JP5599433B2 - Hair cosmetics - Google Patents
Hair cosmetics Download PDFInfo
- Publication number
- JP5599433B2 JP5599433B2 JP2012140091A JP2012140091A JP5599433B2 JP 5599433 B2 JP5599433 B2 JP 5599433B2 JP 2012140091 A JP2012140091 A JP 2012140091A JP 2012140091 A JP2012140091 A JP 2012140091A JP 5599433 B2 JP5599433 B2 JP 5599433B2
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- Japan
- Prior art keywords
- weight
- acid
- hair cosmetic
- hair
- cosmetic composition
- Prior art date
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- 239000003676 hair preparation Substances 0.000 title description 3
- 239000002537 cosmetic Substances 0.000 claims description 24
- 210000004761 scalp Anatomy 0.000 claims description 19
- -1 glyceryl glycyrrhetinate Chemical compound 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 206010000496 acne Diseases 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 7
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 7
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 6
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 239000003093 cationic surfactant Substances 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 3
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 3
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 3
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 3
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 3
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 3
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 2
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 2
- 229960003720 enoxolone Drugs 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 claims description 2
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims description 2
- CCXAYLQLOLXXKE-DWJAGBRCSA-K trisodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-t Chemical compound [Na+].[Na+].[Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O CCXAYLQLOLXXKE-DWJAGBRCSA-K 0.000 claims description 2
- QDWKGBODFCIIJK-IHMBCTQLSA-N azanium;(2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound [NH4+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C QDWKGBODFCIIJK-IHMBCTQLSA-N 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 description 27
- 229920001296 polysiloxane Polymers 0.000 description 21
- 238000011156 evaluation Methods 0.000 description 15
- 208000003251 Pruritus Diseases 0.000 description 14
- 230000007803 itching Effects 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 9
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 6
- 239000004166 Lanolin Substances 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 6
- 235000019388 lanolin Nutrition 0.000 description 6
- 229940039717 lanolin Drugs 0.000 description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 6
- 230000006866 deterioration Effects 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 239000002453 shampoo Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 229960000735 docosanol Drugs 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
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- 150000007513 acids Chemical class 0.000 description 2
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- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
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- 125000004122 cyclic group Chemical group 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Description
本発明は、特定の有機酸及び消炎剤を含み、乾燥後の毛髪に良好な柔軟性を付与し、フケ・かゆみ・吹き出物・かさつき抑制などの地肌ケア効果に優れる毛髪化粧料に関する。 The present invention relates to a hair cosmetic that contains a specific organic acid and an anti-inflammatory agent, imparts good flexibility to dried hair, and is excellent in skin care effects such as dandruff, itching, pimples, and suppression of roughness.
ヘアリンスやヘアトリートメントなどの毛髪化粧料は、洗浄剤とは異なり、カチオン活性剤やシリコーン類、油剤、高級アルコールなどの成分を毛髪に吸着、残留させることによって、柔軟性や油性感を与え、なめらかな使用感を付与している。しかしながら、個人の体質によっては、各種の吸着成分が毛髪だけでなく頭皮に残留してしまい、頭皮の刺激やかゆみを引き起こし、また炎症等の症状の要因になりえる可能性がある。従って、このような成分の吸着や残留は、毛髪ケアにとっては効果的な方法である一方、頭皮ケアにとっては決して好ましい方法とはいえない。 Hair cosmetics such as hair rinses and hair treatments, unlike cleaning agents, give softness and a feeling of softness and oiliness by adsorbing and leaving cationic active agents, silicones, oils, higher alcohols and other ingredients on the hair. It gives a good feeling of use. However, depending on an individual's constitution, various adsorbing components may remain on the scalp as well as the hair, causing irritation and itching of the scalp and possibly causing symptoms such as inflammation. Therefore, the adsorption and residual of such components are effective methods for hair care, but are not preferable methods for scalp care.
一方、フケ・かゆみ等は菌の繁殖に起因すると考えられ、それらの菌の繁殖に由来するフケやかゆみの抑制にはジンクピリチオンに代表されるピリジンチオン塩や、塩化ベンザルコニウム、オクトピロックスなどの抗菌剤又は殺菌剤を含む抗フケ用毛髪化粧料が使用されてきた(例えば、特許文献1及び2を参照)。しかしながら近年では、洗髪頻度の向上により、菌の繁殖に主たる原因を持つフケ自体よりも、地肌の乾燥に主たる原因を持つフケやかゆみ、かさつきが、地肌トラブルの主流になってきている。そこで、頭皮ケアと毛髪ケアが同時にできる毛髪化粧料が望まれていた。 On the other hand, dandruff and itching are thought to be caused by the growth of fungi, and pyridinethione salts such as zinc pyrithione, benzalkonium chloride, octopirox, etc. are used to suppress dandruff and itching resulting from the growth of these fungi. An anti-dandruff hair cosmetic containing an antibacterial or bactericidal agent has been used (see, for example, Patent Documents 1 and 2). However, in recent years, dandruff, itching, and roughness, which have a main cause of dryness of the skin, have become the mainstream of skin troubles, rather than dandruff itself, which has the main cause of bacterial growth, due to an increase in hair washing frequency. Therefore, a hair cosmetic that can simultaneously perform scalp care and hair care has been desired.
本発明の目的は、乾燥後の毛髪に良好な柔軟性を付与し、フケ・かゆみだけでなく、吹き出物・かさつきも抑制する地肌ケア効果に優れる毛髪化粧料を提供することにある。 An object of the present invention is to provide a hair cosmetic that is excellent in a skin care effect that imparts good flexibility to hair after drying and suppresses not only dandruff and itching but also pimples and roughness.
本発明者らは、特定の有機酸、消炎剤と、高級アルコールを併用し、更に一定の低pH領域に調整することにより、乾燥後の毛髪に良好な柔軟性を付与し、フケ・かゆみ・吹き出物・かさつき抑制などの地肌ケア効果に優れる毛髪化粧料が得られることを見出した。 The present inventors use a specific organic acid, an anti-inflammatory agent, and a higher alcohol in combination, and further adjust to a certain low pH region to give good hair flexibility after drying, dandruff, itching, The present inventors have found that a hair cosmetic composition excellent in scalp care effects such as breakouts and suppression of bulkiness can be obtained.
すなわち本発明は、次の成分(A)、(B)及び(C)を含有し、水で20重量倍に希釈したときの25℃におけるpHが1〜4.5である毛髪化粧料を提供するものである。
(A) ヒドロキシ基を有していてもよい有機ジカルボン酸若しくはヒドロキシモノカルボン酸又はそれらの塩 0.1〜20重量%
(B) 少なくとも1種の消炎剤 0.001〜10重量%
(C) 高級アルコール 0.1〜20重量%
That is, the present invention provides a hair cosmetic comprising the following components (A), (B) and (C) and having a pH of 1 to 4.5 at 25 ° C. when diluted 20 times by weight with water: It is.
(A) Organic dicarboxylic acid or hydroxymonocarboxylic acid which may have a hydroxy group or a salt thereof 0.1 to 20% by weight
(B) at least one flame retardant 0.001 to 10% by weight
(C) Higher alcohol 0.1-20% by weight
本発明の毛髪化粧料は、乾燥後の毛髪に良好な柔軟性を付与し、頭皮のふけ・かゆみ、吹き出物、かさつきなどの抑制効果に優れる。 The hair cosmetic composition of the present invention imparts good flexibility to the hair after drying, and is excellent in suppressing effects such as dandruff / itchiness of the scalp, pimples, and roughness.
本発明の毛髪化粧料は、水で20重量倍希釈したときの25℃におけるpHが1〜4.5であるが、頭皮のふけ・かゆみ、吹き出物、かさつきなどの抑制効果又は改善効果(以下、頭皮症状改善効果という)の点から、上記pHが2〜4、特に3〜4であるのが好ましい。 The hair cosmetic composition of the present invention has a pH of 1 to 4.5 at 25 ° C. when diluted 20 times by weight with water, but it has an inhibitory effect or an improving effect on the scalp, such as dandruff, itching, pimples, and roughness (hereinafter referred to as the scalp). From the viewpoint of the symptom improving effect), the pH is preferably 2 to 4, particularly 3 to 4.
成分(A)のヒドロキシ基を有してもよいジカルボン酸としては、例えばマロン酸、コハク酸、グルタル酸、アジピン酸、マレイン酸、フマル酸、フタル酸、シュウ酸等のヒドロキシ基を有しないジカルボン酸、及びリンゴ酸、酒石酸等のヒドロキシジカルボン酸が挙げられる。また、ヒドロキシモノカルボン酸としては、グリコール酸、乳酸、ヒドロキシアクリル酸、オキシ酪酸、グリセリン酸等が挙げられる。なかでも、乳酸、マロン酸、マレイン酸、リンゴ酸が好ましい。また、これら有機カルボン酸の塩としては、アルカリ金属、アルカリ土類金属、アンモニア、有機アミン化合物との塩が挙げられる。 Examples of the dicarboxylic acid having a hydroxy group as component (A) include dicarboxylic acids having no hydroxy group such as malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, phthalic acid, and oxalic acid. Examples include acids and hydroxydicarboxylic acids such as malic acid and tartaric acid. Examples of the hydroxy monocarboxylic acid include glycolic acid, lactic acid, hydroxyacrylic acid, oxybutyric acid, and glyceric acid. Of these, lactic acid, malonic acid, maleic acid and malic acid are preferred. In addition, examples of salts of these organic carboxylic acids include salts with alkali metals, alkaline earth metals, ammonia, and organic amine compounds.
本発明において、成分(A)は、単にpHを調整する目的で使用されるのではなく、有効成分として必須であり、本発明の毛髪化粧料中に0.1〜20重量%配合することが必要であるが、十分な頭皮症状改善効果の点から、0.2〜15重量%含まれることが好ましく、特に0.2〜10重量%含まれることが好ましい。 In the present invention, the component (A) is not simply used for the purpose of adjusting the pH but is essential as an active ingredient, and it is necessary to add 0.1 to 20% by weight in the hair cosmetic composition of the present invention. However, it is preferably contained in an amount of 0.2 to 15% by weight, particularly preferably 0.2 to 10% by weight, from the viewpoint of a sufficient scalp symptom improving effect.
成分(B)の消炎剤としては、グリチルレチン酸、グリチルリチン酸、それらの誘導体等の抗炎症剤のほか、消炎機能を有する成分、例えばε-アミノカプロン酸、アラントイン、グアイアズレンスルホン酸ナトリウム、d-カンフル、l-メントール、尿素、ジパルミチン酸ピリドキシン、ステアリン酸グリチルレチニル、トラネキサム酸、ビタミンA油、ヒドロコルチゾン、プレドニゾロン、塩酸ピリドキシン、感光素301号、酸化亜鉛、酢酸ヒドロコーチゾン等が含まれる。グリチルレチン酸又はグリチルリチン酸の誘導体としては、ナトリウム塩、カリウム塩等のアルカリ金属塩やアンモニウム塩等の塩類、グリセリンエステル、ステアリルエステル等のエステル類が挙げられる。具体的には、グリチルリチン酸ジカリウム、グリチルリチン酸二ナトリウム、グリチルリチン酸三ナトリウム、グリチルリチン酸モノアンモニウム、グリチルレチン酸グリセリン、グリチルレチン酸ステアリル等が挙げられる。成分(B)の消炎剤は、本発明の毛髪化粧料中に0.001〜10重量%含まれるが、0.005〜5重量%、特に0.01〜1重量%含有するのが好ましい。 In addition to anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizic acid and derivatives thereof, as an anti-inflammatory agent of component (B), for example, ε-aminocaproic acid, allantoin, sodium guaiazulene sulfonate, d-camphor, 1-menthol, urea, pyridoxine dipalmitate, glycyrrhetinyl stearate, tranexamic acid, vitamin A oil, hydrocortisone, prednisolone, pyridoxine hydrochloride, photosensitizer 301, zinc oxide, hydrocortisone acetate and the like. Examples of derivatives of glycyrrhetinic acid or glycyrrhizic acid include salts such as alkali metal salts such as sodium salt and potassium salt and ammonium salts, and esters such as glycerin ester and stearyl ester. Specific examples include dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, glyceryl glycyrrhetinate, and stearyl glycyrrhetinate. The anti-inflammatory agent of component (B) is contained in the hair cosmetic composition of the present invention in an amount of 0.001 to 10% by weight, preferably 0.005 to 5% by weight, particularly 0.01 to 1% by weight.
成分(C)の高級アルコールとしては、炭素数12〜28のアルキル基を有するものが好ましく、更には炭素数16〜24、特に22のアルキル基を有するものが好ましく、またこのアルキル基は直鎖アルキル基であるのが好ましい。具体的には、セチルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール等が挙げられ、特にベヘニルアルコールが好ましい。 The higher alcohol of component (C) is preferably one having an alkyl group having 12 to 28 carbon atoms, more preferably one having an alkyl group having 16 to 24 carbon atoms, particularly 22 carbon atoms. An alkyl group is preferred. Specific examples include cetyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, and the like, and behenyl alcohol is particularly preferable.
成分(C)の高級アルコールは、2種以上を併用してもよく、またその含有量は、本発明の毛髪化粧料の0.1〜20重量%であるが、滑らかさ、使いやすさ、安定性等の向上の点から、0.5〜15重量%、特に1〜10重量%が好ましい。 The higher alcohol of component (C) may be used in combination of two or more, and its content is 0.1 to 20% by weight of the hair cosmetic of the present invention, but it is smooth, easy to use and stable. From the viewpoint of improvement, etc., 0.5 to 15% by weight, particularly 1 to 10% by weight is preferable.
本発明の毛髪化粧料には、乾燥後の仕上がり向上のため、一般式(1)で表される第4級アンモニウム塩及び第3級アミン型の塩から選ばれる1種以上のカチオン界面活性剤、シリコーン類及び油剤から選ばれるコンディショニング剤を含むことができる。 The hair cosmetic composition of the present invention contains at least one cationic surfactant selected from a quaternary ammonium salt and a tertiary amine type salt represented by the general formula (1) for improving the finish after drying. In addition, a conditioning agent selected from silicones and oils can be included.
〔式中、R1及びR2は、水素原子、炭素数1〜28のアルキル基又はベンジル基を示すが、同時に水素原子又はベンジル基となることはなく、少なくとも1つは炭素数8以上のアルキル基である。R3及びR4は、炭素数1〜5のアルキル基若しくはヒドロキシアルキル基、又は合計付加モル数10以下のポリオキシエチレン基を示し、An-は、陰イオンを示す。〕 [In the formula, R 1 and R 2 represent a hydrogen atom, an alkyl group having 1 to 28 carbon atoms or a benzyl group, but at the same time, they do not become a hydrogen atom or a benzyl group, and at least one of them has 8 or more carbon atoms. It is an alkyl group. R 3 and R 4 represent an alkyl group having 1 to 5 carbon atoms or a hydroxyalkyl group, or a polyoxyethylene group having a total number of added moles of 10 or less, and An − represents an anion. ]
特に、モノ長鎖アルキル(C12〜22)四級アンモニウム塩、ジ長鎖アルキル(C12〜22)四級アンモニウム塩、分岐鎖アルキル(C12〜28)四級アンモニウム塩等の四級アンモニウム塩、又はアルキルオキシアルキレン三級アミン塩、アルキルアミドアルキレン三級アミン塩等が使用可能である。具体的には、塩化ラウリルトリメチルアンモニウム、塩化セチルトリメチルアンモニウム、臭化セチルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、臭化ラウリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩;塩化ジセチルジメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、塩化ジココイルジメチルアンモニウム等のジアルキルジメチルアンモニウム塩が挙げられる。更に、塩化ミリスチルジメチルベンジルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、メチル硫酸ラノリン脂肪酸アミノエチルトリメチルアンモニウム、メチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルトリエチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノエチルトリエチルアンモニウム、エチル硫酸イソステアリン酸アミノプロピルエチルジメチルアンモニウム、エチル硫酸イソノナン酸アミノプロピルエチルジメチルアンモニウム、ステアリルアミドプロピルジメチルアミン(及びその塩)、ステアリルアミドエチルジエチルアミン(及びその塩)、エチル硫酸イソアルカン酸(C14〜C20)アミノプロピルエチルジメチルアンモニウム、エチル硫酸イソアルカン酸(C18〜C22)アミノプロピルエチルジメチルアンモニウム、及びアルキルトリメチルアンモニウムサッカリンなどが使用できる。カチオン界面活性剤は、2種以上を併用してもよく、洗髪時からすすぎ時までの滑らかさ、指通りの良さ、ツヤの付与の点から、その含有量は、本発明の毛髪化粧料中の0.1〜15重量%が好ましく、更には0.2〜10重量%、特に0.5〜5重量%が好ましい。 In particular, quaternary ammonium salts such as mono long chain alkyl (C12-22) quaternary ammonium salts, di long chain alkyl (C12-22) quaternary ammonium salts, branched chain alkyl (C12-28) quaternary ammonium salts, or Alkyloxyalkylene tertiary amine salts, alkylamidoalkylene tertiary amine salts and the like can be used. Specifically, alkyltrimethylammonium salts such as lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, lauryltrimethylammonium bromide; dicetyldimethylammonium chloride, Examples thereof include dialkyldimethylammonium salts such as distearyldimethylammonium chloride and dicocoyldimethylammonium chloride. Furthermore, myristyl dimethyl benzyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, methyl sulfate lanolin fatty acid aminoethyl trimethyl ammonium, methyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium, ethyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium, ethyl sulfate lanolin fatty acid aminopropyl triethyl Ammonium, ethyl sulfate lanolin fatty acid aminoethyltriethylammonium, ethylsulfate isostearate aminopropylethyldimethylammonium, ethylsulfate isononanoate aminopropylethyldimethylammonium, stearylamidopropyldimethylamine (and its salt), stearylamidoethyldiethylamine (and its salt) ), Isoalkenyl ethyl sulfate Acid (C14-C20) aminopropyl dimethylammonium ethyl sulfate isoalkanes acid (C18 to C22) aminopropyl dimethylammonium, and like alkyl trimethylammonium saccharin can be used. Two or more cationic surfactants may be used in combination, and the content of the cationic surfactant in the hair cosmetic composition of the present invention is from the point of smoothness from the time of shampooing to rinsing, good fingering, and gloss. 0.1 to 15% by weight, preferably 0.2 to 10% by weight, more preferably 0.5 to 5% by weight.
シリコーン類としては、例えば以下に示すものが挙げられる。 Examples of silicones include the following.
(シリコーン類-1) ジメチルポリシロキサン
R5(CH3)2SiO−[(CH3)2SiO]a-Si(CH3)2R5
〔式中、R5はメチル基又はヒドロキシ基を示し、aは3〜20000の数を示す。〕
(Silicones -1) dimethylpolysiloxane R 5 (CH 3) 2 SiO - [(CH 3) 2 SiO] a -Si (CH 3) 2 R 5
[Wherein, R 5 represents a methyl group or a hydroxy group, and a represents a number of 3 to 20000. ]
例えば、BY11-026、BY22-19〔東レ・ダウコーニング(株)〕、FZ-3125〔日本ユニカー(株)〕等が挙げられる。高重合ジメチルポリシロキサンは、液状油(例えば、低重合ジメチルポリシロキサンオイル、環状シリコーン等の液状シリコーン油、またイソパラフィン等の液状炭化水素油)に溶解又は分散したものを使用することができる。 For example, BY11-026, BY22-19 [Toray Dow Corning Co., Ltd.], FZ-3125 [Nihon Unicar Co., Ltd.] and the like can be mentioned. As the highly polymerized dimethylpolysiloxane, those dissolved or dispersed in a liquid oil (for example, a liquid polymer oil such as a low polymerized dimethylpolysiloxane oil, a cyclic silicone, or a liquid hydrocarbon oil such as isoparaffin) can be used.
(シリコーン類-2) アミノ変性シリコーン
各種のアミノ変性シリコーンが使用できるが、特に平均分子量が約3000〜100000の、アモジメチコーン(Amodimethicone)の名称でCTFA辞典(米国,Cosmetic Ingredient Dictionary)第3版中に記載されているものが好ましい。このアミノ変性シリコーンは水性乳濁液として用いるのが好ましく、市販品としては、SM8704C〔東レ・ダウコーニング(株)〕、DC 929〔ダウ・コーニング社〕等が挙げられる。
(Silicones-2) Amino-modified silicone Various amino-modified silicones can be used, but in the third edition of the CTFA Dictionary (US, Cosmetic Ingredient Dictionary) with the name of Amodimethicone with an average molecular weight of about 3000 to 100,000. What is described is preferred. This amino-modified silicone is preferably used as an aqueous emulsion, and commercially available products include SM8704C [Toray Dow Corning Co., Ltd.], DC 929 [Dow Corning Co., Ltd.] and the like.
その他のアミノ変性シリコーンとしては、例えば次の式で表されるような化合物が挙げられ、市販品としては、ダウ・コーニング社の「8500 Conditioning Agent」(CAS No.237753-63-8)が挙げられる。 Examples of other amino-modified silicones include compounds represented by the following formula, and commercially available products include “8500 Conditioning Agent” (CAS No.237753-63-8) manufactured by Dow Corning. It is done.
〔式中、R6は炭素数13〜15の直鎖又は分岐鎖のアルキル基を示し、Xのうち75%は基−CH2CH(OH)CH2OHを、25%は水素原子を示す。〕 [Wherein R 6 represents a linear or branched alkyl group having 13 to 15 carbon atoms, 75% of X represents a group —CH 2 CH (OH) CH 2 OH, and 25% represents a hydrogen atom. . ]
アミノ変性ポリシロキサン−ポリオキシアルキレンブロック共重合体の好ましい例としては、下記一般式で表されるものが挙げられる。 Preferable examples of the amino-modified polysiloxane-polyoxyalkylene block copolymer include those represented by the following general formula.
〔式中、bは2以上の数を示し、cは1以上の数を示し、dは4以上の数を示し、eは0〜30の数を示し、fは2以上の数を示す。〕 [Wherein, b represents a number of 2 or more, c represents a number of 1 or more, d represents a number of 4 or more, e represents a number of 0 to 30, and f represents a number of 2 or more. ]
上記一般式において、好ましくは、bは2〜1,000の数、cは1〜50の数、dは4〜200の数、fは2〜100の数を示す。また、−O(C2H4O)d(C3H6O)e−はブロック共重合体及びランダム共重合体のいずれであってもよい。市販品としては、東レ・ダウコーニング(株)のFZ-3789、シリコーンSS-3588を挙げることができる。 In the above general formula, preferably, b is a number of 2 to 1,000, c is a number of 1 to 50, d is a number of 4 to 200, and f is a number of 2 to 100. In addition, —O (C 2 H 4 O) d (C 3 H 6 O) e — may be either a block copolymer or a random copolymer. Examples of commercially available products include FZ-3789 and silicone SS-3588 manufactured by Toray Dow Corning.
(シリコーン類-3) その他のシリコーン類
上記以外に、ポリエーテル変性シリコーン、メチルフェニルポリシロキサン、脂肪酸変性シリコーン、アルコール変性シリコーン、アルコキシ変性シリコーン、エポキシ変性シリコーン、フッ素変性シリコーン、環状シリコーン、アルキル変性シリコーン等が挙げられる。
(Silicones-3) Other silicones Other than the above, polyether modified silicone, methylphenylpolysiloxane, fatty acid modified silicone, alcohol modified silicone, alkoxy modified silicone, epoxy modified silicone, fluorine modified silicone, cyclic silicone, alkyl modified silicone Etc.
これらシリコーン類は、2種以上を併用することもでき、またその含有量は、髪の滑らかさ、指通りの良さ、ツヤの付与の点から、本発明の毛髪化粧料中の0.1〜15重量%が好ましく、更には0.2〜10重量%、特に0.5〜8重量%が好ましい。 Two or more kinds of these silicones can be used in combination, and the content thereof is 0.1 to 15% by weight in the hair cosmetic composition of the present invention in terms of smoothness of hair, good fingering, and gloss. %, More preferably 0.2 to 10% by weight, particularly 0.5 to 8% by weight.
油剤とは、シリコーン類を除く油性物質をいい、例えば、スクワレン、スクワラン、流動パラフィン、流動イソパラフィン、シクロパラフィン等の炭化水素類;ヒマシ油、カカオ油、ミンク油、アボカド油、オリーブ油等のグリセリド類;ミツロウ、鯨ロウ、ラノリン、カルナウバロウ等のロウ類;セチルアルコール、オレイルアルコール、ステアリルアルコール、イソステアリルアルコール、2-オクチルドデカノール、グリセリン等のアルコール類;パルミチン酸イソプロピル、ミリスチン酸イソプロピル、ミリスチン酸オクチルドデシル、ラウリン酸ヘキシル、乳酸セチル、モノステアリン酸プロピレングリコール、オレイン酸オレイル、2-エチルヘキサン酸ヘキサデシル、イソノナン酸イソノニル、イソノナン酸トリデシル等のエステル類;カプリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘニン酸、オレイン酸、ヤシ油脂肪酸、イソステアリル酸、イソパルミチン酸等の高級脂肪酸類、その他イソステアリルグリセリルエーテル、ポリオキシプロピレンブチルエーテルなどが挙げられる。これらのうち、エステル類が好ましく、特に2-エチルヘキサン酸ヘキサデシル、イソノナン酸イソノニル、パルミチン酸イソプロピル等が好ましい。これら油剤は、2種以上を併用することもでき、その含有量は、本発明の毛髪化粧料中の0.01〜15重量%が好ましく、更には0.05〜10重量%、特に0.1〜7重量%が好ましい。 Oil refers to oily substances excluding silicones, for example, hydrocarbons such as squalene, squalane, liquid paraffin, liquid isoparaffin, cycloparaffin; glycerides such as castor oil, cacao oil, mink oil, avocado oil, olive oil, etc. Waxes such as beeswax, whale wax, lanolin and carnauba wax; alcohols such as cetyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, glycerin; isopropyl palmitate, isopropyl myristate, octyl myristate Esters such as dodecyl, hexyl laurate, cetyl lactate, propylene glycol monostearate, oleyl oleate, hexadecyl 2-ethylhexanoate, isononyl isononanoate, tridecyl isononanoate Class: Higher fatty acids such as capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, coconut oil fatty acid, isostearyl acid, isopalmitic acid, other isostearyl glyceryl ether, polyoxypropylene butyl ether Etc. Of these, esters are preferable, and hexadecyl 2-ethylhexanoate, isononyl isononanoate, isopropyl palmitate, and the like are particularly preferable. These oil agents can be used in combination of two or more, and the content thereof is preferably 0.01 to 15% by weight, more preferably 0.05 to 10% by weight, particularly 0.1 to 7% by weight in the hair cosmetic composition of the present invention. preferable.
本発明の毛髪化粧料には、上記成分のほか、通常の毛髪化粧料に用いられる成分を目的に応じて適宜配合できる。このような成分としては、例えばソルビトール、パンテノール等の保湿剤;染料、顔料等の着色剤;ヒドロキシエチルセルロース、メチルセルロース、ポリエチレングリコール、ポリビニルアルコール、粘土鉱物等の粘度調整剤;水酸化カリウム、水酸化ナトリウム、クエン酸等のpH調整剤:植物エキス類;パール化剤;香料;色素;紫外線吸収剤;酸化防止剤;その他エンサイクロペディア・オブ・シャンプー・イングリーディエンツ〔ENCYCLOPEDIA OF SHAMPOO INGREDIENTS (MICELLE PRESS)〕に記載されている成分等が挙げられる。 In addition to the above-described components, the hair cosmetic of the present invention can be appropriately mixed with components used in normal hair cosmetics depending on the purpose. Examples of such components include humectants such as sorbitol and panthenol; colorants such as dyes and pigments; viscosity modifiers such as hydroxyethyl cellulose, methyl cellulose, polyethylene glycol, polyvinyl alcohol, and clay minerals; potassium hydroxide and hydroxide PH adjusters such as sodium and citric acid: plant extracts; pearlizing agents; fragrances; pigments; ultraviolet absorbers; antioxidants; other ENCYCLOPEDIA OF SHAMPOO INGREDIENTS (MICELLE PRESS )] And the like.
本発明の毛髪化粧料は、水溶液、エタノール溶液、エマルション、サスペンション、ゲル、液晶、固形、エアゾール等の所望の形態にすることができ、たとえばヘアリンス、ヘアトリートメント、ヘアパック、ヘアクリーム、コンディショニングムース、ヘアムース、ヘアスプレー、リーブオントリートメント等に適用できる。特にヘアリンス、ヘアコンディショナー、ヘアトリートメント等の洗い流して使用する剤形として好適である。 The hair cosmetic composition of the present invention can be made into a desired form such as an aqueous solution, an ethanol solution, an emulsion, a suspension, a gel, a liquid crystal, a solid, an aerosol, etc., for example, a hair rinse, a hair treatment, a hair pack, a hair cream, a conditioning mousse, Applicable to hair mousse, hair spray, leave on treatment, etc. It is particularly suitable as a dosage form to be used after washing away, such as hair rinse, hair conditioner, hair treatment.
本発明の毛髪化粧料は、頭皮のフケ、かゆみ、吹き出物、かさつきなどの抑制効果に優れ、抗フケリンスとして有用である。 The hair cosmetic composition of the present invention is excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness, and is useful as an anti-dandruff.
以下の実施例及び比較例におけるpHは、水で20重量倍に希釈したときの25℃における値である。 The pH in the following Examples and Comparative Examples is a value at 25 ° C. when diluted 20 times by weight with water.
実施例1〜3及び比較例1〜4
表1に示すリンスを調製し、その評価を行った。
Examples 1-3 and Comparative Examples 1-4
The rinses shown in Table 1 were prepared and evaluated.
(頭皮症状改善効果の評価)
20〜40代の一般男女から、目視により頭皮にフケ症状の見られる群50名(男性25名、女性25名)、頭皮に吹出物症状のみられる群50名(男性25名、女性25名)、及びそれらの症状の見られない健常群50名(男性25名、女性25名)の計150名の被験者を選抜した。これら被験者に対し、1ヶ月間、コントロールシャンプーとコントロールリンスを使用させた後、試験リンスを約6週間使用させ、その前後の頭皮状態変化を目視により評価した。コントロールシャンプーとコントロールリンスの組成を以下に示す。
(1) コントロールシャンプー (重量%)
ポリオキシエチレン(2)ラウリルエーテル硫酸ナトリウム 13.5
ヤシ油脂肪酸モノエタノールアミド 0.5
ポリオキシエチレン(16)ラウリルエーテル 2
ラウリン酸アミドプロピルベタイン 1.5
カチオン化セルロース 0.5
pH調整剤(クエン酸,48重量%水酸化ナトリウム水溶液) pH5.5に調整
精製水 残量
(2) コントロールリンス (重量%)
塩化アルキルトリメチルアンモニウム 1.33
ステアリルアルコール 0.4
ベヘニルアルコール 3.6
パルミチン酸イソプロピル 0.5
プロピレングリコール 0.5
高分子量ジメチルポリシロキサン(重合度1000〜2700) 2
pH調整剤(クエン酸,48重量%水酸化カリウム水溶液) pH5.1に調整
精製水 残量
(Evaluation of scalp symptom improvement effect)
From general men and women in their 20s to 40s, 50 groups (25 men and 25 women) who have dandruff symptoms on the scalp, 50 groups (25 men and 25 women) who have pimple symptoms on the scalp, In addition, a total of 150 subjects were selected from 50 healthy groups (25 men and 25 women) who did not have these symptoms. These subjects were allowed to use a control shampoo and a control rinse for one month, and then used a test rinse for about 6 weeks, and the scalp state change before and after that was visually evaluated. The composition of the control shampoo and control rinse is shown below.
(1) Control shampoo (wt%)
Polyoxyethylene (2) sodium lauryl ether sulfate 13.5
Palm oil fatty acid monoethanolamide 0.5
Polyoxyethylene (16) lauryl ether 2
Amidopropyl betaine laurate 1.5
Cationized cellulose 0.5
pH adjuster (citric acid, 48 wt% sodium hydroxide aqueous solution) Adjusted to pH 5.5 Purified water remaining
(2) Control rinse (% by weight)
Alkyltrimethylammonium chloride 1.33
Stearyl alcohol 0.4
Behenyl alcohol 3.6
Isopropyl palmitate 0.5
Propylene glycol 0.5
High molecular weight dimethylpolysiloxane (degree of polymerization 1000-2700) 2
pH adjuster (citric acid, 48 wt% potassium hydroxide aqueous solution) Adjusted to pH 5.1 Purified water remaining
フケ症状は、頭皮を12の領域に分け、各領域ごとにレベル0〜6の7段階、合計0〜72の段階にレベル分けをし、レベル10以上をフケ群の対象とした。吹き出物症状は、頭皮全体の吹き出物数が3個以上を吹き出物群の対象とした。健常群は、フケ及び吹き出物の症状が、フケ群、吹き出物群の基準未満である場合とした。 For dandruff symptoms, the scalp was divided into 12 regions, and each region was divided into 7 levels ranging from levels 0 to 6, totaling from 0 to 72, and level 10 or higher was targeted for the dandruff group. As for breakout symptoms, the number of breakouts in the entire scalp was 3 or more. In the healthy group, the symptoms of dandruff and pimples were less than the standards of the dandruff group and pimples.
フケ及び吹き出物の評価は、ダブルブラインドの条件下で熟練した研究員により行い、使用前後のフケレベル、吹き出物個数の変化量の平均からランク分けし、表1に示した。
かゆみ、かさつきの評価は、被験者に記入式5段階(改善5点、やや改善4点、変化なし3点、やや悪化2点、悪化1点)のアンケートを行い、評価点の平均(小数点以下第2位を四捨五入)からランク分けし、表1に示した。
Dandruff and blowout were evaluated by skilled researchers under double blind conditions, and ranked according to the average of the amount of change in dandruff level and blowout before and after use, and are shown in Table 1.
For itching and roughness evaluation, subjects were asked to fill out a five-point questionnaire (5 points for improvement, 4 points for improvement, 3 points for no change, 2 points for deterioration, 1 point for deterioration), and the average of the evaluation points (below the decimal point) The results are shown in Table 1.
<吹き出物ランク>
◎(有効) :使用前後で平均吹き出物数が5個以上減少
○(やや有効):使用前後で平均吹き出物数が3個以上減少
△(変化なし):使用前後で平均吹き出物数が±3個未満の変化
×(悪化) :使用前後で平均吹き出物数が3個以上増加
<Breakout rank>
◎ (Effective): Average number of breakouts decreased by 5 or more before and after use ○ (Slightly effective): Average number of breakouts decreased by 3 or more before and after use △ (No change): Average number of breakouts before and after use was less than ± 3 Change × (deterioration): The average number of breakouts increased by 3 or more before and after use.
<かさつきランク>
◎(有効) :平均評価点が3.5以上
○(やや有効):平均評価点が3.2〜3.4
△(変化なし):平均評価点が2.8〜3.1
×(悪化) :平均評価点が2.7以下
<Racing rank>
◎ (Effective): Average evaluation score of 3.5 or higher ○ (Slightly effective): Average evaluation score of 3.2 to 3.4
Δ (no change): Average evaluation score of 2.8 to 3.1
× (Deterioration): Average evaluation score of 2.7 or less
<かゆみランク>
◎(有効) :平均評価点が3.5以上
○(やや有効):平均評価点が3.2〜3.4
△(変化なし):平均評価点が2.8〜3.1
×(悪化) :平均評価点が2.7以下
<Itchy rank>
◎ (Effective): Average evaluation score of 3.5 or higher ○ (Slightly effective): Average evaluation score of 3.2 to 3.4
Δ (no change): Average evaluation score of 2.8 to 3.1
× (Deterioration): Average evaluation score of 2.7 or less
<フケランク>
◎(有効) :使用前後で平均フケレベルが10以上減少
○(やや有効):使用前後で平均フケレベルが5以上減少
△(変化なし):使用前後で平均フケレベルが±5未満の変化
×(悪化) :使用前後で平均フケレベルが5以上増加
<Frank rank>
◎ (Effective): Average dandruff level decreased by 10 or more before and after use ○ (Slightly effective): Average dandruff level decreased by 5 or more before and after use △ (No change): Change of average dandruff level less than ± 5 before and after use × (Deteriorated) : Average dandruff level increased by 5 or more before and after use
乾燥後の毛髪の柔軟性については、パネラー5名により、0〜4の5段階で評価を行い、その平均値からランク分けを行い、表1に結果を示した。
<乾燥後の毛髪の柔軟性ランク>
◎(非常に柔らかい) :平均評価点が3.5以上
○(柔らかい) :平均評価点が2.5〜3.4
△(やや柔らかくない):平均評価点が1.5〜2.4
×(柔らかくない) :平均評価点が1.4以下
About the softness | flexibility of the hair after drying, it evaluated in five steps of 0-4 by five panelists, it ranked according to the average value, and the result was shown in Table 1.
<Flexibility rank of hair after drying>
◎ (very soft): Average evaluation score of 3.5 or more ○ (Soft): Average evaluation score of 2.5 to 3.4
Δ (not somewhat soft): Average evaluation score of 1.5 to 2.4
× (not soft): Average evaluation score of 1.4 or less
実施例1〜3のリンスは、乾燥後の毛髪に良好な柔軟性を付与し、頭皮のフケ・かゆみ・吹出物・かさつきの抑制効果に優れるものであった。これに対し、消炎剤を含まない比較例1、及び本発明の有機酸を含まず、クエン酸を使用している比較例2は、フケの抑制及び吹き出物やかさつきの改善効果に劣るものであった。pH5以上で使用する汎用的な抗菌剤であるジンクピリチオンを用いた比較例3は、吹き出物やかさつきの抑制効果が低かった。本発明の有機酸を含むがpHの高い比較例4は、フケ、かゆみ、吹き出物やかさつき改善効果が認められなかった。 The rinses of Examples 1 to 3 imparted good flexibility to the hair after drying, and were excellent in the effect of suppressing scalp dandruff, itching, pimples, and roughness. On the other hand, Comparative Example 1 not containing an anti-inflammatory agent and Comparative Example 2 not containing the organic acid of the present invention and using citric acid were inferior in suppression of dandruff and improvement in blowout and bulkiness. . Comparative Example 3 using zinc pyrithione, which is a general-purpose antibacterial agent used at a pH of 5 or more, had a low effect of suppressing blowout and bulkiness. In Comparative Example 4 containing the organic acid of the present invention but having a high pH, no dandruff, itching, pimple, or bulkiness improvement effect was observed.
実施例4〜7及び比較例5〜7
実施例1〜3及び比較例1〜4と同様に表2に示すコンディショナーを調製し、その評価を行った。結果を表2にあわせて示す。
Examples 4-7 and Comparative Examples 5-7
The conditioners shown in Table 2 were prepared and evaluated in the same manner as in Examples 1 to 3 and Comparative Examples 1 to 4. The results are shown in Table 2.
実施例4〜7のコンディショナー(pH3.7)は、頭皮のフケ・かゆみ・吹出物・かさつきの抑制・改善効果に優れ、また、乾燥後の毛髪に良好な柔軟性を付与するものであった。 The conditioners (pH 3.7) of Examples 4 to 7 were excellent in suppressing and improving the scalp dandruff, itching, puffed product, and roughness, and imparted good flexibility to the hair after drying. .
Claims (6)
(A) リンゴ酸又はその塩 0.2〜10重量%
(B) グリチルレチン酸、グリチルリチン酸、グリチルリチン酸ジカリウム、グリチルリチン酸二ナトリウム、グリチルリチン酸三ナトリウム、グリチルリチン酸モノアンモニウム、グリチルレチン酸グリセリン及びグリチルレチン酸ステアリルから選ばれる少なくとも1種の消炎剤 0.001〜10重量%
(C) 炭素数12〜28のアルキル基を有する高級アルコール 0.1〜20重量% A hair cosmetic composition for suppressing scalp pimples or roughness, which contains the following components (A), (B) and (C) and has a pH of 2 to 4.3 at 25 ° C. when diluted 20 times by weight with water: .
(A) Malic acid or its salt 0.2-10% by weight
(B) At least one anti-inflammatory agent selected from glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhetinate, glyceryl glycyrrhetinate and stearyl glycyrrhetinate 0.001 to 10% by weight
(C) Higher alcohol having an alkyl group having 12 to 28 carbon atoms 0.1 to 20% by weight
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