JP5437619B2 - 認知障害を患う患者の治療のための薬物の調製を目的とする治療用ヒトアルブミンの使用 - Google Patents
認知障害を患う患者の治療のための薬物の調製を目的とする治療用ヒトアルブミンの使用 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Description
すなわち、上記薬物が血漿交換のために溶液の形態であるヒトアルブミンの使用。
薬物が静脈内使用のために溶液の形態であるヒトアルブミンの使用。
上記アルブミンが初めは4%(p/v)〜25%(p/v)の濃度であるヒトアルブミンの使用。
使用されるアルブミンが4.5%(p/v)〜5.5%(p/v)の濃度であるヒトアルブミンの使用。
使用されるアルブミンが、ヨーロッパ薬局方に従って調合された治療用アルブミンの結合能力よりも優れた結合能力を有するヒトアルブミンの使用。
上記認知障害がアルツハイマー病であるヒトアルブミンの使用。
治療された7人の患者のうち、3人は5回の血漿交換を受け(患者4、5及び6)、2人は4回の血漿交換を受け(患者2及び3)、2人は3回の血漿交換を受けた(患者7及び9)。
神経心理検査による認知評価に関して、MMSE(Folstein MF et al.「『簡易精神状態検査』、臨床医のための患者の認知状態を評価する実用的方法("Mini-mental state", a practical method for grading the cognitive state of patients for the clinician)」J Psychiatr Res 1975; 12: 189-198)及びAdas−Cog(Rosen WG et al.「アルツハイマー病の新たな尺度(A new scale for Alzheimer's disease)」Am J Psychiatry 1984; 141: 1536-1364)と呼ばれる異なる試験を利用した。
Claims (4)
- ヒトアルブミンを有効成分とする、アルツハイマー病を治療するための血漿交換又はプラスマフェレーシス用薬物であって、該血漿交換又はプラスマフェレーシスは、アミロイド−βの血中の濃度又は量を低減しないものである薬物。
- 該薬物が溶液の形態である請求項1に記載のアルツハイマー病を治療するための血漿交換又はプラスマフェレーシス用薬物。
- 該ヒトアルブミンが4%(w/v)〜25%(w/v)の濃度のアルブミン溶液から調製されたものである、請求項1又は2に記載のアルツハイマー病を治療するための血漿交換又はプラスマフェレーシス用薬物。
- 該ヒトアルブミンが4.5%(w/v)〜5.5%(w/v)の濃度である、請求項1〜3のいずれか一項に記載のアルツハイマー病を治療するための血漿交換又はプラスマフェレーシス用薬物。
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ES200702831A ES2332846B1 (es) | 2007-10-26 | 2007-10-26 | Utilizacion de albumina humana terapeutica para la preparacion de un medicamento para el tratamiento de pacientes afectados por desordenes cognitivos. |
ES200702831 | 2007-10-26 |
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JP2009108059A JP2009108059A (ja) | 2009-05-21 |
JP5437619B2 true JP5437619B2 (ja) | 2014-03-12 |
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US (1) | US7851446B2 (ja) |
EP (1) | EP2111868B1 (ja) |
JP (1) | JP5437619B2 (ja) |
CN (1) | CN101417123B (ja) |
AR (1) | AR068901A1 (ja) |
AU (1) | AU2008233025B8 (ja) |
BR (1) | BRPI0804623B8 (ja) |
CA (1) | CA2641830C (ja) |
CL (1) | CL2008003133A1 (ja) |
ES (2) | ES2332846B1 (ja) |
HK (1) | HK1126689A1 (ja) |
MX (1) | MX2008013635A (ja) |
NZ (1) | NZ572131A (ja) |
PL (1) | PL2111868T3 (ja) |
PT (1) | PT2111868E (ja) |
RU (1) | RU2414925C2 (ja) |
UY (1) | UY31418A1 (ja) |
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US10112000B2 (en) | 2010-07-08 | 2018-10-30 | Asahi Kasei Medical Co., Ltd. | Method for reducing amyloid beta concentration in blood |
CN109963582B (zh) * | 2016-08-18 | 2022-12-27 | 万能溶剂有限公司 | 作为衰老相关认知障碍的治疗的血浆级分 |
US10525107B2 (en) | 2016-08-18 | 2020-01-07 | Alkahest, Inc. | Blood plasma fractions as a treatment for aging-associated cognitive disorders |
US11040068B2 (en) | 2017-04-26 | 2021-06-22 | Alkahest, Inc. | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
CN110709098B (zh) * | 2017-04-26 | 2024-01-30 | 万能溶剂有限公司 | 用血浆和血浆制品治疗认知障碍和运动障碍的给药方案 |
SG11202100347QA (en) * | 2018-07-20 | 2021-02-25 | Alkahest Inc | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
EP3643319A1 (en) * | 2018-10-25 | 2020-04-29 | Grifols Worldwide Operations Limited | Use of low volume plasma exchange for the treatment of alzheimer's disease in early and middle stages |
CN113056275A (zh) | 2018-10-26 | 2021-06-29 | 万能溶剂有限公司 | 血浆和血浆组分用于改善疼痛、伤口愈合和术后恢复的用途 |
EP4239069A4 (en) | 2020-10-30 | 2024-09-25 | Shenzhen Protgen Ltd | USE OF HUMAN SERUM ALBUMIN IN THE TREATMENT OF DISEASES |
US20240216477A1 (en) * | 2021-04-30 | 2024-07-04 | Grifols Worldwide Operations Limited | Use of therapeutic plasma exchange and low volume plasma exchange for the treatment of a cognitive impairment |
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DE3612137A1 (de) * | 1986-04-10 | 1987-10-15 | Biotest Pharma Gmbh | Steriles plasmaaustauschmittel |
US5112298A (en) | 1990-06-25 | 1992-05-12 | Baxter International Inc. | Apheresis method and device |
US5178603A (en) | 1990-07-24 | 1993-01-12 | Baxter International, Inc. | Blood extraction and reinfusion flow control system and method |
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CN101417123A (zh) | 2009-04-29 |
CA2641830C (en) | 2013-07-16 |
CA2641830A1 (en) | 2009-04-26 |
PL2111868T3 (pl) | 2014-01-31 |
BRPI0804623A2 (pt) | 2009-06-30 |
BRPI0804623B8 (pt) | 2021-05-25 |
BRPI0804623B1 (pt) | 2020-02-11 |
HK1126689A1 (en) | 2009-09-11 |
AU2008233025A1 (en) | 2009-05-14 |
UY31418A1 (es) | 2009-05-29 |
ES2428698T3 (es) | 2013-11-08 |
AR068901A1 (es) | 2009-12-16 |
CL2008003133A1 (es) | 2009-08-07 |
MX2008013635A (es) | 2009-05-11 |
NZ572131A (en) | 2010-06-25 |
US20090111740A1 (en) | 2009-04-30 |
ES2332846A1 (es) | 2010-02-12 |
EP2111868A1 (en) | 2009-10-28 |
RU2414925C2 (ru) | 2011-03-27 |
CN101417123B (zh) | 2012-06-27 |
JP2009108059A (ja) | 2009-05-21 |
EP2111868B1 (en) | 2013-08-21 |
ES2332846B1 (es) | 2010-07-08 |
US7851446B2 (en) | 2010-12-14 |
AU2008233025B8 (en) | 2013-07-25 |
RU2008141076A (ru) | 2010-04-27 |
AU2008233025B2 (en) | 2013-06-27 |
PT2111868E (pt) | 2013-10-17 |
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