JP5728676B2 - 胚性幹細胞の誘導 - Google Patents

胚性幹細胞の誘導 Download PDF

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JP5728676B2
JP5728676B2 JP2007540021A JP2007540021A JP5728676B2 JP 5728676 B2 JP5728676 B2 JP 5728676B2 JP 2007540021 A JP2007540021 A JP 2007540021A JP 2007540021 A JP2007540021 A JP 2007540021A JP 5728676 B2 JP5728676 B2 JP 5728676B2
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cells
cell
blastomere
blastomeres
embryo
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JP2008518616A (ja
JP2008518616A5 (https=
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チュン、ヤン
ランサ、ロバート
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オカタ セラピューティクス, インコーポレイテッド
オカタ セラピューティクス, インコーポレイテッド
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JP2007540021A 2004-11-04 2005-11-04 胚性幹細胞の誘導 Expired - Lifetime JP5728676B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US62482704P 2004-11-04 2004-11-04
US60/624,827 2004-11-04
US66248905P 2005-03-15 2005-03-15
US60/662,489 2005-03-15
US68715805P 2005-06-03 2005-06-03
US60/687,158 2005-06-03
US72306605P 2005-10-03 2005-10-03
US60/723,066 2005-10-03
US72677505P 2005-10-14 2005-10-14
US60/726,775 2005-10-14
PCT/US2005/039776 WO2006052646A2 (en) 2004-11-04 2005-11-04 Derivation of embryonic stem cells

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JP2012225193A Division JP5841926B2 (ja) 2004-11-04 2012-10-10 胚性幹細胞の誘導

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JP2008518616A JP2008518616A (ja) 2008-06-05
JP2008518616A5 JP2008518616A5 (https=) 2008-12-25
JP5728676B2 true JP5728676B2 (ja) 2015-06-03

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JP2012225193A Expired - Lifetime JP5841926B2 (ja) 2004-11-04 2012-10-10 胚性幹細胞の誘導

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US (4) US7838727B2 (https=)
EP (3) EP2479256A1 (https=)
JP (2) JP5728676B2 (https=)
AU (1) AU2005304978A1 (https=)
CA (2) CA3015835A1 (https=)
HK (1) HK1219295A1 (https=)
WO (1) WO2006052646A2 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
BRPI0507074A (pt) 2004-01-23 2007-06-19 Advanced Cell Tech Inc modalidades aperfeiçoadas para o tratamento de doenças degenerativas da retina
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
US7893315B2 (en) * 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
CA3015835A1 (en) 2004-11-04 2006-05-18 Astellas Institute For Regenerative Medicine Derivation of embryonic stem cells
GB0507755D0 (en) * 2005-04-16 2005-05-25 Univ Sheffield Cytotrophoblast stem cells
EP2302034B1 (en) 2005-08-03 2020-10-14 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
EP2029724A4 (en) * 2006-05-03 2010-03-24 Advanced Cell Tech Inc DERIVATION FROM EMBRYONAL STEM CELLS AND EMBRYO-DERIVED CELLS
US20070298496A1 (en) * 2006-06-23 2007-12-27 Hung-Chih Kuo Method of deriving pluripotent stem cells from a single blastomere
JP2010518857A (ja) 2007-02-23 2010-06-03 アドバンスド セル テクノロジー, インコーポレイテッド 分化した細胞の再プログラムおよび再プログラムされた細胞からの動物および胚幹細胞の生成のための高能率的な方法
IL292561A (en) 2007-10-12 2022-06-01 Astellas Inst For Regenerative Medicine Improved methods of rpe cell production and rpe cell preparations
WO2009067757A1 (en) * 2007-11-30 2009-06-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving oct4 protein
EP2100954A1 (en) * 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
JP2009225675A (ja) * 2008-03-19 2009-10-08 Tohoku Univ 上皮系細胞シートの作製のための同種皮膚由来フィーダー細胞
US9127256B2 (en) 2008-07-16 2015-09-08 Dnavec Corporation Method for production of reprogrammed cell using chromosomally unintegrated virus vector
AU2010289423B2 (en) 2009-09-04 2014-03-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for enhancing genome stability and telomere elongation in embryonic stem cells
US10485829B2 (en) 2009-11-17 2019-11-26 Astellas Institute For Regenerative Medicine Methods of producing human RPE cells and pharmaceutical preparations of human RPE cells
AU2011279250B2 (en) 2010-07-12 2014-12-04 California Institute Of Technology Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
EP2596119B8 (en) 2010-07-23 2021-06-02 Astellas Institute for Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
WO2012013936A1 (en) * 2010-07-30 2012-02-02 Cambridge Enterprise Limited Corticogenesis of human pluripotent cells
US10478206B2 (en) 2011-04-29 2019-11-19 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US20130142762A1 (en) * 2011-11-07 2013-06-06 Hina W. Chaudhry Methods of cardiac repair
TWI719277B (zh) 2011-11-14 2021-02-21 美商安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
CA2933083A1 (en) 2013-12-11 2015-06-18 Pfizer Limited Method for producing retinal pigment epithelial cells
WO2016005985A2 (en) 2014-07-09 2016-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming cells
WO2016044271A2 (en) 2014-09-15 2016-03-24 Children's Medical Center Corporation Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
ES2980659T3 (es) 2015-03-23 2024-10-02 Astellas Inst For Regenerative Medicine Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores
WO2021086911A1 (en) 2019-10-30 2021-05-06 Astellas Institute For Regenerative Medicine Methods for producing retinal pigment epithelium cells
US20240368541A1 (en) 2021-05-03 2024-11-07 Astellas Institute For Regenerative Medicine Methods of generating mature corneal endothelial cells
WO2022235869A1 (en) 2021-05-07 2022-11-10 Astellas Institute For Regenerative Medicine Methods of generating mature hepatocytes
WO2022264132A1 (en) 2021-06-13 2022-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming human cells

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274705B1 (en) * 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
AU1439295A (en) * 1993-12-17 1995-07-03 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
EP0739412B1 (en) * 1993-12-23 2002-02-27 Infigen, Inc. ungulate EMBRYONIC STEM CELLS AS NUCLEAR DONORS AND NUCLEAR TRANSFER TECHNIQUES TO PRODUCE CHIMERIC AND TRANSGENIC ANIMALS
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US20040199935A1 (en) 1999-06-30 2004-10-07 Chapman Karen B. Cytoplasmic transfer to de-differentiate recipient cells
WO2001029206A1 (en) 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
AU784731B2 (en) 1999-12-20 2006-06-08 University Of Massachusetts Embryonic or stem-like cells produced by cross species nuclear transplantation
JP2003533976A (ja) * 2000-01-07 2003-11-18 オレゴン ヘルス アンド サイエンス ユニバーシティ 胚分割による霊長類子孫のクローン性増殖
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
DE10108412B4 (de) 2001-02-21 2006-03-09 Cevec Pharmaceuticals Gmbh Pigmentepithelzelle des Auges, ihre Herstellung und Verwendung in der Therapie einer Augen- oder Nervenerkrankung
US20030082598A1 (en) 2001-08-22 2003-05-01 Ecker David J. Molecular interaction sites of 23S ribosomal RNA and methods of modulating the same
CA2458575C (en) 2001-08-24 2014-07-08 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
US7247477B2 (en) * 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
US6699771B1 (en) * 2002-08-06 2004-03-02 Texas Instruments Incorporated Process for optimizing junctions formed by solid phase epitaxy
AU2003296480A1 (en) * 2002-12-10 2004-06-30 The Wistar Institute Method for programmed differentiation of stem cells
US20050118713A1 (en) 2003-05-12 2005-06-02 Nikolai Strelchenko Morula derived embryonic stem cells
US20040229350A1 (en) * 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
TW200521236A (en) 2003-12-22 2005-07-01 Animal Technology Inst Taiwan Method for generating non-human mammalian chimeric embryo
BRPI0507074A (pt) 2004-01-23 2007-06-19 Advanced Cell Tech Inc modalidades aperfeiçoadas para o tratamento de doenças degenerativas da retina
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
US20070298453A1 (en) 2004-02-12 2007-12-27 University Of Newcastle Upon Tyne Stem Cells
WO2006013519A1 (en) 2004-07-26 2006-02-09 Koninklijke Philips Electronics N.V. Method of storing data in an information carrier, system for reading such an information carrier.
US20080262321A1 (en) 2004-08-06 2008-10-23 Ramot At Tel Aviv University Ltd. Early Detection of Harmful Agents: Method, System and Kit
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
CA3015835A1 (en) 2004-11-04 2006-05-18 Astellas Institute For Regenerative Medicine Derivation of embryonic stem cells
US7818929B2 (en) * 2004-12-14 2010-10-26 Anthony Hardwood Composites, Inc. Laminated support mat
ES2549205T3 (es) * 2005-10-14 2015-10-26 Unisense Fertilitech A/S Determinación de un cambio en una población de células
EP1847595B1 (en) * 2006-04-20 2010-01-06 Northern Sydney and Central Coast Area Health Service Methods of assessing embryo viability
EP2029724A4 (en) * 2006-05-03 2010-03-24 Advanced Cell Tech Inc DERIVATION FROM EMBRYONAL STEM CELLS AND EMBRYO-DERIVED CELLS
US20070298496A1 (en) 2006-06-23 2007-12-27 Hung-Chih Kuo Method of deriving pluripotent stem cells from a single blastomere
JP2010518857A (ja) 2007-02-23 2010-06-03 アドバンスド セル テクノロジー, インコーポレイテッド 分化した細胞の再プログラムおよび再プログラムされた細胞からの動物および胚幹細胞の生成のための高能率的な方法
CN102348811A (zh) * 2009-01-13 2012-02-08 弗卢伊蒂格姆公司 单细胞核酸分析
CN104232566B (zh) * 2011-05-31 2016-11-16 尤尼森斯繁殖技术公司 基于卵裂球的卵裂和形态的胚胎质量评估

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US20170204368A1 (en) 2017-07-20
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