JP5478015B2 - 貴金属の磁気ナノ粒子 - Google Patents
貴金属の磁気ナノ粒子 Download PDFInfo
- Publication number
- JP5478015B2 JP5478015B2 JP2007504428A JP2007504428A JP5478015B2 JP 5478015 B2 JP5478015 B2 JP 5478015B2 JP 2007504428 A JP2007504428 A JP 2007504428A JP 2007504428 A JP2007504428 A JP 2007504428A JP 5478015 B2 JP5478015 B2 JP 5478015B2
- Authority
- JP
- Japan
- Prior art keywords
- magnetic
- nanoparticles
- magnetic nanoparticles
- compound
- noble metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1878—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/16—Metallic particles coated with a non-metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F9/00—Making metallic powder or suspensions thereof
- B22F9/16—Making metallic powder or suspensions thereof using chemical processes
- B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
- B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/62—Record carriers characterised by the selection of the material
- G11B5/68—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent
- G11B5/70—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent on a base layer
- G11B5/712—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent on a base layer characterised by the surface treatment or coating of magnetic particles
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/62—Record carriers characterised by the selection of the material
- G11B5/68—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent
- G11B5/70—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent on a base layer
- G11B5/714—Record carriers characterised by the selection of the material comprising one or more layers of magnetisable material homogeneously mixed with a bonding agent on a base layer characterised by the dimension of the magnetic particles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/81—Of specified metal or metal alloy composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
- Y10S977/838—Magnetic property of nanomaterial
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/925—Bioelectrical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
- Y10S977/953—Detector using nanostructure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
- Y10S977/953—Detector using nanostructure
- Y10S977/96—Of magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Power Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Radiology & Medical Imaging (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
Description
a)磁気記録中の情報密度の増大、
b)生体臨床医学における診断技術の開発、
c)薬剤の制御放出、
d)ハイパーサーミアの処置、
e)核磁気共鳴における画像の改良、
f)バイオセンサー及びバイオチップ、
g)磁気印刷、
h)磁気光学的用途、及び
i)符号化。
図1は、a)ドデカンチオールで機能化された金のナノ粒子、及びb)ドデカンチオールで機能化されたパラジウムのナノ粒子の透過型電子顕微鏡によって得られた顕微鏡写真である。
i)R−SH(式中、Rは一般に脂肪族鎖を示す)型の種々の有機化合物のチオール誘導体の存在下での金又はパラジウムの還元。還元剤はホウ化水素である。所望の微細構造を得るためには、この反応は過剰のチオール誘導体の存在下でおこなう。
ii)水溶性チオール誘導体の存在下における水性媒体中での金塩又はパラジウム塩の還元。この方法は、上記の方法i)と類似する。
本発明によるナノ粒子は、薬剤放出用トレーサーとして使用される放射性物質の代わりに使用することができる。放射性物質の代わりにこの種のナノ粒子を使用する場合には、磁気的特性の変化を測定することにより薬剤の放出を監視することができ、これによって放射線の有害な効果を回避することが可能となる。
磁性ナノ粒子が付着又は蓄積した領域(例えば、腫瘍部位)を局部的に加熱するために外部AC磁場が印加される。供与される製剤も、金属製芯と同様に、特定のリガンドを含んでおり、該リガンドは医薬であってもよく、あるいは、該リガンドは特定の組織中でのナノ粒子の蓄積を支援することができる。
処置や腫瘍等の種類に応じた測定がおこなわれるような機能化の実施の可能性に起因する。
貴金属のナノ粒子は、MRにおける画像改良のために使用することができる。MR画像は、腫瘍等の組織構造の効率的な観察を可能にするために十分なコントラストを欠く場合がある。この種の画像は、例えば、小さなサイズの腫瘍の検知とより良い処置の可能性をもたらす磁性ナノ粒子をコントラスト媒体として使用することによって改良することができる。AuやPdのような貴金属を芯に含有する本発明による磁性ナノ粒子はこのような用途に対して特に有用である。この理由は、元素状態の金属は、同じ金属の酸化物よりも良好な造影剤だからである。さらに、この種のナノ粒子は、その他のナノ粒子(例えば、芯にAuとFeを含むナノ粒子)よりも良好な生体適合性を示す。
図7は、A型リガンド(1)で機能化された磁性ナノ粒子に基づくバイオセンサー器具の模式図である。A型リガンドが生体分子(2)を認識すると、ナノ粒子が付着して信号が磁気センサー(3)内で検知される。この場合、該磁気センサーは保護不動態層(4)によって分離される。模式図に示すような器具のアレイ(array)は、バイオチップ型ユニットが形成されるように配設され、該ユニット内においては、各々の磁気抵抗性センサーは、生体分子アレイの1種の成分に対応する信号を読み取る。
支持体上に所定状態で分布された貴金属のナノ粒子は、データ記憶用磁場を使用することによるコンパクトディスクの製造用基材として利用することができる。情報の読み取りは、磁気センサー(磁気抵抗性型)又はレーザーを用いるカー効果によっておこなうことができる。
貴金属の磁性ナノ粒子は、粉状形態に加工して貯蔵される。コロイド溶液(強磁性流体)調製においては、前駆体の粉末が使用される。ナノ粒子の機能化の態様を変化させることによって、強磁性流体は異なる種類の溶剤(有機溶剤又は水性溶剤)中で調製される。磁性インクは、バーコード等の磁性印刷や筆記等において加工される。
98%のテトラオクチルアンモニウムブロミド[N(C8H17)4Br](アルドリッチ社製)0.11gをトルエン(予め乾燥処理と脱ガス処理に付したトルエン)20ml中に溶解させた溶液中へ、99%テトラクロロ金酸(HAuCl4;アルドリッチ社製)0.075gをミリ−Q水7.5ml中に溶解させた溶液を添加した(金塩に対するアンモニウム塩のモル比:2)。この混合物を室温で30分間の強い電磁撹拌処理に付すことによって、全ての金前駆体を水性相から有機相へ抽出した。水性相はデカント用漏斗内で分離させた後、廃棄した。激しい電磁撹拌下において、有機相へドデカンチオール(0.1ml)を添加し(金前駆体に対するドデカンチオールのモル比:2)、次いで99%ホウ化水素ナトリウム(NaH4B;アルドリッチ社製)0.09gをミリ−Q水6.25mlに溶解させた溶液を滴下した[該還元剤は、金前駆体に対して過剰量(11.7モル)添加した]。数秒後、オレンジ色の溶液は、金属製芯の形成に起因して濃黒色に変色した。強い電磁撹拌を1時間おこなった後、デカント用漏斗を用いて水性相を廃棄した。
98%のテトラオクチルアンモニウムブロミド[N(C8H17)4Br](アルドリッチ社製)0.55gをトルエン(予め乾燥処理と脱ガス処理に付したトルエン)20ml中に溶解させた溶液中へ、99%硝酸パラジウム(Pd(NO3)2;アルドリッチ社製)0.050gを、ミリ−Q水を溶媒とする0.5N塩酸溶液10ml中に溶解させた溶液を添加した。この混合物を室温で30分間の強い電磁撹拌処理に付すことによって、全てのパラジウム前駆体を水性相から有機相へ抽出した。水性相はデカント用漏斗内で分離させた後、廃棄した。激しい電磁撹拌下において、有機相へドデカンチオール(0.1ml)を添加し(パラジウム前駆体に対するドデカンチオールのモル比:2)、次いで電磁撹拌を15分間おこなった後、99%ホウ化水素ナトリウム(NaH4B;アルドリッチ社製)0.10gをミリ−Q水5mlに溶解させた溶液を素早く添加した[該還元剤は、パラジウム前駆体1モルに対して過剰量(12モル)添加した]。数秒後、オレンジ色の溶液は、金属製芯の形成に起因して鈍い色に変色した。この反応は、パラジウムの再酸化を回避するために、窒素雰囲気下でおこなった。強い電磁撹拌を30分間おこなった後、デカント用漏斗を用いて水性相を廃棄した。
2 生体分子
3 磁気センサー
4 保護不動態層
Claims (18)
- (a)貴金属から形成される芯、及び(b)少なくとも1つの金属−硫黄共有結合を含
む化合物から形成される異方性外層を含む貴金属の磁性ナノ粒子であって、室温で強磁性挙動及びヒステリシスサイクルを示し、非強磁性貴金属前駆体から形成され、芯用貴金属がAu、Pd、Pt又はAgであり、異方性外層が、Au−S、Pd−S、Pt−S又はAg−S化合物およびAu−S−R、Pd−S−R、Pt−S−R又はAg−S−R化合物(式中、Rは脂肪族鎖又はタンパク質若しくはその他の生体分子へ結合した脂肪族鎖を表す)を含有する、粒径が5nm未満である該磁性ナノ粒子。 - 芯がAuから形成され、異方性外層がAu−S化合物とAu−S−R化合物(式中、R
は脂肪族鎖を示す)を1/1000〜1000/1(Au−S/Au−S−R)割合で含
有する請求項1に記載の磁性ナノ粒子。 - 芯がPdから形成され、異方性外層がPd−S化合物とPd−S−R化合物(式中、R
は脂肪族鎖を示す)を1/1000〜1000/1(Pd−S/Pd−S−R)割合で含
有する請求項1に記載の磁性ナノ粒子。 - 非強磁性貴金属前駆体及び化学量論的に過剰量の一般式HS−R(式中、Rは脂肪族鎖
を示す)で表されるチオール誘導体を還元剤の存在下で、異方性外層が金属-硫黄共有結
合を含むような条件下において反応させることを含む請求項1から3いずれかに記載の磁
性ナノ粒子の製造方法。 - 非強磁性貴金属が金であり、該前駆体が、テトラクロロ金酸に化学量論的に過剰
量のいずれかの第四アンモニウム塩を反応させることによって調製される請求項4記載の
方法。 - 非強磁性貴金属がパラジウムであり、該前駆体が、硝酸塩、硫酸塩又は塩化物を
含むいずれかのパラジウム塩に化学量論的に過剰量のいずれかの第四アンモニウム塩を反
応させることによって調製される請求項4記載の方法。 - 磁気記録中の情報密度を増大させるための方法であって、請求項1から3いずれかに記
載の磁性ナノ粒子を、磁気記録支持体上に、所定状態で分布させることを含む該方法。 - 薬剤の制御放出用器具において請求項1から3いずれかに記載の磁性ナノ粒子をトレー
サーとして使用する方法。 - ハイパーサーミアの処置のために請求項1から3いずれかに記載の磁性ナノ粒子を、加熱すべき領域において使用する方法。
- 核磁気共鳴における画像の改良のために請求項1から3いずれかに記載の磁性ナノ粒子
を、コントラスト媒体として使用する方法。 - 請求項1から3いずれかに記載の磁性ナノ粒子を含有するバイオセンサー。
- 請求項1から3いずれかに記載の磁性ナノ粒子を、インキ形成性分散液中の粉体として
使用することを含む磁気印刷法。 - 請求項1から3いずれかに記載の磁性ナノ粒子を含む磁気光学装置。
- 請求項1から3いずれかに記載の磁性ナノ粒子を含む符号化装置。
- 請求項1から3いずれかに記載の1種若しくは複数種の磁性ナノ粒子の個体群を含むシ
ステム。 - 異なる官能基を有する複数種の磁性ナノ粒子を含む請求項15記載のシステム。
- ナノ粒子の粒径が1.2〜1.4nmである請求項1記載の貴金属の磁性ナノ粒子。
- ナノ粒子の粒径が1.0〜2.0nmである、請求項1に記載の磁性ナノ粒子。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200400735A ES2242528B1 (es) | 2004-03-25 | 2004-03-25 | Nanoparticulas magneticas de metales nobles. |
ESP200400735 | 2004-03-25 | ||
PCT/ES2005/070035 WO2005091704A2 (es) | 2004-03-25 | 2005-03-23 | Nanopartículas magnéticas de metales nobles |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007533847A JP2007533847A (ja) | 2007-11-22 |
JP2007533847A5 JP2007533847A5 (ja) | 2014-02-06 |
JP5478015B2 true JP5478015B2 (ja) | 2014-04-23 |
Family
ID=35056599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007504428A Expired - Fee Related JP5478015B2 (ja) | 2004-03-25 | 2005-03-23 | 貴金属の磁気ナノ粒子 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7960025B2 (ja) |
EP (1) | EP1746610B1 (ja) |
JP (1) | JP5478015B2 (ja) |
AU (1) | AU2005226898B2 (ja) |
CA (1) | CA2560892C (ja) |
ES (2) | ES2242528B1 (ja) |
WO (1) | WO2005091704A2 (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090019781A (ko) * | 2006-04-12 | 2009-02-25 | 나노마스 테크놀러지스, 인코포레이티드 | 나노입자, 제조 방법 및 용도 |
ES2320837B1 (es) * | 2007-07-26 | 2010-03-04 | Consejo Superior De Investigaciones Cientificas | Dispositivo de hipertermia y su utilizacion con nanoparticulas. |
US8389175B2 (en) * | 2008-05-16 | 2013-03-05 | Utc Power Corporation | Fuel cell having a stabilized cathode catalyst |
WO2009139747A1 (en) * | 2008-05-16 | 2009-11-19 | Utc Power Corporation | A stabilized platinum catalyst |
KR101127056B1 (ko) * | 2008-09-25 | 2012-03-23 | 삼성전기주식회사 | 금속 씨앗을 이용한 금속 나노 입자의 제조 방법 및 금속씨앗을 함유하는 금속 나노 입자 |
US20120076830A1 (en) * | 2008-12-01 | 2012-03-29 | Sitharaman Balaji | Differentiation of stem cells with nanoparticles |
US8114807B2 (en) * | 2010-03-05 | 2012-02-14 | Cem Corporation | Synthesis and use of intermetallic iron palladium nanoparticle compositions |
JP5755732B2 (ja) | 2010-06-10 | 2015-07-29 | ミダテック リミテッド | ペプチド担持ナノ粒子 |
EP2579844B1 (en) | 2010-06-10 | 2016-02-24 | Midatech Ltd. | Nanoparticle film delivery systems |
MX2014002764A (es) | 2011-09-07 | 2014-12-04 | Midatech Ltd | Vacunas en nanoparticulas para tumor. |
JP6077544B2 (ja) | 2011-09-07 | 2017-02-08 | ミダテック リミテッド | ナノ粒子−ペプチド組成物 |
IN2012DE01790A (ja) * | 2012-08-11 | 2015-10-16 | Council Scient Ind Res | |
ES2446359B1 (es) * | 2012-09-07 | 2014-12-23 | Mikel LARRAÑAGA OTANO | Cartucho para armas de fuego y método para su identificación |
GB201301991D0 (en) | 2013-02-05 | 2013-03-20 | Midatech Ltd | Permeation enhanced active-carrying nanoparticles |
GB201302427D0 (en) | 2013-02-12 | 2013-03-27 | Midatech Ltd | Nanoparticle delivery compositions |
GB201303787D0 (en) | 2013-03-04 | 2013-04-17 | Midatech Ltd | Nanoparticle peptide compositions |
GB201303771D0 (en) | 2013-03-04 | 2013-04-17 | Midatech Ltd | Nanoparticles peptide compositions |
US20180003960A1 (en) * | 2014-01-30 | 2018-01-04 | Duke Ellington Cooke, JR. | Vision correction system |
US10261387B2 (en) * | 2014-01-30 | 2019-04-16 | Isee, Llc | Vision correction system |
GB201401706D0 (en) | 2014-01-31 | 2014-03-19 | Midatech Ltd | Nanoparticle-insulin and insulin analogue compositions |
US20160358708A1 (en) * | 2014-11-17 | 2016-12-08 | John Kissane | Production of supermagnet |
US10688125B2 (en) | 2014-12-23 | 2020-06-23 | Midatech Ltd. | Nanoparticles and their use in cancer therapy |
GB2541166A (en) | 2015-07-24 | 2017-02-15 | Midatech Ltd | Nanoparticle-based liver-targeting therapy and imaging |
US9627114B2 (en) * | 2015-09-14 | 2017-04-18 | Elwha Llc | Magnetic plasmonic nanoparticle positioned on a magnetic plasmonic substrate |
US9627115B2 (en) * | 2015-09-14 | 2017-04-18 | Elwha Llc | Magnetic plasmonic nanoparticle dimer |
GB201701745D0 (en) | 2017-02-02 | 2017-03-22 | Midatech Ltd | Nanoparticle-based liver-targeting therapy and imaging |
CN109283206B (zh) * | 2018-11-02 | 2021-07-06 | 东南大学 | 一种用于生物标志物的核磁共振快速检测装置及方法 |
GB201819430D0 (en) | 2018-11-29 | 2019-01-16 | Midatech Ltd | Therapeutic compounds, nanoparticles and uses thereof |
GB201820471D0 (en) | 2018-12-14 | 2019-01-30 | Midatech Ltd | Nanoparticle-based therapy of inflammatory disorders |
GB201820470D0 (en) | 2018-12-14 | 2019-01-30 | Midatech Ltd | Antifolate-carrying nanoparticles and their use in medicine |
KR102461313B1 (ko) * | 2020-05-19 | 2022-11-01 | 엠케이전자 주식회사 | 리버스 리플로우용 심재를 이용한 반도체 패키지 |
CN115155469B (zh) * | 2022-07-26 | 2023-10-27 | 中国科学院苏州纳米技术与纳米仿生研究所 | 水溶性ib族贵金属亚10纳米胶粒、其制备方法及应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294369A (en) * | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
EP0914244A1 (en) | 1995-12-28 | 1999-05-12 | James R. Heath | Organically-functionalized monodisperse nanocrystals of metals |
AU5248600A (en) * | 1999-06-15 | 2001-01-02 | Kimoto, Masaaki | Ultrafine composite metal powder and method for producing the same |
JP4361168B2 (ja) * | 1999-06-18 | 2009-11-11 | 独立行政法人科学技術振興機構 | 有機・無機複合磁性材料とその製造方法 |
AUPQ326499A0 (en) | 1999-10-05 | 1999-10-28 | Commonwealth Scientific And Industrial Research Organisation | Nanoparticle films |
CA2402955C (en) * | 2000-03-28 | 2010-03-09 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
JP2004525607A (ja) * | 2000-08-11 | 2004-08-26 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
GB0025414D0 (en) * | 2000-10-16 | 2000-11-29 | Consejo Superior Investigacion | Nanoparticles |
CA2459749A1 (en) * | 2001-09-14 | 2003-03-27 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Mouldings made from core/shell particles |
CA2463323C (en) * | 2001-10-09 | 2010-12-21 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
JP2003132519A (ja) | 2001-10-25 | 2003-05-09 | Hitachi Ltd | 磁性ナノ粒子で形成された磁気記録媒体およびそれを用いた記録方法 |
US6923923B2 (en) * | 2001-12-29 | 2005-08-02 | Samsung Electronics Co., Ltd. | Metallic nanoparticle cluster ink and method for forming metal pattern using the same |
ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
WO2003073444A1 (en) | 2002-02-22 | 2003-09-04 | Purdue Research Foundation | Fe/au nanoparticles and methods |
EP1339075A1 (en) | 2002-02-25 | 2003-08-27 | Motorola, Inc. | Magnetic nanomaterials and synthesis method |
US6929675B1 (en) * | 2003-04-24 | 2005-08-16 | Sandia Corporation | Synthesis metal nanoparticle |
-
2004
- 2004-03-25 ES ES200400735A patent/ES2242528B1/es not_active Expired - Fee Related
-
2005
- 2005-03-23 EP EP05735150A patent/EP1746610B1/en not_active Not-in-force
- 2005-03-23 CA CA2560892A patent/CA2560892C/en not_active Expired - Fee Related
- 2005-03-23 ES ES05735150T patent/ES2401149T3/es active Active
- 2005-03-23 JP JP2007504428A patent/JP5478015B2/ja not_active Expired - Fee Related
- 2005-03-23 AU AU2005226898A patent/AU2005226898B2/en not_active Ceased
- 2005-03-23 WO PCT/ES2005/070035 patent/WO2005091704A2/es active Application Filing
-
2006
- 2006-09-22 US US11/525,119 patent/US7960025B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20070151631A1 (en) | 2007-07-05 |
ES2242528B1 (es) | 2006-12-01 |
EP1746610A2 (en) | 2007-01-24 |
AU2005226898A1 (en) | 2005-10-06 |
US7960025B2 (en) | 2011-06-14 |
CA2560892A1 (en) | 2005-10-06 |
WO2005091704A3 (es) | 2005-12-29 |
JP2007533847A (ja) | 2007-11-22 |
AU2005226898B2 (en) | 2010-05-27 |
ES2242528A1 (es) | 2005-11-01 |
EP1746610B1 (en) | 2012-12-19 |
ES2401149T3 (es) | 2013-04-17 |
CA2560892C (en) | 2012-10-16 |
WO2005091704A2 (es) | 2005-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5478015B2 (ja) | 貴金属の磁気ナノ粒子 | |
Wu et al. | Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications | |
Tartaj et al. | Synthesis, properties and biomedical applications of magnetic nanoparticles | |
Insin et al. | Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres | |
Jeong et al. | Superparamagnetic colloids: controlled synthesis and niche applications | |
Cabrera et al. | Synthesis and surface modification of uniform MFe 2 O 4 (M= Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities | |
Karaagac et al. | A simple way to synthesize superparamagnetic iron oxide nanoparticles in air atmosphere: iron ion concentration effect | |
Kim et al. | Scalable solvothermal synthesis of superparamagnetic Fe3O4 nanoclusters for bioseparation and theragnostic probes | |
Aslam et al. | Synthesis of amine-stabilized aqueous colloidal iron oxide nanoparticles | |
EP2673006B1 (en) | Method of preparing iron oxide nanoparticles coated with hydrophilic material, and magnetic resonance imaging contrast agent using the same | |
CN111330023B (zh) | 一种磁性纳米复合材料及其制备方法与应用 | |
Kataby et al. | Coating of amorphous iron nanoparticles by long-chain alcohols | |
Rezaei et al. | Magnetic nanoparticles: a review on synthesis, characterization, functionalization, and biomedical applications | |
Khosroshahi et al. | Physicochemical characterization of Fe3O4/SiO2/Au multilayer nanostructure | |
Escoda-Torroella et al. | Selective control over the morphology and the oxidation state of iron oxide nanoparticles | |
Acidereli et al. | Magnetic nanoparticles | |
Antarnusa et al. | Synthesis of Fe3O4 at different reaction temperatures and investigation of its magnetic properties on giant magnetoresistance (GMR) sensors for bio-detection applications | |
Iacob et al. | Nanomaterials developed by processing iron coordination compounds for biomedical application | |
Chen et al. | Preparation and characterization of magnetic nanoparticles and their silica egg-yolk-like nanostructures: a prospective multifunctional nanostructure platform | |
Schütz et al. | Nanoparticle arrays having directed hybrid topology via covalent self-assembly of iron oxide and silica nanoparticles | |
El-Sherbiny et al. | Physical properties, classification, synthesis, and functionalization of magnetic nanomaterials | |
EP2942064B1 (en) | Mri contrast agent including t1 contrast material coated on surface of nanoparticle support | |
Cernat et al. | Applications of magnetic hybrid nanomaterials in Biomedicine | |
Büyüktiryaki et al. | Synthesis of Core-Shell Magnetic Nanoparticles | |
KR101136190B1 (ko) | 생체 적합 고분자가 코팅된 상자성 나노입자 및 그 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080219 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080219 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110208 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110509 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120214 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120511 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120518 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120719 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130122 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130419 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130426 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130513 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131001 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131210 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20131210 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140121 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140210 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5478015 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |