JP5422695B2 - Chemical container - Google Patents

Description

  The present invention relates to a chemical solution container that is used to separately store various unstable chemical solutions that change with time when mixed in advance, and to aseptically mix them during administration.

  Among drugs administered to a patient by intravenous injection, there are unstable drugs that cause an undesirable change over time when pre-mixed. For example, when an amine acid infusion solution and a glucose infusion solution are blended and stored, the mixed solution browns by a so-called Maillard reaction. Further, when the fat emulsion and the electrolyte solution are blended and stored, the fat is aggregated, and when the phosphoric acid-containing solution and the calcium-containing solution are blended, calcium phosphate is precipitated and an undesirable change occurs.

  For such drugs, a multi-chamber container is often used in which the components before mixing are individually stored. This multi-chamber container is provided with a plurality of storage chambers for individually storing medicines, and a partition weak seal portion that can be opened by applying pressure from the outside between the storage chambers. Such a multi-chamber container is configured to keep the drug isolated by the weak seal part for partitioning until it is used and to mix aseptically the drug solution to be mixed at the time of administration. It has begun to be pointed out that there is a risk that a trouble (medical accident) may occur in which the patient forgets to open the door and accidentally administers only one room.

  Therefore, in order to prevent the occurrence of such troubles, a medical multi-chamber container has been proposed in which a medicine stored in each storage chamber is reliably mixed and then administered. For example, a plurality of storage chambers are connected via a partition weak seal portion, and a discharge weak seal portion is provided between at least one storage chamber and a discharge port, and the seal strength ( A medical multi-chamber container has been proposed in which the bonding strength is set larger than that of the partition weak seal portion (see, for example, Patent Document 1). In this medical multi-chamber container, when the medicines are mixed by pressing each storage chamber, the partition weak seal portion is opened before the discharge weak seal portion, so that only the discharge weak seal portion is opened. It is said that this can prevent misadministration.

  There has also been proposed a medical multi-chamber container in which the sealing strength of the discharge weak seal portion is set smaller than that of the partition weak seal portion (see, for example, Patent Document 2). In this medical multi-chamber container, at the time of administration, the medicine is first mixed by pressing the storage chamber on the side away from the discharge port to open the partition weak seal, and then pressing the whole to discharge When the weak seal portion is opened, since the sealing strength of the discharge weak seal portion is set small, it is said that there is an advantage that it is easy to open the weak seal portion.

JP 2002-136570 A JP 2003-159310 A

  However, when a difference in seal strength is set between the partition weak seal portion and the discharge weak seal portion as in the above two conventional examples, the seal width, heating time, heating temperature, pressure, etc. The design conditions for setting the value are complicated, and the manufacturing process is complicated, resulting in high costs. For example, if the seal width is set large in order to improve the seal strength, there is a problem that the volume of the storage chamber becomes small, and if the heating time is lengthened to enhance the seal strength, there is a problem that productivity is lowered. .

  In particular, a plurality of chemical liquid storage chambers each storing different chemical liquids are connected via a partition weak seal portion, and an empty chamber having a mouth portion in one of the chemical liquid storage chambers is a weak seal for discharge. In the case of a chemical container that is continuously connected via the section, even if the chemical storage chamber adjacent to the empty chamber is pressed, the discharge weak seal part may be opened before the partition weak seal part. Therefore, there is a need for a simple and reliable means that can surely improve the sealing strength (bonding strength between films) of the discharge weak seal portion.

  In view of such circumstances, an object of the present invention is to provide a low-cost chemical container in which the joint strength of the discharge weak seal portion is improved from the joint strength of the partition weak seal portion.

  (1) In the chemical container of the present invention, one of a plurality of chemical solution storage chambers connected in series via a partition weak seal portion is connected in series through an empty chamber having a mouth portion and a discharge weak seal portion. In the chemical solution storage chamber connected to the empty chamber, a film material for improving the bonding strength of the discharge weak seal portion is adjacent to the discharge weak seal portion without a gap. Then, it is affixed to the entire circumference or one side.

  According to such a configuration, the discharge weak seal is obtained by a simple process of adhering to the entire periphery or one side of the discharge weak seal portion adjacent to the discharge weak seal portion without a gap by heat sealing or adhesive bonding. The portion can be effectively reinforced, and the joint strength can be reliably improved. As a result, at the time of administration of the chemical solution, the weak seal part for partitioning is opened first regardless of which chemical solution storage chamber is pressed, and the discharge weak seal part is opened first as in the prior art. Occurrence can be prevented. As described above, since the weak seal portion can be reliably reinforced simply by attaching the film material to the chemical solution storage chamber, it is easy to design and manufacture and to provide a low cost. In pasting by heat sealing, a heat-sealable thermoplastic film material may be selected, and in adhesion by an adhesive, heat sealing property and thermoplasticity are not required, and an appropriate material may be selected.

  (2) The discharge weak seal portion may be provided with an easy opening portion for facilitating opening. In this way, the closed space is expanded after the partition weak seal part is opened, but since the easy opening part is provided in the discharge weak seal part, the entire chemical container is pressed for discharge. The weak seal portion can be easily opened.

(3) The film material can be formed in two rectangular shapes covering the entire surface of each surface of the chemical solution storage chamber .

(4) The easy opening portion may be formed in a continuous uneven shape toward the chemical solution storage chamber. In this way, when a pressing force is applied to the chemical solution storage chamber, a difference occurs in the pressing force that acts between the concave portion and the convex portion, and the total pressure that acts on the edge portion of the convex portion is another region. Since it becomes larger than (concave part), it becomes easy to peel from the edge part.

(5) The easy opening portion may be formed in a protruding shape toward the chemical solution storage chamber . Even if it does in this way, since the total pressure which acts on the protrusion edge periphery when a chemical | medical solution container is pressed becomes larger than the other area | region of the weak seal part for discharge | emission, it will become easy to peel from the protrusion end.

  (6) A plurality of easy opening portions formed in the protruding shape may be provided. In this way, it becomes easier to peel off.

  (7) The easy opening portion may be formed in a V shape, and the apex angle may be set to 20 ° to 150 °. If the apex angle is set to such an angle, it can be easily peeled off from the apex.

  The chemical container according to the present invention is a simple process of adhering to the entire circumference or one side of the chemical liquid storage chamber adjacent to the discharge weak seal part without gap by heat sealing or bonding with an adhesive, etc. The discharge weak seal portion can be effectively reinforced, and the joint strength can be reliably improved. As a result, at the time of administration of the chemical solution, the partition weak seal portion can be opened first regardless of which chemical solution storage chamber is pressed, and the discharge weak seal portion is accidentally opened before the partition weak seal portion. It is possible to prevent the occurrence of troubles. In addition, since the weak seal portion can be reliably reinforced by simply attaching the film material to the chemical solution storage chamber, the design and manufacture thereof are easy, and the cost can be reduced.

The front view of the chemical | medical solution container which concerns on embodiment of this invention. It is sectional drawing of the same chemical | medical solution container, and is AA arrow sectional drawing of FIG. (A) is expansion explanatory drawing of the easy opening part, (b) is the CC sectional view taken on the line of (a). Explanatory drawing which shows the experimental result for confirming the reinforcement effect of the weak seal part by the film material. The front view of the chemical | medical solution container which concerns on different embodiment of this invention. (A) is expansion explanatory drawing of the easy opening part, (b) is the EE arrow directional cross section of (a).

  Hereinafter, a chemical container according to the best embodiment of the present invention will be described in detail with reference to the drawings. FIG. 1 is a front view of a chemical container, and FIG. 2 is a cross-sectional view. This chemical solution container is formed into a bag shape by heat-sealing the peripheral portions of two films. Reference numerals 1 and 3 denote chemical solution storage chambers for storing various chemical solutions to be mixed. A weak seal portion for partition provided, 4 is a weak seal portion for discharge provided on the other end side of the chemical solution storage chamber 3, 5 is a sterilized empty chamber, and 6 is a discharge mouth portion. A film material 7 for improving the bonding strength of the discharge weak seal portion 4 is attached to the discharge weak seal portion 4 by heat sealing or bonding with an adhesive or the like. That is, both side edges 71 and 71 of the film material 7 are affixed to both side edges of the chemical solution storage chamber 3, and the affixed portion 72 is polymerized and affixed to the discharge weak seal portion 4.

  The above-mentioned weak sealing portion 4 for discharge is provided with an easy opening portion 8 for facilitating opening. The easy opening portion 8 is formed in a concavo-convex shape continuous toward the chemical solution storage chamber 3. By forming such an easy opening portion 8 in the discharge weak seal portion 4, when a pressing force is applied to the chemical solution storage chamber 3, as shown in FIGS. And the concave portion 4b causes a pressure difference and the total pressure acting on the edge of the convex portion 4a becomes larger than that of the other region (the concave portion 4b), so that the protruding end B including the apex P of the convex portion 4a It becomes easy to peel from the neighborhood. That is, the discharge weak seal portion 4 can be easily opened from the outside of the projecting end portion B with a small pressing force even if the volume pressed after the partition weak seal portion 2 is opened is increased.

  And as above-mentioned, the empty room 5 side of the weak seal part 4 for discharge | emission which avoided the easy opening part 8 formed in the continuous uneven | corrugated shape for the affixing part 72 of the film material 7 affixed on the chemical | medical solution storage chamber 3 It is superimposed on the part of. The reinforcing effect by sticking (heat sealing) the film material 7 has been confirmed by experiments. The experimental results are shown in FIG.

  As a result of the experiment, as in sample 3, the pasting portion (shown as a barrier seal position) 72 of the film material 7 is polymerized on the discharge side of the discharge weak seal portion (shown as an EPS seal portion in the experiment) 4. In this case, after the partition weak seal portion 2 is opened, it is confirmed that there was a sufficient reinforcing effect because it was not easily opened when the entire chemical container was pressed. In this experiment, the easy opening portion 8 is not provided in the discharge weak seal portion 4, and only the reinforcing effect is confirmed.

In the other samples 2 and 4, although not as much as sample 3, a responsive reinforcing effect was recognized. In sample 2, the affixed portion 72 is adjacent to the discharge side of the discharge weak seal portion 4 without a gap, and in sample 4, the affixed portion 72 is placed on the side of the chemical discharge chamber 3 of the discharge weak seal portion 4. Overlapping. Sample 1 in which the affixed portion 72 is affixed to the discharge side of the discharge weak seal portion 4 with an interval of 5 mm, and the sample in which the affixed portion 72 is adjacent to the chemical solution storage chamber 3 side of the discharge weak seal portion 4 In 5, the reinforcing effect was low, but it was not easily opened. Further, the sample 6 in which the affixed portion 72 was spaced by 5 mm on the side of the chemical storage chamber 3 of the discharge weak seal portion 4 was easily opened without a reinforcing effect. From the above results, it was confirmed that Samples 2, 3, and 4 could be adopted as the best mode.

Since the discharge weak seal portion 4 is reinforced with the film material 7 in this way, the bonding strength between the films of the discharge weak seal portion 4 is improved. Problems such as opening up in preparation are prevented. And when administering a chemical | medical solution, after first opening the weak seal part 2 for a partition by making pressing force act on one chemical | medical solution storage chamber 1 and mixing chemicals, and confirming the mixing state By pressing the whole, the easy-to-open portion 8 can be opened to administer the drug solution. Thus, since the chemical | medical solution container which affixes the film material 7 to a chemical | medical solution storage chamber is easy to design and manufacture, it can provide at low cost. In this chemical solution container, since the vacant chamber 5 having the mouth portion 6 is connected through the chemical solution storage chamber 3 and the discharge weak seal portion 4, the vacant chamber 5 is always mixed with the chemical solution. Therefore, the occurrence of erroneous administration can be prevented. Needless to say, it is easy to dispose of the environment without any problems.

5 and 6 show different embodiments. In this example, the easy-opening portion 8 provided in the discharge weak seal portion 4 has a shape protruding in a V shape. In such an easy-to-open portion 8, when the chemical container is pressed, as shown in FIGS. 6 (a) and 6 (b), pressure acts in the direction indicated by the arrow, and the outside of the protruding end D including the apex P Since the total pressure acting on the periphery becomes larger than the other regions of the discharge weak seal portion 4, it is easy to peel from the outside of the protruding end D. That is, even if the volume to be pressed is increased, the discharge weak seal portion 4 can be easily opened from the outside of the protruding end portion D with a small pressing force. The apex angle of the protruding end D can be set to 20 ° to 150 °. In this case, it is easy to open the position of the apex P of the easy opening portion 8 on the inner side (the side of the chemical solution storage chamber 3) than the inner horizontal edge 72a (see FIG. 1) of the attaching portion 72 of the film material 7. It becomes a requirement for. Although not shown, a plurality of such V-shaped easy opening portions 8 may be provided, and in that case, it is preferable to provide them continuously.

  It should be noted that the present invention is not limited to the best mode for carrying out the invention, and it is free to make design changes, improvements, etc. as necessary, as long as it does not depart from the gist of the invention. The material 7 may be attached only to one side when a sufficient reinforcing effect is obtained. In the case of application by heat sealing, a heat-sealable thermoplastic material may be selected as the film material, and a film material without heat-sealability may be applied with an adhesive.

DESCRIPTION OF SYMBOLS 1, 3 ... Chemical solution storage chamber 2 ... Partition weak seal part 4 ... Discharge weak seal part 5 ... Empty room 6 ... Mouth part 7 ... Film material 72 ... Pasting part 8 ... Easy opening part

Claims (7)

A chemical solution container in which one of a plurality of chemical solution storage chambers provided continuously through a partition weak seal portion is provided continuously through an empty chamber having a mouth portion and a discharge weak seal portion,
In the chemical storage chamber connected to the vacant chamber, a film material for improving the bonding strength of the discharge weak seal portion is adjacent to the discharge weak seal portion without a gap on the entire circumference or one side thereof. Pasted chemical container.   The chemical solution container according to claim 1, wherein the discharge weak seal portion is provided with an easy opening portion for facilitating opening.   The chemical | medical solution container of Claim 1 or 2 which made the adhering part of the edge of the one end side of the said film material adjoin the opening part side of the said weak seal part for discharge | emission. The chemical solution container according to claim 2 , wherein the easy opening portion is formed in a continuous uneven shape toward the chemical solution storage chamber. The chemical solution container according to claim 2 , wherein the easy opening portion is formed in a protruding shape toward the chemical solution storage chamber .   The chemical solution container according to claim 5, wherein a plurality of easy-open portions are formed in the protruding shape.   The chemical solution container according to claim 5 or 6, wherein the easy opening portion is formed in a V shape, and an apex angle thereof is set to 20 ° to 150 °.

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