JP5681723B2 - ２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 - Google Patents
２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 Download PDFInfo
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- JP5681723B2 JP5681723B2 JP2012540093A JP2012540093A JP5681723B2 JP 5681723 B2 JP5681723 B2 JP 5681723B2 JP 2012540093 A JP2012540093 A JP 2012540093A JP 2012540093 A JP2012540093 A JP 2012540093A JP 5681723 B2 JP5681723 B2 JP 5681723B2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Immunology (AREA)
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- Molecular Biology (AREA)
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- Dermatology (AREA)
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- Pulmonology (AREA)
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- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26316909P | 2009-11-20 | 2009-11-20 | |
| US61/263,169 | 2009-11-20 | ||
| PCT/US2010/057442 WO2011063241A1 (en) | 2009-11-20 | 2010-11-19 | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013511547A JP2013511547A (ja) | 2013-04-04 |
| JP2013511547A5 JP2013511547A5 (https=) | 2014-01-16 |
| JP5681723B2 true JP5681723B2 (ja) | 2015-03-11 |
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|---|---|---|---|
| JP2012540093A Expired - Fee Related JP5681723B2 (ja) | 2009-11-20 | 2010-11-19 | ２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8389515B2 (https=) |
| EP (1) | EP2501705B1 (https=) |
| JP (1) | JP5681723B2 (https=) |
| CA (1) | CA2780777C (https=) |
| ES (1) | ES2524127T3 (https=) |
| WO (1) | WO2011063241A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| JP5681723B2 (ja) | 2009-11-20 | 2015-03-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 |
| CA2792278C (en) | 2010-04-13 | 2019-05-14 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| HRP20190186T4 (hr) | 2011-07-28 | 2024-12-20 | Rigel Pharmaceuticals, Inc. | Nove formulacije (trimetoksifenilamino)pirimidinila |
| US9480745B2 (en) | 2012-02-29 | 2016-11-01 | University Hospitals Cleveland Medical Center | Targeted treatment of anerobic cancer |
| CN103958526B (zh) * | 2012-06-20 | 2015-09-09 | 上海恒瑞医药有限公司 | 嘧啶二胺类衍生物、其制备方法及其在医药上的应用 |
| RU2519546C1 (ru) * | 2013-01-16 | 2014-06-10 | Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") | КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а |
| SI3083648T1 (sl) * | 2013-12-20 | 2019-02-28 | Rigel Pharmaceuticals, Inc., | Farmacevtski postopek in vmesne spojine |
| US10981951B2 (en) * | 2014-01-31 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Therapeutics for the treatment of glaucoma |
| CA3159771A1 (en) | 2019-12-12 | 2021-06-17 | Thurein M. Htoo | Controlled-delivery cromakalim prodrugs |
| WO2022175829A1 (en) * | 2021-02-17 | 2022-08-25 | Cellix Bio Private Limited | Topical formulations and compositions |
| US20250017895A1 (en) * | 2021-11-29 | 2025-01-16 | The Children's Hospital Of Philadelphia | Flavanoid containing compositions and methods of use thereof for the treatment of mitochondrial disorders |
| CN119431398A (zh) * | 2023-07-31 | 2025-02-14 | 中国科学院上海有机化学研究所 | R406及其衍生物协同trail的抗肿瘤应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| FR2785284B1 (fr) | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6924400B2 (en) | 2001-12-10 | 2005-08-02 | Galderma Research & Development, Snc | Triaromatic vitamin D analogues |
| US6849245B2 (en) * | 2001-12-11 | 2005-02-01 | Catalytic Materials Llc | Catalysts for producing narrow carbon nanostructures |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| HRP20050089B1 (hr) * | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| EP1635773A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. (a New Jersey corp.) | Combination therapy for the treatment of hypertension |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| ATE506953T1 (de) * | 2003-08-07 | 2011-05-15 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
| US20070092888A1 (en) | 2003-09-23 | 2007-04-26 | Cornelius Diamond | Diagnostic markers of hypertension and methods of use thereof |
| AU2006206458B2 (en) * | 2005-01-19 | 2012-10-25 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| US8227455B2 (en) * | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
| US7713987B2 (en) * | 2005-12-06 | 2010-05-11 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2,4-diamines and their uses |
| JP2008013527A (ja) * | 2006-07-10 | 2008-01-24 | Sankyo Co Ltd | チエノ［３，２−ｄ］ピリミジン−２，４−ジアミン誘導体 |
| ATE540041T1 (de) * | 2006-11-21 | 2012-01-15 | Rigel Pharmaceuticals Inc | Prodrug-salze von 2,4-pyrimidindiaminverbindungen und anwendungen davon |
| JP5815411B2 (ja) * | 2008-12-30 | 2015-11-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ピリミジンジアミンキナーゼ阻害剤 |
| JP5681723B2 (ja) | 2009-11-20 | 2015-03-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 |
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2010
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- 2010-11-19 ES ES10782509.3T patent/ES2524127T3/es active Active
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- 2010-11-19 EP EP10782509.3A patent/EP2501705B1/en not_active Not-in-force
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| Publication number | Publication date |
|---|---|
| US20110124599A1 (en) | 2011-05-26 |
| WO2011063241A1 (en) | 2011-05-26 |
| JP2013511547A (ja) | 2013-04-04 |
| US8642593B2 (en) | 2014-02-04 |
| EP2501705A1 (en) | 2012-09-26 |
| CA2780777C (en) | 2017-12-05 |
| US20130150329A1 (en) | 2013-06-13 |
| EP2501705B1 (en) | 2014-08-27 |
| US8389515B2 (en) | 2013-03-05 |
| CA2780777A1 (en) | 2011-05-26 |
| ES2524127T3 (es) | 2014-12-04 |
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