JP5717401B2 - Scalp care agent - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a scalp care agent that is excellent in suppressing effects such as dandruff, itching, pimples, and roughness of the scalp.

  Anti-dandruff agents blended in shampoos and rinses that suppress dandruff and itchiness include pyridinethione salts typified by zinc pyrithione, antibacterial agents or bactericides such as benzalkonium chloride and octopirox. These antibacterial agents can suppress the sebum decomposition and prevent dandruff and itching by suppressing the growth of fungus on the scalp, and are particularly effective in suppressing dandruff and itching resulting from the growth of fungi (See, for example, Patent Documents 1 and 2). Furthermore, Patent Document 3 shows that by using a combination of a pyridinethione salt, a hydroxy acid, and a nonionic or amphoteric surfactant, the antifungal effect against Malassezia obalis is improved and a higher antidandruff effect is exhibited. Has been reported.

  However, in recent years, dandruff, itching, and roughness, which have a main cause of dryness of the skin, have become the mainstream of skin troubles, rather than dandruff itself, which has the main cause of bacterial growth, due to an increase in hair washing frequency. In such a dry background, a sufficient scalp care effect cannot be obtained with an antibacterial agent or disinfectant. Further, increasing the blending amount of the antibacterial agent / bactericidal agent may cause a background trouble, and a scalp care agent that does not include these and is effective for dry skin has been desired.

US Pat. No. 3,753,916 JP 58-196300 A Japanese Patent Laid-Open No. 2001-48759

  An object of this invention is to provide the scalp care agent which is excellent in the suppression effect, such as a dandruff, an itch, a pimple, and a bulkiness.

  The present inventor has found that the organic carboxylic acid or a salt thereof is excellent in suppressing effects such as dandruff, itching, blowout, and bulkiness under a specific pH range.

  That is, the present invention provides a scalp care agent containing at least one organic carboxylic acid or a salt thereof as an active ingredient and having a pH of 1 to 5 at 25 ° C when diluted 20 times by weight with water. is there.

  The scalp care agent of the present invention is excellent in suppressing effects such as scalp dandruff, itching, pimples, and roughness.

  The scalp care agent of the present invention contains at least one organic carboxylic acid or salt thereof as an active ingredient. The term “as an active ingredient” used herein means that the organic carboxylic acid or salt thereof itself is dandruff. -It is used as a component having an effect of suppressing or improving itching, pimples, and roughness (hereinafter referred to as scalp symptom improvement effect).

  As the organic carboxylic acid, dicarboxylic acid (which may have a hydroxy group) and hydroxymonocarboxylic acid are preferable. Specifically, examples of the dicarboxylic acid that may have a hydroxy group include malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, phthalic acid, oxalic acid, malic acid, tartaric acid, and the like. Examples of the monocarboxylic acid include glycolic acid, lactic acid, hydroxyacrylic acid, oxybutyric acid, and glyceric acid. Of these, glycolic acid, lactic acid, malonic acid, maleic acid, and malic acid are preferable. In addition, examples of salts of these organic carboxylic acids include salts with alkali metals, alkaline earth metals, ammonia, and organic amine compounds.

  The content of the organic carboxylic acid or a salt thereof in the scalp care agent of the present invention is higher than the amount used for the purpose of merely adjusting the pH, and in the scalp care agent of the present invention from the viewpoint of sufficient scalp symptom improvement effect. 0.1 to 5% by weight, more preferably 0.2 to 3% by weight, and particularly preferably 0.5 to 2% by weight.

  The scalp care agent of the present invention has a pH of 1 to 5 at 25 ° C. when diluted 20 times by weight with water from the viewpoint of scalp symptom improvement effect and stability, but pH 2 to 4.5, particularly pH 3 to 4.5. Preferably there is.

  Common pharmaceutical and cosmetic ingredients known as antibacterial agents, bactericides, antidandruff agents, and the like include pyridinethione salts, benzalkonium chloride, octopirox, and other antibacterial agents and bactericides (antibacterial agents, etc.) Are known. From the viewpoint that the scalp care agent of the present invention can improve scalp symptoms while avoiding skin troubles caused by these antibacterial agents and the like, it is preferable that these antibacterial agents and the like are not substantially contained.

  The scalp care agent of the present invention may be further added with a thickener, surfactant, lower alcohol, polymer, etc. to form a styling agent such as sculpture, hair tonic, hair liquid, etc. An activator or a conditioning agent may be added to form a shampoo composition, a rinse-in shampoo, a treatment, a conditioner or the like used in the bathroom.

  As the lower alcohol, ethanol and 2-propanol are preferable, and ethanol is particularly preferable. The content of the lower alcohol is preferably 0.01 to 90% by weight, particularly 1 to 20% by weight in the scalp care agent of the present invention.

  The scalp care agent of the present invention can further contain clay minerals and various polymers as viscosity modifiers from the viewpoint of usability in application to the scalp. Such polymers include polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymer, vinylpyrrolidone / vinyl acetate / vinyl propionate terpolymer, vinylpyrrolidone / alkylaminoacrylate (quaternary chloride) copolymer, vinyl Polyvinyl pyrrolidone polymer compounds such as pyrrolidone / acrylate / (meth) acrylic acid copolymer, vinyl pyrrolidone / alkylamino acrylate / vinyl caprolactam copolymer; acidic vinyl ether such as methyl vinyl ether / maleic anhydride alkyl half ester copolymer Polymer compounds; acidic polyvinyl acetate polymer compounds such as vinyl acetate / crotonic acid copolymer, vinyl acetate / crotonic acid / vinyl neodecanoate copolymer, vinyl acetate / crotonic acid / vinyl propionate copolymer; Acid acrylic polymer such as (meth) acrylic acid / (meth) acrylic acid ester copolymer, acrylic acid / acrylic acid alkyl ester / alkylacrylamide copolymer; N-methacryloylethyl-N, N-dimethylammonium α Amphoteric acrylic polymer compounds such as -N-methylcarboxybetaine / butyl methacrylate copolymer, hydroxypropyl acrylate / butylaminoethyl methacrylate / octylamide acrylate copolymer; acrylamide / acrylic ester quaternary copolymer Basic acrylic polymer compounds such as coalescence; cellulose derivatives such as hydroxyethyl cellulose, methyl cellulose, and cationic cellulose derivatives; chitin / chitosan derivatives such as hydroxypropyl chitosan, carboxymethyl chitin, and carboxymethyl chitosan; Such as triethylene glycol.

  Two or more of these viscosity modifiers can be used in combination, and the content thereof is preferably 0.1 to 10% by weight, particularly 0.5 to 5% by weight in the scalp care agent of the present invention.

  The scalp care agent of the present invention further includes an anionic surfactant, a nonionic surfactant, an amphoteric surfactant and a cationic surfactant as a cleaning component or a conditioning component in order to improve the stability of the scalp care agent. A selected surfactant may be contained.

  As the anionic surfactant, a sulfuric anionic surfactant is preferable, and specifically, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkenyl ether sulfate, alkyl sulfate, polyoxyalkylene alkyl phenyl ether sulfate, and the like. Particularly preferred are those represented by the following general formula (1) or (2).

R ¹ O (CH ₂ CH ₂ O) _m SO ₃ M (1)
R ² OSO ₃ M (2)

[Wherein, R ¹ represents an alkyl group or alkenyl group having 10 to 18 carbon atoms, R ² represents an alkyl group having 10 to 18 carbon atoms, and M represents an alkali metal, alkaline earth metal, ammonium, alkanolamine or A basic amino acid is shown, m shows the number of 1-5 on a weight average. ]

  These anionic surfactants can be used in combination of two or more, and the content thereof is from the viewpoint of stability of the scalp care agent, liquidity at the time of use, ease of foaming, and ease of washing at the time of washing the hair. The amount is preferably 1 to 50% by weight, more preferably 5 to 30% by weight, and particularly preferably 8 to 22% by weight in the scalp care agent of the present invention.

Nonionic surfactants include polyoxyalkylene sorbitan fatty acid esters, polyoxyalkylene sorbite fatty acid esters, polyoxyalkylene glycerin fatty acid esters, polyoxyalkylene fatty acid esters, polyoxyalkylene alkyl ethers, polyoxyalkylene alkyl. Examples include phenyl ethers, polyoxyalkylene (cured) castor oils, sucrose fatty acid esters, polyglycerin alkyl ethers, polyglycerin fatty acid esters, fatty acid alkanolamides, alkyl glycosides, and the like. Of these, alkylglycosides, polyoxyalkylene (C ₈ -C ₂₀ ) fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, and fatty acid alkanolamides are preferred. As the fatty acid alkanolamide, those having an acyl group having 8 to 18 carbon atoms, particularly 10 to 16 carbon atoms are preferable. The fatty acid alkanolamide may be either a monoalkanolamide or a dialkanolamide, and preferably has a hydroxyalkyl group having 2 to 3 carbon atoms, such as oleic acid diethanolamide, palm kernel oil fatty acid diethanolamide, coconut oil. Examples include fatty acid diethanolamide, lauric acid diethanolamide, polyoxyethylene coconut oil fatty acid monoethanolamide, coconut oil fatty acid monoethanolamide, lauric acid isopropanolamide, and lauric acid monoethanolamide.

  These nonionic surfactants can be used in combination of two or more, and the content thereof is the stability of the scalp care agent, liquidity during use, ease of foaming, ease of washing during hair washing, foam quality From this point, 0.1 to 30% by weight in the scalp care agent of the present invention is preferable, more preferably 0.2 to 20% by weight, and particularly preferably 0.5 to 10% by weight.

  Examples of amphoteric surfactants include betaine surfactants. Of these, betaine surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyl betaine are more preferred, and fatty acid amidopropyl betaine is particularly preferred. The fatty acid amidopropyl betaine is preferably one having an acyl group having 8 to 18 carbon atoms, particularly 10 to 16 carbon atoms, and in particular, lauric acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine and the like. preferable.

  These amphoteric surfactants can be used in combination of two or more, and the content thereof is the stability of the scalp care agent, liquidity during use, ease of foaming, ease of washing during hair washing, fine and soft From the point of foam quality, 0.1 to 30% by weight in the scalp care agent of the present invention is preferable, more preferably 0.2 to 20% by weight, and particularly preferably 0.5 to 10% by weight.

  When the scalp care agent of the present invention is in the form of an aqueous liquid detergent, it is better to use a fatty acid amide propyl betaine or a fatty acid alkanolamide together with a sulfuric acid anionic surfactant for better detergency and foaming power. It is particularly preferable because an appropriate liquid property can be obtained. When fatty acid amide propyl betaine or fatty acid alkanolamide is contained together with the sulfuric acid-based anionic surfactant, the content thereof is preferably 0.1 to 10% by weight, more preferably 0.2 to 5% by weight in the scalp care agent of the present invention. In particular, 0.5 to 3% by weight is preferable because a good foam increasing effect can be obtained.

  Examples of cationic surfactants include quaternary ammonium salts, salts of tertiary amine type compounds, mono long chain alkyl (C12-22) quaternary ammonium salts, dilong chain alkyl (C12-22) quaternary ammonium salts, Examples include branched alkyl (C12-28) quaternary ammonium salts, alkyloxyalkylene tertiary amine salts, alkylamidoalkylene tertiary amine salts, and the like. Specifically, lauryl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, lauryl trimethyl ammonium bromide, dialkyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, chloride Examples include distearyldimethylammonium, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, N, N-dimethyloctadecyloxypropylamine, and stearamidepropyldimethylamine.

  Two or more of these cationic surfactants can be used in combination, and the content thereof is 0.1 to 0.1 in the scalp care agent of the present invention in terms of smoothness of hair, good finger feeling, and glossiness. It is preferably 10% by weight, more preferably 0.2 to 7% by weight, and particularly preferably 0.5 to 5% by weight.

  In addition to the cationic surfactant, a cationic polymer, silicones or oil agent can be blended as a conditioning component in the scalp care agent of the present invention in order to improve the finish after drying.

  Examples of cationic polymers include cationized cellulose derivatives, cationic starch, cationized guar gum derivatives, homopolymers of diallyl quaternary ammonium salts, diallyl quaternary ammonium salts / acrylamide copolymers, quaternized polyvinylpyrrolidone derivatives, polyglycols. Polyamine condensate, vinyl imidazolium trichloride / vinyl pyrrolidone copolymer, hydroxyethyl cellulose / dimethyldiallylammonium chloride copolymer, vinyl pyrrolidone / quaternized dimethylaminoethyl methacrylate copolymer, polyvinyl pyrrolidone / alkylamino acrylate copolymer , Polyvinylpyrrolidone / alkylaminoacrylate / vinylcaprolactam copolymer, vinylpyrrolidone / methacrylamidopropyl trimethyl chloride Ammonium copolymer, alkylacrylamide / acrylate / alkylaminoalkylacrylamide / polyethylene glycol methacrylate copolymer, adipic acid / dimethylaminohydroxypropylethylenetriamine copolymer (Cartaretin manufactured by Sandos, USA), JP-A-53-139734 And cationic polymers described in JP-A-60-36407, and cationized cellulose derivatives, cationized guar gum derivatives, and diallyl quaternary ammonium salts / acrylamide copolymers are particularly preferable.

  These cationic polymers can be used in combination of two or more, and the content thereof is imparted smoothness from the time of foaming to rinsing, united hair after drying, fine and soft foam with good texture, And from the point of adsorption | suction improvement, 0.1 to 2 weight% in the scalp care agent of this invention is preferable, Furthermore, 0.2 to 1.5 weight%, Especially 0.3 to 1 weight% is preferable.

  Examples of silicones include the following.

(Silicones-1) Dimethylpolysiloxane Examples include those represented by the following general formula.
(CH ₃ ) ₃ SiO — [(CH ₃ ) ₂ SiO] _d —Si (CH ₃ ) ₃
[In formula, d shows the number of 3-20000. ]

(Silicones-2) Amino-modified silicone Various amino-modified silicones can be used, but in the third edition of the CTFA Dictionary (US, Cosmetic Ingredient Dictionary) with the name of Amodimethicone with an average molecular weight of about 3000 to 100,000. What is described is preferred. This amino-modified silicone is preferably used as an aqueous emulsion. Examples of commercially available products include SM 8704C (Toray Dow Corning Silicone) and DC 929 (Dow Corning).

(Silicones-3) Other silicones Other than the above, polyether modified silicone, methylphenylpolysiloxane, fatty acid modified silicone, alcohol modified silicone, alkoxy modified silicone, epoxy modified silicone, fluorine modified silicone, cyclic silicone, alkyl modified silicone And oxazoline-modified silicone.

  Two or more kinds of these silicones can be used in combination, and the content thereof is 0.1 to 7% by weight in the scalp care agent of the present invention in terms of smoothness of hair, good finger feeling, and glossiness. %, More preferably 0.2 to 6% by weight, and particularly preferably 0.5 to 5% by weight.

  Oils include hydrocarbons such as squalene, squalane, liquid paraffin, liquid isoparaffin, cycloparaffin; glycerides such as castor oil, cacao oil, mink oil, avocado oil, olive oil; beeswax, whale wax, lanolin, carnauba wax, etc. Waxes; alcohols such as myristyl alcohol, cetyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, glycerin; isopropyl palmitate, isopropyl myristate, octyldodecyl myristate, hexyl laurate, cetyl lactate , Esters such as propylene glycol monostearate, oleyl oleate, hexadecyl 2-ethylhexanoate, isononyl isononanoate, tridecyl isononanoate; capric acid, Examples thereof include higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, coconut oil fatty acid, isostearyl acid and isopalmitic acid, isostearyl glyceryl ether, polyoxypropylene butyl ether and the like. Of these, esters are preferable, and hexadecyl 2-ethylhexanoate, isononyl isononanoate, isopropyl palmitate, and the like are particularly preferable.

  These oil agents can be used in combination of two or more, and the content thereof is in the scalp care agent of the present invention in terms of the smoothness of the hair, the goodness of fingering, and the glossiness of the scalp care agent. It is preferably 0.1 to 7% by weight, more preferably 0.2 to 6% by weight, and particularly preferably 0.5 to 5% by weight.

  In addition to the above components, the scalp care agent of the present invention can be appropriately mixed with components used in normal hair cosmetics depending on the purpose. Examples of such components include vitamins; anti-inflammatory agents; antiseptics; chelating agents; humectants such as sorbitol and panthenol; colorants such as dyes and pigments; pH adjusters such as potassium hydroxide; Pearlizing agents; fragrances; dyes; ultraviolet absorbers; antioxidants; and other components described in ENCYCLOPEDIA OF SHAMPOO INGREDIENTS (MICELLE PRESS).

  The pH shown in the following Examples and Comparative Examples is a value at 25 ° C. when diluted 20 times by weight with water.

Examples 1-4 and Comparative Examples 1-3
The shampoo shown in Table 1 was prepared and evaluated.

(Evaluation of scalp symptom improvement effect)
50 people (25 males, 25 females) who have dandruff on the scalp by visual inspection from general men and women in their 20s and 40s, 50 groups (25 males, 25 females) who have pimple symptoms on the scalp In addition, a total of 150 subjects were selected from 50 healthy groups (25 males and 25 females) who did not have these symptoms. These subjects were allowed to use a control shampoo containing no organic carboxylic acid or a salt thereof for one month, and then used the test shampoo for about 6 weeks, and the scalp state change before and after that was visually evaluated.
For dandruff symptoms, the scalp was divided into 12 regions, and each region was divided into 6 levels of levels 1 to 6, total 0 to 72, and level 10 or higher was targeted for the dandruff group. As for breakout symptoms, the number of breakouts in the entire scalp was 3 or more. In the healthy group, the symptoms of dandruff and pimples were less than the standards of the dandruff group and pimples.
Dandruff and blowout were evaluated by skilled researchers using the double blind method, and were ranked according to the average of the amount of change in the dandruff level and the number of blowouts before and after use, and are shown in Table 1.
For itching and roughness evaluation, subjects were asked to fill out a five-point questionnaire (5 points for improvement, 4 points for improvement, 3 points for no change, 2 points for deterioration, 1 point for deterioration), and the average of the evaluation points (below the decimal point) The results are shown in Table 1. The control shampoo formulation corresponds to Comparative Example 2 in Table 1.

<Frank rank>
◎ (Effective): Average dandruff level decreased by 10 or more before and after use ○ (Slightly effective): Average dandruff level decreased by 5 or more before and after use △ (No change): Change of average dandruff level less than ± 5 before and after use × (Deteriorated) : Average dandruff level increased by 5 or more before and after use

<Breakout rank>
◎ (Effective): Average number of blowouts decreased by 5 or more before and after use ○ (Slightly effective): Average number of blowouts decreased by 3 or more before and after use △ (No change): Average number of blowouts before and after use was less than ± 3 Change × (deterioration): The average number of breakouts increased by 3 or more before and after use.

<Itchy rank>
◎ (Effective): Average rating score of 3.5 or higher before and after use ○ (Slightly effective): Average rating score of 3.2 to 3.4 before and after use
Δ (no change): Average evaluation score before and after use is 2.8 to 3.2
× (Deteriorated): Average evaluation score of 2.7 or less before and after use

<Racing rank>
◎ (Effective): Average rating score of 3.5 or higher before and after use ○ (Slightly effective): Average rating score of 3.2 to 3.4 before and after use
Δ (no change): Average evaluation score before and after use is 2.8 to 3.2
× (Deteriorated): Average evaluation score of 2.7 or less before and after use

(Stability evaluation)
The stability of the shampoo was evaluated according to the following criteria from the performance and appearance after storage at 50 ° C. for one month.

◎: No change ○: Slightly deteriorated △: Deterioration is recognized ×: Remarkably deteriorated

  The shampoos of Examples 1 to 4 were excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and excellent in stability.

Example 5 Hair Conditioner
(weight%)
Alkyltrimethylammonium chloride 2.3
Stearyl alcohol 0.4
Behenyl alcohol 3.6
Isopropyl palmitate 0.5
Propylene glycol 0.5
Lactic acid (90% by weight) 0.1
Malic acid 0.75
High molecular weight dimethylpolysiloxane (degree of polymerization 1000-2700) 2.0
Perfume
Adjusted to 48% by weight potassium hydroxide pH 3.7 Purified water Remaining

  The above-mentioned hair conditioner was excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and excellent in stability.

Example 6 Scalp Care Tonic
(weight%)
Carboxyvinyl polymer 0.15
Glycerin 0.3
Styrene / stearyl methacrylate copolymer 0.1
Malic acid 0.75
Polyoxyethylene (60) hydrogenated castor oil 0.3
Ethanol 31.5
Fragrance 0.05
48% by weight sodium hydroxide adjusted to pH 4.0 Purified water

  The above scalp care tonic was excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and excellent in stability.

Example 7 Scalp Care Tonic
(weight%)
Benzyl alcohol 0.5
Isononyl isononanoate 0.03
Menthol 0.2
Malic acid 1.0
Polyoxyethylene (25) hydrogenated castor oil 0.3
Ethanol 52.5
Perfume 0.06
48% by weight sodium hydroxide adjusted to pH 4.0 Purified water

  The above scalp care tonic was excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and excellent in stability.

Example 8 Scalp Care Tonic
(weight%)
Stearyl trimethyl ammonium chloride 0.05
Glycerin 2.0
Polyoxyethylene (9) monolaurate 0.4
Malic acid 2.0
Polyoxyethylene (60) hydrogenated castor oil 0.3
EDTA 0.05
Ethanol 50.0
Fragrance 0.05
48% by weight sodium hydroxide adjusted to pH 4.0 Purified water

  The above scalp care tonic was excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and excellent in stability.

Claims (6)

A scalp breakthrough suppressing or improving agent comprising malic acid or a salt thereof as an active ingredient, and one or more surfactants selected from anionic surfactants , nonionic surfactants, amphoteric surfactants and cationic surfactants ; A scalp care agent having a pH of 1 to 4.5 at 25 ° C. when diluted 20 times by weight with water, wherein the content of malic acid or a salt thereof is 0.5 to 5% by weight. Scalp care agent . Real qualitatively scalp care agent according to claim 1, wherein it contains no antibacterial Fungicide. Scalp care agent according to claim 1 or 2, wherein the field surfactant is an anionic surfactant. Scalp care agent according to claim 3, wherein the content of A anion surfactant is 1 to 50 wt%. Scalp care agent according to any one of claims 1 to 4 Shi Yanpu composition or shampoo. Scalp care agent according to any one of claims 1 to 5, and further containing mosquitoes thione polymer.