JP5326246B2 - Muscle building agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a muscle-building agent which increases the weight of muscle while suppressing the increase of visceral fat caused by fat component ingestion. <P>SOLUTION: The agent contains mushrooms belonging to the Sparassis crispa family or their extracts as active components, wherein the mushrooms are preferably thermally treated. <P>COPYRIGHT: (C)2009,JPO&amp;INPIT

Description

  The present invention relates to a muscle-increasing agent containing moss of the genus Agaricaceae or an extract thereof as an active ingredient.

Conventionally, various muscle increasing agents are known (see Patent Document 1 and Patent Document 2).
And when using a muscle increasing agent, in order to increase muscle weight efficiently, it is said that it is preferable to take an energy-efficient fat component as a meal in addition to the active component of the muscle increasing agent (patent) (See paragraph [0029] and the like in the specification of Document 1).
JP 2004-168704 A JP 2004-075637 A

However, although most of the fat components contained in meals are used as energy for basal metabolism and muscle weight increase, some of them are inevitably accumulated as visceral fat, and between muscle muscle tissues. It causes various problems by accumulating. For example, excessive intake of fat increases the production of energy by fat even in muscle tissue, but fat components that exceed use accumulate between muscle fibers of the muscle, and at the same time as bioenergy of amino acids due to decomposition of muscle protein Increased use of lowers muscle weight. And in muscle tissue where fat accumulates, the use of sugar is reduced, but the fat component is decomposed to obtain energy, the use of sugar in the living body is reduced, the blood sugar level is increased, and the lipid is increased. Increased parameters and accumulation of visceral fat can be seen. If this situation progresses, so-called metabolic syndrome will result. Such a problem becomes particularly noticeable when eating a high fat diet containing a large amount of fat components (for example, a fat component of more than 5% by weight based on the total weight of the meal).
From this point of view, the muscle increasing agent is preferably one that increases the muscle weight while suppressing the increase in visceral fat accompanying the intake of fat components (especially high fat diet), but conventionally has such an effect. Little practical muscle growth agents were known.

Therefore, as a result of intensive studies to solve the above-mentioned problems, the present inventors have ingested the fat component by ingesting the moss of the family Amanita mushroom or the extract (active ingredient) of the moss together with the fat component. It has been found that muscle weight can be increased while suppressing increase in visceral fat. Furthermore, it has been found that a muscle increasing agent containing moss subjected to a healing treatment has more practical visceral fat increase suppressing action and muscle weight increasing action.
That is, as a means for solving the above-mentioned problems, the muscle-increasing agent of the first invention of the present invention contains “a moss belonging to the genus Oryzae or an extract of the moss” as an active ingredient. This makes it possible to effectively increase muscle weight while suppressing the accumulation of visceral fat at the time of fat consumption (especially at the time of eating fat containing more than 5% by weight of fat components relative to the total weight of the meal). it can.

The muscle enhancer of the first aspect of the present invention, mushrooms Ha Nabiratake family is formed by Shuji process (a type of heat treatment to be described later).
Also, in the high-fat diet Totoki (35% of the fat-containing component with respect to diet weight the total amount For example), while suppressing the more reliably accumulation of visceral fat, it is possible to increase muscle weight.

Further, the first invention is a mosquito of the genus Amanita mushroom that is treated in a temperature range of 130 ° C. or higher and lower than 200 ° C.
The muscle-increasing agent of the present invention can stably increase the muscle weight while suppressing the accumulation of visceral fat during a wide range of fat consumption (for example, containing 5% to 35% fat component relative to the total weight of the meal). Can be increased.

The second aspect of the present invention is a method for producing muscle enhancer according to the first invention, a drying step of heat-treating the mushrooms at a temperature range of less than 40 ° C. or higher 100 ° C., 130 ° C. ~ And a repairing process for repairing dried moss in a temperature range of 300 ° C. In the repair process, the dried moss is heat-treated with the heated gas.
In the second invention, by performing the drying treatment, it is possible to reduce the excess water content contained in the moss of the family Agaricaceae. And by heat-treating the moss with a gas heated in the repairing process performed after the drying process, only the moisture from the moss is lost without losing the muscle increasing action inherently in the moss of the family Amanita mushroom. Further, it can be removed.

Muscle increasing agent obtained as this becomes possible to obtain a more practical visceral fat increase suppressing action and muscle weight increasing effect.

According to the first invention, the muscle weight can be increased while suppressing the increase in visceral fat accompanying the intake of fat components. In addition , when eating a meal containing a wide range of fat components, muscle weight can be stably increased while suppressing the accumulation of visceral fat.
According to the second invention, Ru can be produced muscle enhancer containing a mushroom of inclusive Sparassis crispa family effective ingredient the muscle increases in a suitable state.

The best mode for carrying out the present invention will be described below.
The muscle-increasing agent of this embodiment contains, as an active ingredient, a “moss belonging to the genus Amanita mushroom or an extract of the moss” described later. And the muscle weight can be increased, suppressing the increase in visceral fat accompanying fat component intake by ingesting the muscle increasing agent of this embodiment with the meal containing the "fat component" mentioned later.
At this time, it is preferable that the mosquitoes of the genus Hyraenaceae are subjected to “repair treatment (one form of heat treatment)” described later. The two effects of increasing muscle weight and suppressing visceral fat increase are achieved.

Furthermore, by taking the muscle increasing agent of the present embodiment, the blood environment of the subject can be kept good. Here, maintaining a good blood environment means that the total amount of “total cholesterol”, “LDL cholesterol”, “HDL cholesterol”, “triglyceride”, “free fatty acid” and “blood glucose” in the blood are appropriate. Means to keep the value.
By the way, there are steroid agents, myostatin inhibitors, IGF-I inducers, and the like as conventional muscle increasing agents (agents that increase myosin or actin protein). In addition, side effects such as hypercholesterolemia (a symptom in which the amount of cholesterol in the blood increases beyond the appropriate value) are known in the hormone-based muscle increasing agents such as the above-mentioned steroids, for example, by inhibiting the function of the kidney. ing.
On the other hand, the muscle increasing agent of this embodiment can maintain a favorable blood environment as described above (specifically, see Test Examples 2 and 4 described later). That is, according to the muscle increasing agent of the present embodiment, it is possible to increase the utilization of sugar and lipid components throughout the body of the ingested subject, and therefore, it is possible to suppress the decomposition and utilization as a glucogenic amino acid from the muscle. By increasing the use of fat components in the body, the muscle weight per body weight shows an increased value. In other words, it can be said that the muscle increasing agent of this embodiment can be used to maintain a healthy and healthy muscle state. As a result, since the blood environment is maintained better than usual, it is expected that there are few or very few side effects.

Hereinafter, each component of a muscle increasing agent and its manufacturing method are demonstrated in detail.
[Salmonidae]
The “Amanita mushrooms” is a fungus belonging to the genus Spanassis typified by Sparassis crispa.
And, "Agaricaceae moss" may be used by adding a muscle-increasing agent that maintains the natural state without applying heat, but in order to further improve the muscle weight increasing action, It is preferable to use one that has been subjected to any one of “drying treatment” and “repair treatment” described in the above.

[Drying process]
“Drying treatment” generally means heat treatment in a temperature range of 40 ° C. or more and less than 100 ° C., and typically heat treatment is carried out in the same form (without crushing) of “Agaricidae moss”. It is something to add. And although a drying process is not an essential process of this embodiment, it is preferable to perform as a pre-process of the below-mentioned repair process. That is, by performing the drying process, it is possible to remove excess water contained in the moss of the family Agaricaceae.
The drying temperature may always be set to a constant temperature. For example, the temperature is raised stepwise or continuously in a temperature range of 40 ° C. or more and less than 100 ° C., or the temperature is raised and lowered repeatedly in the same temperature range. It may be.
Note that the lower limit of the drying treatment temperature may be any temperature that is higher than room temperature or the outside air temperature. For example, the drying treatment may be suitably performed in a temperature range of 10 ° C. or more and less than 40 ° C.

[Repair processing]
The “repair treatment” is generally a technique for heat-treating moss, but in the present embodiment, it particularly means heat-treating the moss of the moss family in a temperature range of 100 ° C. to 300 ° C. It is distinguished from the above-mentioned “drying treatment” in which heat treatment is performed in a temperature range of less than 100 ° C. In addition, in the “Suji treatment”, heat treatment may be applied as it is in the form of “Hanabambouraceae moss” after drying, and the “Hanabiratakei moss” after drying is crushed into a crushed or powdered form A heat treatment may be added later. In other words, the “repair treatment” is a heat treatment to such an extent that the “mosquitoes of the moss” are not carbonized (to the extent that they do not become black when visually expressed).

  If the “temperature of the healing treatment” is in the range of 100 ° C. to 300 ° C. (any of constant temperature, temperature rise or temperature fall is possible), “Hanabiratake moss” can be well cured. And, since the muscle increasing agent obtained by repairing the moss has removed excessive water well without losing the muscular increase action inherently in the moss of the moss, (for example, the total amount of meal weight) The desired muscle weight-increasing action can be exerted when eating a high fat (containing 35% fat component) (see FIGS. 5 to 7). When the “temperature of the healing treatment” is in the range of 130 ° C. or more and less than 200 ° C., the internal organs can be consumed in a wide range of fat consumption (for example, containing 5% to 35% fat components with respect to the total weight of the meal). It is preferable because muscle weight can be stably increased while suppressing fat accumulation. On the other hand, when the “temperature of the healing treatment” is in the range of 200 ° C. to 300 ° C., the healing treatment of the moss of the genus Hydrangea can be reliably performed in a shorter time.

In the drying process and the repair process described above, the heating medium for transferring heat to the moss of the family Agaricaceae may be in a liquid, gas, or solid state. In other words, various heating methods such as boiling of moss, steaming of moss, hot air treatment of moss, baking of moss, heating by bringing a solid heat medium into direct contact with moss, drying treatment and repair treatment include.
Preferably, the moss is treated with a heated gas in at least one of the drying process and the repair process. By treating with heated gas (hot air treatment), excess water can be removed from the moss of the family Agaricaceae.
And, in the “repair process”, the “mosquitoes of the moss family” are treated with a heated gas (for example, hot air treatment), so that the moss is not carbonized as much as possible even in a temperature range of 100 ° C. to 300 ° C., for example. Can be heat-treated. For this reason, according to the healing treatment with the heated gas, it is possible to further remove only water from the moss of the moss, without detracting as much as possible from the muscular increase action inherently of the moss of the moss.

[Extract of mosquitoes from the genus Agaricaceae]
Uncured or repaired mosquitoes can be used in the form after repair treatment (typically in the form of crushed or powdered form), but because they have a more effective muscle weight increasing action, they increase muscle mass. It is preferable to use it as an “extract” obtained by extracting an active ingredient having an action. As used herein, “an extract of moss of the genus Pleurotus” refers to, for example, a pulverized product or powder obtained by finely dividing the moss, mixed with an aqueous or organic solvent, The active ingredient is eluted in a solvent.

Exemplifying the “production method of the extract”, first, “Agaricaceae moss” is powdered by a hammer crusher type powder processing apparatus, and then φ0.1 to φ1.5 mm (typically φ0.3 mm) A crushed material or powder is obtained by sieving with a mesh screen. Then, this crushed material or powder is dissolved or dispersed in an aqueous solvent such as hot water or an organic solvent such as acetone or ethanol, and an active ingredient is extracted, thereby “an extract of the moss of the moss family” Get. And preferably, after the obtained extract is concentrated under reduced pressure, it is further dried in a vacuum desiccator, and this dried concentrate is referred to as an extract of the moss of the family Agaricaceae. As an extraction method, for example, a method of refluxing crushed material or powder with a solvent can be taken.
In addition, from the "Agaricidae moss", the "crude extract of Amanitacidae moss" obtained by extraction (concentration) with hot water, concentration, and drying treatment is further subjected to ammonium sulfate salting out to obtain a supernatant. A solution obtained by concentrating the supernatant by a method such as dialysis can also be used as a “purified extract of the moss of the family Amanita mushrooms”.

And the muscle increasing agent which uses the above-mentioned "mosa belonging to the genus Oryzae or its extract" as an active ingredient will be ingested with a "fat ingredient". The “fat component” may be included in the muscle increasing agent in advance, or may be included in the meal separately from the muscle increasing agent.
Here, the “muscle increasing agent” may be contained in the range of 0.1% to 10% by weight based on the total amount of meal, and 0.5% to 5.0% based on the total amount of meal. It is preferable because the desired muscle weight action is achieved.

[Fat ingredients]
On the other hand, “fat ingredients” generally include animal fats (lipids) such as lard, beef tallow, fish oil, milk fat, butter, cheese, shortening, margarine, bacterial oil, fungal oil, vegetable oil, microalgal oil, etc. These are selected from the group consisting of vegetable fats (lipids).
The “fat component” should be contained in the range of 3% to 50% by weight based on the total amount of meal, and if it is 5% to 40% of the total amount of meal, the muscle weight can be efficiently increased. It is preferable because it is increased. And it is preferable for the “fatty component” to be more than 5% and not more than 35% with respect to the total amount of meal because the muscle increasing agent of this embodiment acts more reliably.

[Test example]
Hereinafter, although this Embodiment is demonstrated based on a test example, this invention is not limited to a test example. In each test, the following muscle increasing agents of Examples 1 to 3 were used.
[Example 1]
The moss of the genus Agaricaceae {specifically, Parassis crispa} was dried in the temperature range of 40 ° C. to 60 ° C. and then used as a muscle increasing agent in “Example 1”. . Then, the muscle increasing agent of Example 1 was added at a ratio of 0.2%, 1.0%, and 5.0% with respect to the total amount of meal weight described later ([FIG. 1] to [FIG. 4]). In each of the tables, a column of “mixed food concentration (%)” is provided to indicate the ratio). In this test, the drying treatment was performed while increasing the temperature sequentially at 40 ° C. (15 hours), 45 ° C. (5 hours), 50 ° C. (5 hours) and 60 ° C. (5 hours).

[Example 2]
The dried powder was subjected to a healing treatment at 150 ° C. (0.5 hours) (the degree that the red-branched bamboo became brown) and used as a muscle increasing agent in “Example 2”. . The muscle increasing agent of Example 2 was added at a ratio of 0.2%, 1.0%, and 5.0% with respect to the total meal weight.

[Example 3]
After applying dry treatment to Hanabira bamboo, it was used as a muscle increasing agent in “Example 3” after being treated at 170 ° C. (0.5 hours) and then powdered. did. The muscle increasing agent of Example 3 was added at a ratio of 0.2%, 1.0%, and 5.0% with respect to the total meal weight.

[Test Example 1: Changes in muscle weight and visceral fat during high-fat diet]
In Test Example 1, male SD rats (sales company: Japan SLC Co., Ltd.) were used as ingestion subjects. And "high fat diet {meal in which beef tallow (Lard) is added to MF powder (made by Oriental Yeast) and the total fat content is 35%}" relative to the total amount of the muscle increasing agent of Example 1 at the above ratio Each “mixed sample of Example 1” was prepared.
Similarly, “mixed samples of Example 2” in which the muscle increasing agent of Example 2 was mixed in the above ratio with respect to the total amount of the high fat diet were prepared. And "the mixed sample of Example 3" which mixed the muscle increasing agent of Example 3 in the said ratio with respect to high fat diet whole quantity was prepared, respectively.
The “mixed sample” of each example was given to another rat and bred for 4 months. The rearing environment of the rats was set to a temperature of 23 ± 2 ° C., a humidity of 50 ± 5%, and 12 hours (light / dark). Then, the “rat body weight”, “muscle weight”, “white adipose tissue around the kidney” and “white adipose tissue around the testis” after breeding are determined according to the procedures 1) to 3) below for each example and each ratio. It was measured.
On the other hand, in Comparative Example 1 (control), a high fat diet (containing no muscle-increasing agent) was given to the rats and reared for 4 months. In the same manner as in the Examples, the “rat body weight”, “muscle weight”, “white adipose tissue around the kidney” and “white adipose tissue around the testis” after the breeding were measured.

1) “Muscle weight value” is calculated by dividing the weight of “soleus muscle” exfoliated from both lower limbs of each rat by each “rat body weight”.
2) The “white adipose tissue value around the kidney” is calculated by exfoliating the adipose tissue around the adrenal glands on both sides, measuring the adipose tissue weight, and dividing by the individual “rat body weight”.
3) The “white adipose tissue value around the testis” was calculated by exfoliating the adipose tissue around the testes on both sides, measuring the adipose tissue weight, and dividing by the individual “rat body weight”.

[Test Example 2: Blood environment when eating a high fat diet]
Rat blood after the implementation of [Test Example 1] for each example and each ratio was collected. And “total cholesterol level (T-Cho)”, “LDL cholesterol level (LDL-C)”, “HDL cholesterol level (HDL-C)”, “triglyceride level” (Triglyceride), “free fatty acid level” in rat blood (NEFA) "and" blood glucose level (Glucose) "were measured by entrusting to Nagahama Life Science Laboratory (Oriental Yeast Co., Ltd.).
And [Test Example 1] Blood was collected from the rat of Comparative Example 1 after the implementation, and in the same manner as in the above Example, “total cholesterol level”, “LDL cholesterol level”, “HDL cholesterol level”, “ The “triglyceride level”, “free fatty acid level” and “blood glucose level” were measured.

[Test Example 3: Changes in muscle weight and visceral fat during normal fat consumption]
In Test Example 3, instead of the above “high fat diet”, “ordinary fat diet {meal in which beef fat (lard) is added to MF powder (made by Oriental Yeast Co., Ltd.) and the total fat content is 5%}” is used. It was. In the same manner as in Test Example 1, a “mixed sample” was prepared by mixing any of the muscle increasing agents of Examples 1 to 3 in the above ratio with respect to the total amount of the normal fat diet. Each of the mixed samples was given to rats and reared for 4 months. The rearing environment of the rats was the same as the rearing environment of Test Example 1. Then, for each example and each ratio, the “rat body weight”, “muscle weight”, “white adipose tissue around the kidney” and “white adipose tissue around the testis” after breeding are subjected to the above procedures 1) to 3). Measured.
On the other hand, as Comparative Example 2 (control), rats were fed with a normal fat diet (containing no muscle-increasing agent) and bred for 4 months. In the same manner as in the Examples, the “rat body weight”, “muscle weight”, “white adipose tissue around the kidney” and “white adipose tissue around the testis” after the breeding were measured.

[Test Example 4: Blood environment during normal fat consumption]
Rat blood after the implementation of [Test Example 3] for each example and each ratio was collected. Then, the “total cholesterol level”, “LDL cholesterol level”, “HDL cholesterol level”, “triglyceride level”, “free fatty acid level”, and “blood glucose level” in the blood of the rat were calculated using the Nagahama Life Science Laboratory (Oriental Yeast Co., Ltd.). ) And measured.
And [Test Example 3] Blood was collected from the rat of Comparative Example 2 after the implementation, and in the same manner as in the above Example, “total cholesterol level”, “LDL cholesterol level”, “HDL cholesterol level”, “ The “triglyceride level”, “free fatty acid level” and “blood glucose level” were measured.

[Results of Test Example 1]
The table of FIG. 1 is a table showing the results of Test Example 1 (“Rat body weight”, “Muscle weight”, “White adipose tissue around the kidney”, and “White adipose tissue around the testis” when eating a high fat diet). is there.
With reference to the table of FIG. 1, in the rats of Examples 1 to 3, an increase in “muscle weight” was confirmed as compared with the rat of Comparative Example 1. In addition, in the rats of Examples 1 to 3, a decrease in “white adipose tissue around the kidney” and “white adipose tissue around the testis” was confirmed as compared with the rat of Comparative Example 1. Further, in the rats of Examples 1 to 3, a decrease in “body weight” was confirmed as compared with the rat of Comparative Example 1.
In particular, the accumulation of visceral fat was more reliably suppressed in the rats of Examples 2 and 3 (rats to which a muscle-increasing agent containing “Hanabiratake treated” was given) compared to the rats of Comparative Example 1. As a result, it was found that the muscle weight further increased.

[Results of Test Example 2]
The table of FIG. 2 is a table showing the results of Test Example 2 (changes in blood environment when eating high fat). The unit “mg / dL” represents the component content (mg) contained in 1 dL of blood, and the unit “μEq / L” represents the component equivalent (μEq) contained in 1 L of blood.
With reference to the table of FIG. 2, the blood environment of the rats of Examples 1 to 3 was generally better than that of the rat of Comparative Example 1. Specifically, in the rats of Examples 1 to 3, “total cholesterol amount” and “LDL cholesterol amount” (so-called bad cholesterol) decrease, and “HDL cholesterol amount” (so-called good cholesterol) tends to increase. I understood it. In the rats of Examples 1 to 3, the “triglyceride amount” decreased, while the “free fatty acid (NEFA) amount” did not increase significantly. And it was found that the “blood glucose level” decreased in the rats of Examples 1 to 3.
From the above results, it was suggested that in the rats of Examples 1 to 3, the use of sugar and the use of fat components in the muscle tissue and the inhibition of synthesis of lipid components in the liver were enhanced.

[Results of Test Example 3]
The table of FIG. 3 is a table showing the results of Test Example 3 (“rat body weight”, “muscle weight”, “white adipose tissue around the kidney”, and “white adipose tissue around the testis” when eating a normal fat diet). is there.
Referring to the table of FIG. 3, the rats of Example 2 (rats to which a muscle increasing agent containing “Hanabiratake mushroom treated at 150 ° C.” was given) were compared with the rats of Comparative Example 1 more. It was confirmed that the accumulation of visceral fat was suppressed and the muscle weight increased.
Then, when the results of Test Example 3 and the results of Test Example 1 described above are combined, in the temperature range of 130 ° C. or more and less than 200 ° C., including the muscle increasing agent of Example 2 (to the extent that it becomes brownish brown to koge brown). The muscle-enhancing agent containing the treated bamboo shoots suppresses visceral fat accumulation in a wide range of fat consumption (containing 5% to 35% fat component based on the total meal weight), and It was confirmed that the muscle weight was stably increased.

[Results of Test Example 4]
The table in FIG. 4 is a table showing the results of Test Example 2 (changes in blood environment during normal fat consumption).
Referring to the table of FIG. 4, in the rats of Examples 1 to 3, the “HDL cholesterol level” (so-called good cholesterol) tends to increase as compared with the rat of Comparative Example 2, whereas “LDL cholesterol level”. (So-called bad cholesterol) tended to decrease. In the rats of Examples 1 to 3, the “free fatty acid (NEFA) amount” was significantly reduced, while the “triglyceride amount” was not significantly increased.

[Comprehensive evaluation]
FIG. 5 is a bar graph showing the muscle weight values shown in the table of FIG. FIG. 6 is a bar graph showing the visceral fat values shown in the table of FIG. FIG. 7 is a bar graph showing muscle weight values and visceral fat values shown in the tables of FIGS. 1 and 3. In these figures, each value of Comparative Example 1 or Comparative Example 2 is used as a reference (100), and the value of each Example is shown in percentage (%).
Then, referring to FIG. 5 and FIG. 6, when the results of Test Examples 1 to 4 are comprehensively evaluated, the muscle increasing agent (Examples 1 to 3) of the present embodiment is ingested together with a diet containing “fat component”. Thus, it was found that the muscle weight can be increased while suppressing the increase in visceral fat accompanying the intake of fat components. At this time, it was found that Hanabiratake increases the muscle weight while more reliably suppressing the accumulation of visceral fat when the “cure treatment” is performed (for example, Example 2).
Further, referring to FIG. 7, when the muscle growth agent (for example, Example 2) has a temperature of 130 ° C. or more and less than 200 ° C. (preferably 140 ° C. or more and less than 170 ° C.), It was found that more effective muscle weight-increasing action and visceral fat increase-inhibiting action were achieved during eating.

Further, considering the results of Test Examples 1 and 3, the muscle increasing agents of Examples 1 to 3 can increase muscles while suppressing the accumulation of visceral fat in proportion to the increase in the amount of fat components in the meal. Was guessed. That is, it was inferred that the visceral fat increase inhibitory action is slightly weakened when the dietary fat component is small, while the visceral fat increase suppressive action is extremely strong when the dietary fat component is large.
Here, when the amount of fat contained in the meal is an appropriate amount, it is not necessary to reduce visceral fat due to basal metabolism. In view of this, the ideal effect of the muscle-increasing agent is to increase muscles while exhibiting a fat increase-inhibiting action only when a large amount of excess fat components are contained in the meal. And the muscle increasing agent of a present Example respond | corresponds fully also to the above-mentioned request | requirement, and it is estimated that it is a thing with higher contribution in health.
In addition, all the assumptions described in this paragraph do not restrain this invention at all.

The muscle increasing agent of the present embodiment is not limited to the above-described embodiment, and can take other various embodiments.
(1) In the present embodiment, an example has been described in which a moss belonging to the family Agaricaceae or an extract thereof is used as an active ingredient. On the other hand, if it is a related species (for example, “mosquitoes belonging to the order of Coleoptera” or “mosaid belonging to the order of Candidae”) of the family Abysthiaceae, at least the muscle weight increasing effect can be achieved. There is a possibility that it can be an alternative to the moss of the family Abyssidae in form (note that this speculation does not bind the present invention in any way). The above-mentioned Hidanastake belongs to the order of the family Coralidaceae (Heliciaceae), Thripphoraceae, Polypoaceae, Ganodermataceae. In addition, examples of the “mosquitoes belonging to the order of the licorice” include moss of the family Schizophyllaceae, Lachnellaceae, and Stigmatoleaceae.

(2) Addition of vitamins, minerals, hormones, antioxidants, physiologically active substances, sweeteners, acidulants, fragrances, salt, sugars, etc. as additives to the muscle increasing agent of this embodiment Can do.
(3) The muscle increasing agent of this embodiment can be ingested or administered to humans in various forms such as foods and drinks and drugs, and can be used as diet foods, sports foods, and the like. Examples of the food and drink include beverages (eg, drinks, milk beverages, coffee beverages, tea beverages, green tea beverages, juices, etc.), seasonings (eg, juices), meat products (eg, ham) , Sausages, etc.), confectionery (eg, biscuits, cookies, candy, snack confectionery, ramune confectionery, etc.), fish products (eg, kamaboko, chikuwa etc.), dairy products (eg, cheese etc.), etc. Such foods and drinks contain an active ingredient (i.e., “Agaricaceae moss”), and the active ingredient is ingested by eating and drinking it. The above food and drink can be prepared according to a conventional method except that an active ingredient is added in an appropriate process in the preparation stage.
(4) The “drying process” includes a cooling process such as a freeze-drying method in addition to the heat treatment.

6 is a table showing the results of Test Example 1. 10 is a table showing the results of Test Example 2. 10 is a table showing the results of Test Example 3. 10 is a table showing the results of Test Example 4. (A) is the figure which displayed increase / decrease in the muscle weight in Example 1 of FIG. 1 with the bar graph, (b) is the figure which displayed increase / decrease in muscle weight in Example 2 of FIG. 1 with the bar graph. (A) is the figure which displayed the increase / decrease of the visceral fat (testis periphery) in Example 1 of FIG. 1 with the bar graph, (b) is the figure which showed the increase / decrease of the visceral fat (kidney periphery) in Example 1 of FIG. It is the figure displayed by the bar graph, (c) is the figure which displayed increase / decrease of the visceral fat in Example 2 (periphery test area) of FIG. 1 by the bar graph, (d) is the viscera in Example 2 of FIG. It is the figure which displayed increase / decrease in fat (kidney periphery) with the bar graph. (A) is the figure which integrated and displayed the increase / decrease in the muscle weight in Example 2 of FIG.1 and FIG.3 with the bar graph, (b) is the increase / decrease in visceral fat in Example 2 of FIG.1 and FIG.3. It is the figure which integrated and displayed with the bar graph.

Claims (2)

A muscle increasing agent to extract the active ingredients of mushrooms or the mushrooms belong to Shuji treated Sparassis crispa family, said Shuji process is characterized in processing Sarukoto at a temperature range below 200 ° C. 130 ° C. or higher Muscle increaser. A method of manufacturing a muscle enhancer according to claim 1, a drying step of heat-treating the mushrooms at a temperature range of less than 40 ° C. or higher 100 ° C., after drying at a temperature range of 130 ° C. to 300 ° C. A method for producing a muscle-increasing agent, comprising: a step of repairing the moss of the cocoon, wherein the dried moss is heat-treated with a heated gas.

Images