JP2005281238A - Medical electrolyte liquid utilizing sea water and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prepare a medical electrolyte liquid, capable of being produced aseptically from sea water by a simple production process at a low cost and further containing rich mineral components contained in the sea water, and to provide a method for producing the same. <P>SOLUTION: The medical electrolyte liquid is obtained by removing foreign materials such as viruses, bacteria by passing the sea water through a membrane separation means, but cleaning so as to remain the mineral components contained in the sea water, blending aseptic distilled water to obtain diluted, cleaned sea water and adjusting the osmotic pressure of the diluted, cleaned sea water to a prescribed value. The medical electrolyte liquid can be used as physiological saline adjusted to have an equivalent osmotic pressure with human body fluid, various transfusion, dialyzing liquid, or the like. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a medical electrolyte solution using seawater, particularly deep ocean water taken from a depth deeper than 200 m below the sea level, and a method for producing the same.

  Saline, artificial dialysis solution, various infusion solutions, organ preservation solution, surgical washing solution, etc. used for treatment of the human body are artificially prepared by using Na, Ca, K, Mg, Cl, etc. with a predetermined concentration in distilled water. In addition, an electrolyte solution in which an amino acid, a saccharide, or the like is added according to the intended use and the osmotic pressure is adjusted to an appropriate value according to the intended use is used. For example, physiological saline is an electrolyte solution prepared by dissolving 9 g of sodium chloride in 1 liter of distilled water (Na concentration: 154 mEq / L) so as to be equal to the osmotic pressure of human body fluid (isotonic pressure). .

  Moreover, as a high calorie infusion solution, an electrolyte solution containing Na, K, Mg, Ca, Zn, Cl, acetic acid, saccharides, etc. and having an osmotic pressure ratio (saline ratio) adjusted to 4 to 8 is used. . Further, in the peritoneal dialysis solution, an electrolyte solution containing Na, K, Mg, Ca, Cl, etc. and having an osmotic pressure ratio (saline ratio) adjusted to 1.2 to 1.8 is used.

  On the other hand, seawater, particularly deep seawater taken from a depth of 200 m below sea level or deeper than this, has few viable bacteria, hardly contains pathogenic bacteria, and is rich in mineral components. As this mineral component, Na, Ca, Mg, K, P, I (iodine), Zn, Cu, Se (selenium), etc. are included. These elements are trace elements essential for the human body.

Seawater contains about 34 g / L of salinity (salt concentration: 3.2 to 3.5 w / v%), but because it contains abundant mineral components as described above, it was desalted. Many techniques for using seawater as drinking water and soft drinks have been proposed. For example, Japanese Patent Application Laid-Open No. 2002-335923 and Japanese Patent Application Laid-Open No. 2003-24939 are proposed as techniques for using the seawater as drinking water and soft drinks.
Japanese Patent Laid-Open No. 2002-335923 proposes mineral water obtained by mixing osmotic water obtained by reverse osmosis membrane separation from deep ocean water and high mineral water generated by an electrodialyzer at a predetermined blending ratio.
In Japanese Patent Laid-Open No. 2003-24939, deep sea water is separated into fresh water and concentrated water by a reverse osmosis membrane, and at least a part of the concentrated water is sterilized by an ultrafiltration membrane and added to fresh water. A water production method has been proposed.

  On the other hand, as described above, 9 g of physiological saline is dissolved so that the concentration of sodium chloride in 1000 mL (milliliter) of distilled water is equivalent to human body fluid. And in the medical field, this physiological saline is used as a stock solution for injectable solution diluents, various infusions, skin and mucous membrane cleaning liquids, affected area cleaning liquids, medical equipment cleaning liquids, or contact lens cleaning liquids. in use. In this way, the physiological saline solution must be sterilized in order to be applied directly to the human body or used as a cleaning liquid for medical equipment. As described above, as a technique for sterilizing or sterilizing physiological saline, JP-B-59-39139, JP-B-8-7336, JP-A-1-180293, JP-A-2001-269393, etc. Proposed.

  Moreover, the following patent document 1 is proposed as a technique which purifies seawater and uses it as a physiological saline.

Japanese Patent Laying-Open No. 2003-290772 (Specifications, pages 2 to 3, FIG. 1)

  In Patent Document 1, a voltage is applied to a pair of electrodes having a structure through which seawater can pass so that a direct current set to a certain value of 5 A or less flows, and seawater flows between the electrodes. After that, by passing through an activated carbon channel made of electrical insulating material, minerals in seawater remained in the same composition as the amount and ratio in seawater, and sterilization and removal of pollutants including organic compounds were made. Purified seawater has been proposed. Furthermore, Patent Document 1 discloses that when seawater is introduced and passed between the electrodes, the seawater becomes electron-rich and the charge potential is increased to kill bacteria and viruses in the seawater. It is disclosed that an organic compound in seawater is adsorbed by activated carbon as the charge potential moves to the activated carbon interface. Patent Document 1 also proposes that this purified seawater is made into diluted seawater prepared to have the same salt concentration as Ringer's solution or physiological saline diluted with fresh water or demineralized water obtained from seawater.

  Furthermore, the following Patent Document 2 proposes a health method in which seawater is adjusted to a salinity equivalent to that of human body fluid and is used to maintain the mineral balance in the body.

Japanese Unexamined Patent Publication No. 2003-335685 (Specification, second page, FIG. 1)

  In Patent Document 2, minerals have the same composition and amount as in seawater, purified seawater from which contaminants including bacteria and organic compounds have been removed is diluted with fresh water, and has the same salinity as human body fluids. There has been proposed a mineral balance health method that normalizes mineral balance in the body by ingesting seawater that has been allowed to be consumed as it is at a concentration (0.85 to 0.9%).

  In the invention described in Patent Document 1, the method for removing bacteria and viruses contained in seawater is such that the bacteria and viruses contained in seawater are allowed to flow in and through between the electrodes to which a DC voltage is applied. It will be killed. However, if seawater is allowed to flow between electrodes to which a DC voltage is applied, the ionized minerals contained in the seawater undergo electrolysis, so the mineral components contained in the raw seawater The content ratio of may change when it passes between the electrodes. That is, the mineral component contained in the seawater obtained by purification is naturally reduced as compared with the mineral component contained in the seawater that is the raw water. Moreover, the invention described in Patent Document 1 adjusts the salinity of the purified seawater, the manufacturing process for obtaining Ringer's solution and physiological saline, the process of passing seawater between the electrodes, the process of passing the activated carbon channel, and the purified seawater. Since at least three steps are necessary, the manufacturing cost naturally increases.

  In the invention described in Patent Document 2, no specific means is disclosed for a method for removing contaminants including bacteria and organic compounds contained in seawater. In addition, when the purified seawater is drunk with a salinity equivalent to that of human body fluids, the mineral components contained in the purified seawater are absorbed through the human digestive tract. Depending on the composition concentration, the absorption efficiency of the mineral component becomes extremely low. Therefore, in order to ingest the target mineral component, a considerable amount of purified seawater must be drunk, and this method is not suitable for patients with digestive tract diseases, heart diseases, or kidney diseases.

  Therefore, an object of the present invention is to provide a medical electrolyte solution used directly in the human body in the medical field, particularly aseptic, such as seawater rich in minerals, particularly deep sea water, physiological saline, various infusions, and washing solutions. Another object of the present invention is to provide a medical electrolyte solution that can be manufactured at a very simple and inexpensive cost and a method for manufacturing the same.

  The present invention provides purified seawater that has been purified so that it contains a mineral component contained in the seawater while allowing seawater to pass through a membrane separation means to remove foreign substances such as viruses and bacteria contained in the seawater. A medical electrolyte solution using diluted purified seawater containing aseptic distilled water, wherein the osmotic pressure of the diluted purified seawater is adjusted to a predetermined value.

  Furthermore, the medical electrolyte solution of the present invention is a medical electrolyte solution adjusted by blending the sterile distilled water so as to have an osmotic pressure equivalent to that of human body fluid, and used as a physiological saline. It is.

  Furthermore, the medical electrolyte solution of the present invention is a medical electrolyte using seawater as an infusion electrolyte solution in which at least one of amino acid, lactic acid, acetic acid, phosphoric acid, and glucose is further blended with the diluted purified seawater. It is a liquid.

  Furthermore, the seawater used in the present invention is a medical electrolyte solution using seawater as deep ocean water taken from a depth deeper than 200 m below the sea level.

In addition, the present invention allows seawater to pass through membrane separation means to remove foreign substances such as viruses and bacteria contained in the seawater and to purify the seawater so that mineral components contained in the seawater are contained. Purification process;
An osmotic pressure adjusting step for diluting the purified seawater by adding aseptic distilled water to the purified seawater obtained by purification in the seawater purification step, and adjusting the osmotic pressure of the diluted purified seawater to a predetermined value; A method for producing a medical electrolyte solution using seawater.

  Further, in the present invention, the membrane separation means uses a porous membrane having micropores that separate foreign substances such as viruses and bacteria contained in the seawater and allow mineral components contained in the seawater to permeate. This is a method for producing a medical electrolyte solution using the prepared seawater.

  Furthermore, the present invention is a method for producing a medical electrolyte solution using seawater in which a porous membrane having fine pores having an average pore diameter of 0.001 μm to 0.1 μm is used as the porous membrane. .

  Furthermore, the present invention is a method for producing a medical electrolyte solution using seawater in which a hollow fiber membrane is used as the porous membrane.

The present invention has been made based on the following technical idea.
In recent years, various diseases caused by a shortage of trace elements have been developed. In particular, diseases caused by this shortage of trace elements are often found in elderly people who can only take artificial nutritional foods or patients at the end of cancer. Moreover, the trace elements, that is, various minerals, are abundant in types, and not all of the elements obtained at the present time are known. Furthermore, when ingesting a large amount of minerals, there is a risk of causing metal poisoning if ingested in large amounts. For this reason, it has been considered safer to contain no trace elements in the short term. Therefore, medical saline such as physiological saline and infusion replacement fluid currently in widespread use does not contain any trace elements except sodium chloride. This is because it is extremely difficult to find a component ratio of minerals that are safe for life and to purify them artificially.

  Therefore, seawater, the birthplace of life, still contains abundant minerals that humans need. Therefore, by removing foreign substances such as viruses and bacteria based on seawater and adjusting the salt concentration and osmotic pressure to the desired values according to the purpose of use, it is not necessary to artificially define and mix mineral components. It is considered that a medical electrolyte solution that is necessary for various medical uses and contains abundant mineral components can be obtained.

  Currently, Zn, Cu, Se (selenium), Cr, Mn, I (iodine), Mo, and Co are known as trace elements essential for humans (Japan Medical Association Journal Vol. 129, No. 5). , March 1, 2003, P607-P612 "What are trace elements-deficiencies and excesses").

  In the present invention, medical electrolyte solution using seawater is physiological saline, various infusions (Ringer solution, high calorie infusion, electrolyte infusion, etc.), artificial liver replacement fluid, dialysis fluid such as peritoneal dialysis fluid, and affected part at the time of surgery. It can be used as a cleaning solution for various medical devices, a cleaning solution for various medical devices, a cleaning solution for a contact lens, a storage solution, or the like, or a stock solution for each of these solutions. In particular, when the medical electrolyte solution of the present invention is used for physiological saline, various infusions, etc., mineral components abundantly contained in these aqueous solutions are directly administered into the body, so that the mineral components are absorbed into cells. The efficiency is extremely good, and the medical effect on the above-mentioned elderly and patients with terminal cancer is considered to be improved.

The present invention has the following effects.
(1) The medical electrolyte solution of the present invention was obtained by removing contaminants including organic compounds such as viruses, bacteria, and proteins in a state in which the mineral components contained in seawater, particularly deep seawater, are contained as they are. An electrolyte solution prepared by adding sterile (sterilized) distilled water to purified seawater and adjusting the concentration and osmotic pressure of sodium chloride according to the intended use. For this reason, for example, a physiological saline containing abundant mineral components can be obtained as compared with a physiological saline in which only sodium chloride is dissolved in distilled water that has been conventionally used. Since the absorption efficiency of this mineral component is improved when administered directly from, etc., the medical effect is expected to increase in each stage.

  (2) The medical electrolyte solution of the present invention uses purified seawater obtained by purifying seawater using a membrane separation means such as a hollow fiber membrane that has been proven in hemodialysis. For this reason, foreign substances such as viruses, bacteria, and proteins contained in seawater can be surely removed, so there is no need to use a reverse osmosis membrane device that becomes expensive equipment or a special device for sterilization. . Thereby, the process for producing the medical electrolyte solution of the present invention basically includes a seawater purification process for obtaining purified seawater using a porous membrane, and a purification seawater obtained through the seawater purification process. Only two steps of the osmotic pressure adjusting step for adjusting the salt concentration and the osmotic pressure to desired values are required. Therefore, the manufacturing process for manufacturing the medical electrolyte solution of the present invention is extremely simplified, the manufacturing cost is low, and it is possible to manufacture a medical electrolyte solution that is aseptic and rich in mineral components. It becomes possible.

  (3) According to the above (1) and (2), a medical electrolyte solution that is sterile and does not artificially contain mineral components but contains abundant mineral components as they are in seawater. In the medical field, if it is directly administered to the body of a patient with various diseases as physiological saline, various infusions, dialysate, washing solution, etc., the absorption efficiency of mineral components will increase, so patients It is possible to improve the medical effect on the child.

  Hereinafter, embodiments for carrying out the present invention will be described with reference to the drawings. FIG. 1 shows an example of a production process for producing a medical electrolyte solution using seawater of the present invention, and is an example using a hollow fiber membrane as a membrane separation means. In FIG. 1, seawater, preferably seawater (deep seawater) 1 taken from a depth of 200 m or less below the sea level is temporarily stored in a seawater storage tank 2. The seawater 1 stored in the seawater storage tank 2 is guided to a seawater purification device 3 that is a seawater purification process via a pipe. The seawater purification device 3 is provided with a hollow fiber membrane unit configured by bundling thousands to tens of thousands of hollow fiber membranes 4 as membrane separation means for purifying seawater. In FIG. 1, V1 to V5 and P1 to P5 indicate a flow rate adjusting valve installed in a pipe connecting the devices and a pump for applying a flow pressure to seawater or the like flowing in the pipe. .

  As shown in FIG. 2, the seawater purification apparatus 3 includes a cylindrical casing 3a, lids 3b and 3b fixed to both ends of the casing 3a, and the number of the cylindrical casing 3a inserted in the axial direction. Thousand to several tens of thousands of hollow fiber membranes 4 are provided. Furthermore, an inlet 3c for seawater 1 is provided on one lid 3b, and an outlet 3d for seawater that has passed through the hollow flow path 4b of the hollow fiber membrane 4 is provided on the other lid 3b. Further, the casing 3a is provided with a purified seawater outlet 3e serving as an outlet of seawater (hereinafter referred to as purified seawater 1a) purified by passing the seawater flowing in from the inlet 3c through the hollow fiber membrane 4. The hollow fiber membrane 4 is configured as a unit (hollow fiber membrane unit) in which several thousand to several tens of thousands of hollow fiber membranes 4 are bundled, and both ends of the hollow fiber membrane 4 are sealed by a sealing member 3f. The outer peripheral surface of each hollow fiber membrane 4 is liquid-tightly fixed so that the path 4b is not blocked. The sealing member 3f is made of silicon, polyurethane, epoxy resin, or the like. Furthermore, the outer peripheral surface of the sealing member 3f is fixed so as to be liquid-tight with respect to the inner peripheral surface of the casing 3a.

  The unit of the hollow fiber membrane 4 is disposed in the casing 3a so that a gap S1 is formed with the inner peripheral surface of the casing 3a. Further, each hollow fiber membrane 4 constituting the unit of the hollow fiber membrane 4 is arranged so that a slight gap S2 is generated between the outer peripheral surfaces thereof. The material of the hollow fiber membrane 4 is composed of a polymer-based porous membrane such as polyethylene or a cellulose-based porous membrane that has a proven record as a filter for artificial dialysis.

  As shown in FIG. 3, each hollow fiber membrane 4 constituting the membrane separation means is composed of a porous membrane 4a (hereinafter referred to as porous membrane 4a) and a hollow flow path 4b. The thickness of the porous film 4a is about 20 μm to 100 μm, and the porous film 4a is formed so that innumerable fine holes 4c are dispersed in multiple stages. Generally, the average pore diameter of the micropores 4c of the hollow fiber membrane 4 is 0.001 μm to 2 μm depending on the application. In the present invention, the average pore diameter of the micropores 4c is 0.001 μm. It is characterized by using the hollow fiber membrane 4 set in a range of ˜0.1 μm.

  In the present invention, the reason for using the hollow fiber membrane 4 in which the average pore diameter of the fine pores 4c formed in the porous membrane 4a is 0.001 μm to 0.1 μm is as follows. That is, it is generally said that the diameter of microorganisms such as viruses and bacteria is 0.01 μm to 1 μm, proteins are 0.01 μm to 1 μm, and metal ions are 0.001 μm or less. Therefore, when seawater is dialyzed using the hollow fiber membrane 4 in which the average pore diameter of the micropores 4c is set to 0.001 μm to 0.1 μm, desirably 0.001 μm (10 cm) to 0.006 μm (60 mm), When seawater passes through the porous membrane 4a of the hollow fiber membrane 4, organic substances such as viruses, bacteria, and proteins contained in the seawater can be removed by the porous membrane 4a and contained in the seawater to be ionized. This is because the mineral component can pass through the porous membrane 4a as it is to obtain purified sterilized seawater. In particular, since deep sea water taken from 200 m or less below the sea surface contains almost no viruses, bacteria, and organic matter, it is more preferable to use deep sea water as the seawater used in the present invention.

  The seawater introduced into the seawater purification device 3 from the seawater inlet 3c is given a predetermined pressure by the height difference between the seawater storage tank 2 and the seawater purification device 3, or by a pump or the like. It flows into the flow path 4b. Then, as shown in FIG. 3, the seawater 1 that has flowed into the hollow flow path 4b permeates through the porous membrane 4a due to the inflow pressure of the seawater and is provided on the outer side (outer peripheral surface side) of the porous membrane 4a. Outflow (permeate) to S1 and S2. At this time, since the porous membrane 4a has countless fine pores 4c having an average pore diameter of 0.001 μm to 0.1 μm as described above, viruses, bacteria, and proteins contained in the seawater 1 are formed. Foreign matters such as Na, K, Mg, Ca, P, Zn, Cu, Mn, Mo,..., Which are trapped in the porous membrane 4a and dissolved in seawater, are porous membrane 4a. It permeates as it is and flows out into the clearances S1 and S2 provided outside the hollow fiber membrane 4 as purified seawater 1a. The purified seawater 1a that has flowed out into the gaps S1 and S2 in the seawater purification device 3 flows out from the purified seawater outlet 3e, and is temporarily stored in the purified seawater storage tank 5 via a pipe. On the other hand, the seawater 1b that passes through the hollow flow path 4b of the hollow fiber membrane 4 and has little or no mineral component is discharged from the seawater outlet 3d, returned to the seawater inlet 3c, and subjected to permeation treatment again. Or, dispose of it.

  The purified seawater 1a from which contaminants made of organic compounds such as viruses, bacteria and proteins have been removed by the seawater purification apparatus 3 contains various mineral components, but also contains about 34 g / liter of salt (sodium chloride). Yes. In the present invention, in the subsequent steps, sterile distilled water is added to the purified seawater 1a for dilution, and the sodium chloride concentration and osmotic pressure become appropriate values according to the intended use as a medical electrolyte. Adjust as follows.

  The purified seawater 1a once stored in the purified seawater storage tank 5 is guided to the osmotic pressure adjusting tank 6 in which a predetermined amount is used in the osmotic pressure adjusting step. Subsequently, a predetermined amount of sterile distilled water is added to the osmotic pressure adjusting tank 6 from the distilled water storage tank 7 which stores sterilized and sterile distilled water, and the purified seawater 1a and this distilled water are added by a stirrer (not shown). Stir and mix with water to make diluted purified seawater (hereinafter referred to as diluted purified seawater). At this time, the concentration of sodium chloride contained in the diluted purified seawater is measured by the sodium chloride concentration measuring device 8, and the concentration of sodium chloride contained in the diluted purified seawater in the osmotic pressure adjusting tank 6 is an appropriate value depending on the purpose of use. Adjust the amount of sterile distilled water added so that Further, the diluted purified seawater in the osmotic pressure adjusting tank 6 is sampled and the osmotic pressure thereof is measured by, for example, the osmotic pressure measuring device 9 based on the freezing point depression method, so that the diluted purified seawater having a desired osmotic pressure value can be obtained. Adjust the amount of sterile distilled water to be added.

  The physiological saline is an aqueous electrolyte solution adjusted to have an osmotic pressure equivalent to that of human body fluid. Currently used physiological saline solution has an osmotic pressure equivalent to that of human body fluid by dissolving 9 g of sodium chloride (Na concentration is 154 mEq / L) in 1 liter of distilled water. In the present invention, when a physiological saline having an osmotic pressure equivalent to that of human body fluid is produced, the osmotic pressure measuring device 9 determines the osmotic pressure of diluted purified seawater obtained by adding sterile distilled water to the purified seawater 1a. And the osmotic pressure is adjusted so as to be a value equivalent to that of human body fluid (280 to 295 mOsm / L). In the physiological saline which is the medical electrolyte solution of the present invention thus manufactured, Na, K, Mg, Ca, P, Zn, Cu, Mn which are various mineral components previously contained in the seawater 1 are included. , Mo, I, Se,... Are included as they are. Therefore, when adding sterilized distilled water to the purified seawater 1a and adjusting its osmotic pressure to be equivalent to that of human body fluid, the amount of sodium chloride contained in 1 liter is less than 9 g of physiological saline. You can get water. That is, a physiological saline having a Na concentration (154 mEq / L) lower than that of conventionally used physiological saline, for example, a Na concentration of 130 to 135 mEq / L and containing the various mineral components described above. Can be manufactured. As described above, when a physiological saline having a sodium chloride content lower than that of a conventional physiological saline is administered to a patient, there is an effect that the risk of hypernatremia can be prevented.

The sterile distilled water stored in the distilled water storage tank 7 is preferably produced by the same procedure as the following known method for producing distilled water for injection.
(1) First, raw water such as tap water is desalted and then sterilized by heating to 80 ° C. or higher.
(2) Subsequently, membrane treatment such as reverse osmosis membrane treatment is performed to remove impurities such as metal ions.
(3) After performing the process of (2) above, a distillation process is performed to obtain distilled water which is sterile pure water.
Since the medical electrolyte solution of the present invention is directly administered to the human body, the distilled water used for diluting the purified seawater is the sterile distilled water produced by the above method.

  The diluted purified seawater whose sodium chloride concentration and osmotic pressure are adjusted to predetermined values in the osmotic pressure adjusting tank 6 is guided to the medical electrolyte storage tank 10. The diluted purified seawater stored in the medical electrolyte solution storage tank 10 is filled in a predetermined container or the like (not shown) and used as a physiological saline or the like at a medical site or the like. Further, when used as various infusion solutions, a predetermined amount of diluted purified seawater stored in the medical electrolyte storage tank 10 is transferred to the tank 11, and amino acids, lactic acid, acetic acid, A predetermined amount of phosphoric acid, glucose, etc. is added and blended, and if necessary, aseptic liquid is added from the distilled water storage tank 7 to produce an infusion solution adjusted to a desired osmotic pressure. . For example, when producing an electrolyte solution for high-calorie infusion, glucose, phosphoric acid, etc. are added to diluted purified seawater to adjust the osmotic pressure ratio (compared with physiological saline) to 4 to 8 to produce a peritoneal dialysis solution. In some cases, glucose is added to adjust the osmotic pressure ratio to 1.2-1.8. Even in this case, when producing various infusions, dialysate, etc., the mineral components are not artificially added, and the various mineral components contained in the seawater 1 are included in the infusion, dialysate, etc. as they are. To do.

  In addition, although the seawater inflow port 3c and the seawater outflow port 3d provided in the seawater purification apparatus 3 shown in FIG. 2 showed the example which made the diameter substantially the same, as shown in FIG. 4, the diameter of the seawater inflow port 3c Is d1 and the diameter of the seawater outlet 3d is d2, it is desirable that d1> d2 and that the cross-sectional area of the seawater inlet 3c be larger than the cross-sectional area of the seawater outlet 3d. d2 / d1 is preferably set to about 0.5 to 0.1. Thus, by setting the value of d2 / d1, it is possible to prevent a decrease in pressure loss when the seawater 1 introduced into the hollow flow path 4b of the hollow fiber membrane 4 flows through the hollow flow path 4b, and Supply of seawater from the seawater storage tank 2 to the seawater purification device 3 can obtain purified seawater 1a by dialysis of the seawater with the hollow fiber membrane 4 using the water pressure of the height difference without using the pump P1. .

  FIG. 5 is a cross-sectional view showing another embodiment of the seawater purification apparatus used in the present invention. The seawater purification device 3 shown in FIG. 5 is provided with an inlet 3c1 for seawater 1 and an outlet 3e1 for purified seawater 1a on one of the lids 3b near one end of a cylindrical casing 3a. The purified seawater 1a is recovered from the hollow flow path 4b of the hollow fiber membrane 4 by being supplied to the outer peripheral surface side of the hollow fiber membrane 4. In addition, one end of the membrane separation means configured as a unit of several thousand to several tens of thousands of hollow fiber membranes 4 is also closed by the sealing member 3f1 with the interval S2 between the hollow flow path 4b and the hollow fiber membranes 4. It is fixed liquid-tight. Further, the outer peripheral surface of the sealing member 3f1 is also liquid-tightly fixed to the inner peripheral surface of the casing 3a. The other end of the hollow fiber membrane 4 constituting the membrane separation means is fixed in a liquid-tight manner by the sealing member 3f2, but the hollow flow path 4b is opened and communicated with the outlet 3e1. The outer peripheral surface of the sealing member 3f2 is liquid-tightly fixed to the inner peripheral surface of the casing 3a. A seawater outlet 3d1 is provided near the other end of the casing 3a. The diameter of the seawater outlet 3d1 is made smaller than the diameter of the seawater inlet 3c1 in the same manner as the seawater purification apparatus 3 shown in FIG. 2, so that pressure is generated in the seawater flowing into the seawater purification apparatus 3. Accordingly, it is preferable that the seawater has a permeation effect from the outer peripheral surface of the hollow fiber membrane 4 in the direction of the hollow flow path 4b. In the seawater purification device 3 shown in FIG. 5, seawater is permeated from the outer peripheral surface side of the hollow fiber membrane 4 to the hollow flow path 4b, so that the membrane of the porous membrane 4a is compared with the seawater purification device shown in FIG. Since the area becomes large, there is an effect that the permeation efficiency of seawater is improved.

  The embodiment of the seawater purification device 3 shown in FIGS. 2 and 4 has been described with respect to an example in which one unit in which several thousand to several tens of thousands of hollow fiber membranes 4 are bundled. The seawater purification device 3 as shown in FIG. 4 may be arranged in parallel to increase the purification amount of seawater per unit time.

  In addition, when the seawater purification apparatus 3 is used for a long period of time, the amount of foreign matter such as viruses, bacteria, and organic substances contained in the seawater increases in the hollow fiber membrane 4. Accordingly, the seawater purification device 3 has a structure in which a unit in which the hollow fiber membranes 4 are bundled can be detachably mounted in the casing 3a. When the seawater purification device is operated for a predetermined time, the unit is replaced with a new unit. It is good to.

  In the above-described embodiment of the present invention, an example of the operation operation for continuously supplying the seawater 1 to the seawater purification device 3 has been described. After the seawater outlet 3d of the seawater purification device 3 is closed, A fixed amount of seawater 1 is supplied to the seawater purification device 3 to purify the seawater for a predetermined time, and then the seawater outlet 3d is opened to remove a small amount of seawater that does not contain mineral components from the seawater outlet 3d to the outside. The driving operation for discharging may be repeated.

  In the embodiment of the present invention described above, the membrane separation means for purifying seawater has been described as an example using a hollow fiber membrane, but a flat membrane type membrane module applied to various water treatments, Spiral membrane modules can also be used. What is important for the present invention is a porous material capable of removing foreign substances such as viruses, bacteria, and proteins contained in seawater and purifying seawater so that mineral components contained in seawater are contained as they are. Is to use a membrane. For this purpose, as described above, a membrane separation means having fine pores having an average pore diameter of 0.001 μm to 0.1 μm is used as the porous membrane.

  The osmotic pressure of seawater is said to be about 1000 mOsm. The medical electrolyte solution of the present invention is prepared by adding aseptic distilled water (osmotic pressure 0) to purified seawater, for example, an electrolyte solution (physiological saline) having an osmotic pressure (280 to 295 mOsm) equivalent to a human body fluid. ) Can be manufactured. At this time, in the method of adjusting the osmotic pressure of the electrolyte solution of the present invention to a target value, first, a predetermined amount of sterile distilled water is added to the purified seawater so that the osmotic pressure becomes a value within a predetermined range. Then, for the diluted purified seawater whose osmotic pressure is adjusted to a predetermined range, for example, by finely adjusting the addition amount of sterile distilled water so that the osmotic pressure becomes the target 280-295 mOsm, It is possible to easily obtain a medical electrolyte solution accurately adjusted to an osmotic pressure according to the purpose of use.

  As described above, the medical electrolyte solution of the present invention does not contain foreign substances such as viruses, bacteria, and proteins, and contains abundant mineral components contained in seawater as they are. Therefore, it is possible to provide a medical electrolyte solution in which the concentration and the osmotic pressure are adjusted to appropriate values according to the purpose of use. For this reason, even if it is directly administered to the human body as various medical electrolyte solutions, it contains no minerals (trace elements) contained in seawater and is useful for the human body. When used as physiological saline, various infusions, dialysate, or the like for patients at the end stage, improvement of the medical effect can be expected. The human extracellular fluid has a pH of 7.35 to 7.45 in order to maintain acid-base equilibrium. Therefore, since the medical electrolyte solution obtained in the present invention is diluted with distilled water, the pH value is not abnormal, but the pH value should be adjusted to around 7.

It is a manufacturing process figure for demonstrating the example about the manufacturing method of the medical electrolyte solution of this invention. It is sectional drawing which shows an example of the seawater purification apparatus shown in FIG. It is a fragmentary sectional view of the hollow fiber membrane for demonstrating a state when seawater is purified with the hollow fiber membrane used for the seawater purification apparatus shown in FIG. It is sectional drawing for demonstrating other embodiment about the seawater purification apparatus shown in FIG. Similarly, it is sectional drawing for demonstrating other embodiment about the seawater purification apparatus shown in FIG.

Explanation of symbols

1: Seawater 1a: Purified seawater 2: Seawater storage tank 3: Seawater purification device 3a: Casing 3b: Lid 3c: Seawater inlet 3d: Seawater outlet 3e: Purified seawater outlet 3f: Sealing members 3f1, 3f2: Sealed Stop member 4: Hollow fiber membrane 4a: Porous membrane 4b: Hollow flow path 4c: Fine pore 5: Purified seawater storage tank 6: Osmotic pressure adjustment tank 7: Distilled water storage tank 8: Sodium chloride concentration measuring device 9: Osmotic pressure Measuring device 10: Medical electrolyte storage tank 11, 12: Tank S1, S2: Gap

Claims (8)

  The seawater is passed through a membrane separation means to remove foreign substances such as viruses and bacteria contained in the seawater, and the purified seawater purified to include mineral components contained in the seawater is aseptically distilled. A medical electrolyte solution using seawater, which is diluted purified seawater mixed with water, wherein the osmotic pressure of the diluted purified seawater is adjusted to a predetermined value.   The medical electrolyte solution using seawater according to claim 1, wherein the diluted purified seawater is adjusted by blending the distilled water so as to have an osmotic pressure equivalent to that of a human body fluid.   The medical electrolyte solution using seawater according to claim 1, wherein the diluted purified seawater is an electrolyte solution for infusion containing at least one of amino acid, lactic acid, acetic acid, phosphoric acid, and glucose. .   4. The medical electrolyte solution using seawater according to any one of claims 1 to 3, wherein the seawater is deep ocean water taken from a depth deeper than 200 m below the sea level. Seawater purification step of purifying the seawater so that the mineral components contained in the seawater are contained while allowing the seawater to pass through the membrane separation means and removing foreign substances such as viruses and bacteria contained in the seawater;
An osmotic pressure adjusting step for diluting the purified seawater by adding aseptic distilled water to the purified seawater obtained by purification in the seawater purification step, and adjusting the osmotic pressure of the diluted purified seawater to a predetermined value; A method for producing a medical electrolyte solution using seawater.   The said membrane separation means uses the porous membrane which has the micropore which isolate | separates foreign materials, such as a virus and bacteria contained in the said seawater, and the mineral component contained in the said seawater permeate | transmits. 5. A method for producing a medical electrolyte solution using seawater according to 5.   The method for producing a medical electrolyte solution using seawater according to claim 6, wherein a porous membrane having fine pores having an average pore diameter of 0.001 μm to 0.1 μm is used as the porous membrane. . The method for producing a medical electrolyte solution using seawater according to claim 6 or 7, wherein a hollow fiber membrane is used as the porous membrane.

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