JP5400908B2 - 流体分析装置用の流体無しインタフェース - Google Patents
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Description
Claims (4)
- 流体分析装置(10)であって、
流路壁によって画定された流路(64,84,92)を有するカートリッジ(14,61)と、
カバー膜(62)を含む1つまたは複数のチャンバ壁によって画定された体積を有し、前記流路(64,84,92)に流体連通する流体が充填されたチャンバ(66)と、
前記カートリッジ(14,61)を受け取る機器(12)とを備え、前記機器(12)は、前記チャンバ壁の少なくとも1つを少なくとも一時的に選択的に変形させて、前記チャンバ(66)の前記体積を変え、それにより、前記チャンバ(66)内の前記流体の少なくとも一部に、前記カートリッジの前記流路(64,84,92)内に流れを誘導するように構成されるプランジャ(70)を含み、
前記プランジャ(70)は、前記機器(12)に取り付けられる第1端部と、前記カバー膜(62)および前記チャンバ(66)に隣接するように位置決めされる第2端部とを備え、
前記プランジャ(70)は、前記プランジャ(70)の前記第1端部から前記プランジャ(70)の第2端部まで延びるプランジャシャフトと、
前記プランジャ(70)の前記第2端部の前記プランジャシャフト上に位置決めされ、且つ、前記カバー膜(62)に当接するように構成されるプランジャ膜(78)と、
前記機器(12)の圧力源から前記プランジャシャフトと前記プランジャ膜(78)との間のキャビティまで延びる1つ以上の流路(79a、79b)と、を有し、
前記プランジャ膜(78)は、前記1つ以上の流路(79a、79b)を通して前記プランジャ膜(78)に付与される流体圧力を介して拡張し、前記カバー膜(62)を変位させて前記カートリッジ(61)の前記流路(64)内に流れを誘導するように構成され、
前記機器(12)は、カバー(18)、ベース(16)、光源(22a、22b)、及び光検出器(24a、24b)を含む、流体分析装置(10)。 - 流体分析装置(10)であって、
流路壁によって画定された流路(64)を有するカートリッジ(14,61)を備え、
開口が、前記カートリッジ(14,61)の外側から前記流路(64)内に延び、
前記分析装置(10)はさらに、
前記開口内にまたは前記開口を覆って配設され、かつ、流体が漏れないシールによって前記カートリッジ(14,61)の少なくとも一部分に固定された、カバー膜(62)と、
前記カートリッジ(14,61)を受け取る機器(12)とを備え、前記機器(12)は、前記カートリッジ(14,61)が前記機器(12)によって受け取られたときに、前記カバー膜(62)と位置合わせ状態になるプランジャ(70)を有し、
前記プランジャ(70)は、前記機器(12)に取り付けられる第1端部と、前記カバー膜(62)および前記開口に隣接して位置決めされるように構成される第2端部とを備え、
前記プランジャ(70)は、前記プランジャ(70)の前記第1端部から前記プランジャ(70)の前記第2端部まで延びるプランジャシャフトと、
前記プランジャ(70)の前記第2端部の前記プランジャシャフト上に位置決めされ、且つ、前記カバー膜(62)に当接するように構成されるプランジャ膜(78)と、
前記機器(12)内の圧力源から前記プランジャシャフトと前記プランジャ膜(78)との間のキャビティまで延びる1つ以上の流路(79a、79b)と、を有し、
前記プランジャ膜(78)は、前記1つ以上の流路(79a、79b)を通って前記プランジャ膜(78)に付与される流体圧力を介して拡張し、前記カバー膜(62)を変位させて前記カートリッジ(61)の前記流路(64)内に流れを誘導するように構成され、
前記機器(12)は、前記カバー膜(62)に係合するように前記プランジャ(70)の少なくとも前記第2端部を移動させ、前記カバー膜(62)の変形を促進し、それにより、前記カートリッジ(14,61)の前記流路(64)内に流れを誘導する移動機構を含み、
前記機器(12)は、カバー(18)、ベース(16)、光源(22a、22b)、及び光検出器(24a、24b)を含む、流体分析装置(10)。 - カートリッジ(14、61)内に流体の流れを提供する方法であって、前記カートリッジ(14、61)は、チャンバ(66)と、前記チャンバ(66)に流体連通する1つまたは複数の流路(64)を有し、前記カートリッジ(14、61)は、機器(12)が受け取るようになっており、前記機器(12)はプランジャ(70)、カバー(18)、ベース(16)、光源(22a、22b)、及び光検出器(24a、24b)を含み、
前記方法は、前記カートリッジ(14,61)を前記機器(12)内に挿入するステップと、
前記機器の前記プランジャ(70)を前記カートリッジ(14,61)の前記チャンバ(66)に隣接して配置するステップと、
前記カートリッジ(14、61)の前記チャンバ(66)に対して、前記機器(12)の前記プランジャ(70)から力を加えて、前記カートリッジ(14、61)の前記チャンバ(66)の少なくとも一部を圧壊させるステップと、を含み、
前記チャンバ(66)に対して前記機器(12)の前記プランジャ(70)から力を加えるステップは、
前記機器(12)内の圧力源から前記プランジャ(70)の前記キャビティまで延びる1つ以上の流路(79a、79b)を通じて流体を流すことで、前記プランジャ(70)のプランジャシャフトとプランジャ膜(78)との間のキャビティを膨張させ、カバー膜(62)に対してプランジャ膜(78)を拡張して前記カバー膜(62)を前記チャンバ(66)内へ変位させるステップを含み、
前記プランジャ(70)の前記キャビティを膨張させるステップは、前記カートリッジ(61)の前記流路(64)内の流体に所望の流速を誘導する速度プロファイルで膨張するように、前記機器(12)により制御される、方法。 - 請求項1に記載の流体分析装置(10)であって、
前記機器(12)は、圧力源を備えるポンプを含み、
前記機器(12)は、前記圧力源に流体連通する圧力源出口(80,90)、および、前記流路(64,84)に流体の所望の流速を提供するように、前記流路(64,84)内に延びる開口を備える、流体分析装置。
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US11/306,401 | 2005-12-27 | ||
US11/306,401 US7485153B2 (en) | 2005-12-27 | 2005-12-27 | Fluid free interface for a fluidic analyzer |
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EP (1) | EP1968747B1 (ja) |
JP (2) | JP2009521699A (ja) |
CN (1) | CN101389406B (ja) |
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CN101389406B (zh) | 2012-08-15 |
JP2012112969A (ja) | 2012-06-14 |
US20070144277A1 (en) | 2007-06-28 |
EP1968747B1 (en) | 2011-09-14 |
JP2009521699A (ja) | 2009-06-04 |
US7485153B2 (en) | 2009-02-03 |
WO2007075289A2 (en) | 2007-07-05 |
WO2007075289A3 (en) | 2008-01-10 |
EP1968747A2 (en) | 2008-09-17 |
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