JP5583028B2 - オキサゾリジン及びチアゾリジン選択的サブタイプアルファ２アドレナリン作用薬並びにこれらの使用方法 - Google Patents

オキサゾリジン及びチアゾリジン選択的サブタイプアルファ２アドレナリン作用薬並びにこれらの使用方法 Download PDF

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JP5583028B2
JP5583028B2 JP2010543198A JP2010543198A JP5583028B2 JP 5583028 B2 JP5583028 B2 JP 5583028B2 JP 2010543198 A JP2010543198 A JP 2010543198A JP 2010543198 A JP2010543198 A JP 2010543198A JP 5583028 B2 JP5583028 B2 JP 5583028B2
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pyridin
compound
alpha
pain
compounds
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JP2011510008A (ja
JP2011510008A5 (https=
Inventor
トッド エム ハイデルボー
ケン チャウ
サントーシュ シー シンハ
フォン エックス グエン
ウェンクイ ケイ ファン
リン リー
ジャネット エイ タケウチ
スミタ エス バート
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Allergan Inc
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Allergan Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
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JP2010543198A 2008-01-18 2009-01-14 オキサゾリジン及びチアゾリジン選択的サブタイプアルファ２アドレナリン作用薬並びにこれらの使用方法 Expired - Fee Related JP5583028B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2215208P 2008-01-18 2008-01-18
US61/022,152 2008-01-18
PCT/US2009/030887 WO2009091760A1 (en) 2008-01-18 2009-01-14 Oxazolidine and thiazolidine selective subtype alpha 2 adrenergic agents and methods for use thereof

Publications (3)

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JP2011510008A JP2011510008A (ja) 2011-03-31
JP2011510008A5 JP2011510008A5 (https=) 2012-03-01
JP5583028B2 true JP5583028B2 (ja) 2014-09-03

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JP2010543198A Expired - Fee Related JP5583028B2 (ja) 2008-01-18 2009-01-14 オキサゾリジン及びチアゾリジン選択的サブタイプアルファ２アドレナリン作用薬並びにこれらの使用方法

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Country Link
US (2) US8735399B2 (https=)
EP (1) EP2242753B1 (https=)
JP (1) JP5583028B2 (https=)
AU (1) AU2009205473B8 (https=)
BR (1) BRPI0906875A2 (https=)
CA (1) CA2712190A1 (https=)
WO (1) WO2009091760A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8809379B2 (en) * 2008-01-18 2014-08-19 Allergan, Inc. Selective subtype alpha 2 adrenergic agents and methods for use thereof
AU2010289703A1 (en) * 2009-08-26 2012-04-12 Allergan, Inc. Method of treating compulsive disorders with alpha-2B adrenergic receptor agonists
HUE038366T2 (hu) 2010-08-16 2018-10-29 Allergan Inc Módszer szabályozó T-sejtek alfa-2B adrenerg receptor agonistákkal való aktiválásához

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* Cited by examiner, † Cited by third party
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MXPA06006501A (es) 2003-12-23 2006-08-23 Basf Ag Compuestos de 1-(azolin-2-il)amino-1,2-difeniletano para combatir insectos, aracnidos y nematodos.
CN101346374A (zh) * 2005-12-22 2009-01-14 巴斯夫欧洲公司 农业组合物
US7709507B2 (en) * 2006-05-17 2010-05-04 Allergan, Inc. Therapeutic fluoroethyl ureas
WO2008123821A1 (en) * 2007-03-01 2008-10-16 Albireo Ab 4, 5-dihydro-lh-imidazol-2-amine derivatives for use in the treatment of respiratory, cardiovascular, neurological or gastrointestinal disorders
US8809379B2 (en) * 2008-01-18 2014-08-19 Allergan, Inc. Selective subtype alpha 2 adrenergic agents and methods for use thereof
JP5480819B2 (ja) * 2008-01-18 2014-04-23 アラーガン インコーポレイテッド 選択的サブタイプアルファ２アドレナリンアゴニスト及びその使用方法

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WO2009091760A1 (en) 2009-07-23
JP2011510008A (ja) 2011-03-31
US20140206701A1 (en) 2014-07-24
US20110105526A1 (en) 2011-05-05
CA2712190A1 (en) 2009-07-23
US8735399B2 (en) 2014-05-27
AU2009205473A1 (en) 2009-07-23
EP2242753B1 (en) 2015-04-08
EP2242753A1 (en) 2010-10-27
AU2009205473B2 (en) 2014-05-01
AU2009205473B8 (en) 2014-09-11
BRPI0906875A2 (pt) 2015-07-07

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