JP5559540B2 - 体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法 - Google Patents

体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法 Download PDF

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JP5559540B2
JP5559540B2 JP2009534846A JP2009534846A JP5559540B2 JP 5559540 B2 JP5559540 B2 JP 5559540B2 JP 2009534846 A JP2009534846 A JP 2009534846A JP 2009534846 A JP2009534846 A JP 2009534846A JP 5559540 B2 JP5559540 B2 JP 5559540B2
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pharmaceutical composition
eye
photoinitiator
composition according
tissue
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JP2010507686A5 (cg-RX-API-DMAC10.html
JP2010507686A (ja
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シュワーツ、ダニエル、エム．
マットソン、マシュー、エス．
コーンフィールド、ジュリア、エー．
マロニー、ロバート、ケイ．
グラブス、ロバート、エイチ．
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California Institute of Technology
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California Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00865—Sclera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
    • A61F2009/00893—Keratoconus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Electromagnetism (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009534846A 2006-10-24 2007-10-24 体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法 Expired - Fee Related JP5559540B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85394906P 2006-10-24 2006-10-24
US60/853,949 2006-10-24
US95454107P 2007-08-07 2007-08-07
US60/954,541 2007-08-07
PCT/US2007/082435 WO2008052081A2 (en) 2006-10-24 2007-10-24 Photochemical therapy to affect mechanical and/or chemical properties of body tissue

Publications (3)

Publication Number Publication Date
JP2010507686A JP2010507686A (ja) 2010-03-11
JP2010507686A5 JP2010507686A5 (cg-RX-API-DMAC10.html) 2011-04-21
JP5559540B2 true JP5559540B2 (ja) 2014-07-23

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JP2009534846A Expired - Fee Related JP5559540B2 (ja) 2006-10-24 2007-10-24 体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法

Country Status (5)

Country Link
US (1) US8414911B2 (cg-RX-API-DMAC10.html)
JP (1) JP5559540B2 (cg-RX-API-DMAC10.html)
KR (2) KR101502632B1 (cg-RX-API-DMAC10.html)
SG (1) SG175568A1 (cg-RX-API-DMAC10.html)
WO (1) WO2008052081A2 (cg-RX-API-DMAC10.html)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
US8580789B2 (en) * 2007-04-02 2013-11-12 The Cleveland Clinic Foundation Treating glaucoma
US8545487B2 (en) * 2007-12-05 2013-10-01 Avedro Inc. Eye therapy system
CZ18420U1 (cs) * 2008-01-25 2008-04-07 Benedík@Jaroslav Prístroj na zjištování kvality a pevnosti cévní steny
US20110060267A1 (en) * 2008-03-14 2011-03-10 Dewoolfson Bruce Ultraviolet irradiation to treat corneal weakness disorders
GB0816399D0 (en) * 2008-09-09 2008-10-15 Sharma Anant Irradiation treatment
WO2010039854A1 (en) * 2008-09-30 2010-04-08 Neal Marshall Eye therapy system
KR20180023070A (ko) 2008-11-07 2018-03-06 클록스 테크놀로지스 인크. 히알루론산, 글루코사민 또는 알란토인을 포함하는 산화성의 광활성화된 피부 회춘용 조성물
SG177635A1 (en) 2009-07-17 2012-03-29 Klox Technologies Inc Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US20110077468A1 (en) * 2009-09-30 2011-03-31 Finger Paul T Drug eluting eyelid speculum
WO2011050164A1 (en) 2009-10-21 2011-04-28 Avedro, Inc. Eye therapy
DE102010008146B4 (de) * 2010-02-12 2022-03-31 Carl Zeiss Meditec Ag Messsystem und Verfahren zum Ermitteln des Innendrucks eines Auges sowie Verfahren und System zum Einstellen des Augeninnendrucks
WO2011116306A2 (en) 2010-03-19 2011-09-22 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
DE102010020194B4 (de) 2010-05-07 2022-09-08 Carl Zeiss Meditec Ag Vorrichtung zur Stabilisierung der Augenhornhaut
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
WO2012154627A2 (en) * 2011-05-06 2012-11-15 California Institute Of Technology Light delivery device and related compositions, methods and systems
WO2012162529A1 (en) 2011-05-24 2012-11-29 Avedro, Inc. Systems and methods for reshaping an eye feature
WO2012167260A2 (en) 2011-06-02 2012-12-06 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
ES2856698T3 (es) 2011-08-23 2021-09-28 Yeda Res & Dev Fotosensibilizadores de (bacterio)clorofila para el tratamiento de enfermedades y trastornos oculares
EP2830554A1 (en) 2012-03-29 2015-02-04 CXL Ophthalmics, LLC Ocular cross-linking system and method for sealing corneal wounds
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP4420725A3 (en) 2012-03-29 2025-04-16 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
EP2872081B2 (en) 2012-07-16 2025-07-16 Avedro, Inc. Systems for corneal cross-linking with pulsed light
BR112015005593B1 (pt) 2012-09-14 2019-09-24 Valeant Pharmaceuticals International, Inc. Método para branqueamento de dentes
DE102013004482A1 (de) 2013-03-12 2014-09-18 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zur Stabilisierung der Augenhornhaut
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
EP3441049B1 (en) * 2013-03-14 2025-08-20 Epion Therapeutics, Inc. Ophthalmic treatment device
WO2014205145A1 (en) 2013-06-18 2014-12-24 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US9498114B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
WO2015000058A1 (en) 2013-07-03 2015-01-08 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US9920147B2 (en) 2013-09-13 2018-03-20 Brandeis University Polymeric materials having active cross-linkers, methods for making them, and use thereof
JP2017509433A (ja) 2014-04-01 2017-04-06 クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 組織充填剤組成物および使用方法
EP3212140B1 (en) 2014-10-27 2021-12-01 Avedro, Inc. Systems for cross-linking treatments of an eye
EP3212826B1 (en) 2014-10-31 2020-10-14 Klox Technologies Inc. Photoactivatable fibers and fabric media
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3827792A1 (en) 2015-04-24 2021-06-02 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
WO2016183424A1 (en) 2015-05-14 2016-11-17 California Institute Of Technology Light adjustable intraocular lenses using upconverting nanop articles and near infrared (nir) light
EP4483884A3 (en) 2015-05-22 2025-03-05 Avedro Inc. Systems for monitoring cross-linking activity for corneal treatments
WO2017015471A1 (en) 2015-07-21 2017-01-26 Avedro, Inc. Systems and methods for treaments of an eye with a photosensitizer
WO2017096400A1 (en) 2015-12-03 2017-06-08 Avedro, Inc. Systems and methods for treating an eye with a mask device
DE102016208012A1 (de) 2016-05-10 2017-11-16 Carl Zeiss Meditec Ag Augenchirurgisches Verfahren
WO2019005943A1 (en) 2017-06-28 2019-01-03 California Institute Of Technology LIGHT ADJUSTABLE INTRAOCULAR LENSES USING ASCENDING CONVERSION OF HEART-WOOD NANOPARTICLES AND INFRARED NEAR-LIGHT (NIR)
US12042433B2 (en) 2018-03-05 2024-07-23 Avedro, Inc. Systems and methods for eye tracking during eye treatment
EP3761928B1 (en) 2018-03-08 2026-07-22 Avedro, Inc. Micro-devices for treatment of an eye
CA3112937A1 (en) 2018-09-19 2020-03-26 Avedro, Inc. Systems and methods treating for corneal ectatic disorders
CN113316411B (zh) 2018-09-19 2025-01-17 艾维德洛公司 用于眼部治疗期间的眼部追踪的系统及方法
AU2019356934B2 (en) 2018-10-09 2024-10-17 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
US11702546B2 (en) 2018-10-24 2023-07-18 California Institute Of Technology Near-infrared heptamethine dyes for generation of singlet oxygen
CN111140774B (zh) * 2019-01-31 2025-10-14 中国科学院昆明动物研究所 一种可抑制眼轴过度增长的新型光源及其模拟方法、灯具
WO2020176598A1 (en) 2019-02-26 2020-09-03 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
JP6853446B2 (ja) * 2019-02-28 2021-03-31 地方独立行政法人神奈川県立産業技術総合研究所 流動体試料の内部構造観察装置及び内部構造解析システム、流動体試料の内部構造観察方法及び内部構造解析方法、並びにセラミックスの製造方法
US11298263B2 (en) * 2019-07-16 2022-04-12 Jack T. Holladay Method of mitigating myopia development and related instrumentation
AU2020326998B2 (en) 2019-08-06 2024-08-22 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
CA3213111A1 (en) 2021-03-08 2022-09-15 Avedro, Inc. Systems and methods for generating patient-specific corneal cross-linking treatment patterns
DE102021131244A1 (de) * 2021-11-29 2023-06-01 Philipps-Universität Marburg, Körperschaft des öffentlichen Rechts Orts- und zeitaufgelöste Bestimmung der dermalen Penetration von nicht- oder schwachfluoreszierenden Substanzen
WO2025255364A1 (en) * 2024-06-07 2025-12-11 The Regents Of The University Of California Methods and devices for transscleral multiphoton imaging and laser therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6161544A (en) 1998-01-28 2000-12-19 Keratoform, Inc. Methods for accelerated orthokeratology
JP2002058695A (ja) 1999-09-03 2002-02-26 Carl Zeiss Jena Gmbh 眼の照射方法及び装置
WO2005110397A1 (en) 2004-05-07 2005-11-24 The Regents Of The University Of California Treatment of myopia
US20060276777A1 (en) * 2005-04-08 2006-12-07 Coroneo Minas T Corneal shaping
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair

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Publication number Publication date
WO2008052081A2 (en) 2008-05-02
WO2008052081A8 (en) 2008-08-14
KR101551590B1 (ko) 2015-09-08
SG175568A1 (en) 2011-11-28
KR20090082392A (ko) 2009-07-30
KR20140096371A (ko) 2014-08-05
JP2010507686A (ja) 2010-03-11
US20080114283A1 (en) 2008-05-15
US8414911B2 (en) 2013-04-09
WO2008052081A3 (en) 2008-06-19
KR101502632B1 (ko) 2015-03-17

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