JP5405782B2 - Ceramide production promoter and moisturizer - Google Patents
Ceramide production promoter and moisturizer Download PDFInfo
- Publication number
- JP5405782B2 JP5405782B2 JP2008239984A JP2008239984A JP5405782B2 JP 5405782 B2 JP5405782 B2 JP 5405782B2 JP 2008239984 A JP2008239984 A JP 2008239984A JP 2008239984 A JP2008239984 A JP 2008239984A JP 5405782 B2 JP5405782 B2 JP 5405782B2
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- JP
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- Prior art keywords
- extract
- ceramide
- barberry
- manufactured
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims description 46
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims description 46
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Description
本発明は、セラミド産生促進剤及び保湿剤に関する。 The present invention relates to a ceramide production promoter and a humectant.
スフィンゴ脂質の一つであるセラミドは、生体全体の中では微量な脂質であるが、皮膚の最も外側の層である角層中では、脂質の半分以上を占め、皮膚の保湿機構、バリア機構に重要な役割を果たしている。このセラミドは表皮細胞中において産生、分泌された後に角層中の細胞間においてラメラ構造を構築することにより機能する。しかし、乾燥肌、荒れ肌、アトピー性皮膚炎、老人性乾皮症、乾癬等の皮膚疾患においては、セラミドの健全な代謝が妨げられ、角層中のセラミド量が減少し、皮膚の保湿能やバリア能の低下等を引き起こしていることが数多く報告されている。 Ceramide, one of the sphingolipids, is a very small amount of lipid in the whole body, but in the stratum corneum, which is the outermost layer of the skin, it occupies more than half of the lipid, and is a moisturizing and barrier mechanism for the skin. Plays an important role. This ceramide functions by constructing a lamellar structure between cells in the stratum corneum after being produced and secreted in epidermal cells. However, in skin diseases such as dry skin, rough skin, atopic dermatitis, senile psoriasis and psoriasis, the healthy metabolism of ceramide is hindered, and the amount of ceramide in the stratum corneum is reduced, resulting in skin moisturizing ability and It has been reported a lot that the barrier ability is lowered.
また、近年、細胞内セラミドの産生を亢進することにより、アポトーシス、分化誘導、増殖抑制といった現象が誘導されることが報告され、細胞の増殖、分化、アポトーシス等を制御する細胞内シグナル分子として注目を集めている。従って、セラミドの産生を促進する物質には、動物細胞の増殖抑制、分化誘導、アポトーシスを誘導するなどの効果が期待でき、ひいては炎症性疾患、悪性腫瘍など、細胞の増殖あるいは分化の異常に起因する疾患に対する治療効果が期待できると考えられている（非特許文献１参照）。
また、セラミドには、骨吸収抑制作用、骨強化作用、歯槽骨減少抑制作用があり、骨粗鬆症、骨折、腰痛、リウマチなどの骨関節疾患の予防及び改善に有用であること（特許文献１参照）、歯周病の予防に効果があること（特許文献２参照）が報告されている。従って、セラミド産生促進剤には、斯かる疾患に対する治療効果も期待できる。
更に、セラミドには、毛髪のハリ、コシの付与及び感触改善作用があることも報告され（特許文献３参照）、セラミド産生促進物質には、斯かる効果も期待できる。
In recent years, it has been reported that by increasing intracellular ceramide production, phenomena such as apoptosis, differentiation induction, and growth inhibition are induced, and it has attracted attention as an intracellular signal molecule that controls cell proliferation, differentiation, apoptosis, etc. Collecting. Therefore, substances that promote ceramide production can be expected to have effects such as suppression of animal cell growth, induction of differentiation, and induction of apoptosis, and as a result, abnormalities in cell growth or differentiation such as inflammatory diseases and malignant tumors. It is thought that the therapeutic effect with respect to the disease which carries out can be anticipated (refer nonpatent literature 1).
Ceramide has a bone resorption inhibitory action, a bone strengthening action, and an alveolar bone loss inhibitory action, and is useful for the prevention and improvement of osteoarthritis such as osteoporosis, fracture, low back pain, rheumatism (see Patent Document 1). It has been reported that it is effective in preventing periodontal disease (see Patent Document 2). Therefore, the ceramide production promoter can be expected to have a therapeutic effect on such diseases.
Furthermore, it has been reported that ceramide has an effect of imparting hair firmness, firmness and feeling (see Patent Document 3), and such an effect can be expected from a ceramide production promoting substance.
そこで、このような皮膚疾患、癌細胞の増殖又は活性化の抑制、毛髪のハリ、コシの向上、及び骨形成の促進に関して、減少したセラミドを外部から補給する方法も試みられている。しかし、必ずしもその効果は十分なものではない。 Therefore, a method of replenishing reduced ceramide from the outside has also been attempted with respect to such skin diseases, suppression of cancer cell proliferation or activation, hair firmness, improvement of stiffness, and promotion of bone formation. However, the effect is not always sufficient.
本発明は、高いセラミド産生促進効果を有するセラミド産生促進剤を提供することを目的とする。
また、本発明は、保湿効果に優れた保湿剤を提供することを目的とする。
An object of this invention is to provide the ceramide production promoter which has a high ceramide production promotion effect.
Moreover, an object of this invention is to provide the moisturizing agent excellent in the moisturizing effect.
本発明者等は上記課題に鑑み、鋭意検討を行った。その結果、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）と呼ばれる植物の抽出物が高いセラミド産生促進作用を有することを見出した。さらに、この抽出物を保湿剤に配合することで、優れた保湿効果を有する保湿剤を提供することができることを見出した。本発明はこの知見に基づいて完成させたものである。 In view of the above problems, the present inventors have conducted intensive studies. As a result, it was found that plant extracts called Barberry and Black Walnut have a high ceramide production promoting action. Furthermore, it discovered that the moisturizing agent which has the outstanding moisturizing effect could be provided by mix | blending this extract with a moisturizing agent. The present invention has been completed based on this finding.
本発明は、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）からなる群より選ばれる少なくとも１種の植物の抽出物を含有するセラミド産生促進剤に関する。
また、本発明は、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）からなる群より選ばれる少なくとも１種の植物の抽出物を含有する保湿剤に関する。
The present invention relates to a ceramide production promoter containing an extract of at least one plant selected from the group consisting of Barberry and Black Walnut.
The present invention also relates to a humectant containing an extract of at least one plant selected from the group consisting of Barberry and Black Walnut.
本発明によれば、セラミド産生促進剤を提供することができる。また、本発明によれば、保湿効果に優れた保湿剤を提供することができる。 According to the present invention, a ceramide production promoter can be provided. Moreover, according to this invention, the moisturizing agent excellent in the moisturizing effect can be provided.
以下、本発明を詳細に説明する。
本発明のセラミド産生促進剤は、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）からなる群より選ばれる少なくとも１種の植物の抽出物を有効成分として含有する。前記植物は、抗炎症作用、抗菌作用、抗腫瘍作用などの各種の薬効を有することが知られている。しかし、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）の抽出物がセラミド産生促進効果を有することについては全く知られていなかった。
また、本発明の保湿剤は、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）からなる群より選ばれる少なくとも１種の植物の抽出物を含有する。前記抽出物は高いセラミド産生促進効果を有する。したがって、本発明の保湿剤により、生体の有するセラミド産生機構を健常に戻すことができ、減少した角層中のセラミドを増加させ、高いバリア機能及び保湿機能を有する皮膚を取り戻すこと、癌細胞の増殖又は活性化の抑制、毛髪のはり、こしの向上、及び骨形成の促進、等が可能となる。
Hereinafter, the present invention will be described in detail.
The ceramide production promoter of the present invention contains, as an active ingredient, an extract of at least one plant selected from the group consisting of Barberry and Black Walnut. The plant is known to have various medicinal effects such as anti-inflammatory action, antibacterial action, and antitumor action. However, it has not been known at all that extracts of Barberry and Black Walnut have an effect of promoting ceramide production.
Moreover, the moisturizing agent of the present invention contains an extract of at least one plant selected from the group consisting of Barberry and Black Walnut. The extract has a high ceramide production promoting effect. Therefore, with the humectant of the present invention, the ceramide production mechanism of the living body can be restored to normal, the ceramide in the reduced stratum corneum is increased, the skin having high barrier function and moisturizing function is recovered, and cancer cells It is possible to suppress proliferation or activation, to improve hair tension, to improve strain, to promote bone formation, and the like.
本発明において、バーベリー（Barberry）は、メギ科（Berberidacaeae）に属し、学名はberberis vulgaris、和名はメギおよびセイヨウメギ、慣用名はアグラセホ（Agracejo）である。 In the present invention, Barberry belongs to the Berberidacaeae family, the scientific name is berberis vulgaris, the Japanese name is barberry and barberry, and the common name is Agracejo.
本発明において、ブラックウォルナット（Black Walnut）は、クルミ科（Juglandaceae）に属し、学名はJuglans nigra、慣用名は黒くるみである。 In the present invention, Black Walnut belongs to the family of Juglandaceae, scientific name is Juglans nigra, and common name is black walnut.
本発明において、バーベリー（Barberry）および／またはブラックウォルナット（Black Walnut）の全ての任意の部分が使用可能である。例えば、上記植物の全木、または任意の部位（根、根茎、幹、枝、茎、葉、樹皮、樹液、樹脂、花、果実、種子等）、およびそれらの組み合わせのいずれか１つまたは複数を使用することができる。本発明においては、バーベリー（Barberry）を用いる場合、前記植物の根または根皮を用いるのが好ましい。また、ブラックウォルナット（Black Walnut）を用いる場合、前記植物の種子の外皮（殻の部分）を用いるのが好ましい。 In the present invention, any arbitrary part of Barberry and / or Black Walnut can be used. For example, any one or more of the whole tree of the above plant, or any part (root, rhizome, stem, branch, stem, leaf, bark, sap, resin, flower, fruit, seed, etc.), and combinations thereof Can be used. In the present invention, when using Barberry, it is preferable to use the root or root bar of the plant. When black walnut is used, it is preferable to use the seed shell (shell part) of the plant.
本発明において用いる、バーベリー（Barberry）および／またはブラックウォルナット（Black Walnut）の抽出物は、適当な溶媒を用いた常法の抽出方法によって調製することができる。 The extract of Barberry and / or Black Walnut used in the present invention can be prepared by a conventional extraction method using a suitable solvent.
本発明においては、上記植物をそのまま、又は乾燥粉砕して用いることもできるが、その抽出物、水蒸気蒸留物又は圧搾物を用いることもでき、これらは精油等、より精製したものを用いることもでき、また市販品を利用することもできる。上記植物又はその抽出物、水蒸気蒸留物若しくは圧搾物は、いずれかを単独で、又は２種以上を組み合わせて使用してもよい。 In the present invention, the above plant can be used as it is or after being dried and pulverized, but an extract, a steam distillate or a pressed product can also be used, and these can be used as a refined one such as an essential oil. It is also possible to use a commercial product. You may use the said plant or its extract, a steam distillate, or a pressing thing individually or in combination of 2 or more types.
抽出に用いる溶媒としては、通常植物成分の抽出に用いられるもの、例えば水、石油エーテル、ｎ−ヘキサン、トルエン、クロロホルム、エーテル、酢酸エチル、アセトン、メタノール、エタノール、プロパノール、ブタノール、エチレングリコール、プロピレングリコール、ブチレングリコール等が挙げられ、特に水、エタノール、プロピレングリコール、ブチレングリコールが好ましい。これらは単独で又は２種以上を組み合わせて使用できる。また抽出条件も通常の条件を適用でき、例えば上記植物を3〜100℃で数時間〜数週間浸漬又は加熱還流すればよい。上記植物の抽出物は、そのまま本発明のセラミド産生促進剤の有効成分として使用できるが、さらに適当な分離手段、例えばゲル濾過、クロマトグラフィー、精密蒸留等により活性の高い画分を分画して用いることもできる。 Solvents used for extraction are those usually used for extraction of plant components, such as water, petroleum ether, n-hexane, toluene, chloroform, ether, ethyl acetate, acetone, methanol, ethanol, propanol, butanol, ethylene glycol, propylene. Examples include glycol, butylene glycol, and water, ethanol, propylene glycol, and butylene glycol are particularly preferable. These can be used alone or in combination of two or more. Moreover, normal conditions can be applied as extraction conditions. For example, the above-mentioned plant may be immersed or heated to reflux at 3 to 100 ° C. for several hours to several weeks. The plant extract can be used as it is as an active ingredient of the ceramide production promoter of the present invention, but the fraction having high activity can be fractionated by an appropriate separation means such as gel filtration, chromatography, precision distillation and the like. It can also be used.
本発明において、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）の抽出物はそのままセラミド産生促進剤として用いてもよい。または、上記抽出物に、例えば酸化チタン、炭酸カルシウム、蒸留水、乳糖、デンプン等の適当な液体または固体の賦形剤または増量剤を加えてセラミド産生促進剤として用いてもよい。この場合、セラミド産生促進剤中の前記抽出物の量は特に制限されないが、前記抽出物が固形分換算で０．００００１〜２０重量％含まれるのが好ましく、０．０００１〜１０重量％程度含まれるのが特に好ましい。 In the present invention, the extract of Barberry and Black Walnut may be used as a ceramide production promoter as it is. Alternatively, an appropriate liquid or solid excipient or extender such as titanium oxide, calcium carbonate, distilled water, lactose, starch or the like may be added to the above extract and used as a ceramide production promoter. In this case, the amount of the extract in the ceramide production promoter is not particularly limited, but the extract is preferably contained in an amount of 0.00001 to 20% by weight in terms of solid content, and contains about 0.0001 to 10% by weight. It is particularly preferred that
本発明のセラミド産生促進剤を医薬品として用いる場合の投与形態としては、例えば錠剤、カプセル剤、顆粒剤、散剤、シロップ剤等による経口投与又は注射剤、外用剤、坐剤、経皮吸収剤等による非経口投与のいずれでもよい。当該医薬製剤を調製するには、本発明のセラミド産生促進剤を単独で、又は他の薬学的に許容される賦形剤、結合剤、増量剤、崩壊剤、界面活性剤、滑沢剤、分散剤、緩衝剤、保存剤、嬌味剤、香料、被膜剤、担体、希釈剤等を適宜組み合わせて用いることができる。該製剤中の前記植物の抽出物の含有量は、乾燥固形成分として０．００００１〜２０質量％が好ましく、特に０．０００１〜１０質量％含有することが好ましい。なお、本発明のセラミド産生促進剤を医薬品として使用する場合、成人１人当たりの１日の投与量は、前記植物の抽出物（乾燥固形分換算）が例えば０．００１〜１０００ｍｇが好ましく、特に０．０１〜１００ｍｇとなるのが好ましい。 Examples of the dosage form when the ceramide production promoter of the present invention is used as a pharmaceutical include oral administration by tablets, capsules, granules, powders, syrups, etc. or injections, external preparations, suppositories, transdermal absorption agents, etc. Any of parenteral administration may be used. To prepare the pharmaceutical preparation, the ceramide production promoter of the present invention alone or other pharmaceutically acceptable excipients, binders, extenders, disintegrants, surfactants, lubricants, A dispersant, buffer, preservative, flavoring agent, fragrance, coating agent, carrier, diluent and the like can be used in appropriate combination. The content of the plant extract in the preparation is preferably 0.00001 to 20% by mass, particularly preferably 0.0001 to 10% by mass as a dry solid component. When the ceramide production promoter of the present invention is used as a pharmaceutical, the daily dose per adult is preferably 0.001 to 1000 mg of the plant extract (in terms of dry solid content), particularly 0. 0.01 to 100 mg is preferred.
本発明の保湿剤は、バーベリー（Barberry）及びブラックウォルナット（Black Walnut）からなる群より選ばれる少なくとも１種の植物の抽出物の抽出物を含有する。本発明において、前記バーベリー（Barberry）及び／またはブラックウォルナット（Black Walnut）の抽出物をそのまま保湿剤として用いることができる。また、必要に応じて濃縮し、あるいは希釈して用いることもできる。さらに、凍結乾燥などの方法により粉末化して用いてもよい。また、本発明の保湿剤には、通常用いられる添加剤、既知のセラミド産生促進剤、擬似セラミド、天然セラミド、糖セラミド、皮膚老化防止剤、美白剤等を添加してもよい。
前記セラミド産生促進剤としては、特に限定されるものではないが、例えば、アセチルヒドロキシプロリン、グリチルリチン酸カリウム、Ｌ-カルニチン、アスコルビン酸、アスコルビルグルコシド、アスコルビルリン酸マグネシウム、dl-α-トコフェリル-dl-アスコルビルリン酸、dl-α-トコフェリルリン酸、ニコチン酸アミド、ニコチン酸トコフェロール、L-乳酸、ビタミンＣ、アスパラガス抽出物、ブッチャーブルーム、ゲンクワニン、ローズマリー、ラベンダー、セージ、ナツメ、黒（赤）霊芝、トウキ、クジン、ヨクイニン、ベニセアンヌ抽出物、ライスパワーエキスなどが挙げられる。
また、擬似セラミドとしては、特に限定されるものではないが、例えば、市販のセラミドＲ（ユニリーバ製）、セラミドＰＣ-１０４（太平洋化学製）、セラミドＨＯ３（sederma製）、エルデュウＰＳ-２０３（味の素製）などが挙げられる。
また、糖セラミドとしては、特に限定されるものではないが、グルコシルセラミド、ガラクトシルセラミド等が挙げられるが、市販のものとしては、ニップンセラミド（日本製粉製）、オリザセラミド（オリザ油化製）、ニッサンセラミド、ネオリキッドセラミドN（日本油脂製）、セラミド（ユニチカ製）等が挙げられる。
The humectant of the present invention contains an extract of at least one plant extract selected from the group consisting of Barberry and Black Walnut. In the present invention, the extract of Barberry and / or Black Walnut can be used as a moisturizer as it is. Further, it can be concentrated or diluted as necessary. Further, it may be used after being pulverized by a method such as freeze-drying. In addition, commonly used additives, known ceramide production promoters, pseudoceramides, natural ceramides, sugar ceramides, skin antiaging agents, whitening agents, and the like may be added to the humectant of the present invention.
The ceramide production promoter is not particularly limited. For example, acetylhydroxyproline, potassium glycyrrhizinate, L-carnitine, ascorbic acid, ascorbyl glucoside, magnesium ascorbyl phosphate, dl-α-tocopheryl-dl- Ascorbyl phosphate, dl-α-tocopheryl phosphate, nicotinamide, tocopherol nicotinate, L-lactic acid, vitamin C, asparagus extract, butcher bloom, genquanine, rosemary, lavender, sage, jujube, black (red ) Ganoderma, Toki, Kujin, Yokuinin, Beniceanne extract, Rice power extract, etc.
The pseudo ceramide is not particularly limited. For example, commercially available ceramide R (manufactured by Unilever), ceramide PC-104 (manufactured by Taiheiyo Chemical), ceramide HO3 (manufactured by sederma), Erduo PS-203 (Ajinomoto) Manufactured).
In addition, the sugar ceramide is not particularly limited, and examples thereof include glucosyl ceramide, galactosyl ceramide, and the like, but as commercially available products, nippon ceramide (manufactured by Nippon Flour), oryzae ceramide (manufactured by Oriza Oil), Nissan ceramide, neo-liquid ceramide N (manufactured by Nippon Oil & Fats), ceramide (manufactured by Unitika) and the like.
本発明の保湿剤は、その多くは人や動物に適用される。この保湿剤は、人や動物の皮膚、爪、粘膜、毛髪等に適用されうるすべての形態を含む。本発明の保湿剤の形態としては、例えば、軟膏、ローション、クリーム、美容液、化粧水、マッサージ剤、パック、ファンデーション、口紅、入浴剤、シャンプー、ヘアコンディショナー、ヘアトニック、錠剤、カプセル、サニタリー用品等の吸収性物品、おしり拭き、ウェットティッシュ等のシート状製品等が挙げられる。その剤型も限定されず、液状、固形状、乳液状、ペースト状、ゲル状、パウダー状(粉末状)、顆粒状、ペレット状、スティック状等の各種剤型が挙げられる。 Most of the humectants of the present invention are applied to humans and animals. This humectant includes all forms that can be applied to human and animal skin, nails, mucous membranes, hair and the like. Examples of the moisturizing agent of the present invention include ointments, lotions, creams, serums, lotions, massage agents, packs, foundations, lipsticks, bathing agents, shampoos, hair conditioners, hair tonics, tablets, capsules, sanitary products. Absorbent articles such as wiping cloths, sheet-like products such as wet tissues, and the like. The dosage form is not limited, and examples thereof include various dosage forms such as liquid, solid, emulsion, paste, gel, powder (powder), granule, pellet, and stick.
本発明の保湿剤におけるバーベリー（Barberry）及び／またはブラックウォルナット（Black Walnut）の抽出物の配合量は特に限定されないが、固形分換算で０．００００１〜２０重量％が好ましく、０．０００１〜１０重量％程度が特に好ましい。 Although the compounding quantity of the extract of Barberry and / or Black Walnut (Black Walnut) in the moisturizing agent of the present invention is not particularly limited, it is preferably 0.00001 to 20% by weight in terms of solid content, and 0.0001 to 10%. A weight percentage of about is particularly preferred.
以下、本発明を実施例に基づきさらに詳細に説明するが、本発明はこれに限定されるものではない。 EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited to this.
（製造例１）バーベリー（Barberry）の抽出物の調製
バーベリー（Barberry）の根（Mountain Rose Herbs社）４０ｇを細切し、５０％エタノール４００ｍＬを加え、室温で２３日間抽出後、濾過して抽出液を得た（収量３２４ｍＬ、蒸発残分０．５８ｗ／ｖ％）。
(Production Example 1) Preparation of Barberry extract 40 g of Barberry root (Mountain Rose Herbs) was shredded, 400 mL of 50% ethanol was added, extracted at room temperature for 23 days, filtered and extracted. A liquid was obtained (yield 324 mL, evaporation residue 0.58 w / v%).
（製造例２）ブラックウォルナット（Black Walnut）の抽出物の調製
ブラックウォルナット（Black Walnut）の種子の外皮（Mountain Rose Herbs社）４０ｇを細切し、５０％エタノール４００ｍＬを加え、室温で２３日間抽出後、濾過して抽出液を得た（収量２８４ｍＬ、蒸発残分１．３０ｗ／ｖ％）。
(Production Example 2) Preparation of Black Walnut Extract 40 g of Black Walnut seed hull (Mountain Rose Herbs) was shredded, added with 400 mL of 50% ethanol, and extracted at room temperature for 23 days. Thereafter, filtration was performed to obtain an extract (yield 284 mL, evaporation residue 1.30 w / v%).
（実施例）セラミド産生促進試験
６ウェルプレートを用い、培養液（商品名：EpiLife-KG2、KURABO社製）中にて、正常ヒト表皮角化細胞（商品名：NHEK(F)、KURABO社製）を３７℃でコンフルエントの状態になるまで培養した。
その後、培養液を上皮成長因子などの増殖因子を除いたEpiLife-KG2に換え、濃度を固形分換算で０．１％（ｗ／ｖ）、１％（ｗ／ｖ）となるように調製した上記抽出物、またはコントロール溶液（５０％エタノール）を１％量添加した。
３日間培養した後、各々の細胞を１ｗｅｌｌごと回収した。
(Example) Ceramide production promotion test Normal human epidermal keratinocytes (trade name: NHEK (F), manufactured by KURABO) in a culture solution (trade name: EpiLife-KG2, manufactured by KURABO) using a 6-well plate. ) At 37 ° C. until confluent.
Thereafter, the culture solution was replaced with EpiLife-KG2 excluding growth factors such as epidermal growth factor, and the concentration was adjusted to 0.1% (w / v) and 1% (w / v) in terms of solid content. 1% amount of the above extract or control solution (50% ethanol) was added.
After culturing for 3 days, each cell was collected together with 1 well.
回収した細胞からBligh and Dyer法により脂質を抽出した有機相をガラス管に移し、窒素乾固した後、クロロホルム、メタノールで再溶解し、脂質サンプルとした。
また、脂質を抽出した後の細胞に０．１Ｎ ＮａＯＨ、１％ＳＤＳ水溶液を加え、６０℃で２時間加熱することにより、タンパク質を可溶化し、室温まで冷却した後２Ｎ ＨＣｌを加えて中和し、タンパク量をＢＣＡ法により定量した。
The organic phase from which the lipid was extracted from the collected cells by the Bligh and Dyer method was transferred to a glass tube, solidified with nitrogen, and then redissolved with chloroform and methanol to obtain a lipid sample.
In addition, 0.1N NaOH, 1% SDS aqueous solution is added to the cells after lipid extraction, and the protein is solubilized by heating at 60 ° C. for 2 hours, cooled to room temperature, and then neutralized by adding 2N HCl. The amount of protein was quantified by the BCA method.
調製した脂質サンプルを薄膜クロマトグラフィー（ＴＬＣ）でクロロホルム：メタノール：酢酸＝１９０：９：１で２回水平展開した。硫酸銅液をスプレーで噴霧し、ホットプレートで焼き付けセラミドを検出した。その後、各サンプルのタンパク量で割り、セラミド量とした。
その結果を図１に示す。なお、図１に示すグラフの縦軸は、コントロール溶液添加群のセラミド量を１とした場合の相対値を示している。
The prepared lipid sample was horizontally developed twice by chloroform: methanol: acetic acid = 190: 9: 1 by thin film chromatography (TLC). The copper sulfate solution was sprayed and sprayed with a hot plate to detect ceramide. Then, it divided by the amount of protein of each sample, and made it the amount of ceramide.
The result is shown in FIG. In addition, the vertical axis | shaft of the graph shown in FIG. 1 has shown the relative value when the ceramide amount of the control solution addition group is set to 1.
図１から明らかなように、バーベリー（Barberry）またはブラックウォルナット（Black Walnut）の抽出物において、セラミド産生促進効果が認められた。 As is clear from FIG. 1, an effect of promoting ceramide production was observed in the extract of Barberry or Black Walnut.
（処方例）
前記製造例で得られた抽出物を有効成分として、下記に示す組成の化粧水、0/W（オイルインウォーター）型乳液、W/O（ウォーターインオイル）型クリーム、サンスクリーン剤、ジェル状化粧料、液体入浴剤、シート状製品（おしり拭き）の含浸液を常法により各々調製した
(Prescription example)
Using the extract obtained in the above production example as an active ingredient, lotion having the following composition, 0 / W (oil-in-water) type emulsion, W / O (water-in-oil) type cream, sunscreen agent, gel-like Cosmetics, liquid bath agent, and sheet-like product (wiping wipes) impregnating solutions were prepared by conventional methods.
１−１．化粧水の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.01
ポリエチレングリコール（商品名：ＰＥＧ−１５４０、三洋化成社製） 1.00
ポリオキシエチレン（20）ソルビタンモノラウリン酸エステル 1.50
グリセリン 2.00
パラべン 0.10
精製水 残余
1-1. Preparation of lotion 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.01
Polyethylene glycol (trade name: PEG-1540, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Polyoxyethylene (20) sorbitan monolaurate 1.50
Glycerin 2.00
Paraben 0.10
Purified water residue
１−２．化粧水の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.01
ポリエチレングリコール（商品名：ＰＥＧ−１５４０、三洋化成社製） 1.00
ポリオキシエチレン（20）ソルビタンモノラウリン酸エステル 1.50
グリセリン 2.00
パラべン 0.10
精製水 残余
1-2. Preparation of lotion 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.01
Polyethylene glycol (trade name: PEG-1540, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Polyoxyethylene (20) sorbitan monolaurate 1.50
Glycerin 2.00
Paraben 0.10
Purified water residue
２−１．0/W型乳液の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.02
ポリエチレングリコール（商品名：ＰＥＧ−２０００、三洋化成社製） 1.00
プルラン（商品名：プルランＰＴ−２０、林原社製） 0.40
セチルアルコール 1.00
ワセリン 2.00
スクワラン 6.00
ジメチルポリシロキサン 2.00
グリセリン 2.00
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 1.00
ポリオキシエチレン（10）モノオレイン酸エステル 1.00
グリセロールモノステアリン酸エステル 1.00
植物のカルス由来の酸性へテロ多糖類（チュベロース多糖１重量％水溶液）2.00
パラべン 0.20
精製水 残余
2-1 Preparation of 0 / W type emulsion 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.02
Polyethylene glycol (trade name: PEG-2000, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Pullulan (trade name: Pullulan PT-20, manufactured by Hayashibara) 0.40
Cetyl alcohol 1.00
Vaseline 2.00
Squalane 6.00
Dimethylpolysiloxane 2.00
Glycerin 2.00
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 1.00
Polyoxyethylene (10) monooleate 1.00
Glycerol monostearate 1.00
Acid heteropolysaccharide derived from plant callus (1% by weight aqueous solution of tuberose polysaccharide) 2.00
Paraben 0.20
Purified water residue
２−２．0/W型乳液の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.02
ポリエチレングリコール（商品名：ＰＥＧ−２０００、三洋化成社製） 1.00
プルラン（商品名：プルランＰＴ−２０、林原社製） 0.40
セチルアルコール 1.00
ワセリン 2.00
スクワラン 6.00
ジメチルポリシロキサン 2.00
グリセリン 2.00
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 1.00
ポリオキシエチレン（10）モノオレイン酸エステル 1.00
グリセロールモノステアリン酸エステル 1.00
植物のカルス由来の酸性へテロ多糖類（チュベロース多糖１重量％水溶液）2.00
パラべン 0.20
精製水 残余
2-2. Preparation of 0 / W type emulsion 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.02
Polyethylene glycol (trade name: PEG-2000, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Pullulan (trade name: Pullulan PT-20, manufactured by Hayashibara) 0.40
Cetyl alcohol 1.00
Vaseline 2.00
Squalane 6.00
Dimethylpolysiloxane 2.00
Glycerin 2.00
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 1.00
Polyoxyethylene (10) monooleate 1.00
Glycerol monostearate 1.00
Acid heteropolysaccharide derived from plant callus (1% by weight aqueous solution of tuberose polysaccharide) 2.00
Paraben 0.20
Purified water residue
３−１．W/O型クリームの調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.02
アクリル酸アルキル共重合体（商品名：ヨドゾールＧＨ８１０、カネボウＮＳＣ社製）
1.30
ポリビニルピロリドン（商品名：ルビスコールＫ−９０、ＢＡＳＥジャパン社製）
0.70
ジメチルポリシロキサン 10.00
メチルフェニルポリシロキサン 3.00
オクタメチルシクロテトラシロキサン 12.00
ポリオキシアルキレン変性シリコーン 5.00
1,3-ブチレングリコール 6.00
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 1.20
パラべン 0.20
香料 微量
精製水 残余
3-1. Preparation of W / O type cream 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.02
Alkyl acrylate copolymer (trade name: Yodosol GH810, manufactured by Kanebo NSC)
1.30
Polyvinylpyrrolidone (Brand name: Rubiscol K-90, manufactured by BASE Japan)
0.70
Dimethylpolysiloxane 10.00
Methylphenylpolysiloxane 3.00
Octamethylcyclotetrasiloxane 12.00
Polyoxyalkylene modified silicone 5.00
1,3-butylene glycol 6.00
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 1.20
Paraben 0.20
Perfume Trace amount Purified water Residual
３−２．W/O型クリームの調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.02
アクリル酸アルキル共重合体（商品名：ヨドゾールＧＨ８１０、カネボウＮＳＣ社製）
1.30
ポリビニルピロリドン（商品名：ルビスコールＫ−９０、ＢＡＳＥジャパン社製）
0.70
ジメチルポリシロキサン 10.00
メチルフェニルポリシロキサン 3.00
オクタメチルシクロテトラシロキサン 12.00
ポリオキシアルキレン変性シリコーン 5.00
1,3-ブチレングリコール 6.00
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 1.20
パラべン 0.20
香料 微量
精製水 残余
3-2. Preparation of W / O type cream 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.02
Alkyl acrylate copolymer (trade name: Yodosol GH810, manufactured by Kanebo NSC)
1.30
Polyvinylpyrrolidone (Brand name: Rubiscol K-90, manufactured by BASE Japan)
0.70
Dimethylpolysiloxane 10.00
Methylphenylpolysiloxane 3.00
Octamethylcyclotetrasiloxane 12.00
Polyoxyalkylene modified silicone 5.00
1,3-butylene glycol 6.00
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 1.20
Paraben 0.20
Perfume Trace amount Purified water Residual
４−１．サンスクリーン剤の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.02
アクリル酸アルキル共重合体（商品名：ヨドゾールＧＨ８１０、カネボウＮＳＣ社製）
1.00
ポリエチレングリコール（商品名：ＰＥＧ−４０００Ｓ、三洋化成社製） 1.00
パラメトキシ桂皮酸オクチル 5.00
シリコン被覆酸化亜鉛 6.00
シリコン被覆酸化チタン 0.50
ジメチルポリシロキサン 5.00
オクタメチルシクロテトラシロキサン 20.00
ポリオキシアルキレン変性シリコーン 3.00
エタノール 3.00
グリセリン 3.00
硫酸マグネシウム 1.00
パラべン 0.20
香料 微量
精製水 残余
4-1. Preparation of sunscreen agent 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.02
Alkyl acrylate copolymer (trade name: Yodosol GH810, manufactured by Kanebo NSC)
1.00
Polyethylene glycol (trade name: PEG-4000S, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Octyl paramethoxycinnamate 5.00
Silicon coated zinc oxide 6.00
Silicon coated titanium oxide 0.50
Dimethylpolysiloxane 5.00
Octamethylcyclotetrasiloxane 20.00
Polyoxyalkylene-modified silicone 3.00
Ethanol 3.00
Glycerin 3.00
Magnesium sulfate 1.00
Paraben 0.20
Perfume Trace amount Purified water Residual
４−２．サンスクリーン剤の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.02
アクリル酸アルキル共重合体（商品名：ヨドゾールＧＨ８１０、カネボウＮＳＣ社製）
1.00
ポリエチレングリコール（商品名：ＰＥＧ−４０００Ｓ、三洋化成社製） 1.00
パラメトキシ桂皮酸オクチル 5.00
シリコン被覆酸化亜鉛 6.00
シリコン被覆酸化チタン 0.50
ジメチルポリシロキサン 5.00
オクタメチルシクロテトラシロキサン 20.00
ポリオキシアルキレン変性シリコーン 3.00
エタノール 3.00
グリセリン 3.00
硫酸マグネシウム 1.00
パラべン 0.20
香料 微量
精製水 残余
4-2. Preparation of sunscreen agent 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.02
Alkyl acrylate copolymer (trade name: Yodosol GH810, manufactured by Kanebo NSC)
1.00
Polyethylene glycol (trade name: PEG-4000S, manufactured by Sanyo Chemical Co., Ltd.) 1.00
Octyl paramethoxycinnamate 5.00
Silicon coated zinc oxide 6.00
Silicon coated titanium oxide 0.50
Dimethylpolysiloxane 5.00
Octamethylcyclotetrasiloxane 20.00
Polyoxyalkylene-modified silicone 3.00
Ethanol 3.00
Glycerin 3.00
Magnesium sulfate 1.00
Paraben 0.20
Perfume Trace amount Purified water Residual
５−１．ジェル状化粧料の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.01
ポリエチレングリコール（商品名：ＰＥＧ−２０００、三洋化成社製） 0.50
キサンタンガム（商品名：ネオソフトＸＫＫ、興人社製） 0.20
グリセリン 3.00
エタノール 3.00
カルボキシビニルポリマー 0.50
水酸化カリウム 0.15
ポリオキシエチレン硬化ヒマシ油 1.00
クエン酸 0.80
クエン酸三ナトリウム 0.80
ナイロンパウダー 1.00
パラべン 0.10
香料 微量
精製水 残余
5-1. Preparation of gel cosmetics 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.01
Polyethylene glycol (trade name: PEG-2000, manufactured by Sanyo Chemical Co., Ltd.) 0.50
Xanthan gum (trade name: Neosoft XKK, manufactured by Kojinsha) 0.20
Glycerin 3.00
Ethanol 3.00
Carboxyvinyl polymer 0.50
Potassium hydroxide 0.15
Polyoxyethylene hydrogenated castor oil 1.00
Citric acid 0.80
Trisodium citrate 0.80
Nylon powder 1.00
Paraben 0.10
Perfume Trace amount Purified water Residual
５−２．ジェル状化粧料の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.01
ポリエチレングリコール（商品名：ＰＥＧ−２０００、三洋化成社製） 0.50
キサンタンガム（商品名：ネオソフトＸＫＫ、興人社製） 0.20
グリセリン 3.00
エタノール 3.00
カルボキシビニルポリマー 0.50
水酸化カリウム 0.15
ポリオキシエチレン硬化ヒマシ油 1.00
クエン酸 0.80
クエン酸三ナトリウム 0.80
ナイロンパウダー 1.00
パラべン 0.10
香料 微量
精製水 残余
5-2. Preparation of gel cosmetics 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.01
Polyethylene glycol (trade name: PEG-2000, manufactured by Sanyo Chemical Co., Ltd.) 0.50
Xanthan gum (trade name: Neosoft XKK, manufactured by Kojinsha) 0.20
Glycerin 3.00
Ethanol 3.00
Carboxyvinyl polymer 0.50
Potassium hydroxide 0.15
Polyoxyethylene hydrogenated castor oil 1.00
Citric acid 0.80
Trisodium citrate 0.80
Nylon powder 1.00
Paraben 0.10
Perfume Trace amount Purified water Residual
６−１．液体入浴剤の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.02
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 0.10
ミリスチン酸イソプロピル 15.00
ポリオキシエチレン（１２）オレイルエーテル 10.00
ポリオキシエチレン（６）オレイルエーテル 6.00
植物のカルス由来の酸性へテロ多糖類（チュベロース多糖１重量％水溶液）2.00
パラべン 0.30
香料 微量
流動パラフィン 残余
6-1. Preparation of liquid bath 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.02
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 0.10
Isopropyl myristate 15.00
Polyoxyethylene (12) oleyl ether 10.00
Polyoxyethylene (6) oleyl ether 6.00
Acid heteropolysaccharide derived from plant callus (1% by weight aqueous solution of tuberose polysaccharide) 2.00
Paraben 0.30
Perfume Trace amount Liquid paraffin Residue
６−２．液体入浴剤の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.02
擬似セラミド（Ｎ−（３−ヘキサデシロキシ−２−ヒドロキシプロピル）−Ｎ−２−ヒドロキシエチルヘキサデカミナド） 0.10
ミリスチン酸イソプロピル 15.00
ポリオキシエチレン（１２）オレイルエーテル 10.00
ポリオキシエチレン（６）オレイルエーテル 6.00
植物のカルス由来の酸性へテロ多糖類（チュベロース多糖１重量％水溶液）2.00
パラべン 0.30
香料 微量
流動パラフィン 残余
6-2. Preparation of liquid bath 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.02
Pseudoceramide (N- (3-hexadecyloxy-2-hydroxypropyl) -N-2-hydroxyethylhexadecaminad) 0.10
Isopropyl myristate 15.00
Polyoxyethylene (12) oleyl ether 10.00
Polyoxyethylene (6) oleyl ether 6.00
Acid heteropolysaccharide derived from plant callus (1% by weight aqueous solution of tuberose polysaccharide) 2.00
Paraben 0.30
Perfume Trace amount Liquid paraffin Residue
７−１．シート状製品（おしり拭き）の含浸液の調製１
（組成） （配合：質量％）
バーベリーエキス（固形分換算） 0.02
ジプロピレングリコール 5.00
ポリオキシエチレン（９）ラウリルエーテル 0.50
精製水 残余
7-1. Preparation of impregnating solution for sheet-like products (wiping wipes) 1
(Composition) (Composition: Mass%)
Barberry extract (solid content conversion) 0.02
Dipropylene glycol 5.00
Polyoxyethylene (9) lauryl ether 0.50
Purified water residue
７−２．シート状製品（おしり拭き）の含浸液の調製２
（組成） （配合：質量％）
ブラックウォルナットエキス（固形分換算） 0.02
ジプロピレングリコール 5.00
ポリオキシエチレン（９）ラウリルエーテル 0.50
精製水 残余
7-2. Preparation of impregnating solution for sheet-like products (wiping wipes) 2
(Composition) (Composition: Mass%)
Black walnut extract (solid content conversion) 0.02
Dipropylene glycol 5.00
Polyoxyethylene (9) lauryl ether 0.50
Purified water residue
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008239984A JP5405782B2 (en) | 2008-09-18 | 2008-09-18 | Ceramide production promoter and moisturizer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008239984A JP5405782B2 (en) | 2008-09-18 | 2008-09-18 | Ceramide production promoter and moisturizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010070498A JP2010070498A (en) | 2010-04-02 |
| JP5405782B2 true JP5405782B2 (en) | 2014-02-05 |
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| JP2008239984A Expired - Fee Related JP5405782B2 (en) | 2008-09-18 | 2008-09-18 | Ceramide production promoter and moisturizer |
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| US9445987B2 (en) | 2009-10-05 | 2016-09-20 | Kao Corporation | Ceramide production enhancer and moisturizer |
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| JP2788166B2 (en) * | 1993-08-30 | 1998-08-20 | ポーラ化成工業株式会社 | Composition for eliminating active oxygen |
| US5690944A (en) * | 1994-12-20 | 1997-11-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions containing lactate dehydrogenase inhibitors |
| KR101154772B1 (en) * | 2004-04-01 | 2012-06-18 | (주)아모레퍼시픽 | Cosmetic composition containing the zizyphus jujuba fruit extract and walnut extract for moisturizing effect on the skin |
| JP2007186457A (en) * | 2006-01-13 | 2007-07-26 | Ichimaru Pharcos Co Ltd | Tryptase activity inhibitor and its utilization |
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