JP5444325B2 - 改善された機能性及び効能を有する自己崩壊性経皮治療システム - Google Patents
改善された機能性及び効能を有する自己崩壊性経皮治療システム Download PDFInfo
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- JP5444325B2 JP5444325B2 JP2011502263A JP2011502263A JP5444325B2 JP 5444325 B2 JP5444325 B2 JP 5444325B2 JP 2011502263 A JP2011502263 A JP 2011502263A JP 2011502263 A JP2011502263 A JP 2011502263A JP 5444325 B2 JP5444325 B2 JP 5444325B2
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- active ingredient
- disintegrating
- self
- therapeutic system
- transdermal therapeutic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/0075—Disposal of medical waste
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
- A62D3/00—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B2101/00—Type of solid waste
- B09B2101/65—Medical waste
- B09B2101/68—Transdermal patches
Description
10/2003,42; Transdermal Controlled Systemic Medications, Y.W.Chien, Drugs and the Pharmaceutical Sciences, Vol.31; Polymers in Transdermal Drug Delivery Systems), S.Kandavilliet al., Pharmaceutical Technology, May 2002, 62-80)。
酢酸エチル、ヘプタン及びイソプロパノール/トルエンの有機溶媒混合物中のアクリル酸2−エチルヘキシル、酢酸ビニル、アクリル酸ブチル及びアクリル酸の単量体から成る自己架橋型ポリアクリレートの溶液(1.14g)に、レブリン酸(100g)、オレイン酸オレイル(150g)、ポリビニルピロリドン(100g)、エタノール(150g)、酢酸エチル(200g)及びブプレノルフィン塩基(100g)を加えた。この混合物を均一になるまで約2時間に亘って撹拌した。均一化後、混合物を、厚みが100μmのポリエステルフィルムのシリコン処理された面に塗布し、その後、乾燥室において70℃で10分間、乾燥することによって溶媒を除去した。コーティングにおける被覆厚みは、溶媒の除去で単位面積当たりの質量が約80g/m2になるように選択された。溶媒の除去に続いて、シリコン処理されたポリエステルフィルム及び活性成分を含有するポリマー層から構成される積層体が、第二のより弱くシリコン処理されたポリエステルフィルムで裏打ちされた。その後、得られた積層体を、5×5cmの辺長さを有する四角形に切断した。次いで、この5×5cmのシリコン処理されたポリエステルフィルムを、積層体の側面上で除去して、例えば4×4cmのサイズの吸水性の液透過性材料、例えば不織布を中央部に接着させた。次いで、粉末形態の過マンガン酸カリウムを充填した、エンボス加工の縁部を備えた濾紙パウチを、吸収性の液透過性材料上に置いた:ここでパウチのデザインは、その全面積が、活性成分を含有するポリマー層の面積よりも小さくなるようなものであった。
上部カバー層と、過マンガン酸カリウムを粉末形態で有するパウチとの間に、全ての周辺がシールされ、マルタ十字架及び1.5ミリリッターの水で充たされた液密パウチを、中に結合させた点が異なることを除いて、実施例1が繰り返された。使用したTTSを患者の皮膚から除去する際に、マルタ十字架の少なくとも一点が液体パウチの下方壁を突き刺し、その結果水の排出をもたらし、これがその下に配列された過マンガン酸カリウムと直ちに接触を始める。
Claims (13)
- 少なくとも一つの活性成分を含む層;
活性成分と活性成分を無用にする薬剤の間の分離を達成する層であって、液体に対し透過性であるが、固体に対して不透過性である層;
固体の形態又はペーストの形態の、活性成分を無用にする少なくとも一つの薬剤を含む層;
液体に対し不透過性である層;及び
鈍い外形及び鋭い又は尖った内部領域を有する、少なくとも一つの隣接層を穿孔するための少なくとも一つの機械的手段であって、前記外形及び領域により、移動相を、活性成分を無用にする薬剤に接近させることができ、このようにして活性成分、及び活性成分を無用にする薬剤を互いに接触させ、そして活性成分をこの接触によって破壊させることを確実にすることによって、使用後のTTSを除去する際に、活性成分、及び活性成分を無用にする薬剤の間の分離の解消をもたらす前記穿孔のための手段;
をこの順で含む、自己崩壊性経皮治療システム(TTS)。 - 経皮パッチであることを特徴とする、請求項1に記載の自己崩壊性経皮治療システム。
- 患者の皮膚からのTTSの除去に続いて、活性成分、及び活性成分を無用にする薬剤を、移動相の存在下で互いに化学的に反応させることを特徴とする、請求項1又は2に記載の自己崩壊性経皮治療システム。
- 活性成分が鎮痛剤又は麻薬であることを特徴とする、請求項1〜3の何れか1項に記載の自己崩壊性経皮治療システム。
- 活性成分がモルヒネ誘導体、ヘロイン又はブプレノルフィンであることを特徴とする、請求項1〜4の何れか1項に記載の自己崩壊性経皮治療システム。
- 活性成分がフェンタニル、スフェンタニル又はアルフェンタニルであることを特徴とする、請求項1〜5の何れか1項に記載の自己崩壊性経皮治療システム。
- 活性成分を無用にする薬剤が酸化剤であることを特徴とする、請求項1〜6の何れか1項に記載の自己崩壊性経皮治療システム。
- 活性成分を無用にする薬剤が過マンガン酸カリウムであることを特徴とする、請求項1〜7の何れか1項に記載の自己崩壊性経皮治療システム。
- 移動相が水であることを特徴とする、請求項1〜8の何れか1項に記載の自己崩壊性経皮治療システム。
- 穿孔のための機械的手段が多数の鋭い又は尖った領域を有することを特徴とする、請求項1〜9の何れか1項に記載の自己崩壊性経皮治療システム。
- 穿孔のための機械的手段が星形形状を有することを特徴とする、請求項1〜10の何れか1項に記載の自己崩壊性経皮治療システム。
- 穿孔のための機械的手段に関して、皮膚からTTSを除去する際に、その構造の捻じ曲げによって、内部領域において対応して配置された少なくとも一つの点を、その形状によって決められる旋回軸回りに、隣接層の方向に面から最大90度までの角度で回転し、このようにして少なくとも一つの隣接層の穿孔を行なうことを特徴とする、請求項1に記載の自己崩壊性経皮治療システム。
- 疼痛の治療に使用するための、請求項1〜12の何れか1項に記載の自己崩壊性経皮治療システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008016804.1 | 2008-04-02 | ||
DE102008016804A DE102008016804B4 (de) | 2008-04-02 | 2008-04-02 | Selbstzerstörendes transdermales therapeutisches System mit verbesserter Funktionalität und Wirksamkeit sowie seine Verwendung |
PCT/EP2009/002205 WO2009121514A2 (de) | 2008-04-02 | 2009-03-26 | Selbstzerstörendes transdermales therapeutisches system mit verbesserter funktionalität und wirksamkeit |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011516439A JP2011516439A (ja) | 2011-05-26 |
JP5444325B2 true JP5444325B2 (ja) | 2014-03-19 |
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Application Number | Title | Priority Date | Filing Date |
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JP2011502263A Expired - Fee Related JP5444325B2 (ja) | 2008-04-02 | 2009-03-26 | 改善された機能性及び効能を有する自己崩壊性経皮治療システム |
Country Status (16)
Country | Link |
---|---|
US (2) | US8435219B2 (ja) |
EP (1) | EP2276477B1 (ja) |
JP (1) | JP5444325B2 (ja) |
KR (1) | KR101621569B1 (ja) |
CN (1) | CN101980703B (ja) |
AU (1) | AU2009231149B2 (ja) |
BR (1) | BRPI0911267A2 (ja) |
CA (1) | CA2720400C (ja) |
DE (1) | DE102008016804B4 (ja) |
ES (1) | ES2688185T3 (ja) |
IL (1) | IL208261A (ja) |
MX (1) | MX2010010916A (ja) |
NZ (1) | NZ587998A (ja) |
RU (1) | RU2506948C2 (ja) |
WO (1) | WO2009121514A2 (ja) |
ZA (1) | ZA201006616B (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009036485B4 (de) | 2009-08-07 | 2012-10-04 | Lts Lohmann Therapie-Systeme Ag | Mittel zur zerstörenden Entsorgung von medizinischen Wirkstoffen in transdermalen therapeutischen Systemen |
USD720848S1 (en) | 2012-05-21 | 2015-01-06 | Butterfly Health, Inc. | Body liner for anal leakage |
US8591488B2 (en) | 2012-01-31 | 2013-11-26 | Butterfly Health, Inc. | Devices and methods for treating accidental bowel leakage |
USD721170S1 (en) | 2012-11-16 | 2015-01-13 | Butterfly Health, Inc. | Body liner for anal leakage |
CN104815833B (zh) * | 2015-04-17 | 2017-05-24 | 娄文忠 | 一种用于非易失性存储芯片的自毁微系统及其自毁方法 |
BR112018013711A2 (pt) * | 2016-01-20 | 2018-12-11 | Lts Lohmann Therapie-Systeme Ag | controle da liberação de água de uma composição hidratada dimensionalmente estável |
US10779816B2 (en) * | 2016-07-07 | 2020-09-22 | Medline Industries, Inc. | Orthopedic implant, method, and kit |
GB201616223D0 (en) * | 2016-09-23 | 2016-11-09 | University College Cardiff Consultants Limited | Topical treatment patch |
Family Cites Families (15)
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US4917676A (en) * | 1986-11-20 | 1990-04-17 | Ciba-Geigy Corporation | User-activated transdermal therapeutic system |
US5236714A (en) | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
EP1424973B1 (en) * | 2001-04-23 | 2010-03-03 | Euro-Celtique S.A. | Disposal system for transdermal dosage form |
DK2316439T3 (en) * | 2001-05-01 | 2015-08-10 | Euro Celtique Sa | Abuse-proof transdermal systems containing opioids |
DE10141651B4 (de) * | 2001-08-24 | 2007-02-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
DE10250084A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US7182955B2 (en) | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
US20050112068A1 (en) * | 2003-10-28 | 2005-05-26 | Warner Kevin S. | Systems and methods for reducing unintended use of active ingredients in dermal delivery devices |
US7867511B2 (en) * | 2004-01-23 | 2011-01-11 | Travanti Pharma Inc. | Abuse potential reduction in abusable substance dosage form |
ATE498358T1 (de) | 2005-06-29 | 2011-03-15 | Compumedics Ltd | Sensoranordnung mit leitfähiger brücke |
US7740879B2 (en) * | 2006-01-17 | 2010-06-22 | Harrogate Holdings | Abuse resistant transdermal drug delivery patch |
DE102006025282A1 (de) * | 2006-05-31 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Selbstzerstörendes transdermales therapeutisches System |
US7838715B2 (en) * | 2009-01-21 | 2010-11-23 | Palo Alto Research Center Incorporated | Drug deactivation system and method of deactivating a drug using the same |
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2008
- 2008-04-02 DE DE102008016804A patent/DE102008016804B4/de not_active Expired - Fee Related
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2009
- 2009-03-26 BR BRPI0911267A patent/BRPI0911267A2/pt not_active IP Right Cessation
- 2009-03-26 US US12/935,085 patent/US8435219B2/en active Active
- 2009-03-26 JP JP2011502263A patent/JP5444325B2/ja not_active Expired - Fee Related
- 2009-03-26 CN CN2009801115917A patent/CN101980703B/zh not_active Expired - Fee Related
- 2009-03-26 RU RU2010140102/14A patent/RU2506948C2/ru not_active IP Right Cessation
- 2009-03-26 NZ NZ587998A patent/NZ587998A/en not_active IP Right Cessation
- 2009-03-26 AU AU2009231149A patent/AU2009231149B2/en not_active Ceased
- 2009-03-26 CA CA2720400A patent/CA2720400C/en not_active Expired - Fee Related
- 2009-03-26 EP EP09726650.6A patent/EP2276477B1/de active Active
- 2009-03-26 ES ES09726650.6T patent/ES2688185T3/es active Active
- 2009-03-26 MX MX2010010916A patent/MX2010010916A/es active IP Right Grant
- 2009-03-26 KR KR1020107021859A patent/KR101621569B1/ko active IP Right Grant
- 2009-03-26 WO PCT/EP2009/002205 patent/WO2009121514A2/de active Application Filing
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2010
- 2010-09-15 ZA ZA2010/06616A patent/ZA201006616B/en unknown
- 2010-09-20 IL IL208261A patent/IL208261A/en not_active IP Right Cessation
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2013
- 2013-03-27 US US13/851,575 patent/US8894621B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2009231149B2 (en) | 2014-01-23 |
IL208261A0 (en) | 2010-12-30 |
DE102008016804B4 (de) | 2012-01-05 |
DE102008016804A1 (de) | 2009-10-08 |
CN101980703B (zh) | 2012-10-17 |
US8435219B2 (en) | 2013-05-07 |
EP2276477A2 (de) | 2011-01-26 |
JP2011516439A (ja) | 2011-05-26 |
BRPI0911267A2 (pt) | 2015-09-29 |
CN101980703A (zh) | 2011-02-23 |
CA2720400A1 (en) | 2009-10-08 |
WO2009121514A3 (de) | 2010-06-10 |
US20110022009A1 (en) | 2011-01-27 |
WO2009121514A2 (de) | 2009-10-08 |
AU2009231149A1 (en) | 2009-10-08 |
ES2688185T3 (es) | 2018-10-31 |
NZ587998A (en) | 2012-06-29 |
IL208261A (en) | 2015-09-24 |
KR20100135244A (ko) | 2010-12-24 |
MX2010010916A (es) | 2010-11-05 |
RU2010140102A (ru) | 2012-04-10 |
US8894621B2 (en) | 2014-11-25 |
EP2276477B1 (de) | 2018-08-15 |
RU2506948C2 (ru) | 2014-02-20 |
CA2720400C (en) | 2016-08-16 |
ZA201006616B (en) | 2011-05-25 |
US20130226108A1 (en) | 2013-08-29 |
KR101621569B1 (ko) | 2016-05-16 |
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