JP5714692B2 - Ｉｉｉ型分泌機構の阻害剤の同定方法 - Google Patents

Ｉｉｉ型分泌機構の阻害剤の同定方法 Download PDF

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Publication number
JP5714692B2
JP5714692B2 JP2013500475A JP2013500475A JP5714692B2 JP 5714692 B2 JP5714692 B2 JP 5714692B2 JP 2013500475 A JP2013500475 A JP 2013500475A JP 2013500475 A JP2013500475 A JP 2013500475A JP 5714692 B2 JP5714692 B2 JP 5714692B2
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component
effector
protein
t3ss
antibody
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JP2013500475A
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Japanese (ja)
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JP2013522638A5 (OSRAM
JP2013522638A (ja
Inventor
トーマス・ツェー・マルロヴィッツ
ユリア・ラディクス
ヴォルフガング・シュミート
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Imba Institut Fuer Molekulare Biotechnologie GmbH
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Imba Institut Fuer Molekulare Biotechnologie GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2013500475A 2010-03-23 2011-03-22 Ｉｉｉ型分泌機構の阻害剤の同定方法 Expired - Fee Related JP5714692B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10157397.0 2010-03-23
EP10157397 2010-03-23
PCT/EP2011/054379 WO2011117259A1 (en) 2010-03-23 2011-03-22 Methods for identifying inhibitors of the type iii secretion system

Publications (3)

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JP2013522638A JP2013522638A (ja) 2013-06-13
JP2013522638A5 JP2013522638A5 (OSRAM) 2014-11-13
JP5714692B2 true JP5714692B2 (ja) 2015-05-07

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JP2013500475A Expired - Fee Related JP5714692B2 (ja) 2010-03-23 2011-03-22 Ｉｉｉ型分泌機構の阻害剤の同定方法

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Country Link
US (1) US20130130283A1 (OSRAM)
EP (1) EP2550366B1 (OSRAM)
JP (1) JP5714692B2 (OSRAM)
CA (1) CA2793586A1 (OSRAM)
DK (1) DK2550366T3 (OSRAM)
ES (1) ES2526316T3 (OSRAM)
WO (1) WO2011117259A1 (OSRAM)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
ES2389625T3 (es) * 1996-04-23 2012-10-29 The University Of British Columbia Vacuna que comprende la proteína EspA asociada a Escherichia coli patógena
WO1999045136A1 (en) 1998-03-05 1999-09-10 University Of British Columbia Methods for assaying type iii secretion inhibitors
US6248546B1 (en) * 1998-03-09 2001-06-19 Diagnostic Systems Laboratories, Inc. Assay of IGFBP complex
GB0112687D0 (en) * 2001-05-24 2001-07-18 Microbiological Res Authority Pharmaceutical use of secreted bacterial effector proteins
GB0304993D0 (en) * 2003-03-05 2003-04-09 Univ Nottingham Trent Novel screening method
WO2005113791A2 (en) 2004-05-07 2005-12-01 Johnson & Johnson Product Research And Development Methods of identifying modulators of bacterial type iii protein secretion system
EP1795609A1 (en) * 2005-12-06 2007-06-13 Sanofi-Aventis Deutschland GmbH Method for the diagnosis and treatment of cardiovascular diseases
CA2563214A1 (en) * 2006-10-12 2008-04-12 Institut Pasteur Shigella ipad protein and its use as a potential vaccine against shigella infection
WO2009061491A2 (en) * 2007-11-07 2009-05-14 University Of Massachusetts Type iii secretion inhibitors and uses thereof
WO2009145829A1 (en) 2008-04-01 2009-12-03 University Of Massachusetts Type iii secretion inhibitors, analogs and uses thereof
WO2009137133A2 (en) * 2008-02-14 2009-11-12 University Of Washington 5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection

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Publication number Publication date
ES2526316T3 (es) 2015-01-09
CA2793586A1 (en) 2011-09-29
WO2011117259A9 (en) 2011-11-24
EP2550366A1 (en) 2013-01-30
JP2013522638A (ja) 2013-06-13
WO2011117259A1 (en) 2011-09-29
US20130130283A1 (en) 2013-05-23
EP2550366B1 (en) 2014-11-12
DK2550366T3 (en) 2014-12-15

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