JP5404072B2 - 1-pack type tooth surface covering material - Google Patents

Description

  The present invention relates to a tooth surface covering material used in the field of dentistry, and more particularly to a one-pack type tooth surface covering material which is stored in one package and used to directly form an outer surface covering on a tooth surface.

  Conventionally, a tooth surface covering material made of a curable composition has been used for various purposes in the dental field. For example, for the purpose of preventing caries or suppressing hypersensitivity, a tooth surface covering material is applied to a predetermined portion of the tooth surface and cured to form a cured film. That is, since a predetermined portion of the tooth surface is covered with the cured film of the tooth surface covering material, caries can be prevented and hypersensitivity such as tooth squeezing can be suppressed. In addition, a tooth surface covering material is used as an opaquer for shielding discoloration of the tooth surface and a dental manicure for improving the aesthetics of the tooth surface.

  Such tooth surface coating materials are used to bond and fix composite resins, prosthetics, etc. to teeth in that they directly form an outer surface coating whose hardened film is exposed on the surface. It is different from the dental adhesive that is used, but is common with the dental adhesive in that the adhesiveness to the tooth is required. Therefore, there are not many proposals as a tooth surface covering material, but many adhesive materials having good adhesion to the tooth have been proposed, and such an adhesive material can also be applied as a covering material for the tooth surface. (For example, Patent Document 1 and Patent Document 2).

  By the way, many of the dental curable compositions used as adhesives contain (meth) acrylic acid ester monomers as polymerizable monomers and are blended with a photopolymerization initiator. Adhesion to the tooth is not sufficient, and improvement in adhesion to the tooth is required.

An effective means for improving the adhesion of the adhesive to the tooth is to pre-treat the tooth in two steps before applying the adhesive to the tooth:
(1) Applying an aqueous solution (etching agent) of an acid such as phosphoric acid, citric acid, and maleic acid to the surface of the tooth to etch hard tooth (mainly enamel).
(2) After etching treatment, apply a liquid (also called penetration enhancer or primer) mainly composed of an amphiphilic monomer such as hydroxyethyl methacrylate (HEMA) and an organic solvent. Infiltrate the penetration enhancer
It is known to apply.

  However, since these pretreatments are complicated in operation, those in which the adhesive material itself has a function (primer function) equivalent to the pretreatment has been developed. For example, Patent Document 3 includes a polymerizable monomer having an acidic group such as a phosphoric acid group or a carboxylic acid group (an acidic group-containing polymerizable monomer) as a part of the polymerizable monomer, A dental adhesive containing a predetermined amount of water and a photopolymerization initiator has been proposed. In this adhesive, the acidic group-containing polymerizable monomer has tooth decalcification and affinity for dentin, and contains water, so that tooth decalcification is effectively performed. Therefore, it is possible to form a cured product exhibiting high adhesive strength on both enamel and dentin in the initial stage of bonding without performing the above-described pretreatment.

  Moreover, in the said patent document 3, mix | blending a polyvalent metal ion eluting filler (for example, fluoroaluminosilicate glass) is also proposed, and it is disclosed that this can further improve the adhesiveness with respect to a tooth substance. Yes. That is, this dental adhesive has the above-described primer function (decalcification function for dentine and penetration promotion function for dentin) and at the same time, radical polymerization of the polymerizable monomer upon curing. In addition, an acidic group-containing polymerizable monomer, water, and ionic cross-linking due to the interaction of polyvalent metal ions eluted from the filler are also generated. By synergistic action of these radical polymerization and ionic cross-linking, enamel and ivory It is possible to form a cured product having high adhesive strength in both of the qualities.

  However, the tooth surface coating material alone forms a cured film directly on the tooth surface as an outer surface coating, and this cured film realizes prevention of caries and suppression of hypersensitivity. It is required to be able to maintain high adhesion to the tooth (long-term adhesion), to be excellent in wear resistance and to maintain a constant film thickness over a long period (long-term durability). In particular, from the viewpoint of suppression of hypersensitivity, when applied to the exposed dentin surface, it penetrates deep into the dentinal tubules to prevent external stimuli from transmitting to the nerve cells of the pulp through the dentinal tubules. It must be hardened (dentinal tubule sealing). In addition, it is also required that the cured film be uniformly formed (coating uniformity) without being affected by the air blow treatment after application of the tooth surface coating material. This is because, when a non-uniform film is formed by strong air blow, there is a possibility of seeing from a thin place or a place where no film is formed. Furthermore, aesthetics are also required so as not to impair the appearance of the tooth surface. In particular, aesthetics are the most important characteristic when a covering material is used as a dental nail polish. When the above-mentioned dental adhesive is diverted to a tooth surface coating material, the specific properties required for such a tooth surface coating material, that is, long-term adhesiveness, long-term durability, dentinal tubule sealing property, coating uniformity The aesthetics are unsatisfactory.

  For example, in a dental adhesive (photocurable composition) containing an acidic group-containing polymerizable monomer, the acidic group-containing polymerizable monomer is a relatively high hydrophilic monomer, so that the resulting cured product can be obtained. The water resistance of the body is low, and long-term adhesiveness is not sufficient as a tooth surface covering material. In the tooth surface coating material, the cured film exists for a long time in a state exposed directly to a harsh environment containing a lot of moisture in the oral cavity. This is because the adhesive force decreases. In addition, since the acidic group-containing polymerizable monomer is hydrophilic, the cured film easily absorbs moisture, and as a result, the cured film is easily worn by tooth brushing and the long-term durability is unsatisfactory. Alternatively, the surface of the cured film becomes cloudy, the smoothness of the surface of the cured film is easily impaired, and the improvement is also necessary from the viewpoint of maintaining aesthetics for a long period of time.

  Furthermore, when the dental adhesive as described above is applied to the tooth surface covering material, it is also unsatisfactory in terms of dentinal tubule sealing properties. That is, the above-mentioned dental adhesive has excellent primer functions such as dentine demineralization and dentin permeability, so when applied to the exposed dentin surface, it penetrates deep into the dentinal tubule. However, the amount of light irradiated at the time of curing decreases to a deep part of such a dentinal tubule, and there is a tendency that the polymerization and curing in this interior cannot be effectively performed. For this reason, even if a cured film is formed on the dentin surface, not only the adhesive strength is unsatisfactory, but also the sealing performance of the dentinal tubules is unsatisfactory.

  As described above, many of the dental adhesives that are considered to have excellent adhesiveness to the tooth can be used for the tooth surface coating material as they are, and various characteristics that are specifically required for the use other than the adhesiveness to the tooth. It is not satisfactory in terms of properties and is not satisfactory to a high degree. In addition, as another adhesive having further improved adhesion to the tooth, Patent Document 4 discloses A) a polymerizable monomer component containing 5% by mass or more of an acidic group-containing polymerizable monomer, (B) A one-part dental adhesive composition comprising a polyvalent metal ion-eluting filler, (C) a volatile organic solvent, and (D) water is disclosed. A dental composition comprising a polyvalent metal ion, water, and fumed silica for an adhesive composition comprising a polymerizable monomer comprising at least a part of a polymerizable monomer having an acidic group An adhesive composition is disclosed. However, these adhesive compositions are also intended for use in the above-mentioned dental adhesive materials, and none of them describes the application to the tooth surface covering material. As a result, even if the dental adhesive is excellent in adhesion to the tooth, other properties required for the tooth surface covering material (long-term durability, dentinal tubule sealing property, It is unclear how it is applied to coating uniformity, aesthetics, etc., and it is difficult to predict whether it can be a highly superior tooth surface covering material.

  In addition, as in Patent Document 3, in an adhesive composition in which a polyvalent ion-eluting filler is blended in the composition and ion crosslinking is formed by polyvalent metal ions, the adhesiveness is enhanced. There are also difficulties in terms of stability. That is, when the polyvalent ion-eluting filler is mixed with the acidic group-containing polymerizable monomer and other components and stored in a one-package state, gelation tends to occur. For this reason, in the said photocurable composition, it divides | segments into two liquids, the liquid containing an acidic group containing polymeric monomer, and the liquid containing this polyvalent ion elution filler, and preserve | saves in the form of a two package. It is something that must be left. In such a two-package form, the two liquids must be mixed and used on the spot immediately before being used clinically by the dentist, which is an extremely complicated operation for the dentist and the like. Some variation in the mixing conditions, such as the mixing time, is unavoidable depending on the operator, and causes problems such as requiring proficiency. In this regard, the adhesive compositions of Patent Document 4 and Patent Document 5 are used in the same manner in the presence of polyvalent metal ions to form ionic crosslinks, but in combination with a specific amount of volatile organic solvent. Even if diluted and stored in a single package, this problem of gelation is unlikely to occur and it is excellent. However, the amount of polyvalent metal ions is still 1 g of polymerizable monomer component (A). If it is 1.0 meq or more and the storage period is prolonged, there remains a problem that gelation cannot be suppressed.

Japanese Patent Laid-Open No. 10-236912 Japanese Patent Laid-Open No. 10-245525 Japanese Patent Laid-Open No. 10-236912 International Publication No. 2007/139207 Pamphlet JP 2008-201726 A

  Therefore, the object of the present invention is to provide a cured film excellent in properties such as long-term adhesiveness, long-term durability, dentinal tubule sealing property, coating uniformity, aesthetics, etc. Another object of the present invention is to provide a one-pack type tooth surface covering material that can be formed in a single package and has excellent storage stability.

  As a result of intensive studies to overcome the above technical problems, the present inventor has obtained a polymerizable monomer containing an acidic group-containing polymerizable monomer, a polyvalent metal ion, a volatile water-soluble organic solvent, water, A curable composition in which fumed silica and a photopolymerization initiator are blended so as to satisfy specific conditions is excellent in storage stability and has the characteristics described above as a one-pack type tooth surface coating material. The present inventors have found that a cured film can be formed, and have completed the present invention.

According to the present invention, in a one-component type tooth surface covering material that is stored in one package and used to form an outer surface coating directly on the tooth surface,
(A) a polymerizable monomer component containing 5% by mass or more of an acidic group-containing polymerizable monomer;
(B) a polyvalent metal ion;
(C) A volatile water-soluble organic solvent having a boiling point at 760 mmHg of 100 ° C. or lower and a vapor pressure at 20 ° C. of 1.0 KPa or higher and a solubility in water at 20 ° C. of 20 g / 100 ml or higher ;
(D) water;
(E) fumed silica;
(F) an effective amount of a photopolymerization initiator;
Contains
The polyvalent metal ion (B) is present in an amount of 0.2 to 7.0 meq per 1 g of the polymerizable monomer component (A),
The water-soluble organic solvent (C) is in the range of 30 to 150 parts by mass per 100 parts by mass of the polymerizable monomer component (A), and the following formula (1):
α ≧ 20 · X (1)
In the formula, α is a blending amount per 100 parts by mass of the polymerizable monomer component (A) of the water-soluble organic solvent (C),
X is an amount of the polyvalent metal ion and is a number indicating the amount (meq) per 1 g of the polymerizable monomer component (A).
In such an amount that satisfies the conditions represented by
The water (D) is blended in an amount of 3 to 30 parts by mass per 100 parts by mass of the polymerizable monomer component (A),
The one-fluid surface covering material is provided, wherein the fumed silica (E) is blended in an amount of 0.5 to 20 parts by mass per 100 parts by mass of the polymerizable monomer component (A). The

In the one-pack type tooth surface covering material of the present invention,
(1) The amount of the polyvalent metal ion (B) is such an amount that the meq is 0.3 to less than 1.0 meg per 1 g of the polymerizable monomer component (A),
(2) The polyvalent metal ion (B) is present by elution from a polyvalent metal ion elution filler,
(3) It further contains a colorant (G),
(4) The acidic group-containing polymerizable monomer in the polymerizable monomer component (A) is a polymerizable monomer containing a phosphate group,
(5) The polyvalent metal ion-eluting filler has a polyvalent metal ion elution amount of 5.0 to 5.0 when 0.1 g of the filler is added to 10 ml of 10 wt% maleic acid aqueous solution and held at 23 ° C. for 24 hours. 500 meq / g—indicating filler
Is preferred.

  After the tooth surface coating material of the present invention is applied to a predetermined portion of the tooth surface, for example, the volatile water-soluble organic solvent (C) is volatilized by air blowing, and then light irradiation is performed to polymerize and harden the tooth surface. A cured film that directly becomes an outer surface coating is formed.

  Such a tooth surface covering material of the present invention has a primer function (dental decalcification function) of an acidic group-containing polymerizable monomer contained in the polymerizable monomer component (A) when each component is applied to the tooth surface. In addition to the polymerization and hardening of the polymerizable monomer component (A), the acidic group-containing polymerizable monomer (A) and the polyvalent metal ion (B) And (D) polymer chain ionic crosslinks are formed by the interaction of water, and such polymerization curing and ionic crosslinks act synergistically, and further, fumed silica having a good affinity for the ionic crosslinks ( Since E) is blended, the strength of the cured body is improved, so that a cured film firmly bonded to both enamel and dentin can be formed.

  As shown in Examples described later, this cured film has high water resistance, exhibits high adhesion to the tooth surface (enamel and dentin) over a long period of time, and has a smooth surface. Sawabi is also maintained for a long time, and is excellent in terms of aesthetics. Furthermore, it is excellent in abrasion resistance. For example, even when tooth brushing is repeated many times, the abrasion of the cured film is remarkably suppressed, and the durability of the cured film is extremely excellent.

  Furthermore, the tooth surface covering material of the present invention has its composition adjusted to an appropriate concentration range by the water-soluble organic solvent (C) so that the amount of the polyvalent metal ion (B) becomes a predetermined amount. , Has great features. As a result, gelation due to ionic crosslinking during storage is suppressed to a level where there is no problem, and storage in one package (one-pack type) is possible. In particular, the fumed silica (E) component is blended to further increase the strength of the cured product, and in addition to adhesion to enamel and dentin, it is also excellent in dentinal tubule sealing and film uniformity, which will be described later. Even if the blending amount of the polyvalent metal ion (B) is reduced to a range of 0.2 to less than 1.0 meq per 1 g of the polymerizable monomer component (A), it can be used as a tooth surface coating material. It can be made practically satisfactory, and as a result, the above storage stability can be further improved.

  And since the water-soluble organic solvent (C) used for the density | concentration adjustment of a polyvalent metal ion is volatile, this component (C) can be volatilized easily by the air blow after application | coating. That is, it can be concentrated in a short time so that ionic cross-linking with polyvalent metal ions becomes strong. As a result, adhesion by polymerization and curing of monomer components and polymerization of acidic group-containing polymerizable monomers The synergistic effect with the adhesion by ionic cross-linking of the product can be exerted with almost no loss, and it is possible to ensure a remarkably high adhesive strength for both the enamel and the dentin.

  Moreover, as also shown in Examples described later, the cured film formed by the tooth surface covering material of the present invention exhibits extremely excellent dentinal tubule sealing properties.

  For example, FIG. 2 is an SEM photograph showing the surface of the hypersensitivity model used in the dentinal tubule sealing test, but as can be seen from FIG. The end of the dentinal tubule is present in an open state. That is, when the dentin of a tooth is exposed due to caries or the like, external stimuli are transmitted to the nerve cells of the pulp through the dentinal tubules, causing hypersensitivity such as tooth squeezing.

  However, the tooth surface covering material of the present invention penetrates deeply into the dentinal tubule, and even in the deeply penetrated portion, the formation of the ion crosslinks and the compounded hardening of fumed silica (E) act synergistically. Since it cures effectively, it exhibits extremely excellent dentinal tubule sealing properties and can effectively suppress hypersensitivity. For example, FIG. 3 shows a case where the tooth surface coating material of the present invention is applied to the surface of the above-mentioned hypersensitivity model, polymerized and cured by irradiation with light, and then acid-treated to remove the dentin surface portion of the model. The SEM photograph of the cut surface when melt | dissolving and removing and cut | disconnecting this vertically is shown. According to FIG. 3, a large number of tags are observed, but these tags are portions that have penetrated into the dentinal tubule and hardened, and thus have penetrated deeply into the dentinal tubule and are effectively cured. I understand.

  The reason why the tooth surface covering material of the present invention has excellent dentinal tubule sealing properties as described above is not clearly elucidated, but the present inventors presume as follows: Yes.

  That is, the tooth surface covering material of the present invention contains an acidic group-containing polymerizable monomer, exhibits an excellent primer function, has good storage stability, and gelation is effectively suppressed. . In addition, the organic solvent is removed by air blowing, the polyvalent metal ion concentration is increased, ionic cross-linking is sufficiently formed, and light is irradiated in a state where the viscosity is rapidly increased, whereby polymerization and curing are performed. As a result, it is considered that such thickening significantly increases the polymerization efficiency, and a hardened solidified product is formed even in the deep part of the dentinal tubule, and an excellent dentinal tubule sealing property is obtained.

  Furthermore, the tooth surface covering material of the present invention forms a uniform film without being affected by the strength of air blow after application. For example, FIG. 4 shows that the tooth surface coating material of the present invention is applied to a simulated cavity, air blown, light irradiated to polymerize and harden, then filled with a composite resin, light irradiated and polymerized to harden. FIG. The reason why the composite resin is filled is to facilitate observation of the coating of the tooth surface covering material. As shown in the examples, a uniform film having an appropriate thickness is formed in the simulated cavity. The reason why such an effect appears is not clearly elucidated, but the present inventors presume as follows.

  That is, when the tooth surface coating material of the present invention is applied to the tooth surface, in addition to the polymerization curing of the acidic group-containing polymerizable monomer component contained in the polymerizable monomer component, the acidic group-containing polymerizable monomer In addition to the ionic crosslinking caused by the action of the derived acidic groups, water, and polyvalent metal ions, such an ionic crosslinked product has a hydrophilic ionic bond portion and a hydrophobic polymer chain portion, Furthermore, since the ionic cross-linked product and fumed silica are mixed in a complicated manner, the affinity and familiarity with the tooth quality are enhanced. It is believed that a uniform film having an appropriate thickness can be easily formed on the tooth surface by such a synergistic effect of polymerization hardening, ionic crosslinking, affinity, and familiarity.

  The tooth surface covering material of the present invention having the above-described characteristics is applied for the purpose of preventing oral diseases and improving the aesthetics of teeth, for example, an opaquer for preventing discoloration of tooth surfaces, dental nail polish, and caries prevention Alternatively, it is used as a coating material for suppressing hypersensitivity, and depending on the purpose, it may be applied to the entire surface of the tooth to form a hardened film that becomes the outer surface coating, or it may be applied only to a part of the tooth surface to cover the outer surface. Can be formed.

It is the schematic which shows the test piece used for a toothbrush abrasion test. It is a scanning electron microscope (SEM) photograph which shows the surface of the hypersensitivity model used for the test of dentinal tubule sealing property. When the cut surface of the sample piece in which the cured film by the tooth surface covering material (Example 1) of the present invention is formed on the surface of the hypersensitivity model of FIG. 2 is acid-treated to dissolve and remove the dentin surface portion. It is a SEM photograph which shows a cut surface. It is the schematic which shows the test piece used for a film uniformity test.

The one-pack type tooth surface covering material of the present invention comprises, as basic components, (A) a polymerizable monomer component, (B) a polyvalent metal ion, (C) a volatile water-soluble organic solvent, (D) water, It contains (E) fumed silica and (F) a photopolymerization initiator, and further, depending on its use, (G) a colorant is blended as necessary and stored in the form of a single package. . Moreover, various compounding agents known in the dental field can be appropriately blended with this product within a range that does not impair the storage stability and the properties of the cured film.
<Polymerizable monomer component (A)>
In the present invention, the polymerizable monomer component (A) (hereinafter simply referred to as “monomer component”) is a component used for polymerization and curing to impart adhesion to the tooth surface. In order to express etching ability (dental demineralization) and dentin permeability to dentine, at least 5% by mass in the polymerizable monomer component (A) is an acidic group-containing polymer (A1). It is necessary to be. That is, when the amount of the acidic group-containing polymer (A1) is small, this tooth surface covering material does not exhibit a sufficient etching ability for the tooth, and therefore has a sufficient adhesive strength for the tooth. This is because the pretreatment of the tooth quality is necessary to ensure.

  In addition, the monomer component (A) may all be an acidic group-containing polymer (A1), but the strength of the adhesive interface and permeability to the tooth are adjusted, and the monomer component (A) is superior to the tooth. In order to adjust the balance between the adhesive strength and water resistance, and the hydrophilicity and hydrophobicity necessary for the tooth surface coating material, it is preferable to further contain a polymerizable monomer (A2) having no acidic group.

  For example, the content ratio of the acidic group-containing polymer (A1) in the monomer component (A) is in the range of 5 to 50 mass%, particularly 10 to 30 mass%, and the balance does not contain acidic groups. It is preferable that it is a polymerizable monomer (A2). Here, when there are few compounding quantities of an acidic group containing polymeric monomer (A1), there exists a tendency for the adhesive strength with respect to enamel to fall, and conversely when it is large, there exists a tendency for the adhesive strength with respect to dentin to fall.

Acidic group-containing polymerizable monomer (A1):
In the present invention, the acidic group-containing polymerizable monomer (A1) is not particularly limited as long as it is a compound having at least one acidic group and at least one polymerizable unsaturated group in one molecule. Can be used.

  Examples of the acidic group that the monomer (A1) has in the molecule include the following.

  Examples of acidic groups;

  Examples of the polymerizable unsaturated group in the monomer (A1) include acryloyl group, methacryloyl group, acrylamide group, methacrylamide group, vinyl group, allyl group, ethynyl group, and styryl group. Can be mentioned.

  In the present invention, as a specific example of the polymerizable monomer (A1) having an acidic group and a polymerizable unsaturated group as described above in the molecule, a compound represented by the following formula is representative. .

  Representative examples of acidic group-containing polymer (A1);

(In the above compounds, R ¹ represents a hydrogen atom or a methyl group.)
In addition to the above compounds, vinyl phosphonic acids in which a phosphonic acid group is directly bonded to a vinyl group, acrylic acid, methacrylic acid, vinyl sulfonic acid and the like can be used as the acidic group-containing polymer (A1).

  The acidic group-containing polymer (A1) exemplified above can be used alone or in admixture of two or more. Among these, compounds having a valence of two or more acids in the molecule (polybasic) It is preferable to use an acid compound from the viewpoint of enhancing ion binding with a polyvalent metal ion (B) described later and obtaining strong adhesive strength. Such a polybasic acid compound may have two or more monovalent acid groups in the molecule, or may have at least one divalent or more acid group in the molecule. . However, when only such a polybasic acid compound is used as the acidic group-containing polymerizable monomer (A1), it is preferable from the viewpoint of improving the strength, but the storage stability in a one-component state tends to be slightly lowered. is there. Therefore, it is more preferable to use a polybasic acid compound in combination with an acidic compound having a monovalent acid valence in the molecule in order to achieve both adhesive strength and storage stability. The compounding ratio is 1 to 5: 1, more preferably 1 to 3: 1 of polybasic acid compound: acidic compound having a monovalent acid valence in the molecule.

In addition, when the polybasic acid compound and the monovalent acidic compound are used in combination as the acidic group-containing polymerizable monomer (A1) as described above, any compound may be a phosphoric acid group (specifically, an acidic group). It is most preferable that -O—P (═O) (OH) ₂ , (—O—) ₂ P (═O) OH, etc.). In the system in which the acidic group-containing polymerizable monomer (A1) is used in such a combination, the decalcification action on the tooth (mainly due to the acid group of phosphoric acid group having strong acidity). Not only is it high, but it also has a high bond strength to the tooth substance and the like, a particularly high adhesive strength is obtained, and a good storage stability in a one-pack state is also obtained.

  Furthermore, from the viewpoint of curing speed, the acidic group-containing polymerizable monomer (A1) is preferably a compound having an acryloyl group, a methacryloyl group, an acrylamide group, or a methacrylamide group as a polymerizable unsaturated group. .

Polymerizable monomer (A2) not containing an acidic group:
The polymerizable monomer (A2) containing no acidic group that can be used in combination with the monomer (A1) does not contain an acidic group and has at least one polymerizable unsaturated group in the molecule. As long as the condition that it is satisfied, known compounds can be used without any limitation. Examples of the polymerizable unsaturated group possessed by the polymerizable monomer include the same ones as exemplified for the monomer (A1) described above, and in particular, an acryloyl group, a methacryloyl group, an acrylamide. Group, methacrylamide group is preferred.

  Typical examples of such a polymerizable monomer (A2) include the following (meth) acrylate monomers, which may be used alone or in combination of two or more. it can.

1. Mono (meth) acrylate monomers;
Methyl (meth) acrylate,
Ethyl (meth) acrylate,
Glycidyl (meth) acrylate,
2-cyanomethyl (meth) acrylate,
Benzyl (meth) acrylate,
Polyethylene glycol mono (meth) acrylate,
Allyl (meth) acrylate,
2-hydroxyethyl (meth) acrylate,
Glycidyl (meth) acrylate,
3-hydroxypropyl (meth) acrylate,
Glyceryl mono (meth) acrylate,
2- (meth) acryloxyethyl acetyl acetate and the like.

2. Polyfunctional (meth) acrylate monomers;
Ethylene glycol di (meth) acrylate,
Diethylene glycol di (meth) acrylate,
Triethylene glycol di (meth) acrylate,
Nonaethylene glycol di (meth) acrylate,
Propylene glycol di (meth) acrylate,
Dipropylene glycol di (meth) acrylate,
2,2′-bis [4- (meth) acryloyloxyethoxyphenyl] propane,
2,2′-bis [4- (meth) acryloyloxyethoxyethoxyphenyl] propane,
2,2′-bis {4- [3- (meth) acryloyloxy-2-hydroxypropoxy] phenyl} propane,
1,4-butanediol di (meth) acrylate,
1,6-hexanediol di (meth) acrylate,
Trimethylolpropane tri (meth) acrylate,
Urethane (meth) acrylate,
Epoxy (meth) acrylate and the like.

  Moreover, it is also possible to mix and use polymerizable monomers other than the (meth) acrylate monomers. Examples of such other polymerizable monomers include fumaric acid ester compounds such as monomethyl fumarate, diethyl fumarate, and diphenyl fumarate; styrenes such as styrene, divinylbenzene, α-methylstyrene, and α-methylstyrene dimer. Compounds; allyl compounds such as diallyl phthalate, diallyl terephthalate, diallyl carbonate, and allyl diglycol carbonate; These other polymerizable monomers can be used alone or in admixture of two or more.

In the present invention, when a highly hydrophobic polymerizable monomer is used as the polymerizable monomer (A2), 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, etc. It is preferable to use an amphiphilic monomer. By using such an amphiphilic monomer in combination, it is possible to prevent separation of water, which is an essential component of the tooth surface coating material of the present invention, and to ensure the uniformity of the composition, and to stably provide high adhesive strength. This is because the smoothness of the surface of the coating layer can be improved. The compounding amount of the amphiphilic monomer is 10 to 60% by mass, more preferably 30 to 45% by mass in the polymerizable monomer (A2).
<Multivalent metal ion (B)>
It is important that the tooth surface covering material of the present invention contains a polyvalent metal ion as the component (B). That is, the polyvalent metal ion introduces ionic crosslinking into the acidic group-containing polymerizable monomer (A1) (or a polymer thereof), and is cured by the synergistic effect of such ionic crosslinking and polymerization curing. Not only can the film have high adhesion strength to the dentin (enamel and dentin), it also ensures film properties such as water resistance and wear resistance, and high adhesion strength over a long period of time. Durability and surface lubricity (aesthetics) are also maintained for a long period of time, and dentinal tubule sealing and coating uniformity are also improved.

  This polyvalent metal ion is a divalent or higher valent metal ion that can be bonded to the acidic group of the polymerizable monomer (A1), and any ion can be used as long as it can bond to the acidic group. Multivalent ions may be used, but from the viewpoint of being used for dentistry, calcium, strontium, barium, aluminum, scandium, ytterbium, titanium, zinc, magnesium, zirconium, vanadium, chromium, manganese, iron, cobalt, nickel Ions such as copper and lanthanoid are preferred. Among these, trivalent or higher ions are suitable because of their high adhesiveness, and they contain aluminum ions, lanthanum ions, and titanium ions as components. From the viewpoint of the above, it is most preferable.

  The amount of the polyvalent metal ion (B) present in the tooth surface coating material of the present invention is adjusted so as to be an amount of 0.2 to 7.0 meq per 1 g of the monomer component (A) described above. This is very important. That is, by adjusting the amount of polyvalent metal ions per gram of monomer component (A) within the above range, it is possible to form a hardened film layer firmly adhered on the tooth surface by appropriate ion crosslinking. It becomes. When the amount of metal ions is less than the above range, ion crosslinking is insufficient and the adhesive strength to the tooth is lowered. In addition, when the amount is larger than the above range, not only the tooth decalcification power of the acidic group-containing polymer (A1) is reduced, but also volatile water solubility necessary for ensuring storage stability in one package. The amount of the organic solvent (C) becomes large, the tooth surface coating material is applied to the surface of the tooth, and after the air blow treatment, the polymerizable monomer component that forms the cured film tends to be insufficient. In this case, the adhesive strength is reduced. More preferably, it is present in an amount of 0.3 to 3.0 meq per 1 g of the monomer component (A) described above, from the viewpoint of both storage stability in one liquid (one package) and adhesive strength. It is preferable that Furthermore, in the one-pack type tooth surface covering material of the present invention, the improvement of the adhesive strength with the tooth is not limited to the formation of ionic crosslinks by blending the polyvalent metal ions (B), but also fumed silica (E). Therefore, even when the blending amount of the polyvalent metal ion (B) is a small amount of 0.3 to less than 1.0 meq, it is used as a one-pack type tooth surface covering material. In this case, it is possible to exhibit sufficient adhesiveness to the tooth, sealing of dentinal tubules, and the like. In this case, the storage stability in one package can be drastically improved, which is preferable.

  In the present invention, the amount of polyvalent metal ions present in the tooth surface coating material is determined by measuring the concentration of various ions by ICP emission spectroscopic analysis or atomic absorption analysis, etc. The amount of ionic bonds with the monomer component (A) is expressed in terms of milliequivalents per gram of the monomer component (A), and each polyvalent metal ion per gram of the monomer component (A). It can be determined as the sum of values obtained by multiplying the concentration (mmol / g) by the valence of each metal ion.

  In the present invention, as the ion source for allowing the polyvalent metal ion (B) to be present in the amount as described above, the polyvalent metal alkoxide, water-soluble salt, water-soluble hydroxide, water-soluble oxide described above are used. An ionic compound such as a complex salt can be used in an amount corresponding to its solubility or dissociation degree. A specific example of such a polyvalent metal supply source is not limited to this, but is as follows.

Multivalent metal alkoxide:
Aluminum triisopropoxide Magnesium hydroxide Calcium hydroxide Barium hydroxide Lanthanum triisopropoxide Ytterbium triisopropoxide Chromium triisopropoxide Titanium tetraisopropoxide Zirconium tetraisopropoxide Iron (III) ethoxide Copper (II) Ethoxide Zinc bis (2-methoxyethoxide)
Water-soluble salts of polyvalent metals:
Aluminum salicylate Water-soluble hydroxide of aluminum chloride polyvalent metal:
Aluminum hydroxide Calcium hydroxide Lanthanum hydroxide Magnesium hydroxide Barium hydroxide Water-soluble oxide of polyvalent metal:
Complex salts of aluminum oxide polyvalent metals:
Vanadium (III) tetrakisacetylacetonato Manganese (III) tetrakisacetylacetonato Cobalt (III) tetrakisacetylacetonato Nickel (II) tetrakisacetylacetonate In the present invention, the polyvalent metal ion source is as described above. In addition to the polyvalent metal compound, a polyvalent metal ion-eluting filler (hereinafter simply referred to as a polyvalent metal filler) can also be used. That is, since the polyvalent metal filler has a function of improving the mechanical strength of the cured film, it has the advantage of particularly improving the wear resistance and improving the durability of the cured film.

  Further, such a polyvalent metal filler may contain a monovalent metal ion such as sodium as long as the polyvalent metal ion can be eluted within the above-described range, but the monovalent metal ion is not much. Since a large amount also affects the ion cross-linking property of polyvalent metal ions, it is preferable that the monovalent metal ions have as little content as possible. A metal ion content of 10 mol% or less, particularly 5 mol% or less of the content of polyvalent metal ions is preferred.

  The elution of polyvalent metal ions from the polyvalent metal filler is usually completed in about 3 to 12 hours at room temperature (23 ° C.) after preparing the tooth surface coating material. Therefore, the amount of polyvalent metal ions when using a polyvalent metal filler is substantially equal to the amount of polyvalent metal ions after 24 hours of preparation at room temperature (23 ° C.), and the total amount contained in the polyvalent metal filler. It can be calculated from the amount of valent metal ions and the content of the monomer component (A) in the tooth surface covering material.

  The polyvalent metal filler described above is not particularly limited as long as it can elute polyvalent metal ions in the above-mentioned range. However, the polyvalent metal ion is a counter anion that can be eluted simultaneously with the polyvalent metal ions. When it is contained as a salt, the eluted and dissociated counter anion may adversely affect the adhesive strength (this is the same as when a water-soluble salt of a polyvalent metal is used). Therefore, in the present invention, it is preferable to use a polyvalent metal filler that does not elute the counter anion of the polyvalent metal ion at the same time. Examples of the polyvalent metal filler that satisfies such conditions include glass having a chain, layered, or network-like skeleton, and containing a polyvalent metal ion in the gap between the skeletons.

  As the above glasses, those containing oxide glass components such as aluminosilicate glass, borosilicate glass and soda lime glass, and those containing fluoride glass components such as zirconium fluoride glass are suitable. . That is, the polyvalent metal filler made of glass containing these components becomes porous particles having a network-like structure after the polyvalent metal ions are eluted, and the cured film formed by this coating material. Has the effect of improving mechanical strength and adhesive layer strength.

  In the present invention, from the viewpoint of the strength of the cured film and the like, among the polyvalent metal fillers described above, aluminosilicate glass is suitable, and furthermore, it has a fluorine release property, and is a fluoride that strengthens the teeth. Most preferred is fluoroaluminosilicate glass in which fluoride ions are gradually released from the cured film.

  The elution characteristics of polyvalent metal ions in the polyvalent metal filler can be controlled by the mixing ratio of various elements contained in the filler. For example, if the content of polyvalent metal ions such as aluminum and calcium is increased, these elution amounts generally increase, and the elution amount of polyvalent metal ions can be changed by changing the content of sodium and phosphorus. Therefore, the elution characteristics of polyvalent metal ions can be controlled relatively easily.

  The elution characteristics of the polyvalent metal filler can also be controlled by using a generally known method. As a typical method, the polyvalent metal filler is treated with an acid to form a polyvalent metal on the filler surface. A method of previously removing ions and controlling the elution characteristics is known. As the acid used in this method, generally known acids such as inorganic acids such as hydrochloric acid and nitric acid, and organic acids such as maleic acid and citric acid are used. What is necessary is just to determine suitably the density | concentration of an acid, processing time, etc. by the quantity of the ion to remove.

  Moreover, as the fluoroaluminosilicate glass suitable as the polyvalent metal filler, for example, a known glass ionomer cement used for dentistry can be used. Generally known fluoroaluminosilicate glass is expressed in terms of ion mass% and has the following composition.

Silicon; 10 to 33%, especially 15 to 25%
Aluminum; 4-30%, especially 7-20%
Alkaline earth metals; 5-36%, especially 8-28%
Alkali metal; 0-10%, especially 0-10%
Phosphorus; 0.2-16%, especially 0.5-8%
Fluorine; 2-40%, especially 4-40%
Oxygen; remaining amount In addition, it is also preferable to replace part or all of calcium in the alkaline earth metal with magnesium, strontium, or barium. Further, sodium is most commonly used as the alkali metal, but it is also preferable to replace part or all of the alkali metal with lithium, potassium, or the like. Furthermore, if necessary, glass in which a part of the aluminum is replaced with titanium, yttrium, zirconium, hafnium, tantalum, lanthanum, or the like can be used as the polyvalent metal filler.

  The particle shape of the polyvalent metal filler described above is not particularly limited, and may be pulverized particles or spherical particles obtained by normal pulverization, and may be mixed with plate-like, fiber-like particles as necessary. .

Further, from the viewpoint that the polyvalent metal filler can be uniformly dispersed in the tooth surface coating material, for example, an average particle diameter (D ₅₀ ) in terms of volume measured by a laser diffraction scattering method is 0.01 μm to ₅ μm. In particular, it should be in the range of 0.05 μm to 3 μm, most preferably 0.1 μm to 2 μm. Furthermore, from the viewpoint of easily adjusting the elution amount of polyvalent metal ions within the above-mentioned range, 0.1 g of the filler was eluted when held at a temperature of 23 ° C. for 24 hours in 10 ml of a 10 wt% aqueous maleic acid solution. It is preferable that the amount of the valent metal ion is 5.0 to 500 meq / g-filler, particularly 10 to 100 meq / g-filler. The amount of polyvalent metal ions at this time can also be measured by ICP emission spectroscopic analysis or atomic absorption analysis. The amount of polyvalent metal ions eluted after 24 hours under the above conditions is hereinafter also referred to as “24 hours eluted ion amount”.

By the way, when the polyvalent metal filler described above is used as a polyvalent metal ion supply source, as described above, there is an advantage that the wear resistance of the cured film is improved and the durability is further improved. However, on the other hand, the storage stability may be lowered. Therefore, after a predetermined amount of polyvalent metal ions are present in the tooth surface coating material using the polyvalent metal filler, the filler after elution of the polyvalent metal ions can be removed by filtration or the like.
<Volatile water-soluble organic solvent (C)>
In the present invention, a volatile water-soluble organic solvent (C) is used in order to prevent gelation derived from the polyvalent metal ions (B) present in the above-described amounts and to improve storage stability. That is, by diluting the eluted polyvalent metal ions to a specific concentration with this water-soluble organic solvent (C), the tooth surface covering material is in a one-component state in which all the components are blended (that is, in one package). In the form).

Such a water-soluble organic solvent (C) is in the range of 30 to 150 parts by mass per 100 parts by weight of the monomer component (A) described above, and the following formula (I):
α ≧ 20 · X (I)
In the formula, α is a blending amount per 100 parts by mass of the polymerizable monomer component (A) of the water-soluble organic solvent (C),
X is an amount of the polyvalent metal ion and is a number indicating the amount (meq) per 1 g of the polymerizable monomer component (A).
It is necessary to mix | blend in the quantity which satisfies the conditions represented by these. That is, when the blending amount of the water-soluble organic solvent (C) is less than 30 parts by mass, the permeability of the tooth surface covering material to the tooth substance is lowered, and sufficient adhesive force cannot be obtained, and the blending amount is 150 masses. If the air pressure exceeds the area, the organic solvent will remain on the tooth surface unless excessive air blowing is performed, so that sufficient adhesive strength cannot be obtained. The active ingredient (curing ingredient) remaining on the surface of the material tends to be insufficient, and the adhesive strength and water resistance are lowered.

  Further, even when the blending amount of the water-soluble organic solvent (C) is in the range of 30 to 150 parts by mass, when the condition of the formula (1) is not satisfied (that is, α <20 · X In this case, the degree of dilution of the polyvalent metal ions is low, and thus gelation occurs, and as a result, storage in the form of one package in which all components are blended becomes impossible.

In the present invention, particularly from the viewpoint of obtaining high adhesive strength to the tooth, the amount of the water-soluble organic solvent (C) is preferably in the range of 60 to 100 parts by mass, From the viewpoint of enhancing the storage stability, this blending amount is represented by the following formula (II):
α ≧ 25 · X (II)
In the formula, α and X are as shown in the formula (I).
It is good to be satisfied.

  In addition, the tooth surface covering material of the present invention volatilizes the water-soluble organic solvent (C) by air blowing after being applied to the tooth surface and prior to curing by light irradiation. That is, the active ingredient is concentrated on the tooth surface due to volatilization of the water-soluble organic solvent (C), ionic crosslinking between the acidic group-containing polymerizable monomer (A1) and the polyvalent metal ion is promoted, and the tooth surface Excellent adhesion strength can be obtained, water resistance is improved, smoothness of the cured film surface is excellent, and even deep penetration of the dentinal tubule is cured. Is effectively performed. Therefore, the water-soluble organic solvent (C) used in the present invention must be water-soluble and volatile at room temperature.

  In the present specification, “volatile” means that the boiling point at 760 mmHg is 100 ° C. or lower and the vapor pressure at 20 ° C. is 1.0 KPa or higher. “Water-soluble” means that the solubility in water at 20 ° C. is 20 g / 100 ml or more.

Examples of such a volatile water-soluble organic solvent include methanol, ethanol, n-propanol, isopropyl alcohol, acetone, and methyl ethyl ketone. A plurality of these organic solvents can be mixed and used as necessary. In view of toxicity to the living body, ethanol, isopropyl alcohol and acetone are preferable.
<Water (D)>
In the present invention, the water of component (D) has a function as a solvent for uniformly dispersing various components, and at the same time, demineralization of teeth and acidic group-containing polymerizable monomer (A1). Necessary for promoting ionic crosslinking with the valent metal ion (B). As this water, distilled water or deionized water which does not substantially contain impurities harmful to storage stability and medical components is preferably used.

The amount of such component (D) added to water is 3 to 30 parts by mass, particularly 5 to 25 parts by mass, per 100 parts by mass of the monomer component (A). When the amount of water added is less than this range, tooth decalcification and ionic crosslinking become insufficient, and high adhesive strength cannot be obtained. Moreover, if it is used in a larger amount than the above range, the removability by air blow after applying this tooth surface covering material to the tooth surface will be reduced, and a lot of water will remain on the tooth surface, and sufficient adhesive strength will be obtained. Cannot be obtained, and the water resistance is also lowered.
<Fumed silica (E)>
In the present invention, fumed silica is amorphous silica produced by a flame hydrolysis method, and is also referred to as fumed silica. Specifically, silicon tetrachloride can be produced without going through a liquid phase by hydrolyzing silicon tetrachloride in an oxyhydrogen flame. Silica produced by this method has an average primary particle size of about 100 to 100 nm measured with a transmission electron microscope, and has a moderate tertiary aggregate structure. And since this agglomerated structure and the ionic cross-linked product are mixed through water in an intricate manner, the affinity and familiarity with the tooth structure are enhanced. Therefore, the tooth surface coating material composition of the present invention can adhere to the tooth structure. The strength is further improved, and the dentinal tubule sealing property and film uniformity are further improved. On the other hand, not only inorganic fillers other than silica, but also the same silica, those obtained by other production methods such as wet method, sol-gel method, flame melting method, etc. In the adhesive composition, it is difficult to form a gradual tertiary aggregate structure, and when only these are used to form coarse secondary aggregate particles, the present invention using the fumed silica is used. Such excellent adhesive properties as described above and other effects on improving properties cannot be obtained.

Fumed silica that can be utilized in the present invention include, but conventionally known materials can be any available without limitation, a specific surface area of ^{50 m} 2 / g or more, more preferably those of 100 to 300 m ² / g. The specific surface area is referred to as a value measured using the BET method.

On the other hand, as described above, fumed silica is predicted to achieve high adhesive strength because the surface silanol groups and the polyvalent metal ions at the ion cross-linking points are bonded via water. Therefore, the fumed silica preferably has at least 0.1 silanol groups / nm ^{2 on the} surface, more preferably 0.5 to 2 / nm ² . The number of silanol groups on the surface of fumed silica may be measured by Karl Fischer method after the fumed silica is immersed in water once and dried at 150 ° C.

  The fumed silica used in the present invention can be adjusted with a surface treatment agent typified by a silane coupling agent in order to make the number of silanol groups within the above-mentioned preferable range. The coupling treatment may be performed by a known method. Examples of the silane coupling agent include methyltrimethoxysilane, methyltriethoxysilane, methyltrichlorosilane, dimethyldichlorosilane, trimethylchlorosilane, hexamethyldisilazane, and vinyltrimethoxy. Silane, vinyltriethoxysilane, vinyltrichlorosilane, vinyltriacetoxysilane, vinyltris (β-methoxyethoxy) silane, γ-methacryloyloxypropyltrimethoxysilane, γ-methacryloyloxypropyltris (β-methoxyethoxy) silane, γ- Chloropropyltrimethoxysilane, γ-chloropropylmethyldimethoxysilane, γ-glycidoxypropyltrimethoxysilane, γ-glycidoxypropylmethyldiethoxysilane, β- 3,4-epoxycyclohexyl) ethyltrimethoxysilane, N-phenyl-γ-aminopropyltrimethoxysilane, hexamethyldisilazane, etc. are preferably used, and particularly preferably methyltrichlorosilane, dimethyldichlorosilane, hexamethyldi Silazane is used.

The compounding amount of these fumed silicas improves the adhesive strength, suppresses the viscosity of the composition within a certain range, and maintains the penetrability into the tooth substance, so that the polymerizable monomer component (A) It mix | blends in the quantity of 0.5-20 mass parts per 100 mass parts. A more preferable amount of fumed silica is 5 to 15 parts by mass with respect to 100 parts by mass of the polymerizable monomer component.
<Photopolymerization initiator (F)>
As the photopolymerization initiator (F) to be blended in the tooth surface coating material of the present invention, a compound that itself decomposes by light irradiation to generate radical species, or a mixture obtained by adding a polymerization accelerator to such a compound is used. Is done.

  The compound that itself decomposes upon irradiation with light to generate a polymerizable radical species is not limited thereto, but the following can be exemplified.

α-diketones;
Camphorquinone benzyl α-naphthyl acetonaphthene naphthoquinone 1,4-phenanthrenequinone 3,4-phenanthrenequinone 9,10-phenanthrenequinone thioxanthones;
2,4-diethylthioxanthone α-aminoacetophenones;
2-Benzyl-dimethylamino-1- (4-morpholinophenyl) -butanone-1
2-Benzyl-diethylamino-1- (4-morpholinophenyl) -butanone-1
2-Benzyl-dimethylamino-1- (4-morpholinophenyl) -propanone-1
2-Benzyl-diethylamino-1- (4-morpholinophenyl) -propanone-1
2-Benzyl-dimethylamino-1- (4-morpholinophenyl) -pentanone-1
2-Benzyl-diethylamino-1- (4-morpholinophenyl) -pentanone acylphosphine oxide derivative;
2,4,6-trimethylbenzoyldiphenylphosphine oxide bis (2,6-dimethoxybenzoyl) -2,4,4-trimethylpentylphosphine oxide The above-mentioned polymerization accelerators include tertiary amines, barbi Tool acids and mercapto compounds are used. Specific examples thereof are as follows.

Tertiary amines;
N, N-dimethylaniline N, N-diethylaniline N, N-di-n-butylaniline N, N-dibenzylaniline N, N-dimethyl-p-toluidine N, N-diethyl-p-toluidine N, N -Dimethyl-m-toluidine p-bromo-N, N-dimethylaniline m-chloro-N, N-dimethylaniline p-dimethylaminobenzaldehyde p-dimethylaminoacetophenone p-dimethylaminobenzoic acid p-dimethylaminobenzoic acid ethyl ester p-dimethylaminobenzoic acid amyl ester N, N-dimethylanthranic acid methyl ester N, N-dihydroxyethylaniline N, N-dihydroxyethyl-p-toluidine p-dimethylaminophenethyl alcohol p-dimethylaminostilbene N, N- Dimethyl -3,5-Xylidine 4-dimethylaminopyridine N, N-dimethyl-α-naphthylamine N, N-dimethyl-β-naphthylamine tributylamine tripropylamine triethylamine N-methyldiethanolamine N-ethyldiethanolamine N, N-dimethylhexylamine N, N-dimethyldodecylamine N, N-dimethylstearylamine N, N-dimethylaminoethyl acrylate N, N-dimethylaminoethyl methacrylate 2,2 ′-(n-butylimino) diethanol barbituric acids;
5-butyl barbituric acid 1-benzyl-5-phenyl barbituric acid mercapto compound;
Dodecyl mercaptan pentaerythritol tetrakis (thioglycolate)
The blending amount of such a photopolymerization initiator (F) is not particularly limited as long as it is an effective amount capable of curing the tooth surface coating material, and may be set as appropriate. It is good to set it as the range of 0.01-10 mass parts per 100 mass parts of component (A), especially 0.1-5 mass parts. If it is less than 0.01 part by mass, the polymerization tends to be insufficient, and if it exceeds 10 parts by mass, the strength of the produced polymer is undesirably lowered.
<Colorant (G)>
A colorant (G) can be added to the tooth surface coating material of the present invention for the purpose of enhancing the aesthetics of the coating layer after curing. By mix | blending a coloring agent, the color tone of the cured film obtained can be adjusted. As such a colorant, a pigment or dye known per se can be used.

  Suitable examples of dyes (or pigments) include phthalocyanine blue, anthraquinone derivatives, phloxine BK, acid red, fast acid magenta, phloxine B, fast green FCF, rhodamine B, basic fuchsin, acidic fuchsin, eosin, ethysulosin, Examples include safranin, rose bengal, bemel, gentian purple, copper chlorophyll soda, lacqueric acid, sodium fluorescein, cochineal, perilla, talc, and titanium white.

Such colorants can be used alone or in combination of two or more. The blending amount of the colorant is not particularly limited, and may be set to an appropriate amount in consideration of the color tone and aesthetics of the tooth surface coating material. In general, a sufficient color tone is imparted without adversely affecting other characteristics. From the viewpoint of, the range of 0.01 to 1 part by mass, particularly 0.02 to 0.5 part by mass, is preferable per 100 parts by mass of the monomer component (A).
<Other ingredients>
In the tooth surface covering material of the present invention, in addition to the above-mentioned various components, various compounding agents known per se can be blended within a range that does not impair the object of the present invention.

  Examples thereof include organic thickeners such as polyvinyl pyrrolidone, carboxymethyl cellulose, and polyvinyl alcohol. It is also an effective aspect to add other inorganic fillers in addition to fumed silica. Furthermore, various additives such as ultraviolet absorbers, antistatic agents, fluorescent agents, and fragrances can be selected and used as necessary. Needless to say, the addition amount of these compounding agents is also in a range that does not impair the storage stability and the properties of the cured film.

  Each component demonstrated above is mixed in 1 liquid, and is used as a tooth surface coating | covering material of this invention. The mixing method may be in accordance with various methods implemented with known curable compositions. In general, all components to be blended are weighed under an inert light such as red light to obtain a uniform solution. Mix well until it becomes.

Hereinafter, the present invention will be described in detail by way of examples and comparative examples, but the present invention is not limited to these examples. In addition, the kind of each component used in the following examples and the test / evaluation methods of various physical properties are as follows.
<Polymerizable monomer component (A)>
[Acid group-containing polymerizable monomer (A1)]
PM:
Mixture of 2-methacryloyloxyethyl dihydrogen phosphate and bis (2-methacryloyloxyethyl) hydrogen phosphate MDP:
10-methacryloyloxydecyl dihydrogen phosphate [polymerizable monomer containing no acidic group (A2)]
D26E:
2,2-bis (4- (methacryloxyethoxy) phenyl) propane BisGMA:
2,2′-bis [4- (2-hydroxy-3-methacryloxypropoxy) phenyl] propane 3G:
Triethylene glycol dimethacrylate HEMA:
2-hydroxyethyl methacrylate <source of polyvalent metal ion (B)>
Multivalent metal ion-eluting filler F-1: Multivalent metal ion-eluting filler obtained in Production Example 1; average particle size; 0.5 μm,
Elution ion amount for 24 hours; 10 meq / g-filler F-2: Multivalent metal ion elution filler obtained in Production Example 2; Average particle diameter: 0.5 μm
Elution ion amount for 24 hours; 25 meq / g-filler F-3: Multivalent metal ion elution filler obtained in Production Example 3; average particle size: 0.5 μm
Elution amount of ions for 24 hours; 50 meq / g-filler Polyvalent metal compound Al (O-iPr) 3: Aluminum triisopropoxide La (O-iPr) 3: Lanthanum triisopropoxide Ti (O-iPr) 4 : Titanium tetraisopropoxide La (OH) 3: Lanthanum hydroxide <volatile water-soluble organic solvent (C)>
Et-OH: ethyl alcohol IPA: isopropyl alcohol <fumed silica (E) particles>
FS1: Average primary particle size 18 nm, specific surface area 220 m ² / g, number of silanol groups 5 / nm ²
FS2: average primary particle size 18 nm, specific surface area 120 m ² / g, methyltrichlorosilane treatment, number of silanol groups 1.2 / nm ²
FS3: average primary particle size 18 nm, specific surface area 200 m ² / g, dimethylsilane and dichlorohexamethyldisilazane treatment, number of silanol groups 1 / nm ²
FS4: average primary particle size 40 nm, specific surface area 50 m ² / g, methyltrichlorosilane treatment, silanol group number 1.3 / nm ²
[Other silica particles]
MS: fused silica, average primary particle size 0.4 μm, specific surface area 8 m ² / g, 3-methacryloxypropyltrimethoxysilane treatment, number of silanol groups 2 / nm ²
SS: sol-gel silica, average primary particle size 60 nm, specific surface area 70 m ² / g, 3-methacryloxypropyltrimethoxysilane treatment, silanol group number 3 / nm ²
PS: precipitated silica, average primary particle size 30 nm, specific surface area 180 m ² / g, 3-methacryloxypropyltrimethoxysilane treatment, number of silanol groups> 5 / nm ²
<Photopolymerization initiator (F)>
CQ: camphorquinone DMBE: ethyl N, N-dimethyl-p-aminobenzoate TPO: 2,4,6-trimethylbenzoyldiphenylphosphine oxide <colorant (dye, pigment)>
FCB: Phthalocyanine blue TW: Titanium white <Measurement method of adhesive strength>
Preparation of test piece:
Within 24 hours after slaughter, the front teeth of the cow were removed, and the enamel and dentin planes were cut out with water using # 600 emery paper so as to be parallel to the labial surface. Next, compressed air was blown onto the flat surface that had been cut out and exposed for about 10 seconds and dried to prepare a tooth model.

  A double-sided tape with a hole having a diameter of 3 mm is fixed to the plane of the above model, and then a paraffin wax (thickness 0.5 mm) with a hole with a diameter of 8 mm is attached to the hole of the double-sided tape and the hole of the wax. Were fixed so that they were in the same center, and a simulated cavity was formed.

  A sample tooth surface covering material was applied into the simulated cavity and left for 20 seconds, and then dried by blowing compressed air for about 10 seconds.

  Next, light was irradiated for 10 seconds with a visible light irradiator (Power Light, manufactured by Tokuyama Dental Co., Ltd.) to cure the tooth surface coating material.

  Further, a dental composite resin (Palfique Estelite Σ, manufactured by Tokuyama Dental Co., Ltd.) was filled thereon and irradiated with light using the above visible light irradiator for 30 seconds to prepare an adhesion test piece.

Measurement of adhesive strength:
After immersing the above-mentioned adhesion test piece in 37 ° C. water for 24 hours, using a tensile tester (Autograph, manufactured by Shimadzu Corp.), it is pulled at a crosshead speed of 2 mm / min, and the tensile bond strength between the tooth and the composite resin is measured. did. For each test, four tensile bond strengths were measured by the above method, and the average value was taken as the initial bond strength.
<Storage stability evaluation method>
After preparing a tooth surface covering material to be a sample and then storing it in an incubator at 37 ° C. for 3 months, the tooth surface covering material is used to measure the adhesive strength using the same method as the above-described adhesive strength measuring method. Measured and compared with the adhesive strength before storage at 37 ° C. (initial adhesive strength). Moreover, the presence or absence of the deposit of the preserved product and the gelation state were visually observed, and the preservation stability was evaluated according to the following evaluation criteria.
<Evaluation criteria>
1; No precipitate, no gelation 2; Slight precipitate, no gelation 3; Precipitation, no gelation 4; Precipitation, partial gelation 5; Strength and water resistance measurement method>
Production of cured body:
A polytetrafluoroethylene mold is filled with a tooth surface coating material in which compressed air is blown to volatilize a volatile organic solvent, and a polypropylene film is pressed against one surface of the tooth surface coating material to form a tooth surface coating material. While changing the place so that the entire light was exposed to light, the Toxosaw light was brought into close contact with the polypropylene for 30 seconds × 3 times and irradiated with light. Next, polypropylene was pressed against the opposite surface of the tooth surface covering material in the same manner, and similarly irradiated with light for 30 seconds × 3 times to obtain a cured body as a test piece.

Evaluation of bending strength:
After the above cured body was immersed in water at 37 ° C. for 24 hours, the cured body was prepared into a 2 × 2 × 25 mm prismatic shape with a # 800 water-resistant abrasive paper. Graph AG5000D) was mounted, and the three-point bending strength was measured at a fulcrum distance of 20 mm and a crosshead speed of 1 mm / min. For each test, five three-point bending strengths were measured, and the average value was taken as the initial bending strength.

Evaluation of water resistance:
The test piece for measuring the three-point bending strength prepared by the above method was allowed to stand in water at 37 ° C. for one month, and then the three-point bending strength was measured by the same method, and the water resistance was evaluated in comparison with the initial bending strength. .
<Evaluation of smoothness maintenance of cured film surface>
Preparation of test piece:
A tooth model was prepared in the same manner as the measurement of the adhesive strength measurement.

  Next, the tooth surface covering material of the sample was applied to the entire machined plane of the above model, allowed to stand for 20 seconds, and then dried by blowing compressed air for about 10 seconds.

Next, the tooth surface coating material was cured by irradiating with a visible light irradiator (Power Light, manufactured by Tokuyama Dental Co., Ltd.) for 10 seconds. The formed cured film surface was quickly wiped off, the unpolymerized layer formed on the cured film surface was removed, and a test piece was obtained.
Evaluation of smoothness maintenance:
The smoothness of the cured film surface was evaluated according to the following evaluation criteria.

    ○: Gloss can be confirmed on the surface of the cured film.

    X: The cured film surface has no gloss and a cloudy surface can be confirmed. Some terrible things have a tooth surface covering material that is not sufficiently hardened and the surface is crumpled.

In addition, the smoothness of the surface of the cured film was evaluated after leaving each test piece under water at 37 ° C. for 1 month, and compared with the smoothness before leaving in water.
<Measurement method of polymerization rate of cured body surface>
The tooth surface covering material in which the volatile organic solvent is volatilized by blowing compressed air is poured into a polytetrafluoroethylene (thickness 0.5 mm) mold having a cylindrical hole with a diameter of 6 mm, and then the tooth surface The infrared absorption (IR) spectrum of the coating material surface was measured by a single reflection (ATR) method using an infrared spectroscopic analyzer (“Spectrum One” manufactured by Perkin Elmer).

  Next, the surface of the tooth surface covering material was irradiated with a visible light irradiator so that the entire surface was exposed to light for 30 seconds to obtain a cured body.

  The IR spectrum of the cured body surface was measured by the same method as described above, and the polymerization rate of the cured body surface was calculated from the following formula from the IR spectra before and after curing (cured body).

Polymerization rate% = 100− (Pcc · Qco / Pco) · 100
In the formula, Pcc is the C = C peak intensity of the cured product,
Pco is the C = O peak intensity of the cured body,
Qco is the C = O peak intensity of the coating material before curing.
<Method for measuring the amount of polyvalent metal ions>
Each component was mixed to prepare a tooth surface covering material for the sample. After stirring for 24 hours, 0.2 g of the covering material was weighed into a 100 ml sample tube and diluted to 0.1% with isopropanol (IPA). did.

  Using this diluted solution, ICP (inductively coupled plasma) emission spectroscopic analysis was used to measure Al, La, and Ca ion concentrations (mmol / g) contained in 1 g of the polymerizable monomer component (A). Each metal ion concentration was converted using a calibration curve obtained from a standard sample (1 ppm, 2.5 ppm, 6.25 ppm) of each ion. By calculating the sum of the values obtained by multiplying the respective ion concentrations obtained by the respective ion valences, the amount of ion binding to 1 g of component (A), that is, the amount of polyvalent metal ions / meq was determined.

In addition, the polyvalent metal ion eluting from the filler used by the present Example and the comparative example was not detected except the above-mentioned Al, La, and Ca ion.
<Toothbrush wear test>
Preparation of test piece:
A tooth model with dentin exposed on the surface was prepared in the same manner as the measurement of adhesive strength.

  The tooth surface covering material of the sample was applied to the entire surface of the dentin plane of this model, allowed to stand for 20 seconds, and then dried by blowing compressed air for about 10 seconds. Next, light irradiation was performed for 10 seconds using a visible light irradiator to form a cured film of the tooth surface covering material.

  A dental composite resin (Estellite L High Flow, manufactured by Tokuyama Dental Co., Ltd.) is applied to half of the model surface on which the cured film is formed in this way, and irradiated with light for 30 seconds using the above visible light irradiator. A composite resin layer having a thickness of about 100 μm was formed and used as a test piece. A schematic cross section of this test piece is shown in FIG.

Abrasion test:
Next, the test piece was set in a toothbrush tester (manufactured by Tester Sangyo Co., Ltd .: AB-301), a 33% by weight aqueous toothpaste (made by Lion: White & White) solution was added so that the toothbrush was hidden, and a load of 400 gf was applied. A 10,000 toothbrush test was performed.

  A composite resin was built up and cured on the entire treated surface of the test piece after the abrasion treatment.

  Then, using a diamond cutter, the test piece was cut perpendicular to the wear-treated surface, the cut surface was mirror-polished and observed with a laser microscope.

By this microscopic observation, the step from the upper surface of the cured film of the tooth surface covering material covered with the composite resin layer formed on the half of the treated surface to the surface of the cured film of the worn tooth surface covering material is measured, The wear resistance (durability) was evaluated by the size of the step. That is, the smaller this step, the higher the wear resistance of the cured film and the better the durability.
<Evaluation method of ivory tubule sealing properties>
Creating a hypersensitivity model:
Fresh bovine teeth were polished with 600 # water resistant abrasive paper to expose the dentin. The exposed dentin surface was then cleaned and polished for 3 minutes using a Robinson brush and a dentifrice mounted on a dental turbine. The treated bovine teeth were cleaned for 1 hour using an ultrasonic cleaner to produce a hypersensitive model.

  A micrograph of the dentin surface of this hypersensitivity model is shown in FIG.

  As shown in the micrograph of FIG. 2, a large number of dentinal tubules were exposed on the surface of the dentin, and the open rate was about 80%.

Evaluation of sealability:
The tooth surface coating material of the sample was applied to the dentin surface of the hypersensitivity model prepared above, and light irradiation was performed for 10 seconds using a visible light irradiator to form a cured film of the tooth surface coating material.

  After the composite resin is built up and cured on the entire treated surface of the model with the cured film in this way, it is cut perpendicular to the dentin surface using a diamond cutter, and this cut surface is mirror polished. did.

  Next, the above model was immersed in a 6N hydrochloric acid solution for 30 seconds and further immersed in a 1% aqueous sodium hypochlorite solution for 10 minutes to dissolve the surface side of the dentin. After drying, the cut surface was observed with an SEM to evaluate the sealing performance of the dentinal tubules. That is, if the tooth surface coating material penetrates deeply into the dentinal tubule and hardens well even in the deeply penetrated part, a lot of resin tags are formed on the surface where the dentin is dissolved. The sealing ability of dentinal tubules can be evaluated by the presence or absence of.

For Example 1, this SEM photograph is shown in FIG. Moreover, when the tag was formed, the length (length from a dentin plane to the front-end | tip of a tag) of 10 tags selected appropriately was measured, and the average value was compared.
<Method for evaluating film uniformity>
Preparation of test piece:
Using a 4 mm diameter bar attached to the dental turbine, open a first hole 4 mm in diameter and 3 mm in depth from the labial side of fresh bovine teeth. The second hole was overlapped with the first hole by shifting in the radial direction to a depth of 1.5 mm to form a simulated cavity with a staircase structure.

  A sample tooth surface covering material was applied into the simulated cavity and left for 20 seconds, and then dried by blowing compressed air for about 10 seconds.

  Next, light was irradiated for 10 seconds with a visible light irradiator (Power Light, manufactured by Tokuyama Dental Co., Ltd.) to cure the tooth surface coating material. A composite resin was built up and cured over the entire treated surface of the simulated cavity. The reason why the composite resin is filled is to facilitate observation of the coating.

  The bovine tooth in which the simulated cavity was formed was immersed in water at 37 ° C. for 24 hours, and then cut perpendicularly to the simulated cavity using a diamond cutter to obtain a test piece used for coating uniformity. A schematic cross section of this test piece is shown in FIG.

Observation of coating uniformity:
After the cut surface of the test piece used for coating uniformity is mirror-polished, the edges shown in FIG. 4 and the left and right corners of the first hole are observed with a laser microscope and each corner is The thickness of the coating formed by the tooth surface coating material at the apex was measured to evaluate the coating uniformity. In other words, if a film having the same thickness is formed as much as possible at any corner formed in the simulated cavity, it indicates that the film is excellent in film uniformity.
<Manufacture of polyvalent metal filler>
Production Example 1:
Fluoroaluminosilicate glass powder (Tokuso Ionomer, manufactured by Tokuyama Dental Co., Ltd.) is pulverized to a mean particle size of 0.5 μm using a wet continuous ball mill (New My Mill, manufactured by Mitsui Mining Co., Ltd.), and then 1 g of powder The filler surface was treated with 20 g of 5.0N hydrochloric acid for 40 minutes to obtain a polyvalent metal filler (F-1).

  As a result of analyzing the amount of polyvalent metal ions eluted after 24 hours when the obtained filler 0.1 g was immersed in 10 ml of a 10 wt% maleic acid aqueous solution at a temperature of 23 ° C., 10 meq / g filler (24 hours Elution ion amount).

Production Example 2:
Fluoroaluminosilicate glass powder (Tokuso Ionomer, manufactured by Tokuyama Dental Co., Ltd.) is pulverized to a mean particle size of 0.5 μm using a wet continuous ball mill (New My Mill, manufactured by Mitsui Mining Co., Ltd.), and then 1 g of powder The filler surface was treated with 20 g of 5.0N hydrochloric acid for 20 minutes to obtain a polyvalent metal filler (F-2). The amount of ions eluted for 24 hours of this polyvalent metal filler was 25 meq / g-filler.

Production Example 3:
Fluoroaluminosilicate glass powder (Tokuso Ionomer, manufactured by Tokuyama Dental Co., Ltd.) was pulverized to a mean particle size of 0.5 μm using a wet continuous ball mill (New My Mill, manufactured by Mitsui Mining Co., Ltd.), and a polyvalent metal filler (F -3) was obtained. The amount of ions eluted for 24 hours of this polyvalent metal filler was 50 meq / g-filler.
<Example 1>
Each component was mixed according to the following formulation to prepare the tooth surface covering material of the present invention.

(A1) component: PM 2.5g
(A2) component: Bis-GMA 3.0g
3G 2.0g
HEMA 2.5g
(B) component: F-2 0.08g
Component (C): IPA 4.0 g
(D) component: Water 1.5g
(E) component: FS2 1.0g
(F) component: CQ 0.1g
DMBE 0.15g
Using this tooth surface covering material, adhesion strength to enamel and dentin immediately after production, storage stability, bending strength and water resistance of the cured body, smoothness maintenance of the cured film surface, polymerization rate of the cured film surface and The coating uniformity was evaluated. The composition of the tooth surface covering material is shown in Table 1, and the evaluation results are shown in Table 2.
<Examples 2 to 21>
A tooth surface covering material was prepared and evaluated in the same manner as in Example 1 except that the formulation of each component was changed as shown in Table 1. The evaluation results are shown in Table 2.
<Comparative Examples 1-15>
A tooth surface covering material was prepared and evaluated in the same manner as in Example 1 except that the formulation of each component was changed as shown in Table 3. The evaluation results are shown in Table 4.

  Examples 1-21 were formulated so that each component would satisfy the configuration of the tooth surface covering material defined in the present invention, but in any case, against enamel and dentin Good adhesive strength was obtained. Further, even when stored in a 37 ° C. incubator for 3 months, the excellent adhesion performance to the tooth was maintained without gelation, and the storage stability was excellent. Moreover, the initial bending strength of the cured body is also good, and the bending strength value hardly decreases even after standing in water at 37 ° C. for 3 months, and the cured body of the tooth surface coating material of the present invention has excellent water resistance. The polymerization rate on the surface of the cured product was high, and the smoothness maintenance of the cured film surface was excellent. Furthermore, in any case, a uniform film was formed on the simulated cavity, and the film had excellent film uniformity. However, it can be seen that the storage stability by visual evaluation tends to decrease as the amount of ions increases.

  On the other hand, in the tooth surface covering materials of Comparative Examples 1 and 2, whether (A1) the acidic group-containing polymerizable monomer is not blended (Comparative Example 1), or the blending amount is from the specified value of the present invention. Less (Comparative Example 2). In any case, the adhesive strength was low because the decalcification power of the tooth was insufficient. Also, since there is no or little acid component, polyvalent metal ions do not elute from the polyvalent metal ion-eluting filler, the bending strength and water resistance of the cured product, the polymerization rate of the cured product surface, and the cured film surface Lubricity maintenance was also greatly reduced. Moreover, a uniform film was not formed.

  In the tooth surface covering materials of Comparative Examples 3 and 4, the polyvalent metal ions (B) are not present (Comparative Example 3), or the amount of the polyvalent metal ions (B) is less than the specified value of the present invention (Comparison) Example 4). In any case, the formation of ionic crosslinks was insufficient, and the adhesive strength to the tooth, the water resistance of the cured product, the polymerization rate of the cured product surface, and the smoothness maintenance of the cured product surface were greatly reduced. Moreover, a uniform film was not formed.

  Further, the tooth surface covering material of Comparative Example 5 has a larger amount of polyvalent metal ions (B) than the specified value of the present invention. In this case, the tooth decalcification power is reduced and can be stored in one liquid. In order to achieve this, (C) the required amount of volatile water-soluble organic solvent must be increased, and as a result, there are insufficient active ingredients for forming a cured film after air blowing treatment, and adhesion to the tooth The strength, the strength of the cured body, the polymerization rate on the surface of the cured body, and the smoothness maintenance of the surface of the cured body were greatly reduced.

  Since the tooth surface covering material of Comparative Example 6 does not contain (C) a volatile water-soluble organic solvent, the tooth surface covering material has insufficient permeability to the tooth, and the initial adhesive strength decreases. In the storage stability measurement test, the tooth surface covering material gelled after 1 to 5 days had passed after standing at 37 ° C.

  In Comparative Example 7, the amount of (C) the volatile water-soluble organic solvent is larger than the specified value of the present invention, and the active ingredient for forming the cured film after the air blowing treatment tends to be insufficient. The adhesive strength to the tooth, the strength of the cured body, the polymerization rate on the surface of the cured body, and the smoothness maintenance of the surface of the cured body were greatly reduced. Moreover, a uniform film was not formed.

  Since the tooth surface covering material of Comparative Example 8 did not contain (D) water, the adhesive strength was greatly reduced due to the reduction in the demineralization power of the teeth. Further, since the polyvalent metal ions are hardly eluted, the strength of the cured body, the polymerization rate on the surface of the cured body, and the smoothness maintenance of the surface of the cured body are also greatly reduced. Moreover, a uniform film was not formed.

  Further, in the tooth surface covering material of Comparative Example 9, (D) the amount of water is larger than the specified value of the present invention, and even if (C) the volatile water-soluble organic solvent is volatilized by air blowing, a large amount of water is present. The adhesion strength to the tooth, the strength of the cured body, the polymerization rate on the surface of the cured body, and the smoothness maintenance of the surface of the cured body were greatly reduced.

  In the tooth surface covering materials of Comparative Examples 10 and 11, (E) fumed silica was not blended, and the cured body strength of the covering material was low, so the cured body bending strength was greatly reduced. Further, a uniform film was not formed due to low affinity and familiarity with the tooth substance. In particular, in Comparative Example 11 in which the amount of the polyvalent metal ion (B) is large, the deterioration of the coating uniformity was severe.

  In the tooth surface covering materials of Comparative Examples 12 to 14, (E) instead of fumed silica, other silica particles were used, and the adhesive strength to the tooth was reduced. Further, a uniform film was not formed due to low affinity and familiarity with the tooth substance.

The tooth surface covering material of Comparative Example 15 does not contain (F) a photopolymerization initiator. In this case, the tooth surface covering material is not cured and a cured film cannot be formed.
<Examples 22 to 27>
Tooth surface as in Example 1, except that a polyvalent metal ion source other than the polyvalent metal ion-eluting filler was used as the ion source, and the formulation of each component was changed as shown in Table 5. The coating material was adjusted and evaluated. The evaluation results are shown in Table 6.

Examples 22 to 27 are blended so that each component satisfies the constitution of the tooth surface covering material defined in the present invention, and in any case, good adhesion to enamel and dentin Strength was obtained. Further, even when stored in a 37 ° C. incubator for 3 months, the excellent adhesion performance to the tooth was maintained without gelation, and the storage stability was excellent. Moreover, the initial bending strength of the cured body is also good, and the bending strength value hardly decreases even after standing in water at 37 ° C. for 3 months, and the cured body of the tooth surface coating material of the present invention has excellent water resistance. And the polymerization rate on the surface of the cured body was high, and the smoothness maintenance and coating uniformity of the surface of the cured film were excellent. However, it can be seen that the storage stability by visual evaluation tends to decrease as the amount of ions increases.
<Evaluation of abrasion and dentinal tubule sealing properties>
<Examples 28 to 40>
Using the tooth surface covering material of the present invention, the abrasion property and the dentinal tubule sealing property were evaluated. The tooth surface covering materials described in Tables 1 and 5 were used as they were. The evaluation results are shown in Tables 7 and 8.
<Comparative Examples 16-25>
Of the tooth surface covering materials described in Table 3, the wear properties and dentinal tubule sealing properties were evaluated using the materials shown in Table 9 as they were. The evaluation results are shown in Table 9.

  In Examples 28 to 54, each component was blended so as to satisfy the configuration of the tooth surface covering material defined in the present invention. In any case, good wear resistance and dentinal tubule sealing were achieved. You can see that it has sex. Further, even when stored in an incubator at 37 ° C. for 3 months, the above excellent wear resistance and dentinal tubule sealing properties were maintained without gelation, and the storage stability was excellent.

  In the tooth surface covering materials of Comparative Examples 16 and 17, (A1) the acidic group-containing polymerizable monomer is not blended (Comparative Example 16), or the blending amount is less than the specified value of the present invention (Comparative Example 17). ). In the former case, the decalcification power of the tooth was insufficient and the polyvalent metal ions were hardly eluted, so that the effect of improving the strength of the cured film by ionic crosslinking could not be obtained. Further, no tag formation was observed with respect to ivory tubule sealing properties. Even in the latter case, since the demineralization power of the tooth was insufficient, the cured film was peeled off at the interface with the tooth due to wear by the toothbrush. Moreover, the dentinal tubule sealing property is also significantly reduced.

  The tooth surface covering materials of Comparative Examples 18 to 19 are free of polyvalent metal ions (B) (Comparative Example 18), or the amount of polyvalent metal ions (B) is less than the specified value of the present invention (Comparison) Example 19). In either case, the formation of ionic crosslinks is insufficient, and the wear resistance and dentinal tubule sealing properties are significantly reduced.

  Further, the tooth surface covering material of Comparative Example 20 has a larger amount of polyvalent metal ions (B) than the specified value of the present invention. In this case, the tooth decalcification power is reduced and can be stored in one liquid. In order to achieve this, (C) the required amount of volatile water-soluble organic solvent must be increased, resulting in a lack of active ingredients for forming a cured film after the air blowing process, and wear resistance. In addition, the dentinal tubule sealability is significantly reduced.

  Since the tooth surface covering material of Comparative Example 21 does not contain (C) a water-soluble organic solvent, the tooth surface covering material lacks the permeability to the tooth, the dentinal tubule sealing property is significantly reduced, and is preserved. In the stability measurement test, the tooth surface covering material gelled after 1 day to 5 days had passed after standing at 37 ° C.

  In Comparative Example 22, (D) the amount of the volatile water-soluble organic solvent is larger than the specified value of the present invention, and the active ingredient for forming the cured film after the air blowing treatment tends to be insufficient. Abrasion resistance and dentinal tubule sealing properties are significantly reduced.

  Since the tooth surface covering material of Comparative Example 23 was not blended with (D) water, the tooth decalcification power was insufficient, and the cured film was peeled off at the interface with the tooth due to abrasion with a toothbrush. Further, almost no tag formation was observed in the dentinal tubule sealing property.

  In the tooth surface coating material of Comparative Example 24, (D) the amount of water is greater than the specified value of the present invention, and even if (C) the volatile water-soluble organic solvent is volatilized by air blowing, a large amount of water is present. In other words, the abrasion resistance and dentinal tubule sealing property of the cured film were significantly reduced.

  The tooth surface coating material of Comparative Example 25 is not blended with (E) fumed silica, has a reduced cured body strength, and has a low affinity and familiarity with the tooth material. Because of the lack of permeability, wear resistance was reduced. In addition, tag formation was not sufficient in terms of dentinal tubule sealing properties.

Claims (6)

In a one-part tooth surface covering material that is stored in one package and used to form an outer surface coating directly on the tooth surface,
(A) a polymerizable monomer component containing 5% by mass or more of an acidic group-containing polymerizable monomer;
(B) a polyvalent metal ion;
(C) A volatile water-soluble organic solvent having a boiling point at 760 mmHg of 100 ° C. or lower and a vapor pressure at 20 ° C. of 1.0 KPa or higher and a solubility in water at 20 ° C. of 20 g / 100 ml or higher ;
(D) water;
(E) fumed silica;
(F) an effective amount of a photopolymerization initiator;
Contains
The polyvalent metal ion (B) is present in an amount of 0.2 to 7.0 meq per 1 g of the polymerizable monomer component (A),
The water-soluble organic solvent (C) is in the range of 30 to 150 parts by mass per 100 parts by mass of the polymerizable monomer component (A), and the following formula (1):
α ≧ 20 · X (1)
In the formula, α is a blending amount per 100 parts by mass of the polymerizable monomer component (A) of the water-soluble organic solvent (C),
X is an amount of the polyvalent metal ion and is a number indicating the amount (meq) per 1 g of the polymerizable monomer component (A).
In such an amount that satisfies the conditions represented by
The water (D) is blended in an amount of 3 to 30 parts by mass per 100 parts by mass of the polymerizable monomer component (A),
The one-pack type tooth surface covering material, wherein the fumed silica (E) is blended in an amount of 0.5 to 20 parts by mass per 100 parts by mass of the polymerizable monomer component (A).   The one-pack type tooth according to claim 1, wherein the amount of the polyvalent metal ion (B) is such that the amount of the polymerizable monomer component (A) is 0.3 to less than 1.0 meq per 1 g of the polymerizable monomer component (A). Surface covering material.   The one-pack type tooth surface covering material according to claim 1 or 2, wherein the polyvalent metal ion (B) is present by elution from a polyvalent metal ion elution filler.   Furthermore, the 1 liquid type tooth | gear surface covering material as described in any one of Claims 1-3 which contains the coloring agent (G).   The one component according to any one of claims 1 to 4, wherein the acidic group-containing polymerizable monomer in the polymerizable monomer component (A) is a polymerizable monomer containing a phosphate group. Mold tooth surface covering material.   The polyvalent metal ion-eluting filler has a polyvalent metal ion elution amount of 5.0 to 500 meq / g when 0.1 g of the filler is added to 10 ml of 10 wt% maleic acid aqueous solution and kept at 23 ° C. for 24 hours. -The one-component type tooth surface covering material according to any one of claims 3 to 5, which represents a filler.