JP5551697B2 - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP5551697B2
JP5551697B2 JP2011520188A JP2011520188A JP5551697B2 JP 5551697 B2 JP5551697 B2 JP 5551697B2 JP 2011520188 A JP2011520188 A JP 2011520188A JP 2011520188 A JP2011520188 A JP 2011520188A JP 5551697 B2 JP5551697 B2 JP 5551697B2
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JP
Japan
Prior art keywords
methyl
oxy
compound
pyrido
pyrrolo
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Application number
JP2011520188A
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English (en)
Japanese (ja)
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JP2011529071A5 (https=
JP2011529071A (ja
Inventor
ブライアン・アルビン・ジョーンズ
ジェイソン・ゴードン・ウェザーヘッド
恭規 青山
弘志 吉田
善之 垰田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViiV Healthcare Co
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ViiV Healthcare Co
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Publication date
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Publication of JP2011529071A publication Critical patent/JP2011529071A/ja
Publication of JP2011529071A5 publication Critical patent/JP2011529071A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Biochemistry (AREA)
JP2011520188A 2008-07-25 2009-07-23 化合物 Active JP5551697B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8360308P 2008-07-25 2008-07-25
US61/083,603 2008-07-25
PCT/US2009/051501 WO2010011816A1 (en) 2008-07-25 2009-07-23 Chemical compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014084833A Division JP5758024B2 (ja) 2008-07-25 2014-04-16 化合物

Publications (3)

Publication Number Publication Date
JP2011529071A JP2011529071A (ja) 2011-12-01
JP2011529071A5 JP2011529071A5 (https=) 2012-09-06
JP5551697B2 true JP5551697B2 (ja) 2014-07-16

Family

ID=41570597

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011520188A Active JP5551697B2 (ja) 2008-07-25 2009-07-23 化合物
JP2014084833A Active JP5758024B2 (ja) 2008-07-25 2014-04-16 化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014084833A Active JP5758024B2 (ja) 2008-07-25 2014-04-16 化合物

Country Status (5)

Country Link
US (3) US8183372B2 (https=)
EP (2) EP2330902B1 (https=)
JP (2) JP5551697B2 (https=)
ES (2) ES2449752T3 (https=)
WO (1) WO2010011816A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014193898A (ja) * 2008-07-25 2014-10-09 Viiv Healthcare Company 化合物

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2744019C (en) 2008-12-11 2017-03-14 Shionogi & Co., Ltd. Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
KR101682058B1 (ko) * 2008-12-11 2016-12-02 비이브 헬쓰케어 컴퍼니 카르바모일피리돈 ｈｉｖ 인테그라제 억제제를 위한 제조방법 및 중간체
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
MX2013003139A (es) 2010-09-24 2013-06-18 Shionogi & Co Profarmaco de derivado de carbamoilpiridona policiclica substituida.
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
NO2865735T3 (https=) 2013-07-12 2018-07-21
SI3019503T1 (sl) 2013-07-12 2017-11-30 Gilead Sciences, Inc. Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje HIV infekcij
NO2717902T3 (https=) 2014-06-20 2018-06-23
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
JP6402259B2 (ja) 2015-04-02 2018-10-10 ギリアード サイエンシーズ， インコーポレイテッド 多環式カルバモイルピリドン化合物およびそれらの薬学的使用
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
JP6924839B2 (ja) 2017-10-06 2021-08-25 塩野義製薬株式会社 置換された多環性ピリドン誘導体の立体選択的な製造方法
CN109879843B (zh) * 2019-02-11 2020-08-28 常州制药厂有限公司 一种巴洛沙韦的中间体及其制备方法与应用
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
US20200398978A1 (en) 2019-06-20 2020-12-24 Bell Helicopter Textron Inc. Low-drag rotor blade extension
IL295677B1 (en) 2020-02-24 2026-04-01 Gilead Sciences Inc Tetracyclic compounds for the treatment of HIV infection
CA3192145A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
FI4196479T3 (fi) 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
EP4294813B1 (en) * 2021-02-16 2025-09-10 Merck Sharp & Dohme LLC Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB427857A (en) 1934-08-02 1935-05-01 Newsum Sons & Company Ltd H A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames
JP2005516916A (ja) * 2001-12-11 2005-06-09 スミスクライン ビーチャム コーポレーション 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体
US20060246196A1 (en) 2005-04-27 2006-11-02 Lawson John A Low-alcohol, low-calorie wine
US8129385B2 (en) 2005-04-28 2012-03-06 Shionogi & Co., Ltd. Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
TW200716632A (en) * 2005-05-16 2007-05-01 Gilead Sciences Inc Integrase inhibitor compounds
EP2102158A1 (en) * 2006-12-11 2009-09-23 Topo Target A/S Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014193898A (ja) * 2008-07-25 2014-10-09 Viiv Healthcare Company 化合物

Also Published As

Publication number Publication date
ES2395705T3 (es) 2013-02-14
JP2014193868A (ja) 2014-10-09
EP2465858B1 (en) 2013-12-25
US20120209000A1 (en) 2012-08-16
JP5758024B2 (ja) 2015-08-05
ES2449752T3 (es) 2014-03-21
US20130165415A1 (en) 2013-06-27
JP2011529071A (ja) 2011-12-01
EP2330902A1 (en) 2011-06-15
EP2330902A4 (en) 2011-08-17
US20110124598A1 (en) 2011-05-26
EP2330902B1 (en) 2012-11-14
US8691823B2 (en) 2014-04-08
EP2465858A1 (en) 2012-06-20
US8183372B2 (en) 2012-05-22
WO2010011816A1 (en) 2010-01-28

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