JP5693862B2 - Whitening sunscreen cosmetics - Google Patents

Description

  The present invention relates to cosmetics. More particularly, the present invention relates to a whitening sunscreen cosmetic that has both a whitening effect and a sunscreen effect.

  The UV protection effect exhibited in sunscreen cosmetics is the combination of inorganic UV scattering agents typified by titanium oxide and zinc oxide and various organic UV absorbers typified by cinnamic acid derivatives. It is necessary to combine the two in order to be greatly affected by and to achieve a high UV protection effect.

  For example, in Patent Document 1, in order to achieve a high UV protection effect, a wide variety of UV absorbers including cinnamic acid derivatives and UV scattering agents including titanium oxide and zinc oxide are blended. An oil-in-water or water-in-oil emulsified sunscreen cosmetic capable of achieving a high SPF value is disclosed.

  On the other hand, sunscreen cosmetics contain various drugs in addition to the above-mentioned UV scattering agent and UV absorber, and the drug contains many salt-type substances. Tranexamic acid is also a well-known cosmetic ingredient as a type of whitening agent, and is sometimes incorporated into sunscreen cosmetics. For example, Patent Document 2 discloses a skin external preparation containing tranexamic acid and a derivative thereof as a skin external preparation capable of dramatically enhancing the whitening effect.

JP 2007-145722 A JP 2004-131388 A

  However, when sunscreen cosmetics are blended with zinc oxide as an inorganic UV scattering agent, and when tranexamic acid is used as a whitening agent, zinc tranexamic acid easily precipitates in the cosmetic. It was technically difficult to blend.

  Therefore, cosmetics containing tranexamic acid have a technical problem that zinc oxide cannot be used as an ultraviolet scattering agent, and only titanium oxide can be used. When a large amount of titanium oxide is blended in a sunscreen cosmetic, there is a problem that it is accompanied by whiteness and squeaky feeling when applied.

As a result of diligent researches in view of the above-mentioned problems, the present inventors surprisingly found that when phenylbenzimidazolesulfonic acid was neutralized and blended from among a wide variety of ultraviolet absorbers, suntanned with zinc oxide was blended. The present inventors have found that tranexamic acid can be stably blended in the stop cosmetics and have completed the present invention.
Therefore, in the present invention, by blending zinc oxide without blending titanium oxide as a UV scattering agent, a high UV protection effect can be realized, and usability such as whiteness and squeaky feeling at the time of application can be improved. A remarkable effect is exhibited.

  The present invention is a whitening sunscreen cosmetic that contains tranexamic acid as a UV absorber and a whitening agent. The object is to provide a possible whitening sunscreen cosmetic.

That is, the present invention provides a whitening sunscreen cosmetic comprising the following components (A) to (E): (B) a phenylbenzimidazole sulfonic acid neutralizer is added Provided a whitening sunscreen cosmetic characterized in that the concentration of benzimidazole sulfonic acid is within 10% above and below the concentration (mass%) that is the neutralization point of benzimidazole sulfonic acid, and the precipitation of zinc tranexamic acid is suppressed. To do.
(A) Phenylbenzimidazolesulfonic acid (B) Neutralizing agent for phenylbenzimidazolesulfonic acid (C) Perfluoroalkyl phosphoric acid-alkyl acrylate / dimethylsilicone copolymer-coated low-temperature-fired zinc oxide or low-temperature-fired zinc oxide-dextrin palmitate Mixture (D) Tranexamic acid (E) Water

The present invention also provides the whitening sunscreen cosmetic described above, wherein the component (B) neutralizing agent for phenylbenzimidazolesulfonic acid is triethanolamine.
Furthermore, the present invention provides the above-described whitening sunscreen cosmetic, characterized by not containing titanium oxide in the above-mentioned whitening sunscreen cosmetic.

  According to the present invention, even if tranexamic acid is blended in a sunscreen cosmetic blended with zinc oxide as an ultraviolet scattering agent, precipitation of zinc tranexamic acid can be suppressed. Therefore, even in a whitening sunscreen cosmetic containing a UV absorber and a whitening agent tranexamic acid, zinc oxide can be stably added as an UV scattering agent. Therefore, a novel whitening sunscreen cosmetic that is extremely excellent in UV protection effect is provided.

  In the present invention, since zinc oxide can be blended as an ultraviolet scattering agent, it is not necessary to blend a large amount of titanium oxide. Therefore, the remarkable effect that the usability such as whiteness and squeakiness at the time of application due to the titanium oxide blending can be improved is exhibited.

<(A) Phenylbenzimidazolesulfonic acid>
The phenylbenzimidazole sulfonic acid used in the present invention is a known water-soluble ultraviolet absorber. Since it is a water-soluble ultraviolet absorber, it is easy to blend the target amount into water-soluble sunscreen cosmetics, oil-in-water emulsified cosmetics, water-in-oil emulsified cosmetics, and the like.
In the present invention, a commercial product of phenylbenzimidazole sulfonic acid can be used (Eusolex 232, manufactured by Merck KGaA).

<Blending amount>
The blending amount of phenylbenzimidazolesulfonic acid with respect to the total amount of whitening sunscreen makeup is preferably 0.01 to 5% by mass, more preferably 0.1 to 3% by mass, and most preferably 0.5 to 2.5% by mass. is there.

<(B) Neutralizing agent for phenylbenzimidazolesulfonic acid>
Phenylbenzimidazole sulfonic acid blended as a UV absorber must be neutralized with an alkali neutralizer in the formulation. Examples of the neutralizing agent include inorganic hydroxides such as NaOH and KOH, and organic amines. The most preferred neutralizing agent for the present invention is triethanolamine.

<Blending amount>
The blending amount of the neutralizing agent is appropriately determined depending on the phenylbenzimidazole sulfonic acid to be blended. The amount is suitable for neutralizing phenylbenzimidazolesulfonic acid. Specifically, the concentration may be about 10% above and below the concentration (mass%) serving as the neutralization point of the blended phenylbenzimidazolesulfonic acid. For example, when the concentration serving as the neutralization point is 3% by mass, the concentration is within the range of 2.7% by mass to 3.3% by mass.

<(C) Zinc oxide>
In the present invention, zinc oxide powder is blended as an ultraviolet scattering agent. The average particle diameter of the powder is not particularly limited as long as it has a particle diameter usually used as an ultraviolet scattering agent.
The zinc oxide powder is not limited. As a commercial product, a perfluoroalkyl phosphate-alkyl acrylate / dimethylsilicone copolymer-coated low-temperature fired zinc oxide or a low-temperature fired zinc oxide-palmitate dextrin mixture is preferably used.
In the present invention, since zinc oxide can be used, it is not always necessary to use titanium oxide as an ultraviolet absorber. Of course, it is possible to use in combination as long as the effects of the present invention are not impaired. However, when titanium oxide is used in combination, whiteness and squeaky sensation may be caused at the time of application due to the titanium oxide combination. Therefore, in this invention, it is preferable not to mix | blend a titanium oxide substantially.

<Blending amount>
The blending amount of zinc oxide with respect to the total amount of whitening sunscreen makeup is preferably 0.1 to 50% by mass, more preferably 1 to 20% by mass, and most preferably 3 to 15% by mass.

<(D) Tranexamic acid>
Tranexamic acid used in the present invention is trans-4aminomethylcyclohexanecarboxylic acid, which is a known drug as a cosmetic ingredient. Often used as a whitening agent. When used in combination with zinc oxide powder as a whitening sunscreen cosmetic, zinc tranexamic acid was precipitated as crystals, and thus could not be used in combination, but was made possible by the present invention. This effect is a huge technological advance.

<Blending amount>
The amount of tranexamic acid based on the total amount of whitening sunscreen makeup is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass, and most preferably 1 to 2% by mass.

<(E) Water>
In the present invention, water is an essential component for dissolving or neutralizing phenylbenzimidazolesulfonic acid, which is a water-soluble ultraviolet absorber. Ion exchange water is preferred.

<Blending amount>
The blending amount of water relative to the total amount of whitening sunscreen makeup is preferably 5 to 95% by mass, more preferably 10 to 70% by mass, and most preferably 20 to 45% by mass.
In addition, the compounding quantity of water is suitably determined with the oil component to mix | blend with the cosmetics of this invention whether it is an oil-in-water type emulsion cosmetic or a water-in-oil type emulsion cosmetic.

The cosmetics of the present invention include other components usually used in cosmetics in addition to the essential constituents described above, such as powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, esters. Oil, silicone oil, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, moisturizer, water-soluble polymer, thickener, film agent, UV absorber, sequestering agent, Lower alcohol, polyhydric alcohol, sugar, amino acid, organic amine, polymer emulsion, pH adjuster, skin nutrient, vitamin, antioxidant, antioxidant assistant, fragrance, etc. According to the dosage form, it can manufacture by a conventional method.
In the present invention, from the viewpoint of usability, it is preferably prepared as an emulsion such as a water-in-oil emulsified cosmetic or an oil-in-water emulsified cosmetic. These emulsions (water-in-oil emulsified cosmetics or oil-in-water emulsified cosmetics) are produced by emulsifying by an ordinary method by appropriately selecting an oil, water and a surfactant.

  Hereinafter, the present invention will be described more specifically with reference to examples. The present invention is not limited to these examples. Unless otherwise specified, the blending amounts in the examples are indicated by mass%.

  An aqueous solution of a whitening sunscreen cosmetic was prepared according to the following formulation, and the crystal precipitation state of zinc tranexamate was confirmed. From the results of “Table 1”, the aqueous solutions of Examples 1 and 2 in which all the essential components (A) to (E) of the present invention are blended are accelerated in crystal growth as compared with other aqueous solutions (Comparative Examples 1 to 4). At the bottom (70 ° C., storage for a certain period of time), a very significant difference in crystal precipitation suppression effect was observed.

＊１：パーフルオロアルキルリン酸−アクリル酸アルキル・ジメチルシリコンコポリマー被覆低温焼成酸化亜鉛
＊２：低温焼成酸化亜鉛−パルミチン酸デキストリン混合物

* 1: Perfluoroalkyl phosphate-alkyl acrylate / dimethylsilicone copolymer coated low-temperature fired zinc oxide * 2: Low-temperature fired zinc oxide-dextrin palmitate dextrin mixture

<Determination of crystal precipitation>
○ Precipitation of zinc tranexamate is not confirmed during microscopic observation.
Δ: Precipitation of zinc tranexamate is slightly confirmed during microscopic observation.
X Precipitation of zinc tranexamic acid is confirmed in large quantities during microscopic observation.

A milky lotion (water-in-oil emulsified cosmetic) was produced by a conventional method with the following formulation, and the crystal precipitation state of zinc tranexamate was confirmed.
From the results shown in Table 2, Example 3 in which phenylbenzimidazolesulfonic acid, an ultraviolet absorber, was neutralized with triethanolamine was more accelerated than in Comparative Example 5 in which the neutralized product was not blended. At 70 ° C. and 50 ° C. under storage for a certain period of time, a very significant difference in crystal precipitation suppression effect was observed.

<Determination of crystal precipitation>
○ Precipitation of zinc tranexamate is not confirmed during microscopic observation.
Δ: Precipitation of zinc tranexamate is slightly confirmed during microscopic observation.
X Precipitation of zinc tranexamic acid is confirmed in large quantities during microscopic observation.

  The other whitening sunscreen cosmetics of the present invention are shown below. Both are emulsions in which crystal precipitation of zinc tranexamate is suppressed and is excellent in stability and usability.

[Example 4: Water-in-oil type emulsion sunscreen emulsion]
Compounding ingredients Mass%
(1) Decamethylcyclopentasiloxane 20
(2) PEG-9 polydimethylsiloxyethyl dimethicone 2
(3) Trimethylsiloxysilicic acid-decamethylcyclopentasiloxane solution
0.5
(4) Dimethylpolysiloxane 5
(5) Isostearic acid 0.5
(6) Cetyl 2-ethylhexanoate 3
(7) Diisopropyl sebacate 2
(8) 2-Ethylhexyl paramethoxycinnamate 7.5
(9) Polypropylene glycol 2
(10) Perfume appropriate amount (11) quaternium-18-hectorite 0.2
(12) Low-temperature calcined zinc oxide-dextrin palmitate mixture 15
(13) Silica-containing spherical polyalkyl acrylate 5
(14) Methylpolysiloxane-coated talc 1
(15) Water 28.2
(16) Tranexamic acid 2
(17) edetate trisodium 0.3
(18) Glycerin 2
(19) Phenoxyethanol 0.5
(20) Phenylbenzimidazolesulfonic acid 2
(21) Triethanolamine 1.2
[Production method]
The oil phases (1) to (10) are mixed and dissolved. Next, (11) to (14) are added and dispersed and mixed with a disper. (20) is neutralized and dissolved in (21), (15) to (21) are mixed and dissolved, then gradually added to the oil phase with stirring with a disper, and mixed sufficiently uniformly to obtain the desired sunscreen. An emulsion was obtained.

[Example 5: Water-in-oil type emulsion sunscreen emulsion]
Compounding ingredients Mass%
(1) Decamethylcyclopentasiloxane 22
(2) Polyoxyethylene / methylpolysiloxane copolymer 2
(3) Trimethylsiloxysilicic acid-decamethylcyclopentasiloxane solution
1
(4) Dimethylpolysiloxane 3
(5) Cetyl 2-ethylhexanoate 3
(6) Diisopropyl sebacate 5
(7) 2-Ethylhexyl paramethoxycinnamate 5
(8) Perfume appropriate amount (9) quaternium-18-hectorite 0.3
(10) Low-temperature calcined zinc oxide-dextrin palmitate mixture 7
(11) Surface-treated titanium oxide (TTO-S-4) 8
(12) Methylsiloxane network polymer 3
(13) Water 30
(14) Tranexamic acid 2
(15) Dipropylene glycol 5
(16) edetate trisodium 0.05
(17) Erythritol 0.1
(18) Polyoxyethylene (14) Polyoxypropylene (7) Dimethyl ether
0.5
(19) Phenoxyethanol 0.5
(20) Phenylbenzimidazolesulfonic acid 1
(21) Triethanolamine 0.6
[Production method]
The oil phases (1) to (8) are mixed and dissolved. Next, (9) to (12) are added and dispersed and mixed with a disper. (20) is neutralized and dissolved in (21), (13) to (21) are mixed and dissolved, then gradually added to the oil phase with stirring with a disper, and mixed sufficiently uniformly to obtain the desired sunscreen. An emulsion was obtained.

[Example 6: Oil-in-water sunscreen emulsion]
Compounding ingredients Mass%
(1) Water Residue (2) Sodium metaphosphate 0.05
(3) edetate disodium 0.05
(4) Crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer 0.15
(5) Glycerin 3
(6) Succinoglycan 0.3
(7) Sodium carboxymethyl cellulose 0.1
(8) Phenylbenzimidazolesulfonic acid 0.5
(9) Triethanolamine 0.3
(10) Tranexamic acid 2
(11) 2-ethylhexyl paramethoxycinnamate 5
(12) Methylphenylpolysiloxane 2
(13) Glyceryl tri-2-ethylhexanoate 3
(14) Polyoxyethylene hydrogenated castor oil 1
(15) Polyoxyethylene sorbitan monooleate 0.3
(16) Polyoxyethylene polyoxypropylene decyl tetradecyl ether
0.6
(17) Light isoparaffin 5
(18) Isostearic acid 1
(19) Distearyldimethylammonium chloride 0.2
(20) Perfume appropriate amount (21) Low temperature calcined zinc oxide-dextrin palmitate mixture 5
(22) Ethanol 7
(23) Phenoxyethanol 0.5
[Production method]
The oil phase of (11) to (20), in which (21) is dispersed, is gradually added to the aqueous phase in which (1) to (10) is dissolved, while stirring with a disper, and (22) to (23) Preservatives were mixed thoroughly enough to obtain the desired sunscreen emulsion.

According to the present invention, in a whitening sunscreen cosmetic containing tranexamic acid as a specific ultraviolet absorber and whitening agent, whitening capable of stably blending tranexamic acid and zinc oxide while suppressing precipitation of zinc tranexamic acid. Sunscreen cosmetics can be provided.
The present invention is suitably used as an emulsion product such as a water-in-oil emulsified cosmetic or an oil-in-water emulsified cosmetic which is a whitening sunscreen cosmetic.

Claims (3)

In the whitening sunscreen cosmetic characterized by blending the following components (A) to (E), the blending amount of the neutralizing agent of (B) phenylbenzimidazole sulfonic acid is A whitening sunscreen cosmetic characterized by suppressing the precipitation of zinc tranexamic acid within 10% of the concentration centering on the concentration (mass%) serving as a sum point.
(A) Phenylbenzimidazolesulfonic acid (B) Neutralizing agent for phenylbenzimidazolesulfonic acid (C) Perfluoroalkyl phosphoric acid-alkyl acrylate / dimethylsilicone copolymer-coated low-temperature-fired zinc oxide or low-temperature-fired zinc oxide-dextrin palmitate Mixture (D) Tranexamic acid (E) Water   2. The whitening sunscreen cosmetic according to claim 1, wherein the neutralizing agent for component (B) phenylbenzimidazolesulfonic acid is triethanolamine. 3. The whitening sunscreen cosmetic according to claim 1 or 2, wherein the whitening sunscreen cosmetic according to claim 1 or 2 does not contain titanium oxide .