JP5677313B2 - 薬物送達デバイス - Google Patents
薬物送達デバイス Download PDFInfo
- Publication number
- JP5677313B2 JP5677313B2 JP2011542795A JP2011542795A JP5677313B2 JP 5677313 B2 JP5677313 B2 JP 5677313B2 JP 2011542795 A JP2011542795 A JP 2011542795A JP 2011542795 A JP2011542795 A JP 2011542795A JP 5677313 B2 JP5677313 B2 JP 5677313B2
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- cap
- delivery device
- drug delivery
- housing
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000012377 drug delivery Methods 0.000 title claims description 73
- 239000003814 drug Substances 0.000 claims description 40
- 229940079593 drug Drugs 0.000 claims description 40
- 230000013011 mating Effects 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 description 20
- 230000008901 benefit Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000011521 glass Substances 0.000 description 4
- 230000004913 activation Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
グ手段は、L型形状であってもよい。
1 ハウジング
2 キャップ
4 設定手段
5 ピストンロッド
6 栓
7 窓
8 ニードルユニット
9 針
11 ハウジングの遠位部分
12 ハウジングの近位部分
16 クリップの第一の部分
17 クリップの第二の部分
18 開口部
21 キャップの近位端
22 凹部
31、32、33、34 矢印
51 ピストンロッドの第一の部分
52 ピストンロッドの第二の部分
111 使い捨てユニット
113 ロッキング手段
114 使い捨てユニットのフィッティング
121 カートリッジ
171 クリップの第二の部分の遠位端
172 クリップの第二の部分の近位端
221 アンダーカット部
Claims (14)
- 薬物送達デバイスであって:
−ハウジング(1);
−ハウジング(1)に取り付けられるように構成されるキャップ(2);
−キャップ(2)をロックするように構成されるロッキング手段(16、17);
を含み、
ここで、第一の状態において、キャップ(2)は取り外し可能であり、そして第二の状態において、キャップ(2)が取り付けられると、ロッキング手段(16、17)がキャップ(2)をロックし、薬物送達デバイスが、薬物の多数用量を送達するように構成され、そして最終用量が送達されたとき、キャップ(2)が取り付けられると、キャップ(2)がロックされ、薬物送達デバイスが送達すべき薬物を含有するように構成され、そして薬物の所定の量と同量又はそれより少ない量が、薬物送達デバイスに含有されているとき、キャップ(2)が取り付けられると、ロッキング手段(16、17)がキャップをロックし、薬物送達デバイスはさらに、可動エレメント(5)を含み、ここで、キャップ(2)が取り付けられると、エレメント(5)が所定の位置に位置するとき、ロッキング手段(16、17)がキャップ(2)をロックし、所定の位置は最終用量が送達されたときエレメント(5)が到達する位置であり、そしてここでロッキング手段は、エレメント(5)が所定の位置に到達したとき、ハウジングから突出するように構成されている、
薬物送達デバイス。 - キャップ(2)がロックされるとき、キャップ(2)及びハウジング(1)が、薬物を封入するように構成される請求項1に記載の薬物送達デバイス。
- エレメント(5)が、並進的に可動である請求項1又は2に記載の薬物送達デバイス。
- エレメント(5)が、ピストンロッドとして設計される請求項1〜3のいずれか1項に記載の薬物送達デバイス。
- ロッキング手段(16、17)は、エレメント(5)が所定の位置に位置するときに、
ロッキング手段(16、17)が突出するように、エレメント(5)と連結される請求項1〜4のいずれか1項に記載の薬物送達デバイス。 - ハウジング(1)が、ロッキング手段(16、17)が開口部(18)を介して押し出されるように設計される開口部(18)を含む請求項1〜5のいずれか1項に記載の薬物送達デバイス。
- ロッキング手段(16、17)が、ハウジング(1)と一体的に形成される請求項1〜6のいずれか1項に記載の薬物送達デバイス。
- キャップ(2)が、ロッキング手段と係合可能である嵌め合い手段(22)を含む請求項1〜7のいずれか1項に記載の薬物送達デバイス。
- 嵌め合い手段(22)が凹部として形成される請求項8に記載の薬物送達デバイス。
- キャップ(2)が取り付けられると、第二の状態中、キャップ(2)は恒久的にロックされる請求項1〜9のいずれか1項に記載の薬物送達デバイス。
- ハウジング(1)が交換可能なカートリッジ(121)を含有するように構成され、そしてカートリッジ(121)が除去されるとき、ロックされたキャップ(2)がロックを解除される請求項1〜9のいずれか1項に記載の薬物送達デバイス。
- ハウジングが使い捨てユニット(111)を含み、そしてキャップ(2)がロックされると、使い捨てユニット(111)は除去可能となる請求項1〜11のいずれか1項に記載の薬物送達デバイス。
- キャップ(2)及び使い捨てユニット(111)が、カートリッジ(121)を封入するように構成される請求項12に記載の薬物送達デバイス。
- 薬物送達デバイスがペン型薬物送達デバイスとして形成される請求項1〜13のいずれか1項に記載の薬物送達デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08022329A EP2201975A1 (en) | 2008-12-23 | 2008-12-23 | Medication delivery device |
EP08022329.0 | 2008-12-23 | ||
PCT/EP2009/067609 WO2010072698A1 (en) | 2008-12-23 | 2009-12-21 | Medication delivery device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012513269A JP2012513269A (ja) | 2012-06-14 |
JP2012513269A5 JP2012513269A5 (ja) | 2013-01-31 |
JP5677313B2 true JP5677313B2 (ja) | 2015-02-25 |
Family
ID=40475004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011542795A Active JP5677313B2 (ja) | 2008-12-23 | 2009-12-21 | 薬物送達デバイス |
Country Status (6)
Country | Link |
---|---|
US (1) | US9566390B2 (ja) |
EP (2) | EP2201975A1 (ja) |
JP (1) | JP5677313B2 (ja) |
CA (1) | CA2747317A1 (ja) |
DK (1) | DK2381988T3 (ja) |
WO (1) | WO2010072698A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110088986A1 (en) * | 2009-10-20 | 2011-04-21 | Chen Li-Li | Inflatable Furniture |
JP5982370B2 (ja) * | 2010-08-13 | 2016-08-31 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ヒンジを備えたコード化薬物リザーバ連結エレメント |
EP2468343A1 (en) * | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Front end for an auto-injector |
CN103619387B (zh) * | 2011-04-28 | 2017-05-03 | 赛诺菲-安万特德国有限公司 | 具有锁定元件的分配接口 |
TW201636068A (zh) * | 2015-01-13 | 2016-10-16 | 賽諾菲股份有限公司 | 藥物輸送裝置之組件 |
EP3061478A1 (en) * | 2015-02-27 | 2016-08-31 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device and method for assembling same |
EA035182B1 (ru) | 2015-07-12 | 2020-05-12 | Пэйшентс Пендинг Лтд. | Кожух для системы доставки жидкости со встроенным сенсорным обнаружением положения плунжера и соответствующий способ |
WO2017089282A1 (en) | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | An injection device with slidable member for removing a cap with a needle shield |
USD819198S1 (en) | 2016-04-28 | 2018-05-29 | Amgen Inc. | Autoinjector with removable cap |
CN110392588B (zh) * | 2017-03-29 | 2021-10-22 | 艾斯曲尔医疗公司 | 安全装置和药剂输送装置 |
WO2019058382A1 (en) * | 2017-09-19 | 2019-03-28 | Bharat Serums And Vaccines Ltd | AUTOMATED MULTI-PURPOSE INJECTION SYSTEM FOR ADMINISTRATION OF INJECTABLE MEDICINES |
CN111542358A (zh) * | 2017-11-03 | 2020-08-14 | 赛诺菲 | 药物递送装置 |
USD1010811S1 (en) | 2019-09-30 | 2024-01-09 | Amgen Inc. | Handheld drug delivery device |
USD1030041S1 (en) | 2020-01-14 | 2024-06-04 | Amgen Inc. | Handheld drug delivery device |
USD1030040S1 (en) | 2020-01-14 | 2024-06-04 | Amgen Inc. | Handheld drug delivery device |
CN111632219B (zh) * | 2020-06-05 | 2022-07-08 | 湖南朗普医学科技有限公司 | 一种痔疮治疗仪器 |
USD974547S1 (en) | 2020-11-05 | 2023-01-03 | Amgen Inc. | Handheld drug delivery device |
USD973866S1 (en) | 2020-11-05 | 2022-12-27 | Amgen Inc. | Handheld drug delivery device |
JP2021500643S (ja) | 2020-11-05 | 2022-12-27 | 注射器 | |
USD985116S1 (en) | 2021-03-10 | 2023-05-02 | Amgen Inc. | Handheld drug delivery device |
USD985118S1 (en) | 2021-03-10 | 2023-05-02 | Amgen Inc. | Handheld drug delivery device |
USD985117S1 (en) | 2021-03-10 | 2023-05-02 | Amgen Inc. | Handheld drug delivery device |
USD985119S1 (en) | 2021-03-30 | 2023-05-02 | Amgen Inc. | Handheld drug delivery device |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK177187A (da) * | 1987-04-07 | 1988-10-08 | Dcp Af 1988 As | Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glasampul |
US5259840A (en) * | 1991-09-03 | 1993-11-09 | Boris Craig R | Locking syringe |
US5403288A (en) * | 1992-02-13 | 1995-04-04 | Stanners; Sydney D. | Safety sleeve for dental syringe |
US5484413A (en) * | 1994-11-23 | 1996-01-16 | Alexis M. Gevorgian | Disposable medical syringe with safety protection |
US5997513A (en) * | 1995-11-22 | 1999-12-07 | Smith; Jerry A. | Syringe cover cooperating with needle cover |
US6846302B2 (en) * | 2002-12-31 | 2005-01-25 | Teva Medical Ltd. | Needle protector device |
CN101282751B (zh) * | 2005-07-18 | 2011-01-12 | 韦斯特制药服务公司 | 具有通气装置的自动注射注射器 |
DE102006038103B4 (de) | 2006-08-14 | 2017-02-23 | Tecpharma Licensing Ag | Injektionsvorrichtung mit variabler Gewindeführung |
-
2008
- 2008-12-23 EP EP08022329A patent/EP2201975A1/en not_active Ceased
-
2009
- 2009-12-21 DK DK09804025.6T patent/DK2381988T3/da active
- 2009-12-21 US US13/139,693 patent/US9566390B2/en active Active
- 2009-12-21 EP EP09804025.6A patent/EP2381988B1/en active Active
- 2009-12-21 CA CA2747317A patent/CA2747317A1/en not_active Abandoned
- 2009-12-21 JP JP2011542795A patent/JP5677313B2/ja active Active
- 2009-12-21 WO PCT/EP2009/067609 patent/WO2010072698A1/en active Application Filing
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WO2010072698A1 (en) | 2010-07-01 |
EP2201975A1 (en) | 2010-06-30 |
US20120123347A1 (en) | 2012-05-17 |
CA2747317A1 (en) | 2010-07-01 |
US9566390B2 (en) | 2017-02-14 |
EP2381988B1 (en) | 2020-01-22 |
DK2381988T3 (da) | 2020-04-20 |
JP2012513269A (ja) | 2012-06-14 |
EP2381988A1 (en) | 2011-11-02 |
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