JP5688363B2 - 顆粒球−マクロファージコロニー刺激因子に対する抗体 - Google Patents

顆粒球−マクロファージコロニー刺激因子に対する抗体 Download PDF

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JP5688363B2
JP5688363B2 JP2011507586A JP2011507586A JP5688363B2 JP 5688363 B2 JP5688363 B2 JP 5688363B2 JP 2011507586 A JP2011507586 A JP 2011507586A JP 2011507586 A JP2011507586 A JP 2011507586A JP 5688363 B2 JP5688363 B2 JP 5688363B2
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antibody
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csf
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JP2011518886A (ja
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クリストファー アール. ベッビントン
クリストファー アール. ベッビントン
ケニス ルーエールセン
ケニス ルーエールセン
ジェフリー ティー. ヤラントン
ジェフリー ティー. ヤラントン
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カロバイオス ファーマシューティカルズ インコーポレイティッド
カロバイオス ファーマシューティカルズ インコーポレイティッド
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243Colony Stimulating Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
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JP2011507586A 2008-04-28 2009-04-28 顆粒球−マクロファージコロニー刺激因子に対する抗体 Active JP5688363B2 (ja)

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Application Number Priority Date Filing Date Title
US4852208P 2008-04-28 2008-04-28
US61/048,522 2008-04-28
PCT/US2009/041981 WO2009134805A2 (en) 2008-04-28 2009-04-28 Antibodies to granulocyte-macrophage colony-stimulating factor

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JP2011518886A JP2011518886A (ja) 2011-06-30
JP2011518886A5 JP2011518886A5 (enExample) 2012-06-21
JP5688363B2 true JP5688363B2 (ja) 2015-03-25

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US (3) US8168183B2 (enExample)
EP (2) EP3449941A1 (enExample)
JP (1) JP5688363B2 (enExample)
KR (2) KR101852915B1 (enExample)
CN (1) CN102037016B (enExample)
AU (1) AU2009243184B2 (enExample)
BR (1) BRPI0911902A2 (enExample)
CA (1) CA2722137C (enExample)
CO (1) CO6311004A2 (enExample)
DK (1) DK2280732T3 (enExample)
EA (1) EA201001691A1 (enExample)
ES (1) ES2704835T3 (enExample)
IL (1) IL208980A (enExample)
MX (1) MX2010011761A (enExample)
NZ (1) NZ588850A (enExample)
WO (1) WO2009134805A2 (enExample)
ZA (1) ZA201008028B (enExample)

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CN101506235B (zh) 2006-09-01 2012-07-25 人类多细胞株治疗学公司 人或人源化免疫球蛋白在非人转基因动物中增强的表达
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
JP5688363B2 (ja) 2008-04-28 2015-03-25 カロバイオス ファーマシューティカルズ インコーポレイティッド 顆粒球−マクロファージコロニー刺激因子に対する抗体
ES2978209T3 (es) 2008-12-22 2024-09-09 Univ Melbourne Tratamiento del dolor
US9243061B2 (en) * 2008-12-22 2016-01-26 University Of Melbourne Osteoarthritis treatment
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KR20140061379A (ko) 2011-07-06 2014-05-21 모르포시스 아게 항­cd20 및 항­gm­csf 항체의 치료 조합물 및 이의 용도
US9400600B2 (en) * 2011-12-16 2016-07-26 Samsung Electronics Co., Ltd. Method, apparatus, and graphical user interface for providing visual effects on a touchscreen display
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EP2914289B1 (en) 2012-10-31 2019-05-22 Takeda GmbH Lyophilized formulation comprising gm-csf neutralizing compound
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
KR20220045064A (ko) * 2013-08-30 2022-04-12 다케다 야쿠힌 고교 가부시키가이샤 류마티스성 관절염의 치료에서 또는 진통제로서 사용하기 위한 gm-csf 중화 항체
BR112016025126B1 (pt) 2014-05-07 2024-02-15 Takeda Pharmaceutical Company Limited Composição aquosa compreendendo anticorpo neutralizante de gmcsf, e uso da mesma
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US11673962B2 (en) 2017-10-02 2023-06-13 Humanigen, Inc. Method of increasing the efficacy of CAR-T immunotherapy using lenzilumab
US11130805B2 (en) 2017-10-02 2021-09-28 Humanigen, Inc. Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist
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JP5688363B2 (ja) 2008-04-28 2015-03-25 カロバイオス ファーマシューティカルズ インコーポレイティッド 顆粒球−マクロファージコロニー刺激因子に対する抗体

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ZA201008028B (en) 2012-04-25
US9017674B2 (en) 2015-04-28
IL208980A (en) 2015-06-30
KR20110011638A (ko) 2011-02-08
US20090274706A1 (en) 2009-11-05
CN102037016A (zh) 2011-04-27
BRPI0911902A2 (pt) 2015-10-13
KR101824512B1 (ko) 2018-02-02
EA201001691A1 (ru) 2011-10-31
IL208980A0 (en) 2011-01-31
CA2722137A1 (en) 2009-11-05
AU2009243184B2 (en) 2015-06-04
US8168183B2 (en) 2012-05-01
EP2280732A2 (en) 2011-02-09
NZ588850A (en) 2012-12-21
ES2704835T3 (es) 2019-03-20
WO2009134805A3 (en) 2010-06-03
US20150344565A1 (en) 2015-12-03
US20120213776A1 (en) 2012-08-23
CO6311004A2 (es) 2011-08-22
EP2280732A4 (en) 2012-11-14
CN102037016B (zh) 2015-06-03
CA2722137C (en) 2019-03-19
EP2280732B1 (en) 2018-10-17
JP2011518886A (ja) 2011-06-30
EP3449941A1 (en) 2019-03-06
MX2010011761A (es) 2010-11-30
AU2009243184A1 (en) 2009-11-05
KR101852915B1 (ko) 2018-04-27
DK2280732T3 (en) 2019-01-28
KR20170126458A (ko) 2017-11-17
WO2009134805A2 (en) 2009-11-05

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