JP5330122B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer, and in particular, dispenses a reagent or sample in a first container moved to a first position into a second container moved to a second position, and the components of the dispensed sample are dispensed. The present invention relates to an automatic analyzer for analysis.

  For example, an automatic analyzer mixes a sample such as human blood or urine with a reagent, and measures the change in color tone caused by the reaction of the mixed solution to measure the amount of light transmitted. Measure concentration and enzyme activity.

  In this automatic analyzer, measurement is performed on an item selected according to the inspection from among a large number of items that can be measured by setting analysis conditions for each sample. The sample is dispensed from the sample container accommodated in the sampler to the reaction container by the sample dispensing probe, and the reagent is dispensed from the reagent container accommodated in the reagent container to the reaction container by the reagent dispensing probe. The mixed solution of the sample and the reagent dispensed into the reaction container is stirred and then measured by the photometric unit. The sample dispensing probe is washed with washing water every time the sample is dispensed, and the reagent dispensing probe is washed with washing water every time the reagent dispensing is finished (normal washing water washing).

  However, if the previously dispensed sample is carried over to the next sample through the sample dispensing probe only with normal washing water washing, the next sample contains measurement items for trace components such as immunological tests. In this case, there is a problem that the analysis data of the measurement item deteriorates due to carry-over between samples. In addition, if the reagent dispensed previously is carried over to the reagent to be dispensed next through the reagent dispensing probe by washing water washing alone, it reacts with the previous reagent due to carryover between reagents and corresponds to the next reagent. There is a problem of reagent interference that causes the analysis data of the measurement items to deteriorate.

  In order to prevent the occurrence of carry-over, as a conventional technique (for example, Patent Document 1), a special reagent in which the reagent of the measurement item to be affected is discharged into an empty reaction tube as a dummy to familiarize the inner wall of the reagent dispensing probe. There is a special cleaning process in which a detergent is sucked into a reagent dispensing probe and discharged into an empty reaction tube. Furthermore, there is a method of switching the order of measurement items so that the influence of the reagent of the previous measurement item does not occur.

  Further, as a conventional technique (for example, Patent Document 2), there is a special cleaning process in which a high-temperature heating device is provided to clean a sample and a reagent dispensing probe.

JP 2001-305145 A JP 2007-47027 A

  However, the automatic analyzer described in Patent Document 1 requires a special cleaning process and a cleaning device for cleaning the probe separately from normal cleaning water cleaning. In addition, there is a problem that the order of measurement items may not be set freely. The automatic analyzer described in Patent Document 2 also requires a special cleaning process for cleaning the probe separately from the normal cleaning water cleaning.

  An object of the present invention is to solve the above-described problems, and to provide an automatic analyzer capable of improving measurement accuracy.

In order to solve the above problems, the present invention focuses on the fact that a plurality of probes are selectively used when dispensing a reagent or a sample, and the plurality of probes are washed at once in the washing water cleaning.
In the first aspect of the present invention, an automatic analysis is performed in which the reagent or sample in the first container moved to the suction position is dispensed into the second container moved to the discharge position, and the components of the dispensed sample are analyzed. In the apparatus, the cylindrical shaft has a large cylindrical wall portion with a large diameter facing the vertical direction, and a holder member that reciprocates between the suction position and the discharge position, and each is formed in a long shape, A plurality of probes arranged at respective positions spaced apart by a predetermined distance or more in the circumferential direction along the inner wall surface of the large cylindrical wall portion with the longitudinal direction being the vertical direction, and a small diameter cylinder supported by the holder member so as to be movable up and down A small cylindrical wall portion formed in a shape and supported so as to rotate at the upper part of the plurality of probes along the circumference around the cylindrical axis, the small cylindrical wall portion, A first inclined portion inclined downward in the predetermined interval along the circumference, the lowest A flat bottom portion at a position, and a second inclined portion rising upward from the bottom portion, the first inclined portion, the flat portion and the second inclined portion rotating to a selected position of the probe An automatic analyzer comprising: a cam member that applies a downward force to the probe by contacting the probe with the probe.

  According to the present invention, it is possible to improve the measurement accuracy of the automatic analyzer.

  Further, according to the first embodiment of the present invention, for example, when dispensing a reagent or sample that is likely to cause reagent interference, a plurality of probes are selectively used. Regardless of whether the reagent or sample is dispensed or not, each probe is washed repeatedly, so that the probe can be sufficiently washed with ordinary washing water, It is possible to freely set the order of measurement items.

It is a perspective view which shows the principal part of the automatic analyzer which concerns on 1st Embodiment of this invention. It is a functional block diagram of an automatic analyzer. It is a front view of the holder member shown by breaking up and down and the internal mechanism of the holder member. It is a front view of the cam member moved to positions other than the arrangement position of a reagent probe. (A) is a top view which shows the inclination part moved to the arrangement position of a reagent probe with a broken line, (b) is a top view which shows the inclination part moved to a position other than the arrangement position of a reagent probe with a broken line. . (A) The perspective view of the cam member seen from diagonally upward, (b) The perspective view of the cam member seen from diagonally downward. It is a side view of a reagent probe or the like. It is a figure which shows notionally operation | movement of the automatic analyzer which concerns on 2nd Embodiment of this invention. It is a figure which shows notionally operation | movement of the automatic analyzer which concerns on 3rd Embodiment of this invention.

[First Embodiment]
The configuration of the automatic analyzer according to the first embodiment of the present invention will be described with reference to FIGS. FIG. 1 is a perspective view showing a main part of the automatic analyzer, and FIG. 2 is a functional block diagram of the automatic analyzer.

  First, a basic configuration of the automatic analyzer will be described with reference to FIGS. 1 and 2. The automatic analyzer 10 includes a first and second reagent storage 100, a reagent storage case 110, a reagent container 101 for storing a reagent, a reagent arm 102, a reagent probe 103, a sample storage 200, and a sample for storing a sample (biological sample). It has a container 201, a sample arm 202, a sample probe 203, a reaction chamber 300, a reaction container 301, and other components.

  The first and second reagent containers 100 basically have the same configuration. Below, the 1st reagent store 100 is mainly demonstrated and the description which overlaps with the 1st reagent store 100 is abbreviate | omitted about the 2nd reagent store 100. FIG. The reagent storage 100 is provided with a stepping motor that sequentially places a plurality of reagent containers 101 to a suction position by placing the reagent containers 101 in a circumferential direction and rotating the reagent containers 101 in the circumferential direction. A reagent storage drive unit 31 is included. The reagent container 101 contains a reagent that selectively reacts with a specific component contained in the sample.

  The reagent container 101 of the second reagent storage 100 stores a reagent that makes a pair with the reagent stored in the reagent container 101 of the first reagent storage 100.

  The sample store 200 includes a sample rack 230 that is a disk sampler on which a plurality of sample containers 201 are arranged in a circumferential direction, and the sample racks 230 are rotated in the circumferential direction so that the plurality of sample containers 201 are arranged in the circumferential direction. And a sample storage drive unit 32 including a stepping motor that sequentially conveys the sample to the suction position.

  The reaction chamber 300 has a reaction line 330 on which a plurality of reaction vessels 301 are arranged in a circumferential direction, and a rotation position of the reaction line 330 in the circumferential direction, thereby sequentially discharging the plurality of reaction vessels 301 to a discharge position. And a reaction chamber drive unit 33 including a stepping motor for transporting to a discharge position.

  A reagent probe 103 is provided at the tip of the reagent arm 102. A reagent arm drive unit 34 including an electric motor for moving the reagent arm 102 between the suction position and the discharge position is provided.

  A sample probe 203 is provided at the tip of the sample arm 202. A sample arm driving unit 35 including an electric motor for moving the sample arm 202 between the suction position and the discharge position is provided.

Next, the basic operation of the automatic analyzer will be described with reference to FIGS.
A reagent probe driving unit 36 that lowers and raises the reagent probe 103, a pump (not shown) for sucking and discharging the reagent by the reagent probe 103, a solenoid valve (not shown), and an actuator for driving the solenoid valve (not shown) A reagent intake / exhaust section is provided. When the reagent probe 103 moves from the standby position to the suction position, the reagent probe driving unit 36 lowers the reagent probe 103. The electromagnetic valve is activated and the reagent is aspirated from the predetermined reagent container 101 by the reagent probe 103.

  Next, the solenoid valve is operated, and the reagent probe driving unit 36 raises the reagent probe 103. When the reagent probe 103 moves from the suction position to the discharge position, the reagent probe driving unit 36 lowers the reagent probe 103. The electromagnetic valve is activated, and the sample is discharged into the predetermined reaction container 301 by the reagent probe 103. Next, the solenoid valve is activated and closed, and the reagent probe drive unit 36 raises the reagent probe 103. The reagent probe 103 moves from the discharge position to the standby position.

  A sample probe driving unit 37 that lowers and raises the sample probe 203, a pump (not shown) for sucking and discharging the sample by the sample probe 203, an electromagnetic valve (not shown), and an actuator that drives the electromagnetic valve A sample intake / exhaust portion is provided. When the sample probe 203 moves from the standby position to the suction position, the sample probe driving unit 37 lowers the sample probe 203. The electromagnetic valve is activated, and the sample is sucked from the predetermined sample container 201 by the sample probe 203.

  Next, the electromagnetic valve is activated, and the sample probe driving unit 37 raises the sample probe 203. When the sample probe 203 moves from the suction position to the discharge position, the sample probe drive unit 37 lowers the sample probe 203. The electromagnetic valve is activated, and the sample probe 203 discharges the sample to the predetermined reaction container 301. Next, the electromagnetic valve is activated and closed, and the sample probe driving unit 37 raises the sample probe 203. The sample probe 203 moves from the discharge position to the standby position.

  As described above, the reaction container 301 into which the sample and the reagent are dispensed is moved toward the photometric unit 190 by the reaction chamber drive unit 33. Until then, the sample and the reagent in the reaction vessel 301 are stirred by a stirrer (not shown). The photometry unit 190 irradiates the stirred reaction container 301 with light, and measures the absorbance at the set wavelength from the transmitted light.

  The basic configuration and operation of the automatic analyzer according to the first embodiment have been described above. This automatic analyzer further has the following configuration.

  Next, a further configuration of the automatic analyzer will be described with reference to FIGS. 3 is a front view of the holder member shown broken in the vertical direction, and a front view of the internal mechanism of the holder member, FIG. 4 is a front view of the cam member moved to a position other than the arrangement position of the reagent probe, and FIG. Fig. 6A is a plan view showing the inclined portion moved to the arrangement position of the reagent probe by a broken line, Fig. 6B is a plan view showing the inclined portion moved to a position other than the arrangement position of the reagent probe by a broken line, Fig. 6A ) Is a perspective view of the cam member as viewed obliquely from above, (b) is a perspective view of the cam member as viewed from obliquely below, and FIG. 7 is a side view of the reagent probe and the like.

  Hereinafter, the configuration of the reagent store 100 will be described as a representative, and the configuration of the sample store 200 is the same as that of the reagent store 100, and thus the description thereof will be omitted.

  The automatic analyzer has a holder member 120 that reciprocates between a suction position and a discharge position. The holder member 120 is formed in a large-diameter cylindrical shape. A holder member 120 is provided on the lower surface side of the distal end portion of the reagent arm 102 with the center of the cylinder axis in the vertical direction. A cam member drive unit 38 that is an electric motor is provided on the upper surface side of the tip of the reagent arm 102. Both the holder member 120 and the cam member drive unit 38 are provided inside the cover 102 a of the reagent arm 102. The cover 102a is shown by a two-dot chain line in FIGS.

  Two guide holes 122 and 122 are provided in the bottom 121 of the lower end of the holder member 120. The two reagent probes 103 are supported so as to be movable up and down by passing through the two guide holes 122. The two reagent probes 103 are arranged at positions spaced apart by a predetermined distance W1 or more in the circumferential C1 direction on the horizontal plane with the longitudinal direction set as the vertical direction. The circumference C1 is shown by a two-dot chain line in FIGS.

  A cam member 130 formed in a cylindrical shape with a small diameter is fitted into the holder member 120. The cam member 130 is supported by the cylindrical wall portion 123 of the holder member 120 via the bearing member 140 so as to be rotatable about the cylindrical axis. The internal space of the large-diameter holder member 120 can be effectively used as a mounting space for the cam member 130. The cam member 130 is selectively moved on the horizontal plane to the respective arrangement positions of the two reagent probes 103. When the cam member 130 is moved to the selected arrangement position, the cam member 130 comes into contact with the reagent probe 103 at the arrangement position, thereby A downward force is applied to 103.

  The cam member 130 has a cylindrical port 131 that opens downward. The cylindrical wall portion 132 of the cam member 130 is formed so as to correspond to the circumference C1 where the reagent probe 103 is disposed. The cylindrical wall portion 132 has a first inclined portion 133 inclined obliquely downward with respect to the circumferential C1 direction, a flat bottom portion 133a at the lowest position, and a second inclined portion 133 rising obliquely upward. Yes. The first and second inclined parts 133 are formed symmetrically about the bottom part 133a. The bottom portion 133a has a predetermined length along the circumference 1, and holds the reagent probe 103 in the lowered position within the range of the predetermined length. The 1st and 2nd inclination part 133 is provided in the range W2 narrower than the predetermined space | interval W1. By providing the first and second inclined portions 133 within the range W2 narrower than the predetermined interval W1, the two reagent probes 103 separated by the predetermined interval W1 or more can be moved in the descending direction by the first and second inclined portions 133. We do not receive power at the same time. The first and second inclined parts 133 and the bottom part 133a are shown by dotted lines in FIGS. 5 (a) and 5 (b). A range W2 narrower than the predetermined interval W1 is shown in FIG.

  The first and second inclined portions 133 of the cam member 130 have a height corresponding to the amount of raising and lowering of the reagent probe 103. The first and second inclined parts 133 are formed symmetrically about the bottom part 133a. With the first and second inclined portions 133 formed symmetrically, it is possible to apply a downward force to the reagent probe 103 in either the forward or reverse direction of the cam member 130. Become. Further, by rotating the cam member 130 forward or reverse, the two reagent probes 103 can be alternately raised and lowered.

  The first and second inclined portions 133 of the cam member 130 are formed by denting the cylindrical wall portion 132 inward by a predetermined amount. The bottom 133a is formed at a part of the peripheral edge 131a of the tube port 131. The first and second inclined portions 133 may also be formed on a part of the peripheral edge portion 131a of the tube opening 131, but the first and second inclined portions 133 formed by denting the tube wall portion 132 are also provided. In this case, the reagent probe 103 can be moved more stably.

  The cylindrical wall portion 132 of the cam member 130 has a horizontal portion 137 that is formed along the direction of the circumference C1 on the horizontal plane. The horizontal portion 137 has the same height as the highest position 133b of the first and second inclined portions 133. The horizontal portion 137 may also be formed at a part of the peripheral edge portion 131a of the tube opening 131, but the horizontal portion 137 formed by denting the tube wall portion 132 moves the reagent probe 103 more stably. Can be made.

  A rotating shaft 135 centering on the cylinder axis is provided on the ceiling 134 which is the upper end of the cam member 130. The rotation shaft 135 is connected to the output shaft of the cam member drive unit 38. Further, a through hole 136 communicating with the outside of the cam member 130 is provided in the ceiling portion 134 of the cam member 130.

  The reagent probe 103 has an intermediate portion 103a in the longitudinal direction formed in an S shape. FIG. 7 shows a reagent probe 103 which is arranged with the longitudinal direction set in the vertical direction and the middle part 103a in the longitudinal direction is formed in a substantially S shape.

  The upper part 103 b of the reagent probe 103 that is above the intermediate part 103 a is disposed radially inward from the position of the inner wall surface of the cylindrical wall part 132 of the cam member 130. A flexible tube 150 is connected to the upper end of the reagent probe 103. The upper part 103 b of the reagent probe 103 and the tube 150 are formed to extend upward along the inner wall surface of the cam member 130.

  The lower part 103c of the reagent probe 103, which is below the intermediate part 103a, is arranged radially outward from the position of the cylindrical wall part 132 of the cam member 130, and extends downward along the inner wall surface of the holder member 120. Is formed.

  A contact member 160 is provided at the intermediate portion 103 a of the reagent probe 103. The contacted member 160 is formed in an elongated plate shape and is fitted into the intermediate portion 103a from above. Since the intermediate portion 103a is formed in an S shape, it is easy to fit the elongated plate-like contact member 160. The abutted member 160 is disposed at a position along the circumference C1 on the horizontal plane, and can abut on the first and second inclined portions 133, the bottom portion 133a, and the horizontal portion 137. In the present embodiment, a rib-shaped guide groove 124 for guiding the contacted member 160 in the vertical direction is formed along the cylindrical wall portion 123 of the holder member 120. The guide groove 124 guides the contacted member 160 in the vertical direction, thereby supporting the reagent probe 103 more stably via the contacted member 160. Further, the upper end portion of the abutted member 160 is rounded so that it can be easily slid along the first and second inclined portions 133. The abutted member 160 is shown hatched in FIGS. 5 (a) and 5 (b).

  The reagent probe 103 indirectly receives the downward force from the first and second inclined portions 133 via the contacted member 160. Although it may be received directly without the contacted member 160 or the like, the strength of the reagent probe 103 does not need to be increased more than necessary when it is received indirectly.

  The reagent probe 103 receives an upward biasing force by a coiled spring member 170. The spring member 170 is fitted to the lower portion 103 c of the reagent probe 103 in a compressed state between the peripheral portion of the guide hole 122 and the contacted member 160. The spring member 170 fits into the guide groove 124, and the lower portion 103c of the reagent probe 103 fits into the spring member 170, thereby stably supporting the reagent probe 103.

  The tube 150 connected to the upper end of the reagent probe 103 is extended to the outside of the cam member 130 through the through hole 136 of the cam member 130, and further extended to the outside of the holder member 120. The through hole 136 is formed in an arc shape around the rotation shaft 135.

  Next, a series of operations of the automatic analyzer will be described. In the following description, reagent dispensing is described as a representative, and description of sample (sample) dispensing is omitted.

  When dispensing the reagent in the reagent container 101 moved to the suction position to the reaction container 301 moved to the discharge position, the reagent arm 102 is rotated to move the holder member 120 between the suction position and the discharge position. Move. During the movement, the reagent probe 103 is held at the raised position. At this time, the horizontal portion 137 of the cam member 130 is in contact with the contacted member 160.

  When the holder member 120 is moved to the suction position or the discharge position, the cam member 130 is rotated by the cam member drive unit 38. Accordingly, the first inclined portion 133 of the cam member 130 contacts the contacted member 160, and the contacted member 160 extends from the highest position 133b along the first inclined portion 133 obliquely downward. It comes to slide relatively toward the bottom 133a at the lower position. As a result, the reagent probe 103 receives a downward force and descends against the biasing force of the spring member 170. The contacted member 160 brought into contact with the bottom 133a of the cam member 130 is shown in FIGS. At this time, the reagent probe 103 is lowered to the lowest position. With the lowered reagent probe 103, the reagent in the reagent container 101 can be aspirated or the reagent can be discharged into the reaction container 301.

  When the aspiration or protrusion of the reagent by the reagent probe 103 is completed, the cam member 130 is rotated clockwise by the cam member driving portion 38 in FIG. As a result, the abutted member 160 slides relatively along the second inclined portion 133 in the diagonally upward direction from the bottom portion 133a at the lowest position toward the highest position 133b. As a result, the reagent probe 103 is raised by the biasing force of the spring member 170. The reagent probe 103 can be held in the raised position. FIG. 4 and FIG. 5B show the contacted member 160 that is separated from the first and second inclined portions 133 of the cam member 130 and is in contact with the horizontal portion 137. Thereby, the two reagent probes 103 can be held at the raised position. By rotating the reagent arm 102, the holder member 120 can be moved between the suction position and the discharge position. Further, the holder member 120 can be moved to the cleaning position.

  Next, cleaning of the reagent probe 103 will be described. Washing is performed in the state shown in FIG. 4 in which the two reagent probes 103 are both held in the raised position. Regardless of whether or not the reagent probe 103 is used for reagent dispensing, the two reagent probes 103 are washed together. Thereby, the reagent probe 103 can be sufficiently washed by normal washing with water.

  The automatic analyzer performs a series of operations based on a program. The control unit 21 receives the selection of the reagent probe 103 based on the program, reads out the position information corresponding to the reagent probe 103 from the storage unit 23, and controls the control information (cam member driving unit 38 which is a motor) based on the position information. The number of pulses corresponding to the rotation amount) is generated and output to the cam member drive unit 38. The determination unit 22 receives the position information of the cam member 130 from the cam member drive unit 38 and determines whether the position information of the selected reagent probe 103 corresponds to the position information of the cam member 130. In response to the determination from the determination unit 22 that both pieces of position information correspond to each other, the control unit 21 writes the current position information of the cam member 130 in the storage unit 23. On the other hand, the control unit 21 receives a determination from the determination unit 22 that both pieces of position information do not correspond even when a predetermined time has elapsed, and outputs error information to a display control unit (not shown). The display control unit displays error information on a monitor (not shown).

  The control unit 21 receives an operation of the probe selection switch 41 provided on the control panel 40, reads operation information corresponding to the selected reagent probe 103 from the storage unit 23, and outputs it to the cam member drive unit 38. To do. As described above, the reagent probe 103 can be selectively held at the lowered position and used for reagent dispensing. With this configuration, it is necessary to selectively use the reagent probe 103 and change the order of measurement items so that reagent interference does not occur even when a reagent that easily causes reagent interference is dispensed. It is possible to set the order of measurement items freely. Similar to the reagent dispensing, the sample dispensing also includes a plurality of sample probes 203, and the sample probe 203 is configured to be selectively usable, thereby dispensing a sample that is likely to cause sample interference. Even in this case, it is possible to freely set the order of measurement items.

Next, a process of assembling the reagent probe 103, the cam member drive unit 38 that is a motor, the holder member 120, the cam member 130, and the like to the reagent arm 102 will be described.
The spring member 170 is fitted into the guide hole 122 of the holder member 120, and the reagent probe 103 is further fitted. Next, the cam member 130 is fitted into the holder member 120 via the bearing member 140. At this time, for example, the cam member 130 is aligned with the rotational position (initial position) shown in FIG. 4 where the contacted members 160 of the two reagent probes 103 are both in contact with the horizontal portion 137. The positioning of the cam member 130 is not limited to this. After all the assembling is completed, the cam member 130 is rotated to a predetermined position, and an operation of the control panel 40 is performed. You may make it memorize | store in the memory | storage part 23 as a position.

  As described above, the cam member 130 and the like are assembled in the holder member 120 in advance. The holder member 120 is fitted into the mounting hole 102b of the reagent arm 102. Next, the mounting plate 381 is covered, and the output shaft of the cam member drive unit 38 is coupled to the rotating shaft 135 of the cam member 130. Further, the lower hole 382 of the mounting plate 381, the lower hole 125 of the holder member 120, Then, the lower holes 102c of the reagent arm 102 are aligned, and the mounting plate 381, the holder member 120, and the reagent arm 102 are fixed through the mounting bolt 383. A large number of each of the lower holes 382, 125, 102c is provided at predetermined intervals in the circumferential direction of the rotating shaft 135.

  According to the above configuration, by appropriately aligning the pilot holes 382, 125, and 102b, each of the mounting plate 381, the holder member, and the reagent arm 102 can be rotated relative to the other two members. It becomes possible to adjust. For example, the relative position of the reagent probe 103 with respect to the reagent arm 102 can be adjusted.

  In the first embodiment, the holder member 120 including two reagent probes 103 is shown. However, three or more reagent probes 103 may be provided.

  In the first embodiment, the cam member 130 similar to the end face cam is shown, but a positive cam may be used. By using a positive cam, the spring member 170 becomes unnecessary. Further, although the cam member 130 is moved in the circumferential direction, it may be moved in the linear direction.

  Furthermore, although the first and second inclined portions 133 of the cam member 130 are formed symmetrically around the bottom portion 133a, they may be formed asymmetrically. For example, the second inclined portion 133 may be formed so as to rise vertically upward. In this case, the cam member 130 rotates in one direction, relatively moves the contacted member 160 of the reagent probe 103 from the first inclined portion 133 to the bottom portion 133a, and is directly above the second inclined portion 133. It moves to the horizontal part 137.

[Second Embodiment]
Next, an automatic analyzer according to a second embodiment of the present invention will be described with reference to FIG. FIG. 8 is a diagram conceptually showing the operation of the automatic analyzer.

  In the second embodiment, sample dispensing will be described as a representative, and reagent dispensing is the same as sample dispensing, and the description thereof is omitted. The cylindrical wall portion 132 of the cam member 130 has a plurality of types of bottom portions 133a having different height positions. In FIG. 8, the first and second inclined portions 133 formed along the circumference C1 and the sample probe 203 arranged at a position on the circumference C1 are shown in an expanded manner.

  The operation of the automatic analyzer having the above configuration is relatively high in the bottom 133a by moving the cam member 130, for example, when the sample in the sample solution 201 is separated into two layers due to its properties. One side is brought into contact with the contacted member 160, the sample probe 203 is lowered to a predetermined position, and the upper layer sample in the sample solution 201 is sucked. FIG. 8A shows the contacted member 160 with which the higher one is contacted.

  After the upper layer sample is sucked, the cam member 130 is further moved to the right in FIG. 8A and the higher one is separated from the contacted member 160. On the other hand, the lower one of the bottom parts 133a is brought into contact with another contacted member 160, the sample probe 203 is lowered to a predetermined position, and the lower layer sample in the sample solution 201 is sucked. FIG. 8B shows the contacted member 160 with which the lower side is contacted.

  As described above, by lowering the two sample probes 203 to the respective predetermined positions, two layers of samples can be sucked continuously without providing a cleaning step between the suction of the samples obtained for the respective layers. It becomes possible.

  Note that, by providing three or more types of bottom portions 133a having different heights, it is possible to apply to a sample that is separated into three or more layers.

  In the above-described embodiment, each of the plurality of probes is used exclusively for the reagent probe 103 or dedicated for the sample probe 203, but this is not restrictive.

[Third Embodiment]
Next, an automatic analyzer according to a third embodiment of the present invention will be described with reference to FIG. FIG. 9 is a diagram conceptually showing the operation of the automatic analyzer.

  A plurality of probes may be provided in one holder member 120, and one or more of the plurality of probes may be used exclusively for the reagent probe 103 while the other probe may be used exclusively for the sample probe 203.

  FIG. 9 shows a circumferential movement trajectory of one holder member 120, on which a reagent suction position P1, a sample suction position P2, and a reagent or sample discharge position P3 are provided. Shown with a dashed line.

  According to the above configuration, the arm and the holder member 120 can be integrated, whereby the installation space for the dispensing mechanism can be reduced, and the number of parts can be reduced.

DESCRIPTION OF SYMBOLS 10 Automatic analyzer 21 Control part 22 Judgment part 23 Storage part 38 Cam member drive part 381 Mounting plate 382 Pilot hole
383 Mounting bolt 40 Control panel 41 Probe selection switch 100 Reagent storage 101 Reagent container 102 Reagent arm 102a Cover 102b Mounting hole 102c Lower hole 103 Reagent probe 110 Reagent storage case 120 Holder member 121 Tube bottom portion 122 Guide hole 123 Tube wall portion 124 Guide groove 125 pilot hole 130 cam member
131 Cylinder mouth 131a Peripheral part 132 Cylinder wall part 133 Inclined part
133a Bottom 133b Highest position 134 Ceiling
135 Rotating shaft 136 Through-hole 137 Horizontal portion 140 Bearing member 150 Tube
160 Contacted member 170 Spring member 190 Measuring unit
200 Sample Chamber 201 Sample Container 202 Sample Arm 203 Sample Probe 230 Sample Rack 300 Reactor
301 Reaction vessel 330 Reaction line

Claims (5)

In an automatic analyzer that dispenses the reagent or sample in the first container moved to the suction position into the second container moved to the discharge position and analyzes the components of the dispensed sample,
A cylindrical member having a large cylindrical wall portion with a large diameter facing the vertical direction, and a reciprocating holder member between the suction position and the discharge position;
Each is formed in a long shape, and is arranged at each position spaced apart by a predetermined distance or more in the circumferential direction along the inner wall surface of the large cylindrical wall portion with the longitudinal direction being the vertical direction, and is supported by the holder member so as to be movable up and down. A plurality of probes,
A small cylindrical wall portion that is formed in a small-diameter cylindrical shape and is supported so as to rotate at the upper part of the plurality of probes along the circumference around the cylindrical axis; The portion includes a first inclined portion that is inclined downward in the predetermined interval along the circumference, a flat bottom portion that is flat at the lowest position, and a second inclined portion that rises upward from the bottom portion, A cam member that rotates to the selected placement position of the probe and abuts the first inclined portion, the flat portion, and the second inclined portion to the probe, thereby applying a downward force to the probe; The automatic analyzer characterized by having. The small tubular wall section, an automatic analyzer according to claim 1, characterized in that height has different types of the bottom portion to one another. There are members to be abutted to the first inclined portion, the bottom portion, and the second inclined portion, which are arranged at respective positions on the circumference and are provided at the intermediate portion in the longitudinal direction of the probe. automatic analyzer according to claim 1 or claim 2, characterized in that it is. An intermediate portion of the probe is formed in an S shape,
The top of the upper and is the probe from the intermediate portion, the disposed inside in the radial direction than the position of the small cylindrical wall portion of the cam member, so as to extend upward along the inner wall surface of the cylindrical wall portion of said cam member Formed,
A lower portion of the probe is lower than the middle portion, the arranged outward in the radial direction than the position of the small cylindrical wall portion of the cam member, it is formed so as to extend downwardly along the inner wall surface of the holder member , By being passed through a guide hole made in the bottom of the cylinder of the holder member, it is guided so as to be lifted and lowered,
The automatic analyzer according to claim 3 , wherein the contacted member is fitted into an intermediate portion of the probe from above. Wherein the peripheral portion of the guide hole in a compressed state between the contacted member, according to claim 4, characterized in that it has a fitted coiled spring member on the bottom of the probe Automatic analyzer.

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