component (A) linear fatty acid and the component (B) branched fatty acid constituting the vesicle is preferably 0.01 to 5% by mass, more preferably 0.05 to 2% by mass. . Such hair cosmetics maintain the flexibility, smoothness, moist feeling, and suppleness achieved by conventional hair cosmetics even if the content of the active ingredient is reduced as compared with conventional hair cosmetics. It can be improved, smooth when rinsed, not sticky, smooth after drying, and can prevent stickiness.
Examples of such hair cosmetics include conditioners, rinses, treatments, and shampoos. Conditioners, rinses and treatments are preferred as particularly effective hair cosmetics. These hair cosmetics may be used after washing hair cosmetic or after use.

  The hair cosmetic containing the vesicle composition can be obtained by adding and mixing the vesicle composition of the present invention separately to the hair cosmetic prepared by a usual method. A hair cosmetic prepared by a normal method is, for example, a base mixture containing one or more surfactants and an aliphatic alcohol. In addition to this, a general hair cosmetic containing silicone, an oily component, etc. Is included. This can be adjusted in any way.

  Cationic surfactants used as the base mixture include quaternary ammonium and tertiary amine compounds, with tertiary amine compounds being particularly preferred. The tertiary amine compound is selected from the compounds listed in Component (C). In particular, it is preferable to use the same component as the tertiary amine compound used in the vesicle composition.

  The aliphatic alcohol used as the base mixture is preferably an aliphatic alcohol having 12 to 26 carbon atoms. Thereby, the hair at the time of application to hair can be made smooth. An aliphatic alcohol having a linear or branched alkyl group or alkenyl group is preferable, and an aliphatic alcohol having a linear or branched alkyl group or alkenyl group having 16 to 22 carbon atoms is particularly preferable. In particular, aliphatic alcohols having a linear or branched alkyl group or alkenyl group having 16 to 18 carbon atoms are more preferred. Specifically, cetyl alcohol and stearyl alcohol are preferable.

The formulation and production method of the hair cosmetic is not particularly limited. For example, an oil phase containing a cationic surfactant, an aliphatic alcohol and an emulsified silicone is added to the heat-stirred aqueous phase and emulsified. can get.
Examples of the method of blending the vesicle composition with normal hair cosmetics include a method comprising a step of mixing the vesicle composition with a base mixture containing at least one cationic surfactant and an aliphatic alcohol. At this time, it is desirable to mix | blend at the temperature below the phase transition temperature of a vesicle from a stability viewpoint of a vesicle. As a result, a hair cosmetic that maintains the structure of the vesicle composition can be obtained.

Example 1A
A vesicle composition (premix) was obtained by the following procedure.
Stearic acid (Lunac S-90V: manufactured by Kao Corporation) 4.2 g, isostearic acid (isostearic acid EX: manufactured by Higher Alcohol Industry Co., Ltd.) 2.8 g, lactic acid (Musashino Lactic Acid 90: manufactured by Musashino Chemical Laboratory Co., Ltd.) 0 .60 g and 12.0 g of Farmin DM E-80 (N, N-dimethyl-3-octadecyloxypropylamine: manufactured by Kao Corporation) are placed in a 300 ml beaker and heated to 80 ° C. with stirring with a propeller to obtain the raw materials. It completely dissolved. In this oil phase, 180.4 g of ion-exchanged water heated to 80 ° C. as an aqueous phase was dropped at a constant rate over 10 minutes and emulsified at 80 ° C. Thereafter, it was allowed to cool to 35 ° C. or lower. The vesicle composition thus obtained was used as a premix. The emulsification method in which the water phase is dropped while stirring the oil phase is generally referred to as phase inversion emulsification. Table 1 shows the premix production conditions and the amount (g) of each component converted to 10.00 g of the premix.

(Examples 2A-8A, Comparative Examples 1B-2B)
Similarly to Example 1A, a vesicle composition was obtained according to the formulation shown in Table 1. However, with regard to Component A, Component B, and Component E, the following were used.
Palmitic acid: LUNAC P-95: manufactured by Kao Corporation Myristic acid: LUNAC MY-98: manufactured by Kao Corporation 16-methyloctadecanoic acid: synthesized by the production method of Example 1 described in JP-A-2008-255050.
Dipropylene glycol: DPG-RF: manufactured by ADEKA Corporation

(Examples 1 to 10, Comparative Example 1)
Here, using the premix which is the prepared vesicle composition, a hair conditioner was blended and evaluated. In addition, the hair conditioner adjusted in Examples 1 to 10 and Comparative Example 1 is a hair cosmetic used in the form of washing away.

(Hair conditioner)
In a 300 ml beaker, 167.8 g of ion exchange water and 1.38 g of Musashino lactic acid 90 were added as an aqueous phase, and heated to 55 ° C. with stirring with a propeller. Thereafter, an oil phase consisting of 4.90 g of Farmin DM E-80, 11.16 g of stearyl alcohol (Calcoal 8098: manufactured by Kao Corporation) and 1.86 g of DPG-RF (same as above) was uniformly dissolved at 80 ° C. The mixture was added to the aqueous phase and emulsified by stirring at 300 rpm for 10 minutes. The mixture was allowed to cool to 35 ° C. or lower with stirring at 300 rpm to prepare a base mixture, and then 7.14 g of the aforementioned vesicle composition (premix) was added to obtain a hair conditioner.
For Examples 4 and 6, instead of adding 4.90 g of Farmin DM E-80, 4.58 g of N- (3- (dimethylamino) propyl) stearamide (amidamine MPS: manufactured by Nikko Chemicals Co., Ltd.) A rinse was prepared in the same procedure as described above except that it was added.

(Measurement of freezing point of component A and component B mixture)
A sample in which a mixture of component A and component B dissolved by heating was precisely weighed and sealed in a measurement cell was prepared, and the freezing point was measured using a differential scanning calorimeter (EXSTAR6000: manufactured by Seiko Instruments Inc.). The measurement condition was that the temperature was raised from 5 ° C. to 90 ° C. at a heating rate of 1 ° C./min, and then cooled to 5 ° C. at a cooling rate of 1 ° C./min. The freezing point was determined from the position where the exothermic peak occurred during cooling.

(Premix vesicle structure observation)
The premix was observed using a light microscope (ECLIPSE E800: manufactured by NIKON) at room temperature under polarized light conditions (crossed Nicols).
The average particle size of the vesicles in the premix was measured at 25 ° C. using Multisizer ^™ 4 manufactured by Beckman Locolter Co., Ltd. The average particle diameter was a volume-based median diameter (D50).

(Feel evaluation)
The hair of a Japanese woman that has been treated once with straight perm and twice with bleach is treated as damaged hair, and each 20 g (length 15-20 cm, average diameter 80 μm) of hair bundle is obtained using 2 g of standard shampoo with the following composition. After applying 2g of the hair conditioner shown in Table 2 to the washed hair bundle, and thoroughly acclimating the entire hair, rinse it under running water of about 40 ° C for about 30 seconds, then dry it with towel and fully dry it with a dryer. Dried.

・ Standard shampoo formulation (pH 7.0)
25% polyoxyethylene (2.5) lauryl ether sulfate sodium salt 62.0%
Lauric acid diethanolamide 2.3%
Edetate disodium 0.15%
Sodium benzoate 0.5%
Sodium chloride 0.8%
75% phosphoric acid appropriate amount Fragrance, methylparaben appropriate amount Purified water remaining

  The hair was evaluated for “smoothness when rinsing”, “non-smoothness when rinsing”, “smoothness after drying”, and “non-stickiness after drying”. Evaluation was performed by 6 people in a four-step evaluation, and the total value of the evaluation was shown.

(Evaluation criteria)
"Smoothness when rinsing"
4: Very smooth 3: Slightly smooth 2: Not very smooth 1: Not smooth

"No lingering when rinsing"
4: No hairiness at all 3: Little hairiness 2: Little hairiness 1: Hairiness

"Smoothness after drying"
4: Very smooth 3: Slightly smooth 2: Not very smooth 1: Not smooth

"No stickiness after drying"
4: Not sticky 3: Little sticky 2: Slightly sticky 1: Sticky

Claims (10)

A vesicle composition in which the continuous phase formed from components (A), (B), (C), (D) and water is an aqueous phase, and the mass ratio of component (A) to component (B) is (A) / (B) = 70/30 to 40/60, containing a vesicle having a higher alcohol content of 2% by mass or less in the vesicle composition and an average particle diameter of 5 to 500 μm Vesicle composition to:
(A) Linear fatty acid having 14 to 24 carbon atoms (B) Branched fatty acid having 14 to 24 carbon atoms and represented by general formula (1)

[In formula (1), the sum of a, b, and c is a + b + c = 11-21, and b is a branched saturated fatty acid of 1. ]
(C) Tertiary amine compound (D) Organic acid having 1 to 8 carbon atoms
The vesicle composition wherein the component (C) is one or more compounds represented by the following general formula (2), (3) or (4) .

[In the above general formula (2), R ¹¹ is a linear or branched chain which may be divided by a functional group represented by —OCO— or —COO— having a total carbon number of 8 to 35 or substituted with —OH. An alkyl group, an alkenyl group, or an aliphatic acyloxy (polyethoxy) ethyl group, R ¹² represents an alkyl group having 1 to 22 carbon atoms, or a hydroxyalkyl group, or a polyoxyethylene group having a total number of added moles of 10 or less; Two R ¹² may be the same or different. ]

[In General Formula (3), R ¹⁷ represents a linear or branched alkyl group or alkenyl group having 6 to 24 carbon atoms, and R ¹⁸ and R ¹⁹ are the same or different and have 1 to 6 carbon atoms. An alkyl group or — (AO) _f H (A represents an alkylene group having 2 to 4 carbon atoms, f represents a number of 1 to 6, and f A may be the same or different, and the arrangement thereof is arbitrary) Indicates. e shows the number of 1-5. ]

[In the general formula (4), R ²⁰ represents a linear or branched alkyl group or alkenyl group having 6 to 24 carbon atoms, and R ²¹ and R ²² are the same or different and have 1 to 6 carbon atoms. Alkyl group or-(AO) _g H (A represents an alkylene group having 2 to 4 carbon atoms, g represents a number of 1 to 6, g A may be the same or different, and the arrangement thereof is arbitrary. Is). ]   The vesicle composition according to claim 1, wherein the freezing point of the mixture of the component (A) and the component (B) is 40 ° C or higher and 55 ° C or lower.   The vesicle composition according to claim 1 or 2, wherein the total of the components (A), (B), (C) and (D) in the vesicle composition is 1 to 20% by mass.   The vesicle composition according to any one of claims 1 to 3, wherein the component (B) is a branched fatty acid having 16 to 22 carbon atoms.   In the components (A), (B) and (D), the ratio of the sum of moles of (A) + (B) to the moles of component (D) is ((A) + (B)) / (D) = 5. The vesicle composition according to any one of claims 1 to 4, which is / 5 or more and 9/1 or less.   In the components (A), (B), (C) and (D), the ratio of the sum of acid equivalents of (A) + (B) + (D) to the base equivalent of (C) is ((A) + (B) + (D)) / (C) = 0.25-4, The vesicle composition according to any one of claims 1 to 5.   The vesicle composition according to any one of claims 1 to 6, wherein a mass ratio of the component (A) to the component (B) is (A) / (B) = 60/40 to 50/50.   The vesicle composition according to any one of claims 1 to 7, wherein the component (A) and the component (B) have the same fatty acid carbon number.   The vesicle composition according to any one of claims 1 to 8, further comprising (E) a polyhydric alcohol.   10. Adding the vesicle composition according to any one of claims 1 to 9 to a base mixture in the form of a treatment, conditioner or rinse and comprising one or more cationic surfactants and an aliphatic alcohol. Hair cosmetics obtained in