JP5543958B2 - オリゴマー−アリールオキシ置換プロパンアミンコンジュゲート - Google Patents
オリゴマー−アリールオキシ置換プロパンアミンコンジュゲート Download PDFInfo
- Publication number
- JP5543958B2 JP5543958B2 JP2011504017A JP2011504017A JP5543958B2 JP 5543958 B2 JP5543958 B2 JP 5543958B2 JP 2011504017 A JP2011504017 A JP 2011504017A JP 2011504017 A JP2011504017 A JP 2011504017A JP 5543958 B2 JP5543958 B2 JP 5543958B2
- Authority
- JP
- Japan
- Prior art keywords
- oligomer
- compound
- water
- aryloxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12392908P | 2008-04-11 | 2008-04-11 | |
| US61/123,929 | 2008-04-11 | ||
| PCT/US2009/002285 WO2009126333A1 (en) | 2008-04-11 | 2009-04-13 | Oligomer-aryloxy-substituted propanamine conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516551A JP2011516551A (ja) | 2011-05-26 |
| JP2011516551A5 JP2011516551A5 (https=) | 2013-03-21 |
| JP5543958B2 true JP5543958B2 (ja) | 2014-07-09 |
Family
ID=41016853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504017A Active JP5543958B2 (ja) | 2008-04-11 | 2009-04-13 | オリゴマー−アリールオキシ置換プロパンアミンコンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9233165B2 (https=) |
| EP (1) | EP2265290B1 (https=) |
| JP (1) | JP5543958B2 (https=) |
| KR (1) | KR101680385B1 (https=) |
| CN (2) | CN101998866A (https=) |
| AU (1) | AU2009234322B2 (https=) |
| CA (1) | CA2720760C (https=) |
| IL (1) | IL208567A (https=) |
| MX (1) | MX2010011101A (https=) |
| WO (1) | WO2009126333A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9226970B2 (en) | 2010-02-22 | 2016-01-05 | Nektar Therapeutics | Oligomer modified diaromatic substituted compounds |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| WO2012088522A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
| CN106478376A (zh) * | 2016-10-08 | 2017-03-08 | 贵州大学 | 一种4‑氟萘‑1‑醇的制备工艺 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE372762B (https=) * | 1969-05-21 | 1975-01-13 | Haessle Ab | |
| JPS5123488A (https=) | 1974-08-21 | 1976-02-25 | Matsushita Electric Industrial Co Ltd | |
| US4992540A (en) * | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) * | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5028703A (en) * | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| KR880007433A (ko) * | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| TR201907313T4 (tr) * | 2003-05-23 | 2019-06-21 | Nektar Therapeutics | İki PEG zinciri içeren PEG türevleri. |
| US7947261B2 (en) * | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| EP2905033B1 (en) * | 2003-12-16 | 2020-09-02 | Nektar Therapeutics | Monodisperse PEGylated naloxol compositions |
| US7740861B2 (en) * | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| DE602005016297D1 (de) * | 2004-11-29 | 2009-10-08 | Lilly Co Eli | Antithrombotische diamide |
| MX2007009797A (es) | 2005-02-14 | 2007-11-06 | Combinatorx Inc | Compuestos y sus usos. |
| WO2007109564A2 (en) * | 2006-03-17 | 2007-09-27 | University Of Massachusetts | Yeast cell particles as oral delivery vehicles for antigens |
| WO2008112287A1 (en) * | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
-
2009
- 2009-04-13 AU AU2009234322A patent/AU2009234322B2/en active Active
- 2009-04-13 WO PCT/US2009/002285 patent/WO2009126333A1/en not_active Ceased
- 2009-04-13 KR KR1020107022518A patent/KR101680385B1/ko active Active
- 2009-04-13 CN CN2009801128052A patent/CN101998866A/zh active Pending
- 2009-04-13 US US12/936,894 patent/US9233165B2/en active Active
- 2009-04-13 CN CN201610131629.9A patent/CN105566284A/zh active Pending
- 2009-04-13 CA CA2720760A patent/CA2720760C/en active Active
- 2009-04-13 JP JP2011504017A patent/JP5543958B2/ja active Active
- 2009-04-13 MX MX2010011101A patent/MX2010011101A/es active IP Right Grant
- 2009-04-13 EP EP09730054.5A patent/EP2265290B1/en active Active
-
2010
- 2010-10-07 IL IL208567A patent/IL208567A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2265290B1 (en) | 2014-06-04 |
| IL208567A (en) | 2015-11-30 |
| CA2720760A1 (en) | 2009-10-15 |
| US20110071207A1 (en) | 2011-03-24 |
| WO2009126333A1 (en) | 2009-10-15 |
| KR101680385B1 (ko) | 2016-11-28 |
| AU2009234322A1 (en) | 2009-10-15 |
| EP2265290A1 (en) | 2010-12-29 |
| US9233165B2 (en) | 2016-01-12 |
| CN105566284A (zh) | 2016-05-11 |
| AU2009234322B2 (en) | 2014-12-04 |
| JP2011516551A (ja) | 2011-05-26 |
| CN101998866A (zh) | 2011-03-30 |
| KR20100132030A (ko) | 2010-12-16 |
| IL208567A0 (en) | 2010-12-30 |
| MX2010011101A (es) | 2010-11-01 |
| CA2720760C (en) | 2016-10-11 |
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