JP5551709B2 - 携帯型腹膜透析システム - Google Patents
携帯型腹膜透析システム Download PDFInfo
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- JP5551709B2 JP5551709B2 JP2011534854A JP2011534854A JP5551709B2 JP 5551709 B2 JP5551709 B2 JP 5551709B2 JP 2011534854 A JP2011534854 A JP 2011534854A JP 2011534854 A JP2011534854 A JP 2011534854A JP 5551709 B2 JP5551709 B2 JP 5551709B2
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- Prior art keywords
- dialysate
- patient
- cartridge
- ammonia
- peritoneal cavity
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- MKWYFZFMAMBPQK-UHFFFAOYSA-J sodium feredetate Chemical compound [Na+].[Fe+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O MKWYFZFMAMBPQK-UHFFFAOYSA-J 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
- A61M1/155—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit with treatment-fluid pumping means or components thereof
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
- A61M1/159—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit specially adapted for peritoneal dialysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/282—Operational modes
- A61M1/284—Continuous flow peritoneal dialysis [CFPD]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
- B01D61/244—Dialysis comprising multiple dialysis steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
Landscapes
- Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US19810208P | 2008-11-03 | 2008-11-03 | |
| US61/198,102 | 2008-11-03 | ||
| PCT/US2009/062967 WO2010062716A2 (en) | 2008-11-03 | 2009-11-02 | Portable peritoneal dialysis system |
Publications (3)
| Publication Number | Publication Date |
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| JP2012507373A JP2012507373A (ja) | 2012-03-29 |
| JP2012507373A5 JP2012507373A5 (enExample) | 2012-10-18 |
| JP5551709B2 true JP5551709B2 (ja) | 2014-07-16 |
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| JP2011534854A Active JP5551709B2 (ja) | 2008-11-03 | 2009-11-02 | 携帯型腹膜透析システム |
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| US (1) | US8777892B2 (enExample) |
| EP (1) | EP2344220B1 (enExample) |
| JP (1) | JP5551709B2 (enExample) |
| CN (1) | CN102202702B (enExample) |
| AU (1) | AU2009320025B2 (enExample) |
| CA (1) | CA2741572C (enExample) |
| MX (1) | MX2011004631A (enExample) |
| WO (1) | WO2010062716A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3071822B2 (ja) | 1990-07-06 | 2000-07-31 | チルマン ホイールアブレーター リミテッド | 研磨材スローイングホイール組立体 |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8202248B2 (en) | 2004-08-18 | 2012-06-19 | Sequana Medical Ag | Dialysis implant and methods of use |
| EP1850910A1 (en) | 2005-02-07 | 2007-11-07 | Medtronic, Inc. | Ion imbalance detector |
| DE102008003090A1 (de) * | 2008-01-03 | 2009-07-16 | Fresenius Medical Care Deutschland Gmbh | Hohlfasermembran |
| MX354635B (es) | 2009-09-08 | 2018-03-14 | Fresenius Medical Care Holdings Inc | Sistema de diálisis peritoneal. |
| US9399091B2 (en) | 2009-09-30 | 2016-07-26 | Medtronic, Inc. | System and method to regulate ultrafiltration |
| ES2625135T3 (es) * | 2010-07-05 | 2017-07-18 | Gambro Lundia Ab | Un dispositivo de ultrafiltración ambulatoria, métodos relacionados y un producto de programa informático |
| GB201019228D0 (en) * | 2010-11-15 | 2010-12-29 | Corp | Dialysis device and method of dialysis |
| EP3552654B1 (en) | 2011-02-16 | 2023-06-21 | Sequana Medical NV | Apparatus for treating intracorporeal fluid accumulation |
| US9861733B2 (en) | 2012-03-23 | 2018-01-09 | Nxstage Medical Inc. | Peritoneal dialysis systems, devices, and methods |
| CA2830085A1 (en) | 2011-03-23 | 2012-09-27 | Nxstage Medical, Inc. | Peritoneal dialysis systems, devices, and methods |
| US8945936B2 (en) * | 2011-04-06 | 2015-02-03 | Fresenius Medical Care Holdings, Inc. | Measuring chemical properties of a sample fluid in dialysis systems |
| US9848778B2 (en) | 2011-04-29 | 2017-12-26 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
| US9456755B2 (en) | 2011-04-29 | 2016-10-04 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
| US9561316B2 (en) | 2011-04-29 | 2017-02-07 | Medtronic, Inc. | Intersession monitoring for blood fluid removal therapy |
| US10695481B2 (en) | 2011-08-02 | 2020-06-30 | Medtronic, Inc. | Hemodialysis system having a flow path with a controlled compliant volume |
| US10857277B2 (en) | 2011-08-16 | 2020-12-08 | Medtronic, Inc. | Modular hemodialysis system |
| WO2013025957A1 (en) * | 2011-08-18 | 2013-02-21 | Fresenius Medical Care Holdings, Inc. | Sorbent and chemical regeneration of dialysate |
| WO2013028809A2 (en) | 2011-08-22 | 2013-02-28 | Medtronic, Inc. | Dual flow sorbent cartridge |
| EP2800592B1 (en) | 2012-01-04 | 2019-03-06 | Medtronic Inc. | Multi-staged filtration system for blood fluid removal |
| US9616163B2 (en) | 2012-01-04 | 2017-04-11 | Fresenius Medical Care Holdings, Inc. | Method and system of enhancing removal of toxic anions and organic solutes in sorbent dialysis |
| US8585635B2 (en) | 2012-02-15 | 2013-11-19 | Sequana Medical Ag | Systems and methods for treating chronic liver failure based on peritoneal dialysis |
| US10905816B2 (en) | 2012-12-10 | 2021-02-02 | Medtronic, Inc. | Sodium management system for hemodialysis |
| US9956335B2 (en) | 2012-12-21 | 2018-05-01 | Fresenius Medical Care Holdings, Inc. | Manifold for wearable artificial kidney |
| US9713666B2 (en) | 2013-01-09 | 2017-07-25 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
| US11565029B2 (en) | 2013-01-09 | 2023-01-31 | Medtronic, Inc. | Sorbent cartridge with electrodes |
| US9707328B2 (en) | 2013-01-09 | 2017-07-18 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
| US11154648B2 (en) | 2013-01-09 | 2021-10-26 | Medtronic, Inc. | Fluid circuits for sorbent cartridge with sensors |
| US9623164B2 (en) | 2013-02-01 | 2017-04-18 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
| US10850016B2 (en) | 2013-02-01 | 2020-12-01 | Medtronic, Inc. | Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection |
| US9173987B2 (en) | 2013-02-01 | 2015-11-03 | Medtronic, Inc. | Degassing module for a controlled compliant flow path |
| US10010663B2 (en) | 2013-02-01 | 2018-07-03 | Medtronic, Inc. | Fluid circuit for delivery of renal replacement therapies |
| US9526822B2 (en) | 2013-02-01 | 2016-12-27 | Medtronic, Inc. | Sodium and buffer source cartridges for use in a modular controlled compliant flow path |
| US10543052B2 (en) | 2013-02-01 | 2020-01-28 | Medtronic, Inc. | Portable dialysis cabinet |
| US9827361B2 (en) | 2013-02-02 | 2017-11-28 | Medtronic, Inc. | pH buffer measurement system for hemodialysis systems |
| US9144640B2 (en) | 2013-02-02 | 2015-09-29 | Medtronic, Inc. | Sorbent cartridge configurations for improved dialysate regeneration |
| US20140263062A1 (en) | 2013-03-14 | 2014-09-18 | Fresenius Medical Care Holdings, Inc. | Universal portable machine for online hemodiafiltration using regenerated dialysate |
| US9433720B2 (en) | 2013-03-14 | 2016-09-06 | Fresenius Medical Care Holdings, Inc. | Universal portable artificial kidney for hemodialysis and peritoneal dialysis |
| CN105848581B (zh) | 2013-11-04 | 2019-01-01 | 美敦力公司 | 用于管理身体中的体液体积的方法和装置 |
| US10052612B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
| US9943780B2 (en) | 2013-11-26 | 2018-04-17 | Medtronic, Inc. | Module for in-line recharging of sorbent materials with optional bypass |
| US10004839B2 (en) | 2013-11-26 | 2018-06-26 | Medtronic, Inc. | Multi-use sorbent cartridge |
| US9974896B2 (en) * | 2014-06-24 | 2018-05-22 | Medtronic, Inc. | Method of zirconium phosphate recharging |
| US9884145B2 (en) | 2013-11-26 | 2018-02-06 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
| US9895477B2 (en) | 2013-11-26 | 2018-02-20 | Medtronic, Inc. | Detachable module for recharging sorbent materials with optional bypass |
| US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
| WO2015081221A1 (en) | 2013-11-27 | 2015-06-04 | Medtronic, Inc. | Precision dialysis monitoring and synchonization system |
| PE20161241A1 (es) | 2014-02-27 | 2016-11-19 | Easydial Inc | Maquina de hemodialisis portatil y cartucho desechable |
| EP3160532B1 (en) | 2014-06-24 | 2019-09-18 | Medtronic Inc. | A urease introduction system for replenishing urease in a sorbent cartridge |
| EP3160529B1 (en) | 2014-06-24 | 2019-11-13 | Medtronic Inc. | Replenishing urease in dialysis systems using urease pouches |
| WO2015199767A1 (en) | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | Reserve zirconium phosphate module for use in sorbent dialysis |
| EP3160531B1 (en) | 2014-06-24 | 2019-08-14 | Medtronic Inc. | Replenisihing urease in dialysis systems using a urease introducer |
| WO2015199766A1 (en) * | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | Modular dialysate regeneration assembly |
| US10286380B2 (en) | 2014-06-24 | 2019-05-14 | Medtronic, Inc. | Sorbent pouch |
| US10357757B2 (en) | 2014-06-24 | 2019-07-23 | Medtronic, Inc. | Stacked sorbent assembly |
| US10172989B2 (en) | 2014-09-12 | 2019-01-08 | Easydial Inc. | Portable hemodialysis machine and disposable cartridge with blood leak sensor |
| US10980929B2 (en) | 2014-09-12 | 2021-04-20 | Diality Inc. | Hemodialysis system with ultrafiltration controller |
| US20160101225A1 (en) * | 2014-10-13 | 2016-04-14 | Purewater Therapeutics, LLC | Dialysis system |
| JP2016087172A (ja) * | 2014-11-06 | 2016-05-23 | 住友ベークライト株式会社 | 尿素含有液処理方法、処理液および尿素含有液処理装置 |
| US9713665B2 (en) | 2014-12-10 | 2017-07-25 | Medtronic, Inc. | Degassing system for dialysis |
| US9895479B2 (en) | 2014-12-10 | 2018-02-20 | Medtronic, Inc. | Water management system for use in dialysis |
| US10098993B2 (en) | 2014-12-10 | 2018-10-16 | Medtronic, Inc. | Sensing and storage system for fluid balance |
| US10874787B2 (en) | 2014-12-10 | 2020-12-29 | Medtronic, Inc. | Degassing system for dialysis |
| WO2016190853A1 (en) * | 2015-05-26 | 2016-12-01 | Medtronic, Inc. | Multi-use sorbent cartridge |
| US20160375190A1 (en) * | 2015-05-28 | 2016-12-29 | Cook Medical Technologies Llc | Peritoneal dialysis systems and methods |
| CN105214624B (zh) * | 2015-11-02 | 2017-08-04 | 李建中 | 一种透析液吸附填料、其制备方法和应用 |
| US10335534B2 (en) | 2015-11-06 | 2019-07-02 | Medtronic, Inc. | Dialysis prescription optimization for decreased arrhythmias |
| US10874790B2 (en) | 2016-08-10 | 2020-12-29 | Medtronic, Inc. | Peritoneal dialysis intracycle osmotic agent adjustment |
| US10994064B2 (en) | 2016-08-10 | 2021-05-04 | Medtronic, Inc. | Peritoneal dialysate flow path sensing |
| US12329892B2 (en) | 2016-04-04 | 2025-06-17 | Mozarc Medical Us Llc | Dextrose concentration sensor for a peritoneal dialysis system |
| US11116881B2 (en) | 2016-05-27 | 2021-09-14 | Cook Medical Technologies Llc | Filtration system and process for peritoneal dialysis |
| CN106039446B (zh) * | 2016-07-25 | 2018-10-26 | 北京卫健医网临床医学研究有限公司 | 一种可穿戴腹膜透析便携装置 |
| US10716922B2 (en) | 2016-08-26 | 2020-07-21 | Sequana Medical Nv | Implantable fluid management system having clog resistant catheters, and methods of using same |
| CA3034358A1 (en) | 2016-08-26 | 2018-03-01 | Sequana Medical Ag | Systems and methods for managing and analyzing data generated by an implantable device |
| US11013843B2 (en) | 2016-09-09 | 2021-05-25 | Medtronic, Inc. | Peritoneal dialysis fluid testing system |
| US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
| WO2018106185A2 (en) * | 2016-12-05 | 2018-06-14 | Temasek Polytechnic | Sorbent for a dialysis device and dialysis system |
| US11167070B2 (en) | 2017-01-30 | 2021-11-09 | Medtronic, Inc. | Ganged modular recharging system |
| US11559618B2 (en) | 2017-05-24 | 2023-01-24 | Sequana Medical Nv | Formulations and methods for direct sodium removal in patients having severe renal dysfunction |
| US10918778B2 (en) | 2017-05-24 | 2021-02-16 | Sequana Medical Nv | Direct sodium removal method, solution and apparatus to reduce fluid overload in heart failure patients |
| US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
| US12048791B2 (en) | 2017-06-24 | 2024-07-30 | Nxstage Medical, Inc. | Peritoneal dialysis fluid preparation and/or treatment devices methods and systems |
| US11278654B2 (en) | 2017-12-07 | 2022-03-22 | Medtronic, Inc. | Pneumatic manifold for a dialysis system |
| US11033667B2 (en) | 2018-02-02 | 2021-06-15 | Medtronic, Inc. | Sorbent manifold for a dialysis system |
| CN108295326B (zh) * | 2018-02-09 | 2021-03-26 | 苏州卓壹医疗器械有限公司 | 一种双腔超纯血液透析器 |
| US11110215B2 (en) | 2018-02-23 | 2021-09-07 | Medtronic, Inc. | Degasser and vent manifolds for dialysis |
| US20190262526A1 (en) | 2018-02-28 | 2019-08-29 | Nxstage Medical, Inc. | Fluid Preparation and Treatment Devices Methods and Systems |
| US12285552B2 (en) | 2018-08-14 | 2025-04-29 | Mozarc Medical Us Llc | Precision dialysis therapy based on sorbent effluent analysis |
| US10973971B2 (en) | 2018-08-17 | 2021-04-13 | University Of Washington | Apparatus and method for urea photo-oxidation |
| US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
| WO2020077338A1 (en) | 2018-10-12 | 2020-04-16 | University Of Washington | System and method for removing uremic toxins from a patient's body |
| US11806457B2 (en) | 2018-11-16 | 2023-11-07 | Mozarc Medical Us Llc | Peritoneal dialysis adequacy meaurements |
| US11806456B2 (en) | 2018-12-10 | 2023-11-07 | Mozarc Medical Us Llc | Precision peritoneal dialysis therapy based on dialysis adequacy measurements |
| US12433976B2 (en) | 2019-01-08 | 2025-10-07 | Mozarc Medical Us Llc | Bicarbonate sensor for dialysis |
| CN109999245A (zh) * | 2019-04-15 | 2019-07-12 | 钱纯钰 | 一种便携式穿戴腹膜透析仪 |
| WO2021076508A1 (en) | 2019-10-14 | 2021-04-22 | University Of Washington | Hydrogels for the entrapment of bacteria |
| EP3868417A1 (en) | 2020-02-18 | 2021-08-25 | ICinnovation BV | Wearable and portable device for recirculating flow dialysis |
| CN115443158A (zh) * | 2020-02-18 | 2022-12-06 | Ic创新有限公司 | 用于再循环流透析的可穿戴便携装置 |
| US12128165B2 (en) | 2020-04-27 | 2024-10-29 | Mozarc Medical Us Llc | Dual stage degasser |
| EP3912656A1 (en) | 2020-05-19 | 2021-11-24 | CoreQuest Sagl | Peritoneal dialysis solution |
| EP4255521A1 (en) * | 2020-12-02 | 2023-10-11 | W. L. Gore & Associates, Inc. | Dialysate filter |
| WO2022123575A1 (en) * | 2020-12-10 | 2022-06-16 | Plas-Free Ltd | Extracorporeal device and matrix for removing ammonia from biological fluids, methods and uses thereof |
| US12397093B2 (en) | 2021-05-18 | 2025-08-26 | Mozarc Medical Us Llc | Sorbent cartridge designs |
| US12154673B2 (en) | 2021-08-02 | 2024-11-26 | Mozarc Medical Us Llc | Artificial intelligence assisted home therapy settings for dialysis |
| US11850344B2 (en) | 2021-08-11 | 2023-12-26 | Mozarc Medical Us Llc | Gas bubble sensor |
| US11965763B2 (en) | 2021-11-12 | 2024-04-23 | Mozarc Medical Us Llc | Determining fluid flow across rotary pump |
| US11944733B2 (en) | 2021-11-18 | 2024-04-02 | Mozarc Medical Us Llc | Sodium and bicarbonate control |
| CN114042197B (zh) * | 2021-12-07 | 2024-04-23 | 北京化工大学 | 一种超细纤维软物质丝束吸附尿毒的装置及其使用方法 |
| CN115154714B (zh) * | 2022-06-06 | 2024-12-20 | 大连理工大学 | 一种高性能膜-吸附耦合式氧合器 |
| WO2024259418A1 (en) * | 2023-06-15 | 2024-12-19 | Arizona Board Of Regents On Behalf Of The Univeristy Of Arizona | Method, system and device for water conservation and dialysate recycling |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825493A (en) | 1972-09-29 | 1974-07-23 | Hydronautics | Peritoneal artificial kidney |
| US3579441A (en) * | 1968-04-19 | 1971-05-18 | Hydronautics | Blood purification by dual filtration |
| US3707967A (en) | 1970-10-01 | 1973-01-02 | Tecna Corp | Steady flow regenerative peritoneal dialysis system and method |
| US4094775A (en) | 1977-02-28 | 1978-06-13 | California Institute Of Technology | Dialysis system |
| PH16373A (en) | 1978-02-27 | 1983-09-14 | Purdue Research Foundation | Dialysis composition and method for removing uremic substances in an artificial kidney |
| US4256102A (en) | 1979-05-14 | 1981-03-17 | Monaco Anthony P | Subcutaneous dialysis system |
| JPS6059010B2 (ja) | 1979-10-02 | 1985-12-23 | 工業技術院長 | マイクロカプセル |
| DE3110128A1 (de) | 1981-03-16 | 1982-09-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Verfahren und vorrichtung zur entgiftung und regeneration von blut, blutbestandteilen und bei der blutreinigung anfallenden loesungen sowie kit fuer die durchfuehrung des verfahrens |
| EP0064393A3 (en) | 1981-05-04 | 1982-12-29 | Purdue Research Foundation | Sorbent mixture for use in hemodialysis |
| EP0118548A1 (en) | 1982-09-09 | 1984-09-19 | Organon Teknika Corporation | Ammonia scavenger |
| JPS60132644A (ja) | 1983-12-22 | 1985-07-15 | Kureha Chem Ind Co Ltd | 人工臓器用吸着剤及びその製造方法 |
| US5026365A (en) | 1987-04-29 | 1991-06-25 | The University Of Massachusetts | Method and apparatus for therapeutically treating immunological disorders and disease states |
| US5409903A (en) | 1992-02-18 | 1995-04-25 | Urecap Corporation | Method and compositions for the treatment of H. pylori and dermatitis |
| US5549674A (en) | 1992-03-02 | 1996-08-27 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
| US5284470A (en) * | 1992-11-02 | 1994-02-08 | Beltz Alex D | Wearable, portable, light-weight artificial kidney |
| US5350357A (en) * | 1993-03-03 | 1994-09-27 | Deka Products Limited Partnership | Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow |
| AU2658195A (en) | 1994-05-31 | 1995-12-21 | Penn State Research Foundation, The | Immobilization of biologically active materials and diagnostic agents in cross-linked poly(organophosphazenes) |
| US5944684A (en) * | 1995-08-31 | 1999-08-31 | The Regents Of The University Of California | Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications |
| GB9601333D0 (en) | 1996-01-23 | 1996-03-27 | Univ Mcgill | Microencapsulated genetically engineered microorganisms for clinical application |
| CA2248158A1 (en) | 1996-03-12 | 1997-09-18 | The Board Of Regents Of The University Of Nebraska | Targeted site specific drug delivery compositions and method of use |
| US5849727A (en) | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
| US5902336A (en) | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
| US5980481A (en) | 1997-05-08 | 1999-11-09 | Transvivo, Inc. | Method and apparatus for continuous peritoneal cascade dialysis and hemofiltration (CPCD/H) |
| US6022477A (en) * | 1997-11-14 | 2000-02-08 | New Jersey Institute Of Technology | Method and apparatus for isolation purification of biomolecules |
| EP0980685B1 (en) | 1998-06-17 | 2006-01-25 | Nipro Corporation | Use of a fluid for the manufacture of a dialysis fluid for continuous recirculating peritoneal dialysis |
| US6254567B1 (en) | 1999-02-26 | 2001-07-03 | Nxstage Medical, Inc. | Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration |
| US6706287B2 (en) | 2001-05-15 | 2004-03-16 | Kibow Biotech Inc. | Prebiotic and probiotic compositions and methods for their use in gut-based therapies |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| US20020052571A1 (en) | 2000-09-13 | 2002-05-02 | Fazio Frank A. | Artificial kidney and methods of using same |
| US6913590B2 (en) | 2000-09-22 | 2005-07-05 | Sorenson Development, Inc. | Apparatus and method for peritoneal dialysis |
| EP1347821B1 (en) | 2000-10-30 | 2010-02-17 | Nephros, Inc. | Dual-stage filtration cartridge |
| US7033498B2 (en) | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
| US6579460B1 (en) | 2001-03-13 | 2003-06-17 | Uop Llc | Process and composition for removing toxins from bodily fluids |
| FR2822681B1 (fr) * | 2001-03-30 | 2003-05-16 | Oreal | Compositions cosmetiques detergentes contenant un tensioactif anionique derive d'acides amines et une silicone et leurs utilisations |
| US7332330B2 (en) | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
| US7241272B2 (en) | 2001-11-13 | 2007-07-10 | Baxter International Inc. | Method and composition for removing uremic toxins in dialysis processes |
| US7309323B2 (en) | 2001-11-16 | 2007-12-18 | National Quality Care, Inc. | Wearable continuous renal replacement therapy device |
| US7645253B2 (en) | 2001-11-16 | 2010-01-12 | National Quality Care, Inc. | Wearable ultrafiltration device |
| US7597677B2 (en) | 2001-11-16 | 2009-10-06 | National Quality Care, Inc. | Wearable ultrafiltration device |
| US6960179B2 (en) | 2001-11-16 | 2005-11-01 | National Quality Care, Inc | Wearable continuous renal replacement therapy device |
| US20030114787A1 (en) * | 2001-12-13 | 2003-06-19 | Victor Gura | Wearable peritoneal dialysis system |
| DK1523351T3 (da) | 2002-07-19 | 2010-04-26 | Baxter Int | System til peritonealdialyse |
| MXPA05000816A (es) | 2002-07-19 | 2005-04-28 | Baxter Int | Sistemas y metodos para realizar dialisis peritoneal. |
| US7276042B2 (en) | 2003-01-23 | 2007-10-02 | National Quality Care, Inc. | Low hydraulic resistance cartridge |
| US7291269B2 (en) | 2003-03-17 | 2007-11-06 | Gambro Lundia Ab | Apparatus and process for extracorporeal treatment of blood with selective extraction of solutes |
| US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
| US7198785B2 (en) | 2003-12-09 | 2007-04-03 | Brown University | Systems and methods related to degradation of uremic toxins |
| JP4903583B2 (ja) | 2003-12-24 | 2012-03-28 | ケミカ テクノロジーズ， インコーポレイテッド | 携帯式個人透析用透析液再生システム |
| US8202248B2 (en) | 2004-08-18 | 2012-06-19 | Sequana Medical Ag | Dialysis implant and methods of use |
| BRPI0614083A2 (pt) * | 2005-08-05 | 2011-03-09 | Nat Quality Care Inc | bomba pulsátil de canal duplo e dispositivo de rim artificial completamente portátil (rap) |
| US8409864B2 (en) | 2006-01-06 | 2013-04-02 | Renal Solutions, Inc. | Ammonia sensor and system for use |
| EP1979020A4 (en) * | 2006-01-30 | 2011-03-30 | Univ California | PERITONEAL DIALYSIS PROCESS AND DEVICE |
| US8012118B2 (en) * | 2006-03-08 | 2011-09-06 | Fresenius Medical Care Holdings, Inc. | Artificial kidney dialysis system |
| US8715221B2 (en) * | 2006-03-08 | 2014-05-06 | Fresenius Medical Care Holdings, Inc. | Wearable kidney |
| WO2009083011A2 (en) | 2007-12-30 | 2009-07-09 | Mohamed Fahim Khaled Mohamed T | A method for dialysis fluid regeneration |
| US8080161B2 (en) | 2009-06-11 | 2011-12-20 | Baxter International Inc. | Dialysis treatment devices for removing urea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3071822B2 (ja) | 1990-07-06 | 2000-07-31 | チルマン ホイールアブレーター リミテッド | 研磨材スローイングホイール組立体 |
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| US20100114012A1 (en) | 2010-05-06 |
| CN102202702B (zh) | 2014-05-21 |
| AU2009320025B2 (en) | 2013-02-28 |
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