JP5558582B2 - 眼科用医薬組成物の調製方法 - Google Patents

眼科用医薬組成物の調製方法 Download PDF

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Publication number
JP5558582B2
JP5558582B2 JP2012541629A JP2012541629A JP5558582B2 JP 5558582 B2 JP5558582 B2 JP 5558582B2 JP 2012541629 A JP2012541629 A JP 2012541629A JP 2012541629 A JP2012541629 A JP 2012541629A JP 5558582 B2 JP5558582 B2 JP 5558582B2
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Prior art keywords
preparing
slurry
polymer
carbonic anhydrase
particle size
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Japanese (ja)
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JP2013512894A (ja
JP2013512894A5 (enExample
Inventor
プラビン・メグラジ・ブタダ
アシシュ・アショクラオ・デシュムク
サジーブ・チャンドラン
シリシュクマール・クルカルニ
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Lupin Ltd
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Lupin Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012541629A 2009-12-03 2010-12-02 眼科用医薬組成物の調製方法 Expired - Fee Related JP5558582B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1415KO2009 2009-12-03
IN1415/KOL/2009 2009-12-03
PCT/IN2010/000784 WO2011067791A2 (en) 2009-12-03 2010-12-02 Process for preparing pharmaceutical ophthalmic compositions

Publications (3)

Publication Number Publication Date
JP2013512894A JP2013512894A (ja) 2013-04-18
JP2013512894A5 JP2013512894A5 (enExample) 2014-05-22
JP5558582B2 true JP5558582B2 (ja) 2014-07-23

Family

ID=44115377

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012541629A Expired - Fee Related JP5558582B2 (ja) 2009-12-03 2010-12-02 眼科用医薬組成物の調製方法

Country Status (6)

Country Link
US (1) US8614210B2 (enExample)
EP (1) EP2506878A2 (enExample)
JP (1) JP5558582B2 (enExample)
AU (1) AU2010325632B2 (enExample)
MX (1) MX2012006401A (enExample)
WO (1) WO2011067791A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013175285A1 (en) 2012-05-21 2013-11-28 Aurobindo Pharma Limited Process for preparing ophthalmic suspension of brinzolamde
EP2906198B1 (en) 2012-10-11 2019-04-03 Indoco Remedies Limited A process for manufacturing sterile brinzolamide ophthalmic suspension
US20140377210A1 (en) * 2013-06-21 2014-12-25 Gnt, Llc Artificial tear compositions
UA116273C2 (uk) * 2013-10-17 2018-02-26 Сентісс Фарма Прайвет Лімітед Офтальмологічний фармацевтичний склад, що не містить консерванта
US10463674B2 (en) 2013-11-08 2019-11-05 Sentiss Pharma Private Limited Process for manufacturing sterile ophthalmic pharmaceutical suspensions
EA036820B1 (ru) * 2014-01-24 2020-12-23 Сентисс Фарма Прайвет Лимитед Фармацевтическая композиция, содержащая бринзоламид
PL407710A1 (pl) * 2014-03-28 2015-10-12 Instytut Farmaceutyczny Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem
JP6279395B2 (ja) * 2014-05-01 2018-02-14 東亜薬品株式会社 ブリンゾラミド懸濁性点眼液組成物の製造方法
WO2016006702A1 (ja) 2014-07-11 2016-01-14 富士フイルム株式会社 眼科用水性組成物
UA124698C2 (uk) * 2014-10-20 2021-11-03 Сентіс Фарма Прайвет Лімітед Офтальмологічний розчин
EP3226904B1 (en) 2014-12-02 2019-03-06 Novartis AG Manufacture of surfactant-containing compositions
US9119876B1 (en) 2015-03-13 2015-09-01 Par Pharmaceutical, Inc. Epinephrine formulations
US20170189352A1 (en) 2015-03-13 2017-07-06 Par Pharmaceutical, Inc. Epinephrine formulations
JP2022513342A (ja) * 2018-10-04 2022-02-07 ミラキ イノベーション シンク タンク エルエルシー スラリー及び溶液組成物
KR102271247B1 (ko) * 2020-11-04 2021-06-30 삼천당제약주식회사 안과용 현탁액 조성물의 제조방법
JP2024506384A (ja) 2021-02-10 2024-02-13 イオリクス セラピューティクス，インコーポレーテッド ロフルミラストの眼科的送達方法
CN116867480A (zh) * 2021-02-10 2023-10-10 洛利克斯治疗有限公司 眼部递送罗氟司特的方法
US12263160B2 (en) 2021-09-22 2025-04-01 Iolyx Therapeutics, Inc. Methods of treating ocular inflammatory diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US6071904A (en) * 1996-12-11 2000-06-06 Alcon Laboratories, Inc. Process for manufacturing ophthalmic suspensions
US6258350B1 (en) * 1999-01-20 2001-07-10 Alcon Manufacturing, Ltd. Sustained release ophthalmic formulation
JP4766653B2 (ja) * 2005-01-28 2011-09-07 株式会社林原生物化学研究所 眼科用医薬組成物
CA2604770C (en) * 2005-04-13 2013-09-24 Abbott Gmbh & Co. Kg Method for carefully producing ultrafine particle suspensions and ultrafine particles and use thereof
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions

Also Published As

Publication number Publication date
WO2011067791A3 (en) 2011-09-09
US8614210B2 (en) 2013-12-24
WO2011067791A2 (en) 2011-06-09
MX2012006401A (es) 2012-07-10
EP2506878A2 (en) 2012-10-10
JP2013512894A (ja) 2013-04-18
AU2010325632B2 (en) 2014-01-30
US20120283252A1 (en) 2012-11-08
AU2010325632A1 (en) 2012-06-21

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