JP5596907B2 - Method for producing composition for wound treatment - Google Patents

Description

The present invention relates to a method for producing a composition for treating wounds containing active oxygen.

A state in which tissue inside or outside the body is destroyed or lost is called a wound. The wound healing process is generally classified into four stages: (1) blood coagulation phase, (2) inflammation phase, (3) proliferative phase, and (4) mature phase (remodeling phase).
That is, when the skin or the like is damaged, bleeding first occurs, and the blood coagulates to form a blood clot and temporarily close the wound portion (blood coagulation phase). Next, in the wound site, inflammation occurs due to progress of the foreign substance removal process before tissue repair, such as removal of bacteria by neutrophils, immune response by lymphocytes, phagocytosis of bacteria and foreign substances by macrophages, and the like.

  Thereafter, various cytokines released by platelets promote angiogenesis and fibroblast activity, and granulation is formed (proliferation phase). Eventually, the redness and swelling of the scars that are granulations are reduced over time, leading to healing (mature stage).

  In the above process, it is known that active oxygen produced by neutrophils and macrophages promotes the activation of various enzymes and factors at the wound site, promotes cell proliferation, and promotes wound healing. ing. For this reason, it has been proposed to promote the activation of the various enzymes and factors described above by supplying active oxygen from the outside.

For example, an ozone-sealed viscous material in which ozone is dissolved or encapsulated in a high-viscosity material such as glycerin to form a viscous material that has an effect such as sterilization, and the effect is maintained by suppressing the loss of ozone (For example, refer to Patent Document 1).
In addition, an ozone-dissolved mixed solution that can maintain a sufficient ozone concentration for a long period of time by exhibiting a bactericidal effect and a wound healing effect by dissolving ozone of 400 ppm or more in non-oxidized glycerin has been proposed. (For example, refer to Patent Document 2).

Japanese Patent Laid-Open No. 10-139645 JP 2005-232094 A

  However, the above-mentioned ozone-sealed viscous body and ozone-dissolved mixed solution are configured by encapsulating active oxygen in a high-viscosity substance such as glycerin. For this reason, it is necessary to introduce ozone into the glycerin from outside as active oxygen, and a high concentration of glycerin and ozone to be introduced must be prepared. Furthermore, active oxygen and ozone must be uniformly dissolved in a high concentration of glycerin. For this reason, when manufacturing the above-mentioned ozone enclosure viscous body and ozone dissolved mixed solution in large quantities, a manufacturing cost will become high.

  Furthermore, Patent Document 1 and Patent Document 2 do not describe active oxygen and active oxygen species other than ozone, and do not disclose application to active oxygen and active oxygen species other than ozone. Therefore, active oxygen and active oxygen species other than ozone cannot be directly applied to the above-mentioned ozone-sealed viscous material or ozone-dissolved mixed solution.

In order to solve the above-described problems, the present invention provides a method for producing a composition for treating wounds containing active oxygen, which can be produced at low cost.

The wound treatment composition according to the method for producing a wound treatment composition of the present invention is dissolved in acidic water in which active oxygen and hypochlorite ions are generated by electrolysis of seawater or deep sea water and dissolved in acidic water. It is characterized by containing 0.01-5 ppm ozone in acidic water by the ozone which carried out and the micro nano bubble of the ozone currently hold | maintained in acidic water.

The method for producing a composition for treating wounds of the present invention includes a step of electrolyzing seawater or deep sea water to generate active oxygen and hypochlorite ions to generate active oxygen and hypochlorite ions ; the ozone introduced into the water, with dissolving ozone in acidic water, to retain the ozone micro-nano bubble acidic water, to have a process for producing water containing ozone 0.01～5Ppm, the acidic water It is characterized by.

Moreover, the skin external preparation concerning the manufacturing method of the composition for wound treatment of this invention contains acidic water which generated active oxygen and hypochlorite ion by electrolysis of seawater or deep sea water, It is characterized by containing 0.01-5 ppm ozone in acidic water by the ozone melt | dissolved in ozone and the micro nano bubble of the ozone currently hold | maintained in acidic water.

According to the composition for wound treatment and the method for producing the composition for wound treatment of the present invention, active oxygen is generated by electrolyzing seawater or deep sea water, and the composition for wound treatment is produced using this active oxygen. Can be manufactured. For this reason, the manufacturing cost of the composition for wound treatment can be reduced.
Moreover, low-cost skin external preparation can be provided using the manufactured composition for wound treatment.

  In the present invention, active oxygen includes active oxygen in a broad sense in addition to active oxygen in a narrow sense. Specifically, singlet oxygen, superoxide, hydroxy radical, hydrogen peroxide, ozone, peroxy radical, alkoxy radical, hydroperoxide, and the like.

  ADVANTAGE OF THE INVENTION According to this invention, the therapeutic composition for wounds containing the active oxygen which can be produced at low cost can be provided.

Hereinafter, specific embodiments of the present invention will be described.
The wound treatment composition of the present embodiment generates active oxygen by electrolyzing seawater or deep sea water, and produces a wound treatment composition containing this active oxygen.

Since the electrolyte is originally dissolved in seawater and deep sea water, electrolysis can be performed without dissolving an electrolyte such as salt. For this reason, the electrolysis using seawater or deep ocean water eliminates the need to add an electrolyte such as sodium chloride to the water to improve the conductivity.
Accordingly, by electrolyzing seawater or deep ocean water, the cost of salt or the like dissolved in fresh water can be reduced. In addition, a process for dissolving the electrolyte in water becomes unnecessary, and the number of manufacturing processes can be reduced.

In addition, deep ocean water has less organic matter because sunlight does not reach and photosynthesis is not performed, and there are very few harmful artificial pollutants from bacteria, land and air compared to surface water. For this reason, deep ocean water is more clean than surface water.
Therefore, as a composition for treating wounds, it is suitable to apply deep sea water to the application of a wound part.

Next, electrolysis of seawater or deep sea water will be described.
The electrolysis of seawater or deep sea water can be performed by a three-chamber electrolysis system or a two-chamber electrolysis system shown in FIG. 1 and FIG.

The three-chamber electrolysis system shown in FIG. 1 will be described.
The three-chamber electrolysis system includes a cathode chamber (cathode chamber) 11, an intermediate chamber 12, and an anode chamber (anode chamber) 13. The intermediate chamber 12 is provided between the cathode chamber 11 and the anode chamber 13.
A cation membrane 16 and a cathode electrode 14 are provided between the intermediate chamber 12 and the cathode chamber 11 from the intermediate chamber 12 side. An anion film 17 and an anode electrode 15 are provided between the intermediate chamber 12 and the anode chamber 13 from the intermediate chamber 12 side.

The cathode chamber 11 is supplied with fresh water (H ₂ O) as a cathode chamber solution, and the cathode chamber solution supply port 18 and alkaline water in the cathode chamber 11 generated by electrolysis by a three-chamber electrolysis system. A discharge port 19 is provided. The anode chamber 13 has an anode chamber liquid supply port 22 to which fresh water (H ₂ O) is supplied as an anode chamber liquid, and acidic water in the anode chamber 13 generated by electrolysis in a three-chamber electrolysis system. A discharge port 23 is provided.
Further, the intermediate chamber 12 is electrolyzed by an intermediate chamber liquid supply port 20 to which water (H ₂ O + NaCl) containing electrolyte as an intermediate chamber liquid, for example, seawater or deep sea water is supplied, and a three-chamber electrolysis system. And a discharge port 21 for circulating water (H ₂ O) in the intermediate chamber 12 that is generated in this manner. The circulating water discharged from the discharge port 21 is supplied again as the intermediate chamber liquid from the supply port 20 of the intermediate chamber 12 and is circulated in the three-chamber electrolysis system.

The intermediate chamber liquid supplied to the intermediate chamber 12 is electrolyzed between the cathode electrode 14 and the anode electrode 15. In the intermediate chamber 12, cations (Na ⁺ ) out of the electrolyte (NaCl) contained in the intermediate chamber liquid are attracted to the cathode electrode 14, pass through the cation film 16, and move to the cathode chamber 11. Further, out of the electrolyte (NaCl) contained in the intermediate chamber liquid, the anion (Cl ⁻ ) is attracted to the anode electrode 15, passes through the anion film 17, and moves to the anode chamber 13.

In the cathode chamber 11, the anode chamber liquid (H ₂ O) is electrolyzed by applying an electric field, and hydrogen (H ₂ ) and hydroxide ions (OH ⁻ ) are generated. A cation hydroxide (NaOH) is generated by a reaction between the cation (Na ⁺ ) and the hydroxide ion (OH ⁻ ) from the intermediate chamber 12.
In the anode chamber 13, electrolysis of the cathode chamber liquid (H ₂ O) occurs by applying an electric field, and hydrogen (H ₂ ) and oxygen ions (O ⁻ ) are generated. Then, oxygen (O ₂ ) that becomes active oxygen and ozone (O ₃ ) that becomes active oxygen species are generated from oxygen ions (O ⁻ ). In addition, a reaction between oxygen ions (O ⁻ ) and anions (Cl ⁻ ) from the intermediate chamber 12 generates hypochlorite ions (ClO ⁻ ) and hypochlorous acid (HClO). Since hypochlorous acid has a bactericidal effect, it works effectively as a component of a wound care composition.

  As described above, acidic water containing active oxygen, hypochlorous acid, and the like can be generated in the anode chamber 13 by electrolyzing seawater or deep sea water supplied to the intermediate chamber 12. And as mentioned above, the active water is contained in the acidic water obtained by electrolysis of seawater or deep sea water. For this reason, this acidic water can be used as it is as a composition for wound treatment, and a composition for wound treatment containing active oxygen can be produced from acidic water.

  Moreover, according to the above-mentioned method, by using seawater or deep ocean water, active oxygen is generated by a three-chamber electrolysis system without previously filling the intermediate chamber 12 with an electrolyte such as salt or a solid electrolyte. be able to. For this reason, the cost for the electrolyte or solid electrolyte to be filled in advance can be reduced.

Next, the two-chamber electrolysis system shown in FIG. 2 will be described.
The two-chamber electrolysis system includes an anode chamber (anode chamber) 31 and a cathode chamber (cathode chamber) 32. A diaphragm 33 in which a cation exchange membrane and an anion exchange membrane are closely integrated (stacked) is provided between the anode chamber 31 and the cathode chamber 32.
In the anode chamber 31, an anode 34 is provided on the opposite side of the diaphragm 33, and in the cathode chamber 32, a cathode 35 is provided on the opposite side of the diaphragm 33. That is, in the two-chamber electrolysis system, the anode 34 and the cathode 35 are provided at the position of the counter electrode with the diaphragm 33 interposed therebetween.

The anode chamber 31 is electrolyzed by an anode chamber liquid supply port 36 to which water (H ₂ O + NaCl) containing an electrolyte as an anode chamber liquid, for example, seawater or deep ocean water is supplied, and a two-chamber electrolysis system. A discharge port 37 for acidic water in the anode chamber 31 is also provided. In addition, the cathode chamber 32 is supplied with electricity as a cathode chamber solution (H ₂ O + NaCl) containing an electrolyte, such as seawater or deep sea water, and supplied with a cathode chamber solution supply port 38 and a two-chamber electrolysis system. A discharge port 39 of alkaline water in the decomposed cathode chamber 32 is provided.

The anode chamber solution and the cathode chamber solution supplied to the anode chamber 31 and the cathode chamber 32 are electrolyzed between the anode electrode 34 and the cathode electrode 35. Then, cations (Na ⁺ ) from the electrolyte (NaCl) contained in the anode chamber solution and the cathode chamber solution are attracted to the cathode electrode 35 and move to the cathode chamber 32 through the diaphragm 33. Further, the anions (Cl ⁻ ) from the electrolyte (NaCl) contained in the anode chamber solution and the cathode chamber solution are attracted to the anode electrode 34 and move to the anode chamber 31 through the diaphragm 33.

In the cathode chamber 32, application of an electric field causes electrolysis of water (H ₂ O) in the anode chamber liquid, generating hydrogen (H ₂ ) and hydroxide ions (OH ⁻ ). The electrolyte in the cathode chamber 32 and electrolyzed positive ions generated by (Na ⁺⁾ and cation have moved from the anode chamber 31 (Na ^+), hydroxide ion - by reaction with, ^(OH) Cation hydroxide (NaOH) is generated.

In the anode chamber 31, electrolysis of water (H ₂ O) in the cathode chamber liquid occurs, and hydrogen (H ₂ ) and oxygen ions (O ⁻ ) are generated. Then, oxygen (O ₂ ) that becomes active oxygen and ozone (O ₃ ) and hydrogen peroxide (H ₂ O ₂ ) that become active oxygen species are generated from oxygen ions (O ⁻ ). Further, the anion electrolyte in the anode chamber 31 has occurred is electrolyzed and oxygen ions (Cl - ^-) and a cathode compartment 32 anion moved from ^(Cl) (O ^-) and is generated, hypophosphorous Chloric acid (HClO) and chlorine (Cl ₂ ) are generated. Since hypochlorous acid has a bactericidal effect, it works effectively as a component of a wound care composition.

  As described above, by electrolyzing the seawater or deep sea water supplied to the anode chamber 31 and the cathode chamber 32, the anode chamber 31 contains acidic oxygen, active oxygen species, hypochlorous acid, and the like. Water can be generated. The generated acidic water contains active oxygen as described above. For this reason, this acidic water can be used as it is as a composition for wound treatment, and a composition for wound treatment containing active oxygen can be produced from acidic water.

In addition to the above-described electrolysis of seawater or deep sea water, active oxygen can be supplied to the wound treatment composition by introducing micro-nano bubbles into water.
FIG. 3 shows an example of the configuration of an apparatus for introducing ozone into water.
The apparatus shown in FIG. 3 includes an ozone generator 41, a mixed water tank 42, and a cavitation pump 43.

The mixed water tank 42 and the cavitation pump 43 are connected by piping. And it is comprised so that water can circulate between the mixing water tank 42 and the cavitation pump 43. FIG.
Moreover, the above-described apparatus includes a water supply unit and a discharge unit (not shown). Water is continuously supplied from the water supply unit into the apparatus and circulates in the apparatus. And a part of the water which circulates in the apparatus is discharged | emitted from a discharge part. Thus, a constant amount of water is always circulated in the apparatus.

The ozone generator 41 is connected to a pipe between the mixed water tank 42 and the cavitation pump 43 by a pipe from the ozone generator 41.
Ozone can be produced using a known method, for example, it can be produced by a method such as a photochemical reaction by ultraviolet rays using air or oxygen as a raw material, electrolysis, radiation irradiation, corona discharge or the like. As the ozone generator 41, a known generator can be used.

The cavitation pump 43 includes a gas / liquid mixing pump and a special mixer.
Ozone generated in the ozone generator 41 is roughly mixed into water by the gas-liquid mixing pump of the cavitation pump 43. Furthermore, the diameter of the ozone bubble can be adjusted to a size from a nanometer unit to a micrometer unit by cavitation generated by a special mixer of the cavitation pump 43.
In this way, micro-nano bubbles are generated in the apparatus, and the micro-nano bubbles are supplied into the circulating water.

A part of the micro-nano bubbles supplied in the water is dissolved in the water, and the rest is dispersed as fine bubbles in the nanometer unit or micrometer unit in the water, and is retained in the state of bubbles in the water.
In the above-described apparatus, ozone can be dissolved in water by the pressure generated at the moment when the supplied ozone bubbles repel in the mixed water tank 42. For this reason, in order to dissolve ozone in water, means for applying pressure to ozone can be omitted. For this reason, the configuration of the apparatus can be simplified. Moreover, since it is not necessary to drive the means which applies pressure to ozone, the manufacturing cost of the composition for wound treatment can be reduced.

  In addition, normal bubbles larger than the micro / nano bubbles rise due to the buoyancy of the bubbles themselves, and thus are discharged from the water to the outside. However, by increasing the size of the bubbles in the water to the nanometer unit or micrometer unit, the rise due to buoyancy is eliminated, and the bubbles can be suspended in the water. For this reason, ozone can be hold | maintained in water by the density | concentration more than the solubility to the water of ozone, and the composition for wound treatment containing high concentration ozone can be manufactured.

  The water into which the micro-nano bubbles of ozone are introduced is not particularly limited, and for example, fresh water such as distilled water, seawater, or deep ocean water can be used. Moreover, the active oxygen density | concentration of the composition for wound treatment can also be further improved using the acidic water etc. which contain active oxygen by the electrolysis of the above-mentioned seawater or deep sea water.

FIG. 4 shows a wound treatment composition production rate [L / min] and ozone concentration [ppm] introduced into water when ozone is introduced into water using the apparatus shown in FIG. 3 described above. .
In the apparatus shown in FIG. 3 described above, each configuration is such that the size of the mixed water tank 42 is 20 L, the amount of ozone supplied from the ozone generator 41 is 0.4 L / min, and the driving speed of the cavitation pump 43 is 20 to 40 L / min. It carried out on condition of min. Moreover, water temperature is 20 degreeC and the average residence time of the water in an apparatus is 0.5-1 min.

From the graph shown in FIG. 4, it can be seen that an ozone concentration of 15 ppm or more could be achieved by setting the production rate of the composition for wound treatment to 5 L / min. Moreover, it turns out that the ozone concentration of 4 ppm or more was able to be achieved even when the production rate of the composition for wound treatment was 40 L / min.
As described above, the solubility of ozone in water is 0.57 g / L (20 ° C.), but by introducing ozone micro-nano bubbles into water, ozone having a saturation solubility or higher can be maintained in water. it can.
Therefore, a wound treatment composition containing high-concentration ozone above the solubility of ozone in water is produced by introducing ozone into water and producing a wound treatment composition using the apparatus having the above-described configuration. can do.

  In addition, when the ozone concentration in the composition for wound treatment is too high, irritation to the skin is increased. Moreover, when the ozone concentration in the composition for wound treatment is too high, it is thought that the ozone currently hold | maintained in the composition for wound treatment becomes easy to be diffused in air | atmosphere. For this reason, about 0.01-5 ppm is preferable and, as for the ozone concentration of the composition for wound treatment, about 0.5-1 ppm is more preferable.

Since the ozone retained as micro-nano bubbles in the composition for wound treatment is difficult to volatilize, water containing high-concentration ozone is produced by the above-mentioned method, and this is used as a stock solution, which is diluted as needed and used. It is possible.
Moreover, ozone is not only an active oxygen species, but also has bactericidal properties. For this reason, the composition for wound treatment which introduce | transduced the micro nano bubble of ozone can have a bactericidal effect in addition to the effect by active oxygen.

When a composition for wound treatment is produced by electrolysis or introduction of ozone using seawater or deep ocean water, the osmotic pressure of the composition for wound treatment may be higher than that of human body fluid. When the difference between the osmotic pressure of the composition for wound treatment and the osmotic pressure of human body fluid is large, a high osmotic pressure shock may occur.
In order to reduce the high osmotic pressure shock when the wound treatment composition contacts the wound site, it is necessary to adjust the osmotic pressure of the wound treatment composition to be isotonic with human body fluid. In addition, it is not necessary to make the composition for wound treatment and human body fluid isotonic completely, and the osmotic pressure of the composition for wound treatment should be reduced to such an extent that the isotonic shock upon contact with the wound site is alleviated. It only needs to be adjustable.

As a method for adjusting the osmotic pressure of the composition for wound treatment, for example, a method of diluting with purified water or a method using a known desalting operation such as reverse osmosis membrane method, electrodialysis method, diffusion dialysis method, etc. it can.
In particular, the diffusion dialysis method using a mosaic charged membrane can be suitably used because there is little modification of the components of the wound treatment composition before and after the desalting operation.

As an example of the desalting operation described above, a diffusion dialysis method using a diffusion dialysis apparatus will be described with reference to FIG. FIG. 5 is an example of the configuration of a diffusion dialysis apparatus having a mosaic charged membrane.
In the diffusion dialysis apparatus having a mosaic charged membrane shown in FIG. 5, the raw water chambers 51, 52, 53 and the water chambers 54, 55, 56 are alternately connected. Further, mosaic charged membranes 57, 58, 59, 60, 61 are interposed between the raw water chambers 51, 52, 53 and the water chambers 54, 55, 56, respectively.

  Mosaic charged membrane is a diffusion of ions by cationic and anionic ion exchange membranes composed of a cationic polymer component and an anionic polymer component that are in contact with each other and penetrate between both sides of the membrane. It is a charged membrane that can be dialyzed. Ion permeation is performed by the difference in osmotic pressure between raw water and dialysed water.

  The mosaic charged membrane is a unique separation membrane in which ions such as salts that easily pass through ion channels of the membrane and non-ionic or high molecular weight molecules that do not easily pass through are easily separated. The mosaic charged membrane is used for diffusion dialysis under normal pressure and pressure dialysis under pressure as a desalting method. For this reason, in the diffusion dialysis method using a mosaic charged membrane, there is little modification | denaturation of a component. Therefore, there is almost no influence on the active oxygen contained in the raw water, and the concentration of active oxygen in the wound treatment composition after adjusting the osmotic pressure and the concentration of active oxygen in the raw water before adjusting the osmotic pressure are Almost no change.

  The raw water chambers 51, 52, and 53 are supplied with raw water by electrolyzing seawater or deep sea water as raw water and introducing active oxygen into the wound water or ozone treatment. Supplied from line 62. This raw water contains an electrolyte (NaCl). Further, distilled water is supplied from the distilled water supply line 63 to the water chambers 54, 55, and 56 as dialysis water.

Then, cations (Na ⁺ ) and anions (Cl ⁻ ) pass through the mosaic charged membranes 57, 58, 59, 60, 61 from the raw water supplied to the raw water chambers 51, 52, 53, Move to 55,56. Thereby, salt moves from raw | natural water to dialysis water, and can demineralize raw | natural water.
For this reason, from the raw water chambers 51, 52, 53, the desalted raw water is discharged through the raw water discharge line 64. Further, dialysis water containing salt is discharged from the water chambers 54, 55, and 56 through a dialysis water discharge line 65.

Next, as another example of the desalting operation described above, an electrodialysis method will be described with reference to FIG. FIG. 6 is an example of a configuration of an electrodialysis apparatus having an electrodialysis membrane.
In the electrodialysis apparatus having the electrodialysis membrane shown in FIG. 6, the water chamber 71, the water chamber 72, the raw water chamber 75, the water chamber 73, the raw water chamber 76, and the water chamber 74 communicate with each other. A cation exchange membrane 77 is interposed between the water chamber 71 and the water chamber 72. An anion exchange membrane 79 is interposed between the raw water chamber 75 and the water chamber 72, and a cation exchange membrane 78 is interposed between the raw water quality 75 and the water chamber 73. Further, an anion exchange membrane 80 is interposed between the raw water chamber 76 and the water chamber 73, and a cation exchange membrane 81 is interposed between the raw water chamber 76 and the water chamber 74.

  A cathode 82 is provided on the opposite side of the cation exchange membrane 77 in the water chamber 71. An anode 83 is provided on the opposite side of the cation exchange membrane 81 in the water chamber 74. Therefore, in the electrodialysis apparatus having an electrodialysis membrane, the cathode electrode 82 and the anode electrode 83 are provided at the position of the counter electrode in the apparatus.

  In the raw water chambers 75, 76, a wound treatment composition into which active oxygen has been introduced by electrolyzing seawater or deep ocean water as raw water, or a wound treatment composition into which ozone has been introduced is supplied to the raw water supply line 84. Supplied from This raw water contains an electrolyte (NaCl). Also, distilled water is supplied from the distilled water supply line 85 to the water chambers 71, 72, 73, 74 as dialysis water.

Then, cations (Na ⁺ ) are attracted to the cathode 82 from the raw water supplied to the raw water chamber 75, pass through the anion exchange membrane 79, and move to the water chamber 72. Further, anions (Cl ⁻ ) are attracted to the anode electrode 83 and pass through the cation exchange membrane 78 and move to the water chamber 73.
Similarly, cations (Na ⁺ ) are attracted to the cathode 82 from the raw water supplied to the raw water chamber 76, pass through the anion exchange membrane 80, and move to the water chamber 73. Further, anions (Cl ⁻ ) are attracted to the anode electrode 83, pass through the cation exchange membrane 81, and move to the water chamber 74.

As described above, cations (Na ⁺ ) and anions (Cl ⁻ ) pass from the raw water supplied to the raw water chambers 75 and 76 through the anion exchange membranes 79 and 80 and the cation exchange membranes 78 and 81, Move to chamber 72, 73, 74. Thereby, salt moves from raw | natural water to dialysis water, and can demineralize raw | natural water.
Therefore, the desalted raw water is discharged from the raw water chambers 75 and 76 through the raw water discharge line 86. Further, dialysis water containing salt is discharged from the water chambers 71, 72, 73, 74 through a dialysis water discharge line 87.

  By the above method, when the osmotic pressure in the composition for wound treatment is higher than that of human body fluid, the osmotic pressure of the composition for wound treatment is adjusted to be isotonic with human body fluid. be able to.

In addition, the above-mentioned composition for treating wounds into which active oxygen has been introduced can be used by directly applying to human skin as it is, or by being immersed in cotton or gauze, or sprayed with a spray bottle or the like. By doing so, it can be supplied to the skin wound site.
In addition, since the composition for treating wounds into which active oxygen has been introduced is a liquid, it can also be used by directly immersing the skin wound site in the composition for treating wounds by a method such as bathing or footbath.

Furthermore, the composition for wound treatment of the present invention can be used not only as it is, but also as a raw material for a skin external medicine. It does not specifically limit as a form of skin external preparation, For example, it can use with various forms, such as a water type, an emulsion type, an ointment type, or a pack type.
In addition, the external preparation for skin includes the above-mentioned composition for treating wounds, such as hydrocarbons such as petroleum jelly, liquid paraffin, squalane, oils and fats, waxes, various ester oils, animal oils, vegetable oils, silicone oils, fatty acids. , Oils such as higher alcohols, alcohols such as ethanol, butanol, polyhydric alcohols, nonionic surfactants, anionic surfactants, emulsifiers such as cationic surfactants, titanium oxide, mica, iron oxide Pigments such as carboxyvinyl polymer, xanthan gum, sodium hyaluronate, natural product extracts such as bamboo vinegar and eucalyptus oil, extracts, pigments, vitamins, UV absorbers, hormones, fragrances, antioxidants It can be used by appropriately mixing it with an agent, antibacterial agent, preservative, chelating agent and the like.
Furthermore, the composition for treating wounds of the present invention and the external preparation for skin containing the composition for treating wounds can be used for livestock and companion animals by appropriately adjusting the osmotic pressure of the composition for treating wounds. Is possible.

  As can be seen from the above description, neutrophils, macrophages, etc. existing in the body are produced by supplying a wound treatment composition according to the present invention and a skin external preparation containing the wound treatment composition to the wound site. In addition to active oxygen, active oxygen is also supplied to the wound site from the wound treatment composition. For this reason, the active oxygen concentration in a wound site | part becomes high and it will be in the state where a lot of biosignals exist. As a result, the formation of tissue cells is promoted and the wound site can be cured in a short period of time.

  The present invention is not limited to the above-described configuration, and various other configurations can be employed without departing from the gist of the present invention.

It is a figure which shows an example of a structure of the three-chamber electrolysis system used in order to manufacture the composition for wound treatment of this invention. It is a figure which shows an example of a structure of the two-chamber electrolysis system used in order to manufacture the composition for wound treatment of this invention. It is a figure which shows an example of a structure of the apparatus used in order to manufacture the composition for wound treatment of this invention which introduce | transduces a micro nano bubble into water. It is a figure which shows the relationship between the composition production rate for wound treatment, and the introduce | transduced ozone concentration. It is a figure which shows an example of a structure of the diffusion dialysis apparatus used in order to manufacture the composition for wound treatment of this invention. It is a figure which shows an example of a structure of the electrodialysis apparatus used in order to manufacture the composition for wound treatment of this invention.

Explanation of symbols

  11, 32 Cathode chamber, 12 Intermediate chamber, 13, 31 Anode chamber, 14, 35, 82 Cathode electrode, 15, 34, 83 Anode electrode, 16 Cation exchange membrane, 17 Anion exchange membrane, 18, 38 Supply of cathode chamber liquid Mouth, 19, 39 Alkaline water discharge port, 20 Intermediate chamber liquid supply port, 21 Water discharge port, 22, 36 Anode chamber liquid supply port, 23, 37 Acid water discharge port, 33 Membrane, 41 Ozone generation Equipment, 42 Cavitation pump, 43 Mixed water tank, 51, 52, 53, 75, 76 Raw water room, 54, 55, 56, 71, 72, 73, 74 Water room, 57, 58, 59, 60, 61 Mosaic charged membrane 62,84 Raw water supply line, 63,85 Distilled water supply line, 64,86 Raw water discharge line, 65,87 Dialysate discharge line, 77,78,81 Exchange membrane, 79, 80 anion exchange membrane

Claims (5)

Electrolyzing seawater or deep ocean water to generate active oxygen and hypochlorite ions, and generating acidic water containing the active oxygen and hypochlorite ions;
Introducing ozone into the acidic water, dissolving ozone in the acidic water, holding ozone micro-nano bubbles in the acidic water, and containing 0.01 to 5 ppm of ozone in the acidic water. A method for producing a composition for treating wounds. The method for producing a wound treatment composition according to claim 1 , further comprising a step of adjusting an osmotic pressure of the acidic water. The wound treatment composition according to claim 2 , wherein the step of adjusting the osmotic pressure of the acidic water is performed by at least one method selected from a reverse osmosis membrane method, an electrodialysis method, and a diffusion dialysis method. Manufacturing method. The said diffusion dialysis method is performed with the diffusion dialysis apparatus which has a mosaic charge membrane, The manufacturing method of the composition for wound treatment of Claim 3 characterized by the above-mentioned. The composition for wound treatment according to claim 1 , wherein the electrolysis of seawater or deep sea water is performed by at least one method selected from a three-chamber electrolysis system and a two-chamber electrolysis system. Manufacturing method.

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