JP5476013B2 - Topical skin preparation - Google Patents
Topical skin preparation Download PDFInfo
- Publication number
- JP5476013B2 JP5476013B2 JP2009078733A JP2009078733A JP5476013B2 JP 5476013 B2 JP5476013 B2 JP 5476013B2 JP 2009078733 A JP2009078733 A JP 2009078733A JP 2009078733 A JP2009078733 A JP 2009078733A JP 5476013 B2 JP5476013 B2 JP 5476013B2
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- JP
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- Prior art keywords
- extract
- acid
- viscosity
- oil
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims description 21
- 230000000699 topical effect Effects 0.000 title 1
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- -1 acyl phosphatidylcholine Chemical compound 0.000 claims description 29
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Description
皮膚外用剤の粘度を高める技術に関する。 The present invention relates to a technique for increasing the viscosity of an external preparation for skin.
皮膚外用剤の粘度を高める技術が求められている。粘度を高めることにより、液ダレを防止したり、皮膚外用剤が皮膚上に保持され易くしたり、滑らかな塗布感触を与えたり、マッサージに適した粘性を与えたりすることが可能となる。水相を増粘させるために、通常水溶性高分子や水溶性粘土鉱物を添加するが、必ずしも所望の粘度が得られるわけではない。そして、粘度を高めるために水溶性高分子や水溶性粘土鉱物の配合量を高めると、べたつきが生じたり、塗布時に水溶性高分子や水溶性粘土鉱物のカスが垢のように生じるなどの問題が生じる。
皮膚外用剤の粘度を高める技術として、水溶性エチレン性不飽和モノマーをラジカル重合して得られる水膨潤性のミクロゲルと疎水変性ポリエーテルウレタンを配合することにより相乗的な増粘効果が得られることが知られている（特許文献１：特開２００７−２９１０２６号公報）。しかしながら、更なる増粘技術が求められており、特に増粘剤として汎用されているアクリル系高分子化合物を用いて効果的に皮膚外用剤の粘度を高める技術が求められている。
There is a need for a technique for increasing the viscosity of an external preparation for skin. By increasing the viscosity, it is possible to prevent dripping, to make it easier for the external preparation for skin to be held on the skin, to give a smooth application feel, and to give a viscosity suitable for massage. In order to increase the viscosity of the aqueous phase, a water-soluble polymer or a water-soluble clay mineral is usually added, but a desired viscosity is not always obtained. And if the amount of water-soluble polymer or water-soluble clay mineral is increased to increase the viscosity, stickiness may occur, or the residue of water-soluble polymer or water-soluble clay mineral may appear like a plaque when applied. Occurs.
Synergistic thickening effect can be obtained by blending water-swellable microgel obtained by radical polymerization of water-soluble ethylenically unsaturated monomer and hydrophobically modified polyether urethane as a technology to increase the viscosity of external preparations for skin (Patent Document 1: Japanese Patent Laid-Open No. 2007-291026). However, there is a need for a further thickening technique, and in particular, a technique for effectively increasing the viscosity of an external preparation for skin using an acrylic polymer compound that is widely used as a thickener.
本発明者はレシチンが、その組成に依存して、アクリル系高分子化合物を含有する乳液状化粧料の粘度を低下あるいは上昇させることを見出した（特許文献２：特開２００８−２９１０１４）。本発明者は、継続してさらに皮膚外用剤として使用可能な増粘効果のある組成物の開発を試みた。 The present inventor has found that lecithin decreases or increases the viscosity of an emulsion cosmetic containing an acrylic polymer compound depending on its composition (Patent Document 2: JP-A-2008-291014). The present inventor has continuously tried to develop a composition having a thickening effect that can be used as a skin external preparation.
本発明者は、鋭意研究を継続した結果、アクリル系高分子化合物の粘度を顕著に増大させるジ脂肪酸アシルホスファチジルコリンを見出し、本発明を完成させた。
本発明の主な構成は、次のとおりである。
１．アクリル系高分子化合物とジステアロイルホスファチジルコリンの含量が９０質量％以上であるジ脂肪酸アシルホスファチジルコリンを含有することを特徴とする皮膚外用剤用増粘剤。
２．アクリル酸系高分子がカルボキシビニルポリマー又は（アクリル酸ヒドロキシエチル／アクリロイルジメチルタウリンＮａ）共重合体であることを特徴とする１に記載の皮膚外用剤用増粘剤。
３．１または２に記載の増粘剤を含みアクリル系高分子化合物が０．６質量％以下である皮膚外用剤。
As a result of continual research, the present inventors have found a difatty acid acylphosphatidylcholine that significantly increases the viscosity of an acrylic polymer compound, and have completed the present invention.
The main configuration of the present invention is as follows.
1. A thickener for an external preparation for skin, comprising a difatty acid acyl phosphatidylcholine having an acrylic polymer compound and distearoylphosphatidylcholine content of 90% by mass or more.
2. 2. The thickener for skin external preparation according to 1, wherein the acrylic acid polymer is carboxyvinyl polymer or (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer.
3. A skin external preparation containing the thickener according to 3.1 or 2 and having an acrylic polymer compound of 0.6% by mass or less.
ジステアロイルホスファチジルコリンの含量が９０質量％以上であるジ脂肪酸アシルホスファチジルコリンを添加することにより、優れた増粘効果を発揮することが確認できた。皮膚外用剤に配合するアクリル系高分子化合物の配合量が少なくても、皮膚外用剤の粘度を高めることができる。従って、アクリル系高分子化合物の配合量を高めたときに生じる、べたつき、塗布時のカスや垢の発生などの問題が解決される。特に、ジ脂肪酸アシルホスファチジルコリンを全体の０．５質量％以上添加すると、著しい増粘が認められ、１．０質量％以内で十分な粘性が得られるので、少量の添加量で十分な粘性を有する皮膚外用剤を提供することができる。 It was confirmed that an excellent thickening effect was exhibited by adding a difatty acid acyl phosphatidylcholine having a distearoylphosphatidylcholine content of 90% by mass or more. Even if the amount of the acrylic polymer compound blended in the external preparation for skin is small, the viscosity of the external preparation for skin can be increased. Therefore, problems such as stickiness and generation of scum and dirt at the time of application, which are generated when the amount of the acrylic polymer compound is increased, are solved. In particular, when difatty acid acyl phosphatidylcholine is added in an amount of 0.5% by mass or more, remarkable thickening is observed, and sufficient viscosity is obtained within 1.0% by mass. An external preparation for skin can be provided.
本発明に用いるジ脂肪酸アシルホスファチジルコリンはジステアロイルホスファチジルコリンを９０％以上含有するものである。ジステアロイルホスファチジルコリンを９０％以上含有するジ脂肪酸アシルホスファチジルコリンとアクリル系高分子化合物を配合することにより、アクリル系高分子化合物を単独で配合するよりも顕著に粘度を増大させることができる。一方、ジステアロイルホスファチジルコリン（日油株式会社製ＣＯＡＴＳＯＭＥ ＭＣ−８０８０）とジパルミトイルホスファチジルコリン（日油株式会社製ＣＯＡＴＳＯＭＥ ＭＣ−６０６０）を８０：２０の質量比で含有するジ脂肪酸アシルホスファチジルコリンを使用した場合には、アクリル系高分子化合物を単独で配合した場合と粘度は殆ど変わらない。 The difatty acid acyl phosphatidylcholine used in the present invention contains 90% or more of distearoylphosphatidylcholine. By blending a difatty acid acyl phosphatidylcholine containing 90% or more of distearoylphosphatidylcholine and an acrylic polymer compound, the viscosity can be remarkably increased as compared with blending an acrylic polymer compound alone. On the other hand, when difatty acid acyl phosphatidylcholine containing distearoylphosphatidylcholine (COATSOME MC-8080 manufactured by NOF CORPORATION) and dipalmitoyl phosphatidylcholine (COATSOME MC-6060 manufactured by NOF CORPORATION) in a mass ratio of 80:20 is used. The viscosity is almost the same as when an acrylic polymer compound is blended alone.
本発明に用いるアクリル系高分子化合物として、カルボキシビニルポリマー、(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンＮａ)共重合体、（アクリル酸Ｎａ/アクリロイルジメチルタウリン）共重合体、ポリアクリルアミド、ポリアクリル酸Ｎａ、（アクリルアミド/アクリル酸アンモニウム）共重合体が挙げられる。いずれのアクリル系高分子化合物も市販品を用いることができる。 Examples of the acrylic polymer used in the present invention include carboxyvinyl polymer, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (Naacrylate / acryloyldimethyltaurine) copolymer, polyacrylamide, and polyacrylic acid Na. , (Acrylamide / ammonium acrylate) copolymer. Any acrylic polymer compound may be a commercially available product.
カルボキシビニルポリマーは化学的に架橋された、主にアクリル酸モノマーを重合した高分子である。市販品としては、和光純薬工業株式会社ハイビスワコー、ノベオン社ｃａｒｂｏｐｏｌ ｐｏｌｙｍｅｒ、３Ｖ ＳＩＧＭＡ社シンタレン等が挙げられる。
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンＮａ)共重合体としては、例えばＳＥＰＰＩＣ社のセピノブＥＭＴ１０もしくは複合原料であるＳＥＰＰＩＣ社のＳＩＭＵＬＧＥＬ ＮＳ（（アクリル酸ヒドロキシエチル／アクリロイルジメチルタウリンＮａ）共重合体、スクワラン、ポリソルベート、水）を用いることができる。
（アクリル酸Ｎａ／アクリロイルジメチルタウリン）共重合体としては、例えば、ＳＥＰＰＩＣ社の複合原料であるＳＩＭＵＬＧＥＬ ＥＧ（（アクリル酸Ｎａ／アクリロイルジメチルタウリン）共重合体、イソヘキサデカン、ポリソルベート８０、水）、ＳＩＭＵＬＧＥＬ ＥＰＧ（（アクリル酸Ｎａ／アクリロイルジメチルタウリン）共重合体、ポリイソブテン、（カプリリル／カプリル）グルコシド、水）等を用いることができる。
ポリアクリルアミドとしては例えばＳＥＰＰＩＣ社の複合原料であるセピゲル３０５（ポリアクリルアミド、水添ポリイソブテン、ラウレス−７、水）を用いることができる。 ポリアクリル酸Ｎａとしては例えば東レ・ダウコーニング株式会社の複合原料であるＲＭ２０５１ Ｔｈｉｃｋｅｎｉｎｇ Ａｇｅｎｔ（ポリアクリル酸Ｎａ、ジメチコン、シクロペンタシロキサン、トリデセス−６、ＰＥＧ／ＰＰＧ−１８／１８ジメチコン）等を用いることができる。
（アクリルアミド/アクリル酸アンモニウム）共重合体としてはＳＥＰＰＩＣ社の複合原料であるＳＥＰＩＰＬＵＳ ２６５（（アクリルアミド/アクリル酸アンモニウム）共重合体、ポリイソブテン、ポリソルベート２０、水）等を用いることができる。
Carboxyvinyl polymers are chemically cross-linked macromolecules polymerized primarily with acrylic acid monomers. As a commercial item, Wako Pure Chemical Industries, Ltd. Hibiswako, Noveon carbopol polymer, 3V SIGMA sinter, etc. are mentioned.
Examples of the (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer include, for example, sepinob EMT10 from SEPPIC or SIMULGEL NS ((hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer from SEPPIC, which is a composite material, and squalane. , Polysorbate, water).
Examples of the (acrylic acid Na / acryloyl dimethyl taurine) copolymer include SIMULGEL EG ((Na / acrylic acid dimethyl taurine acrylate) copolymer, isohexadecane,
For example, Sepigel 305 (polyacrylamide, hydrogenated polyisobutene, laureth-7, water), which is a composite material of SEPPIC, can be used as the polyacrylamide. As polyacrylic acid Na, for example, RM2051 Thickening Agent (polyacrylic acid Na, dimethicone, cyclopentasiloxane, trideceth-6, PEG / PPG-18 / 18 dimethicone), which is a composite material of Toray Dow Corning Co., Ltd., is used. Can do.
As the (acrylamide / ammonium acrylate) copolymer, SEPPIC 265 ((acrylamide / ammonium acrylate) copolymer, polyisobutene,
本発明の皮膚外用剤には、油剤、多価アルコール、保湿剤、糖類、界面活性剤、防腐剤、金属イオン封鎖剤、増粘剤、粉体成分、紫外線吸収剤、紫外線遮断剤、等を含有させることができる。また、ビタミン類、皮膚賦活剤、血行促進剤、活性酸素消去剤、抗炎症剤、美白剤、殺菌剤等の他の化粧成分や薬効成分、生理活性成分を含有させることもできる。 The skin external preparation of the present invention includes oils, polyhydric alcohols, humectants, saccharides, surfactants, preservatives, sequestering agents, thickeners, powder components, UV absorbers, UV blockers, etc. It can be included. In addition, vitamins, skin activators, blood circulation promoters, active oxygen scavengers, anti-inflammatory agents, whitening agents, bactericides, and other cosmetic ingredients, medicinal ingredients, and physiologically active ingredients can also be included.
油剤としては、炭化水素油系油性成分、高級アルコール系油性成分、植物油のような油脂系油性成分、シリコーン系油性成分等が挙げられる。 Examples of the oil agent include hydrocarbon oil-based oil components, higher alcohol-based oil components, oil-based oil-based components such as vegetable oil, silicone-based oil components, and the like.
炭化水素油系油性成分としては、例えば、スクワラン、流動パラフィン、スクワレン、マイクロクリスタリンワックス等が挙げられる。 Examples of the hydrocarbon oil-based oil component include squalane, liquid paraffin, squalene, and microcrystalline wax.
高級アルコール系油性成分として、例えば、ラウリルアルコール、ステアリルアルコール、セチルアルコール、セトステアリルアルコール等の直鎖アルコール、オクチルドデカノール、モノステアリルグリセリンエーテル、ラノリンアルコール、コレステロール、フィトステロール等の分枝鎖アルコール等が挙げられる。 Examples of higher alcohol oil components include linear alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, and cetostearyl alcohol, branched chain alcohols such as octyldodecanol, monostearyl glycerin ether, lanolin alcohol, cholesterol, and phytosterol. Can be mentioned.
油脂系油性成分としては、例えばツバキ油、月見草油、マカデミアナッツ油、（オリーブ油）、ナタネ油、トウモロコシ油、ゴマ油、ホホバ油、胚芽油、小麦胚芽油、トリオクタン酸グリセリン等の液体油脂、カカオ脂、ヤシ油、硬化ヤシ油、パーム油、パーム核油、モクロウ、モクロウ核油、硬化油、硬化ヒマシ油等の固体油脂、ミツロウ、キャンデリラロウ、綿ロウ、ヌカロウ、ラノリン、酢酸ラノリン、液状ラノリン、サトウキビロウ等のロウ類が挙げられる。 Examples of the oil-based oil component include camellia oil, evening primrose oil, macadamia nut oil, (olive oil), rapeseed oil, corn oil, sesame oil, jojoba oil, germ oil, wheat germ oil, glycerin trioctanoate, cocoa butter, Solid oils such as coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, molasses, mollusc kernel oil, hydrogenated oil, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, nuka wax, lanolin, lanolin acetate, liquid lanolin, Examples include waxes such as sugarcane wax.
高級脂肪酸系油性成分として、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸（ＤＨＡ）、エイコサペンタエン酸（ＥＰＡ）等が挙げられる。 Examples of the higher fatty acid oil component include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the like.
シリコーン系油性成分として、例えば、鎖状ポリシロキサンのジメチルポリシロキサン、メチルフェニルポリシロキサン等、環状ポリシロキサンのデカメチルシクロペンタシロキサン等が挙げられる。 Examples of the silicone-based oil component include linear polysiloxanes such as dimethylpolysiloxane and methylphenylpolysiloxane, and cyclic polysiloxanes such as decamethylcyclopentasiloxane.
多価アルコールとしては、ポリエチレングリコール、ジプロピレングリコール、１，３−ブチレングリコール、１，２−ペンタンジオール、プロピレングリコール、イソプレングリコール、グリセリン、ジグリセリン等が挙げられる。 Examples of the polyhydric alcohol include polyethylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, propylene glycol, isoprene glycol, glycerin, diglycerin and the like.
保湿剤として、例えば、キシリトール、マルチトール、マルトース、ソルビトール、ブドウ糖、果糖、コンドロイチン硫酸ナトリウム、ヒアルロン酸ナトリウム、乳酸ナトリウム、ピロリドンカルボン酸、シクロデキストリン等が挙げられる。 Examples of the humectant include xylitol, maltitol, maltose, sorbitol, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, pyrrolidone carboxylic acid, cyclodextrin and the like.
界面活性剤としては、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤等が挙げられる。
非イオン界面活性剤としては、例えば、ソルビタン脂肪酸エステル類、ポリオキシエチレンソルビタン脂肪酸エステル類、ポリオキシエチレン硬化ヒマシ油類、ポリグリセリン脂肪酸エステル類、ショ糖脂肪酸エステル類、ポリオキシエチレンポリオキシプロピレンアルキルエーテル類等が挙げられる。
アニオン界面活性剤としては、例えば、ラウリン酸ナトリウム等の脂肪酸塩、ラウリル硫酸ナトリウム等の高級アルキル硫酸エステル塩、ＰＯＥラウリル硫酸トリエタノールアミン等のアルキルエーテル硫酸エステル塩、Ｎ−アシルサルコシン酸、スルホコハク酸塩、Ｎ−アシルアミノ酸塩等が挙げられる。
カチオン界面活性剤としては、例えば、塩化ステアリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ベンザルコニウム、塩化ベンゼトニウム等が挙げられる。
両性界面活性剤としては、例えば、アルキルベタイン、アミドベタイン等のベタイン系界面活性剤等が挙げられる。
Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.
Nonionic surfactants include, for example, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid esters, sucrose fatty acid esters, polyoxyethylene polyoxypropylene alkyl And ethers.
Examples of the anionic surfactant include fatty acid salts such as sodium laurate, higher alkyl sulfates such as sodium lauryl sulfate, alkyl ether sulfates such as POE lauryl sulfate triethanolamine, N-acyl sarcosine acid and sulfosuccinic acid. Salts, N-acylamino acid salts and the like.
Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride.
Examples of amphoteric surfactants include betaine surfactants such as alkyl betaines and amide betaines.
防腐剤として、例えば、メチルパラベン、エチルパラベン、フェキノキシエタノール等を挙げることができる。 Examples of the preservative include methyl paraben, ethyl paraben, and fequinoxyethanol.
金属イオン封鎖剤として、例えば、エチレンジアミン四酢酸二ナトリウム、エデト酸、エデト酸ナトリウム塩等のエデト酸塩を挙げることができる。 Examples of the sequestering agent include edetates such as disodium ethylenediaminetetraacetate, edetic acid, and sodium edetate.
増粘剤として、例えば、アラビアゴム、トラガカントガム、ガラクタン、グアーガム、カラギーナン、ペクチン、寒天、クインスシード、デキストラン、デキストリン、プルラン、カルボキシメチルデンプン、コラーゲン、カゼイン、ゼラチン、メチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム、アルギン酸ナトリウム、キサンタンガム、カルボキシメチルデキストランナトリウム、ベントナイト等を挙げることができる。 Examples of thickeners include gum arabic, gum tragacanth, galactan, guar gum, carrageenan, pectin, agar, quince seed, dextran, dextrin, pullulan, carboxymethyl starch, collagen, casein, gelatin, methylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose , Hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, xanthan gum, sodium carboxymethyldextran, bentonite and the like.
粉末成分としては、例えば、タルク、カオリン、雲母、シリカ、ゼオライト、ポリエチレン粉末、ポリスチレン粉末、セルロース粉末、無機白色顔料、無機赤色系顔料、酸化チタンコーテッドマイカ、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ等のパール顔料、赤色２０１号、赤色２０２号等の有機顔料を挙げることができる。 Examples of the powder component include talc, kaolin, mica, silica, zeolite, polyethylene powder, polystyrene powder, cellulose powder, inorganic white pigment, inorganic red pigment, titanium oxide coated mica, titanium oxide coated talc, and colored titanium oxide coated mica. And organic pigments such as Red No. 201 and Red No. 202.
紫外線吸収剤としては、例えば、パラアミノ安息香酸、サリチル酸フェニル、パラメトキシケイ皮酸イソプロピル、パラメトキシケイ皮酸オクチル、２,４−ジヒドロキシベンゾフェノン、等を挙げることができる。
紫外線遮断剤として、例えば、酸化チタン、タルク、カルミン、ベントナイト、カオリン、酸化亜鉛等を挙げることができる。
Examples of the ultraviolet absorber include paraaminobenzoic acid, phenyl salicylate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2,4-dihydroxybenzophenone, and the like.
Examples of the ultraviolet blocking agent include titanium oxide, talc, carmine, bentonite, kaolin, and zinc oxide.
薬効成分としては、例えば、ビタミンＡ油、レチノール等のビタミンＡ類、リボフラビン等のビタミンＢ２類、ピリドキシン塩酸塩等のＢ６類、Ｌ−アスコルビン酸、Ｌ−アスコルビン酸リン酸エステル、Ｌ−アスコルビン酸モノパルミチン酸エステル、Ｌ−アスコルビン酸ジパルミチン酸エステル、Ｌ−アスコルビン酸−２−グルコシド等のビタミンＣ類、パントテン酸カルシウム等のパントテン酸類、ビタミンＤ２、コレカルシフェロール等のビタミンＤ類；α−トコフェロール、酢酸トコフェロール、ニコチン酸ＤＬ−α−トコフェロール等のビタミンＥ類等のビタミン類を挙げることができる。プラセンタエキス、グルタチオン、ユキノシタ抽出物等の美白剤、ローヤルゼリー、ブナノキエキス等の皮膚賦活剤、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、カフェイン、タンニン酸、γ−オリザノール等の血行促進剤、グリチルリチン酸誘導体、グリチルレチン酸誘導体、アズレン等の消炎剤、アルギニン、セリン、ロイシン、トリプトファン等のアミノ酸類、常在菌コントロール剤のマルトースショ糖縮合物、塩化リゾチーム等を挙げることができる。さらに、カミツレエキス、パセリエキス、ブナノキエキス、ワイン酵母エキス、グレープフルーツエキス、スイカズラエキス、コメエキス、ブドウエキス、ホップエキス、コメヌカエキス、ビワエキス、オウバクエキス、ヨクイニンエキス、センブリエキス、メリロートエキス、バーチエキス、カンゾウエキス、シャクヤクエキス、サボンソウエキス、ヘチマエキス、トウガラシエキス、レモンエキス、ゲンチアナエキス、シソエキス、アロエエキス、ローズマリーエキス、セージエキス、タイムエキス、茶エキス、海藻エキス、キューカンバーエキス、チョウジエキス、ニンジンエキス、マロニエエキス、ハマメリスエキス、クワエキス等の各種抽出物を挙げることができる。 The medicinal ingredient, for example, vitamin A oil, vitamin A such as retinol, vitamin B 2 such as riboflavin, B 6 such as pyridoxine hydrochloride, L- ascorbic acid, L- ascorbic acid phosphoric acid ester, L- Vitamin Cs such as ascorbic acid monopalmitate, L-ascorbic acid dipalmitate, L-ascorbic acid-2-glucoside, pantothenic acids such as calcium pantothenate, vitamin Ds such as vitamin D 2 and cholecalciferol Vitamins such as vitamin E such as α-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate; Whitening agents such as placenta extract, glutathione, and yukinoshita extract, skin activators such as royal jelly, linden extract, capsaicin, gingeron, cantalis tincture, ictamol, caffeine, tannic acid, blood circulation promoters such as γ-oryzanol, glycyrrhizic acid Derivatives, glycyrrhetinic acid derivatives, anti-inflammatory agents such as azulene, amino acids such as arginine, serine, leucine and tryptophan, maltose sucrose condensates of resident bacteria control agents, lysozyme chloride and the like. In addition, chamomile extract, parsley extract, beech extract, wine yeast extract, grapefruit extract, honeysuckle extract, rice extract, grape extract, hop extract, rice bran extract, loquat extract, buckwheat extract, yakuinin extract, assembly extract, merirot extract, birch extract, licorice extract , Peony extract, bonito extract, loofah extract, capsicum extract, lemon extract, gentian extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, tea extract, seaweed extract, cucumber extract, clove extract, carrot extract, Examples include various extracts such as maroni extract, hamamelis extract and mulberry extract.
本発明の皮膚外用剤は、化粧料、医薬部外品、医薬品として提供される。適用できる剤型としては、化粧液、乳液、クリーム、美容液、パック等が挙げられる。本発明の皮膚外用剤は粘度が高いがべたつきが少なく、使用感に優れる。 The skin external preparation of the present invention is provided as cosmetics, quasi drugs, and pharmaceuticals. Applicable dosage forms include cosmetic liquids, milky lotions, creams, cosmetic liquids, packs and the like. The external preparation for skin of the present invention has a high viscosity but little stickiness, and is excellent in use feeling.
カルボキシビニルポリマーのジステアロイルホスファチジルコリンによる増粘効果の測定
１．試験溶液の調製
５種類のジ脂肪酸アシルホスファチジルコリン（ＰＣと略記する。）
１．ＤＳＰＣ（ジステアロイルホスファチジルコリン）、
２．ＤＳＰＣ：ＤＰＰＣ＝９０：１０（ジステアロイルホスファチジルコリン：ジパ ルミトイルホスファチジルコリン＝９０：１０）、
３．ＤＳＰＣ：ＤＰＰＣ＝８０：２０（ジステアロイルホスファチジルコリン：ジパ ルミトイルホスファチジルコリン＝８０：２０）、
４．ＤＰＰＣ（ジパルミトイルホスファチジルコリン）、
５．Ｓ−１０ＥＸ（水素添加大豆リン脂質 日光ケミカルズ株式会社製レシノールＳ −１０ＥＸ）（ジ脂肪酸アシルホスファチジルコリンを含有する。）
を、最終濃度が０、０．０６２５、０．１２５、０．２５、０．５、１質量％の濃度となるように、最終濃度１０質量％のジプロピレングリコールに８５℃以上で溶解し、室温まで冷却した。
カルボキシビニルポリマー（ハイビスワコー１０３）を、最終濃度０．２４質量％、水酸化カリウムを最終濃度０．０２１６質量％となるように水に溶解し、先のジ脂肪酸アシルホスファチジルコリンのジプロピレングリコール溶液と混合し、水を添加して１００質量％とした。
Measurement of thickening effect of carboxyvinyl polymer by distearoylphosphatidylcholine Preparation of Test Solution Five types of difatty acid acyl phosphatidylcholines (abbreviated as PC)
1. DSPC (distearoylphosphatidylcholine),
2. DSPC: DPPC = 90: 10 (distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 90: 10),
3. DSPC: DPPC = 80: 20 (distearoyl phosphatidylcholine: dipalmitoyl phosphatidylcholine = 80: 20),
4). DPPC (dipalmitoylphosphatidylcholine),
5. S-10EX (hydrogenated soybean phospholipid, Nikko Chemicals, Inc., Resinol S-10EX) (contains difatty acid acyl phosphatidylcholine)
Is dissolved in dipropylene glycol having a final concentration of 10% by mass at 85 ° C. or higher so that the final concentration is 0, 0.0625, 0.125, 0.25, 0.5, 1% by mass, Cooled to room temperature.
Carboxyvinyl polymer (Hibiswako 103) was dissolved in water to a final concentration of 0.24% by mass and potassium hydroxide to a final concentration of 0.0216% by mass, and a dipropylene glycol solution of the aforementioned difatty acid acylphosphatidylcholine and Mix and add water to 100% by weight.
２．粘度測定
Ｂ型粘度計にて粘度を測定した。測定条件は、ローターＮｏ．４、１２ｒｐｍ、３０ｓ、２５±２℃とした。
2. Viscosity measurement Viscosity was measured with a B-type viscometer. The measurement conditions were rotor No. 4, 12 rpm, 30 s, 25 ± 2 ° C.
３．結果
試験溶液の粘度を表１に示す。ジ脂肪酸アシルホスファチジルコリンを配合しない試験溶液の粘度を１００％としたときの粘度の百分率比を表２に示す。
3. Results The viscosities of the test solutions are shown in Table 1. Table 2 shows the percentage ratio of the viscosity when the viscosity of the test solution containing no difatty acid acylphosphatidylcholine is defined as 100%.
カルボキシビニルポリマー溶液にジステアロイルホスファチジルコリンを配合することにより顕著な増粘効果を示した。ジステアロイルホスファチジルコリンを１質量％配合することにより、配合しないものと比べて百分率比で１１７５％（１２倍）に粘度が上昇した。
ジステアロイルホスファチジルコリン：ジパルミトイルホスファチジルコリン＝９０：１０を１質量％配合した場合でも、配合しないものと比べて百分率比で５８４％（６倍）に粘度が上昇した。
しかしながら、ジステアロイルホスファチジルコリン：ジパルミトイルホスファチジルコリン＝８０：２０を１質量％配合した場合は、配合しないものと比べて百分率比で２７５％（３倍）に粘度が上昇した。
The remarkable thickening effect was shown by mix | blending distearoyl phosphatidylcholine with the carboxy vinyl polymer solution. By blending 1% by mass of distearoylphosphatidylcholine, the viscosity increased to 1175% (12 times) in percentage compared to those not blended.
Even when 1% by mass of distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 90: 10 was blended, the viscosity increased to 584% (6 times) as a percentage as compared to those not blended.
However, when 1% by mass of distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 80: 20 was blended, the viscosity increased to 275% (three times) in terms of percentage compared to the case of not blending.
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンＮａ)共重合体のジステアロイルホスファチジルコリンによる増粘効果の測定
１．試験溶液の調製
５種類のジ脂肪酸アシルホスファチジルコリン（ＰＣと略記する。）
１．ＤＳＰＣ（ジステアロイルホスファチジルコリン）、
２．ＤＳＰＣ：ＤＰＰＣ＝９０：１０（ジステアロイルホスファチジルコリン：ジパ ルミトイルホスファチジルコリン＝９０：１０）、
３．ＤＳＰＣ：ＤＰＰＣ＝８０：２０（ジステアロイルホスファチジルコリン：ジパ ルミトイルホスファチジルコリン＝８０：２０）、
４．ＤＰＰＣ（ジパルミトイルホスファチジルコリン）、
５．Ｓ−１０ＥＸ（水素添加大豆リン脂質 日光ケミカルズ株式会社製レシノールＳ −１０ＥＸ）（ジ脂肪酸アシルホスファチジルコリンを含有する。）
を、最終濃度が０、０．０６２５、０．１２５、０．２５、０．５、１質量％の濃度となるように、最終濃度１０質量％のジプロピレングリコールに８５℃以上で溶解し、室温まで冷却した。
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンＮａ)共重合体（セピノブＥＭＴ１０）を、最終濃度０．６質量％となるように水に溶解し、先のジ脂肪酸アシルホスファチジルコリンのジプロピレングリコール溶液と混合し、水を添加して１００質量％とした。
1. Measurement of thickening effect by distearoylphosphatidylcholine of (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer Preparation of Test Solution Five types of difatty acid acyl phosphatidylcholines (abbreviated as PC)
1. DSPC (distearoylphosphatidylcholine),
2. DSPC: DPPC = 90: 10 (distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 90: 10),
3. DSPC: DPPC = 80: 20 (distearoyl phosphatidylcholine: dipalmitoyl phosphatidylcholine = 80: 20),
4). DPPC (dipalmitoylphosphatidylcholine),
5. S-10EX (hydrogenated soybean phospholipid, Nikko Chemicals, Inc., Resinol S-10EX) (contains difatty acid acyl phosphatidylcholine)
Is dissolved in dipropylene glycol having a final concentration of 10% by mass at 85 ° C. or higher so that the final concentration is 0, 0.0625, 0.125, 0.25, 0.5, 1% by mass, Cooled to room temperature.
(Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer (Sepinobu EMT10) is dissolved in water to a final concentration of 0.6% by mass and mixed with the dipropylene glycol solution of difatty acid acylphosphatidylcholine. Water was added to make 100% by mass.
２．粘度測定
Ｂ型粘度計にて粘度を測定した。測定条件は、ローターＮｏ．４、１２ｒｐｍ、３０ｓ、２５±２℃とした。
2. Viscosity measurement Viscosity was measured with a B-type viscometer. The measurement conditions were rotor No. 4, 12 rpm, 30 s, 25 ± 2 ° C.
３．結果
試験溶液の粘度を表３に示す。ジ脂肪酸アシルホスファチジルコリンを配合しない試験溶液の粘度を１００％としたときの粘度の百分率比を表４に示す。
3. Results The viscosity of the test solution is shown in Table 3. Table 4 shows the percentage ratio of the viscosity when the viscosity of the test solution containing no difatty acid acylphosphatidylcholine is defined as 100%.
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンＮａ)共重合体溶液にジステアロイルホスファチジルコリンを配合することにより顕著な増粘効果を示した。ジステアロイルホスファチジルコリンを１質量％配合することにより、配合しないものと比べて百分率比で７６３％（８倍）に粘度が上昇した。
ジステアロイルホスファチジルコリン：ジパルミトイルホスファチジルコリン＝９０：１０を１質量％配合した場合でも、配合しないものと比べて百分率比で３９２％（４倍）に粘度が上昇した。
しかしながら、ジステアロイルホスファチジルコリン：ジパルミトイルホスファチジルコリン＝８０：２０を１質量％配合した場合は、配合しないものと比べて百分率比で１３２％（１．３倍）の粘度であり、粘度は殆ど上昇しなかった。
A remarkable thickening effect was shown by blending distearoyl phosphatidylcholine with a (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer solution. When 1% by mass of distearoyl phosphatidylcholine was added, the viscosity increased to 763% (8 times) in terms of percentage compared to the case of not adding.
Even when 1% by mass of distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 90: 10 was blended, the viscosity increased to 392% (4 times) as a percentage compared to the case of not blending.
However, when 1% by mass of distearoylphosphatidylcholine: dipalmitoylphosphatidylcholine = 80: 20 is blended, the viscosity is 132% (1.3 times) as a percentage compared to those not blended, and the viscosity hardly increases. It was.
処方例１ 乳液
成分 配合量（質量％）
１．ジステアロイルホスファチジルコリン ０．５
２．水素添加大豆リン脂質 ０．０５
３．カルボキシビニルポリマー ０．０５
４．（アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa）共重合体 ０．３５
５．水酸化カリウム ０．０１
６．グリセリン ５
７．１，３−ブチレングリコール ５．５
８．ジプロピレングリコール ５
９．ラフィノース ２
10．トリメチルグリシン ２
11．ＰＥＧ−７５ ０．５
12．ジステアリン酸ポリグリセリル−９ ０．３
13．ステアリン酸ポリグリセリル−１０ ０．５
14．スクワラン ３
15．ホホバ油 ２
16．ジメチコン ０．５
17．精製水 残余
Formulation Example 1 Emulsion Ingredient Amount (% by mass)
1. Distearoylphosphatidylcholine 0.5
2. Hydrogenated soybean phospholipid 0.05
3. Carboxyvinyl polymer 0.05
4). (Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer 0.35
5. Potassium hydroxide 0.01
6). Glycerin 5
7.1,3-Butylene glycol 5.5
8). Dipropylene glycol 5
9. Raffinose 2
Ten. Trimethylglycine 2
11． PEG-75 0.5
12． Polyglyceryl distearate-9 0.3
13. Polyglyceryl stearate-10 0.5
14. Squalane 3
15． Jojoba oil 2
16． Dimethicone 0.5
17． Purified water residue
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