JP5468074B2 - Dosing device and method for filling a cavity - Google Patents

Description

  The present invention comprises a powder hopper and a plate having a surface, wherein the plate is adapted to receive at least one cavity adapted to receive the particulate material and to move the particulate material into the at least one cavity. And a dosing device provided with filling means movable along the surface. The present invention also relates to a method of filling a predetermined amount of particulate material in a cavity provided in a plate of a dosing device.

  Currently, drug delivery and administration is done in many different ways. In order to achieve the administration of specific drugs that are efficient and user-friendly in health care, the possibility of administering the drugs directly in the form of powders to the user's lungs by means of a dosing device, for example an inhalation device, is increasingly More effort is being poured. In most cases, some form of dosage method is used to prepare the inhaled dosage. For example, a predetermined dosage of medication can be provided in a pack having several cavities containing a single dosage of medication. Subsequently, the cavity filled with a single dose is sealed with a sealing sheet, for example, an aluminum foil. The pack is loaded into a dosing device where the foil above the cavity is pierced and a single dose of drug is released for inhalation by the user. With such a seal, the drug is well protected before inhalation.

  There are also other cases that are suitable for containing a single dose of drug and providing a predetermined dose of drug in a pack having a cavity sealed with foil. Each pack containing a predetermined dose of drug can take the form of a blister pack with blisters or an injection-molded disc with cavities to contain powdered drugs, said packs having various shapes. And the cavities can be distributed in various patterns. In order to provide different sized packs containing accurate dosages of drugs, the method of filling the cavities must provide accurate and variable dosages within the cavities.

  In both of the above situations, it is often desirable not to completely fill the cavity with the drug. Thus, a dosing method can be used in which the cavity of the dosing device has a volume that is less than the cavity of the final pack and is filled with the desired dosage of drug, after which the drug is transferred to the final pack. This makes it possible to deliver a specific dosage of powder smaller than the volume of the cavity containing a single dosage with satisfactory accuracy.

  A method and device for filling a cavity of a medication disk with a certain amount of particulate material is disclosed in WO 06/118526. The document discloses a filling element with a bottom surface with several chambers, the total number of which is the same as the total number of cavities in the dosing disc. The filling element has scraper means in the form of four rotating scrapers for rubbing to fill the chamber. During use of the filling element, the powdered drug is supplied to the surface of the filling element and scraped into the chamber by scraper means. After filling the particulate material into the chamber of the filling element, the particulate material is transferred to the dosing disk. However, the above solution has the disadvantage that it is not suitable for all types of particulate material. For example, particulate matter with limited free-flowing can adhere and clump, which can contribute to uneven delivery of material between different cavities, i.e., part of the cavity In some cases, a desired amount of medicine cannot be filled.

  Accordingly, one object of the present invention is to fill at least one cavity with a predetermined amount of granular material (powder, etc.), and then accurately granulate with a dosage smaller than the volume of the cavity containing a single dosage. It is to provide a method and device that can administer substances, can handle agglomerated materials, i.e., particulate substances that do not flow freely, and provide an accurate amount of particulate matter within each cavity.

  The above object is achieved by a drug application device as defined in claim 1. The dosing device comprises a powder hopper and a plate having a surface, the plate having at least one cavity adapted to receive the particulate material and for moving the particulate material into the at least one cavity. Filling means movable along the surface is provided, the filling means exerting a compressive force on the particulate material in a direction towards the surface such that the particulate material is pushed into the at least one cavity. It is a thing.

  Particulate materials with limited free flow ability tend to adhere to each other and contribute to the blob material. When scraping material into the cavity, as described above for prior art devices, such a mass is scraped into the cavity or block, for example, into the inlet opening of the cavity, thereby providing the desired amount of particulate material in the cavity. Is no longer filled. The dosing device according to the present invention instead is to push the particulate material into the cavity of the dosing device. This has the advantage, for example, that a blob formed in the granular material is broken up by the forces acting on it. This makes the filling of the cavities more reliable and thus ensures the exact dosage of the drug in each cavity. However, the device according to the present invention is not only convenient for the packaging of particulate matter when a blob has been formed in the material. It results in accurate packaging of materials with limited free flow even when no lumps are formed therein. Furthermore, the device according to the invention is also suitable for packaging free-flowing particulate material. Experiments have shown that with the device according to the invention, a dose of approximately 5 mg of particulate material can be packaged with a relative standard deviation of only 3%.

  The cavities in the dosing device according to the invention can be configured in any desired shape, preferably to correspond to the pattern of the drug dispenser.

  Suitably, the cavity of the dosing device has a small volume compared to the volume of the cavity containing a single dose in the final pack. Since the particulate material is pushed into the cavity of the dosing device, very accurate dosing is achieved. Thus, subsequent transfer of particulate material to the cavity in the final pack provides very accurate dosing even if the final containment cavity has a large volume.

  Furthermore, the device provides a simple filling of the cavity particulate material at a low cost. Suitably, the cavity of the dosing device is replaceable to fit the dosage to be dispensed within the cavity.

  Materials that can be filled include organic powders having a particle size in the range of 0.5 to 1000 μm. For example, a powder consisting of lactose monohydrate with a particle size in the range of 1-50 μm is successfully filled by the method according to the invention. In the specification of the present application, the particle size means, for example, a mass median diameter measured by a laser diffraction method, that is, MMD (mass median diameter).

  According to at least one exemplary embodiment, the dosing device further comprises scraper means, the scraper means being movable along the surface of the plate.

  When the filling means is moved along the surface of the plate in the dosing device and a force is applied to the particulate material in the direction toward the plate, a portion of the particulate material is pressed against the plate surface located between adjacent cavities. be able to. Therefore, it is preferable to have a scraper means having a structure movable along the surface and capable of loosening the pressed material. Preferably, the scraper means has a structure designed to efficiently scrape particulate matter retained on the surface of the plate. The scraped particulate material can then be moved and pushed into the cavity by filling means or transferred into another dosing device for reuse. As another option, the shaved particulate material can be removed and reused later in the same dispensing device. The scraper means can also loosen the material squeezed above the cavity, ie above the material pushed into the cavity. However, by disposing the scraper means movably along the surface, the scraper means does not scrape or remove the material pushed into the cavity. Therefore, the scraper means does not negatively affect dosing accuracy.

  It is advantageous if the filling means can also be moved in a direction perpendicular to the surface of the plate. The reason for this is that the filling means is moved slightly away from the surface when it comes into contact with a more compressed particulate material, e.g. a blob, and then moved towards the surface, so that the direction This is because a force can be applied to the granular material. Thereby, the filling means functions to divide the mass and pack the particulate material into the cavity.

  According to at least one exemplary embodiment, the filling means is biased towards the surface. In order to allow the filling means to act on the particulate material in a direction towards the plate, it is preferred to bias the filling means towards the plate. This can be achieved, for example, by filling means that are spring loaded against the plate. This mechanism allows the filling means to move slightly away from the surface so that it can "climb" on the mass, for example, as described above, but at the same time it returns to the direction of the plate and becomes granular. Try to push the substance.

  Preferably, the scraper means biases towards the surface. The purpose of the scraper means is to be movable along the surface and to be able to loosen the pressed material. Therefore, it is advantageous when biasing towards the surface to maintain a close relationship with the surface during movement along the surface.

  Preferably, the filling means is biased toward the surface with a force that is less than the force biasing the scraper means toward the surface. This is because the scraper means must follow in close relation to the surface, and the filling means must be able to move slightly away from the surface in a direction substantially perpendicular to the surface. Be beneficial. However, when moving away from the surface, the filling means must be brought back into close contact with the surface.

  According to at least one exemplary embodiment, the surface has a circular shape and several cavities are arranged, the cavities being arranged annularly around the periphery of the surface. Preferably, the filling means and the scraper means are provided on a common boss. Preferably, the common boss is arranged in the center of the annular part of the cavity.

  A circular plate having several cavities disposed thereon with a centrally located boss on which the filling means and scraper means are disposed has proven to be a beneficial design for the dosing device. The circular boss and the filling and scraper means can be arranged to rotate both clockwise and counterclockwise. Even if the filling means presses the particulate material toward the surface, the scraper means loosens the particulate material and moves the particulate material along the surface. By providing a circular plate, the particulate material can move around the surface of the plate without staying at one end of the plate. It is also possible to rotate the boss alternately clockwise and counterclockwise to move the particulate material in both directions along the surface. Thereby, it is possible to provide and maintain a uniform distribution of particulate matter to the surface. This is beneficial in that a uniform distribution of particulate material within each cavity is obtained.

  However, other alternative designs are also conceivable, such as a rectangular plate.

  According to at least one exemplary embodiment, the filling means consists of at least one wheel, which can be rotated on the surface. Thereby, an efficient way of pushing the particulate material into the cavity is achieved. A wheel can be rotated on the surface of the plate and adapted to push the particulate material into the cavity. In this configuration, the wheel need not enter the cavity to compress the particulate material, and therefore the portion of the wheel that pushes the particulate material into a particular cavity may have a larger dimension than the cavity. Good. This is advantageous in terms of manufacturing tolerances since no exact matching of the filling means and the cavity is required. Furthermore, one size wheel can be used to fill different size cavities.

  According to at least one exemplary embodiment, the dosing device comprises a filling mechanism having two wheels and two scrapers disposed on a common boss. The wheels and the scraper are preferably arranged around a common boss, so that a scraper is arranged behind each wheel. This is beneficial because if the first wheel presses on the particulate material, the scraper will loosen it before the second wheel reaches that portion of the particulate material.

  Further in accordance with the present invention, a method for filling a cavity disposed in a plate of a dosing device with a predetermined amount of particulate material is provided, the method comprising the steps of supplying particulate material to a powder hopper, and filling means. Moving along the surface of the plate, and applying a compressive force to the particulate material in a direction toward the plate at the same time as the filling means moves along the surface.

  As described above, the granular materials with limited free flow ability tend to adhere to each other, and contribute to the lump in the powder drug. Using the above method, the particulate material will be pushed into the cavity of the dosing device. This has the advantage that, for example, the mass formed in the granular material will be divided by the force exerted on it. This makes the filling of the cavities more reliable and therefore ensures the exact dosage of the drug in each cavity. However, the method according to the present invention is not only useful for packaging particulate matter when a blob is formed in the material. The method results in accurate packaging of materials with limited free flow even when no lumps are formed in the material. Furthermore, the method according to the invention is also suitable for packaging free-flowing particulate material.

  Preferably, the cavity of the dosing device has a volume that is smaller than the volume of the cavity that contains the predetermined dose in the final pack. Since the particulate material is pushed into the cavity of the dosing device, very accurate dosing is achieved. Thus, if the particulate material is subsequently transferred to a cavity in the final pack, it will still have a very accurate dosage, even if the cavity in the final housing has a larger volume. Experiments have shown that with the method according to the invention, a dosage of approximately 5 mg of particulate material can be packaged with a relative standard deviation of only 3%. The method provides a simple filling of the cavity particulate material at a low cost. Preferably, the cavity of the dosing device is replaceable to fit the size of the dose to be dispensed into the cavity. The particulate material handled by the method according to the invention can be, for example, a pure form of the drug, or can be mixed with a suitable powdery excipient.

  For example, a finely divided mixture of drugs used for the treatment of asthma, such as budesonide, beclomethasone dipropionate (BDP) or lactose monohydrate excipients, has been successfully filled using the method according to the present invention. Yes.

  According to at least one embodiment, the method further comprises the step of loosening the compressed particulate material on the surface by scraper means.

  According to at least one exemplary embodiment, the particulate material comprises a pharmaceutical powder for use in a dry powder inhaler.

  It should be understood that the above-described inventive method encompasses and can be practiced with any of the embodiments and features described in connection with the aforementioned dispensing device of the present invention as long as these embodiments and features are consistent with the method.

  The present invention will now be described in more detail for purposes of illustration through embodiments and with reference to the accompanying drawings.

1 is a schematic perspective view of one embodiment of a dosing device according to the present invention and one embodiment of a filling means and a scraper means. FIG. 1 is a schematic cross-sectional view of one embodiment of a dosing device according to the present invention and one embodiment of a filling means and a scraper means. 3a-3c are partial schematic side cross-sectional views disclosing the pore structure showing the main steps of the dosing and infusion method. It is a schematic perspective view of another cavity structure.

  1 and 2 show a dosing device 1 provided with a powder hopper 2 containing a particulate substance such as a powder medicine (not shown). The powder hopper has a funnel-shaped interior and its inclined surface 12 is intended to guide a powdered drug (not shown) towards a plate 11 having a surface 3, which surface 3 is a powder hopper. Can be seen as forming the bottom of the two. The surface 3 is formed as a hole structure 4 having a cavity 5 that extends into the plate 11. In the present embodiment, the cavities are dispersed in a ring shape around the peripheral edge of the plate 11. A filling mechanism 13 is rotatably disposed in the central portion of the annular portion of the cavity 5.

  The filling mechanism 13 comprises two filling means, which in this exemplary embodiment are two wheels 6 and two scrapers 14. The wheel 6 and the scraper 14 are provided on a common boss 15. A drive shaft 16 is connected to the boss 15 so that the boss 15, the wheel 6 and the scraper 14 can rotate. As can be seen from FIG. 1, the wheel 6 and the scraper 14 are uniformly distributed around the boss, that is, at an interval of approximately 90 °, and the scraper 14 follows each wheel 6. The structure of the scraper 14 is designed to scrape the pressed particulate material on the surface 3. For example, when viewed in the moving direction of the scraper 14, the front surface or the tip surface of the scraper can substantially abut the plate surface 3 at the foremost position. In the present specification, the scraper 14 is illustrated as having an inclined surface and a rectangular cross section, for example. This allows the pressed particulate material to be scraped up so as to move both clockwise and counterclockwise.

  The boss 15 receives a spring load in the axial direction toward the plate 11 and the scraper 14, and the scraper 14 is fixedly arranged with respect to the boss 15, and therefore receives a spring load toward the plate 11. In the illustrated embodiment, a spring 9 is provided for the drive shaft 16 and can be connected to an external housing (not shown) to bias the boss towards the surface 3. The spring load determines the force between the two scrapers 14 and the surface 3 of the plate 11. It is beneficial to place the scraper 14 in intimate contact with the surface 3 for reasons explained in more detail below.

  Each wheel 6 is movable independently in the axial direction with respect to the boss 15, that is, in a direction approaching and separating from the surface 3 of the plate 11. Each wheel is also independently spring loaded towards the surface 3, which is less than the spring load on the boss 15 towards the surface 3. The reason for this is that when the wheel 6 encounters some of the adhering and / or squeezed particulate material, such as a blob, it can be moved slightly away from the surface 3. . The wheel 6 climbs onto the pressed mass of material thanks to the spring load, exerts a force on the mass in the direction towards the plate 11 and can therefore break the mass. A spring or other means for urging each wheel towards the surface can be disposed in the connection between the boss 15 and each wheel 6. In FIG. 3a, a shaft 10 is shown around which a wheel 6 can rotate. The shaft 10 is configured to urge the wheel 6 towards the surface 3 and at the same time to allow an appropriate movement of the wheel 6 in a direction substantially perpendicular to the surface 3 as indicated by the arrow D in FIG. 3a. is there.

  The spring load on the boss 15 and the wheel 6 can be adjusted so that precise dosing of the particulate material in each cavity is achieved.

  The wheel 6 is made of, for example, silicone or has a silicone surface. The reason for this is to eliminate particulate matter adhering to the wheel. However, other materials than silicone can also be used as long as the particulate material does not adhere thereto. Here, explanation will be given when the dosing device is used. First, the particulate material is supplied to the hopper 2. Preferably, the particulate material is supplied in an amount that extends from the surface 3 to approximately the center of the wheel 6 and thereby covers the scraper 14. The filling mechanism 13, ie the boss 15, the wheel 6 and the scraper 14, is then rotated by the drive shaft 16 so that the wheel 6 rotates on the surface 3. Thanks to the spring load that urges the boss 15 toward the surface 3, the scraper 14 follows in a close relationship with the surface 3. The wheel 6 and the scraper 14 pass through the cavity 5 one by one while the filling mechanism 13 is rotating. As the wheel 6 rotates, they exert a compressive force on the particulate material, and as they pass through the cavity 5, they press the particulate material into the cavity. This is illustrated in FIG. 3 a, where arrow A indicates the movement of the wheel 6 relative to the surface 3, arrow B indicates the direction of rotation of the wheel 6, and arrow C indicates that the particulate material 21 is the cavity of the pore structure 4. 5 shows how it is introduced into the system. Thanks to the rotation of the wheel 6, different parts of the wheel press the particulate material into the cavity 5.

  After the wheel has passed, the compressed particulate material layer is retained on the surface 3 between each cavity 5. As the scraper 14 passes through the compressed retained particulate material, the scraper 14 scrapes it up, thus allowing the lifted particulate material to be reused.

  In order to fill the cavity 5 with a desired amount of granular material, the filling mechanism 13 is rotated once or several times. The drive shaft 16 can also be arranged so that the filling mechanism 13 can rotate clockwise and counterclockwise. This allows the filling mechanism to rotate alternately between these two directions to fill the cavity with a uniform amount of particulate material. Once all cavities 5 are filled in the desired amount, excess particulate material can be transferred to another dosing device for use within the system or returned to the storage system.

  When the cavity of the dosing device 1 is filled with the desired amount of particulate material, the particulate material is transferred to a dosing disk and used in a dispensing device such as an inhalation device. Several methods and devices can be used to transfer the particulate material from the dosing device 1 to the dosing disc.

  One such method and device that can be used in connection with the present invention is a jetting means. The cavity 5 can be formed with a rectangular bottom. When the cavities are filled with the desired amount of particulate material, the bottom of each cavity is removed and the injection means can be inserted into the cavities and the material pushed out of the cavities and placed in the final pack of the drug dispenser.

  Another such method and device that can be used in conjunction with the present invention is disclosed in WO 2006/118526, a pending patent application in the name of ASTRA ZENECA AB. In this method, the plate 11 of the dosing device 1 is located at the top of the dosing disk, and the cavities 5 are placed opposite the corresponding cavities in the dosing disk, so that the particulate material is contained in the cavities 5 of the plate 11. To the cavity of the medication disk. Vibrating means or ultrasonic elements can be provided in the dosing device to allow control of emptying the cavity within the corresponding cavity of the dosing device.

  Yet another method and device for transferring a predetermined amount of particulate material from a dosing device 1 to a dosing disk is disclosed in US Provisional Patent Application No. 60/957822, in the name of ASTRA ZENECA AB. In this application, a plate having a hole with a movable wall is disclosed. The method and device can be suitable for use in combination with the present invention and will be further described with reference to FIGS. 3a-3c. FIG. 3 a schematically shows a cross section of one cavity 5 of the hole structure 4. The wall structure of the cavity 5 includes a plurality of movable wall portions 22 that can be moved relative to each other. The cavity 5 of the dosing device 1 is made of a hole in this embodiment and can be closed by a closing mechanism 8. Preferably, the closing mechanism 8 is formed as a plate which can be arranged in the first position so as to block the entry and exit from the hole 5 on the closing mechanism side. Accordingly, the closing mechanism 8 forms the bottom of the hole 5 when in the first position.

  The hole 5 is closed during filling of the hole 5 as disclosed in FIG. 3a. When a sufficient amount of the powder 21 is introduced into the hole 5, the hole 5 can be closed. For this purpose, the dosing system 3 comprises a lid mechanism 7. The lid mechanism 7 has an opening and can be arranged in alignment with the hole 5 of the hole structure 4 at the first position. The first position of the opening of the lid mechanism is disclosed in FIG. 3a showing the first step in the powder supply procedure. During this process, the powder can be introduced into the holes 5 in the manner described above.

  Now continuing to FIG. 3b, an intermediate state of the dosing operation is disclosed. In the intermediate state, the lid mechanism 7 is disposed in the closed state, and the closing mechanism 8 is the same. The movable wall portions of the plates deposited on each other together with the lid mechanism 7 and the closing mechanism 8 define a closed volume. As can be readily seen from the cross-section of FIG. 3b, the holes 5 will be completely filled with the particulate material 21 in this intermediate operating state.

  Still referring to FIG. 3c, the operation of emptying the hole 5 is shown. There is an opening of approximately the same size as the opening of the hole 5 in the side of the hole closing mechanism portion adapted to form the bottom of any of the holes 5. In the second position, the opening of the hole closing mechanism 8 is arranged in a state aligned with the hole 5 when viewed from the side. Powder can be discharged from the hole 5 when the opening of the hole closing mechanism 8 is in its corresponding position in the hole 5. Preferably, when discharging powder from any one of the holes 5, the lid mechanism 7 can be placed in an offset position to prevent the opening of the holes 5. This is done to prevent additional powder from entering the holes 5 once the metered dose is achieved, thus ensuring further delivery of the regular dose powder to the system. Become. To further improve the normal feeding of the powder amount, the hole / hole group wall portions 22 in question are moved relative to each other. The relative movement of the wall portion 22 has been proven to allow reliable emptying effects with low powder retention and accurate further powder dosing.

  Preferably, the relative movement of the wall portions in the exemplary embodiment is achieved by movement of the plates that make up the hole structure 4. As a result, the wall 22 having a structure surrounding the hole 5 constitutes a wall structure for the hole 5. The plate forming the hole structure can be slidable back and forth in a direction substantially perpendicular to the main propagation direction of the hole in question, and this main propagation direction is in the intended path for the powder. It almost agrees. The movement of each hole 22 is preferably in the range of ± 2% to ± 50% of the diameter of the hole 5 based on the aligned start position and stop position, but is not exclusive. Preferably, the movement of the plate is ± 5% to ± 25% of the hole diameter, for example ± 7% to ± 15% of the hole 5 diameter. In referring to the diameter of the holes 5, it is suggested that the holes 5 can be formed differently. Therefore, the diameter according to the present application broadly represents the longest distance across the hole in question, whether it is square or another shape with different distances between its sides. Should be interpreted as

  The dispensing device 1 has been described in connection with an exemplary embodiment. However, several modifications and adaptations are possible within the scope of the invention as defined in the appended claims.

  For example, the plate 11 need not be circular. FIG. 4 shows an embodiment having a rectangular plate 11 ′ with cavities 5 arranged along one straight line of the plate 11 ′. In the present embodiment, the wheel 6 and the scraper 14 can be disposed not on the rotating boss but on a means that moves linearly. The wheel and scraper can then be moved back and forth over the surface 3 'to fill the cavity 5 with particulate material in the same manner as described above for the circular plate. In this rectangular embodiment, it may be preferable to keep the scraper means 14 slightly away from the surface 3 'of the plate 11'. The reason for this is that the filling means and scraper in use can move the particulate material along the surface of the plate. Some material will therefore be positioned at the end of the plate during the filling process. It is therefore beneficial to be able to lift the scraper means from the plate above the particulate material disposed thereon and position the scraper means at the outer end of the plate. The particulate material disposed at the outer end of the plate can then be moved toward the other end of the plate to fill the cavity.

  Another possible modification is to eliminate the need to place the wheel and scraper on a common boss or hub. Alternatively, the scraper and wheel movement can be provided by different means that are controlled to move the wheel and scraper in the desired interrelationship.

  Furthermore, the filling means has been described as a wheel rotating on the surface 3 that packs the particulate material into the cavity 5 by rotational movement. However, it is also possible to provide the filling means as a substantially flat surface such as a mat or similar non-rotating means. This non-rotating means can exert a spring load towards the surface 3 of the plate 11 so as to exert a compressive force on the particulate matter as the non-rotating means moves along the surface 3. For wheels, the means having a flat surface can be made of silicone or have a silicone surface to prevent particulate matter from adhering thereto. The filling means having a substantially flat surface can be used for both the circular plate 11 and other arbitrarily shaped plates such as the rectangular plate 11 '. Furthermore, the filling mechanism 13 has been described in the disclosed embodiment as comprising two filling means, ie in the exemplary embodiment comprising a wheel 6 and two scrapers 14. However, other numbers of filling means and scrapers can also be envisaged, for example one filling means and one scraper.

Claims (13)

A dosing device (1) comprising a powder hopper (2) and a plate (11) having a surface (3),
At least one cavity (5) adapted to receive particulate material in the plate (11) and along the surface (3) for moving particulate material into the at least one cavity (5) And movable filling means (6),
The filling means (6) biases towards the surface so as to apply a compressive force to the particulate material in a direction towards the surface such that the particulate material is pushed into the at least one cavity (5). A dosing device. Further comprising scraper means (14);
2. Dosing device according to claim 1, wherein the scraper means (14) is movable along the surface (3).   3. Dosing device according to claim 1 or 2, wherein the filling means (6) is also movable in a direction substantially perpendicular to the surface (3). 4. A dispensing device according to claim 2 or 3 , wherein the scraper means (14) is biased towards the surface (3). 5. Dosing device according to claim 4, wherein the filling means (6) is biased towards the surface (3) with a smaller force than the scraper means (14). Said surface (3) has a circular shape and comprises several cavities (5),
The cavity (5), said surface (3) drug dispensing device as claimed in claim 1, which is arranged annularly in any one of 5 the periphery of. The dosing device according to any one of claims 2 to 6 , wherein the filling means (6) and the scraper means (14) are provided on a common boss (15). The dispensing device according to claim 7 , combined with claim 6 , wherein the common boss (15) is arranged in the center of the annular part of the cavity (5). Said filling means (6) comprises at least one wheel;
The wheel dosing device according to any one of claims 1 to 8 which is rotatable on said surface (3). Drug dispensing device according to any one of claims 1 9 having a packing mechanism (13) having a common boss two disposed (15) wheel (6) and two scrapers (14) . A method of filling a cavity (5) provided in a plate (11) of a dosing device (1) with a predetermined amount of particulate material,
Supplying a particulate material to the powder hopper (2);
On said surface (3) to the energized filling means (6) provides a compressive force in a direction towards the plate (11) with respect to said particulate material toward the surface (3) of the plate (11) Moving said filling means (6) along. 12. The method according to claim 11 , further comprising the step of loosening the pressed particulate material on the surface (3) by scraper means (14). 13. A method according to claim 11 or 12 , wherein the particulate material comprises a pharmaceutical powder used in a dry powder inhaler.

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