JP5685601B2 - ナノ流体バイオセンサ及び溶液中における生体分子の相互作用の迅速測定のためのその活用及び方法 - Google Patents
ナノ流体バイオセンサ及び溶液中における生体分子の相互作用の迅速測定のためのその活用及び方法 Download PDFInfo
- Publication number
- JP5685601B2 JP5685601B2 JP2012540523A JP2012540523A JP5685601B2 JP 5685601 B2 JP5685601 B2 JP 5685601B2 JP 2012540523 A JP2012540523 A JP 2012540523A JP 2012540523 A JP2012540523 A JP 2012540523A JP 5685601 B2 JP5685601 B2 JP 5685601B2
- Authority
- JP
- Japan
- Prior art keywords
- biomolecule
- biosensor
- solution
- nanoslit
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 10
- 230000003993 interaction Effects 0.000 title claims description 9
- 238000005259 measurement Methods 0.000 title claims description 5
- 230000003287 optical effect Effects 0.000 claims description 15
- 238000001514 detection method Methods 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000009792 diffusion process Methods 0.000 claims description 4
- 238000011109 contamination Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 235000012431 wafers Nutrition 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 3
- 229910021417 amorphous silicon Inorganic materials 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 239000002090 nanochannel Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 238000004186 food analysis Methods 0.000 description 1
- 102000034238 globular proteins Human genes 0.000 description 1
- 108091005896 globular proteins Proteins 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003368 label free method Methods 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 238000004094 preconcentration Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000001039 wet etching Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01824/09 | 2009-11-27 | ||
CH18242009 | 2009-11-27 | ||
PCT/IB2010/055305 WO2011064701A1 (en) | 2009-11-27 | 2010-11-19 | Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013512428A JP2013512428A (ja) | 2013-04-11 |
JP5685601B2 true JP5685601B2 (ja) | 2015-03-18 |
Family
ID=43639465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012540523A Active JP5685601B2 (ja) | 2009-11-27 | 2010-11-19 | ナノ流体バイオセンサ及び溶液中における生体分子の相互作用の迅速測定のためのその活用及び方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9452927B2 (zh) |
EP (1) | EP2504684B1 (zh) |
JP (1) | JP5685601B2 (zh) |
CN (1) | CN102762971B (zh) |
AU (1) | AU2010322751B2 (zh) |
BR (1) | BR112012012787B1 (zh) |
CA (1) | CA2782009C (zh) |
HK (1) | HK1175527A1 (zh) |
WO (1) | WO2011064701A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2684027B1 (en) | 2011-03-09 | 2019-12-11 | Abionic SA | Rapid quantification of biomolecules in a selectively functionalized nanofluidic biosensor and method thereof |
WO2015007559A1 (en) * | 2013-07-17 | 2015-01-22 | Abionic Sa | Method and device for bioassays |
EP3080589B1 (en) * | 2013-12-13 | 2019-05-22 | Abionic SA | Gas evacuation system for nanofluidic biosensor |
CA2953755C (en) | 2014-07-03 | 2022-05-03 | Abionic Sa | Capsule for rapid molecular quantification of a fluid sample such as whole blood |
JP6880001B2 (ja) | 2015-08-28 | 2021-06-02 | ヴェンタナ メディカル システムズ, インク. | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5370842A (en) | 1991-11-29 | 1994-12-06 | Canon Kabushiki Kaisha | Sample measuring device and sample measuring system |
JP2832117B2 (ja) * | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
US6248539B1 (en) * | 1997-09-05 | 2001-06-19 | The Scripps Research Institute | Porous semiconductor-based optical interferometric sensor |
JP4010171B2 (ja) | 2001-04-16 | 2007-11-21 | 東ソー株式会社 | 微小流路構造体、その製造方法及びその用途 |
US7201873B2 (en) | 2001-04-16 | 2007-04-10 | Tosoh Corporation | Fine channel device, method for producing the fine channel device and use of the same |
CA2459570A1 (en) | 2001-09-05 | 2003-03-13 | Genicon Sciences Corporation | Apparatus for reading signals generated from resonance light scattered particle labels |
AU2003248273A1 (en) | 2002-07-12 | 2004-02-02 | Mitsubishi Chemical Corporation | Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip |
JP3991034B2 (ja) | 2004-01-23 | 2007-10-17 | キヤノン株式会社 | 検出方法 |
GB0411162D0 (en) | 2004-05-19 | 2004-06-23 | Precisense As | Optical sensor for in vivo detection of analyte |
US7262859B2 (en) | 2004-10-13 | 2007-08-28 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
US7405434B2 (en) | 2004-11-16 | 2008-07-29 | Cornell Research Foundation, Inc. | Quantum dot conjugates in a sub-micrometer fluidic channel |
US8945909B2 (en) | 2007-04-25 | 2015-02-03 | The Regents Of The University Of Michigan | Tunable elastomeric nanochannels for nanofluidic manipulation |
US20090214392A1 (en) | 2008-02-27 | 2009-08-27 | The Texas A&M University System | Nano-fluidic Trapping Device for Surface-Enhanced Raman Spectroscopy |
US9810680B2 (en) * | 2009-04-16 | 2017-11-07 | Nanonex Corporation | Nanogap electronic detector for measuring properties of a biomolecule stretched in a nanochannel, and method thereof |
-
2010
- 2010-11-19 CN CN201080053842.3A patent/CN102762971B/zh active Active
- 2010-11-19 EP EP10805319.0A patent/EP2504684B1/en active Active
- 2010-11-19 JP JP2012540523A patent/JP5685601B2/ja active Active
- 2010-11-19 CA CA2782009A patent/CA2782009C/en active Active
- 2010-11-19 US US13/511,805 patent/US9452927B2/en active Active
- 2010-11-19 WO PCT/IB2010/055305 patent/WO2011064701A1/en active Application Filing
- 2010-11-19 BR BR112012012787A patent/BR112012012787B1/pt active IP Right Grant
- 2010-11-19 AU AU2010322751A patent/AU2010322751B2/en active Active
-
2013
- 2013-02-26 HK HK13102396.1A patent/HK1175527A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2013512428A (ja) | 2013-04-11 |
BR112012012787A2 (pt) | 2016-08-16 |
HK1175527A1 (zh) | 2013-07-05 |
CA2782009A1 (en) | 2011-06-03 |
EP2504684C0 (en) | 2023-11-15 |
BR112012012787B1 (pt) | 2019-12-17 |
AU2010322751A1 (en) | 2012-06-21 |
CN102762971B (zh) | 2015-05-27 |
CA2782009C (en) | 2017-10-03 |
US20130017967A1 (en) | 2013-01-17 |
AU2010322751B2 (en) | 2014-05-29 |
US9452927B2 (en) | 2016-09-27 |
CN102762971A (zh) | 2012-10-31 |
EP2504684B1 (en) | 2023-11-15 |
WO2011064701A1 (en) | 2011-06-03 |
EP2504684A1 (en) | 2012-10-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2829178C (en) | Rapid quantification of biomolecules in a selectively functionalized nanofluidic biosensor and method thereof | |
JPWO2004036194A1 (ja) | 分析チップおよび分析装置 | |
JP2011196849A (ja) | 回転式分析チップおよびそれを用いた測定システム | |
JP5685601B2 (ja) | ナノ流体バイオセンサ及び溶液中における生体分子の相互作用の迅速測定のためのその活用及び方法 | |
JP5994116B2 (ja) | 回転式分析チップおよび測定システム | |
US8938103B2 (en) | Apparatus and method for detecting and measuring biomolecular interactions | |
AU2014363071B2 (en) | Gas evacuation system for nanofluidic biosensor | |
EP3021968B1 (en) | Method and device for bioassays |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131108 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140310 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140408 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140624 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140812 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141104 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150106 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150119 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5685601 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |