JP5237807B2 - ドーパミンｄ３受容体の調節因子としてのトリアゾール誘導体 - Google Patents

ドーパミンｄ３受容体の調節因子としてのトリアゾール誘導体 Download PDF

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Publication number
JP5237807B2
JP5237807B2 JP2008527370A JP2008527370A JP5237807B2 JP 5237807 B2 JP5237807 B2 JP 5237807B2 JP 2008527370 A JP2008527370 A JP 2008527370A JP 2008527370 A JP2008527370 A JP 2008527370A JP 5237807 B2 JP5237807 B2 JP 5237807B2
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Japan
Prior art keywords
methyl
formula
group
compound
salt
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Expired - Fee Related
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JP2008527370A
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English (en)
Japanese (ja)
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JP2009504791A (ja
JP2009504791A5 (US06653308-20031125-C00015.png
Inventor
ジョルジョ・ボナノーミ
ロマノ・ディ・ファビオ
エレットラ・ファッツォラーリ
ディーター・ハンプレヒト
ファブリツィオ・ミケーリ
ルカ・タルシ
シルヴィア・テッレーニ
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Glaxo Group Ltd
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Glaxo Group Ltd
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Filing date
Publication date
Priority claimed from GB0517181A external-priority patent/GB0517181D0/en
Priority claimed from GB0517202A external-priority patent/GB0517202D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2009504791A publication Critical patent/JP2009504791A/ja
Publication of JP2009504791A5 publication Critical patent/JP2009504791A5/ja
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Publication of JP5237807B2 publication Critical patent/JP5237807B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
JP2008527370A 2005-08-22 2006-08-18 ドーパミンｄ３受容体の調節因子としてのトリアゾール誘導体 Expired - Fee Related JP5237807B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0517181.4 2005-08-22
GB0517181A GB0517181D0 (en) 2005-08-22 2005-08-22 Compounds
GB0517202A GB0517202D0 (en) 2005-08-22 2005-08-22 Compounds
GB0517202.8 2005-08-22
PCT/EP2006/008200 WO2007022933A1 (en) 2005-08-22 2006-08-18 Triazole derivatives as modulators of dopamine d3 receptors

Publications (3)

Publication Number Publication Date
JP2009504791A JP2009504791A (ja) 2009-02-05
JP2009504791A5 JP2009504791A5 (US06653308-20031125-C00015.png) 2009-10-01
JP5237807B2 true JP5237807B2 (ja) 2013-07-17

Family

ID=37309176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008527370A Expired - Fee Related JP5237807B2 (ja) 2005-08-22 2006-08-18 ドーパミンｄ３受容体の調節因子としてのトリアゾール誘導体

Country Status (6)

Country Link
US (1) US7799815B2 (US06653308-20031125-C00015.png)
EP (1) EP1919908B1 (US06653308-20031125-C00015.png)
JP (1) JP5237807B2 (US06653308-20031125-C00015.png)
AT (1) ATE487715T1 (US06653308-20031125-C00015.png)
DE (1) DE602006018152D1 (US06653308-20031125-C00015.png)
WO (1) WO2007022933A1 (US06653308-20031125-C00015.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2380990T3 (es) * 2004-02-23 2012-05-22 Glaxo Group Limited Derivados de azabiciclo[3.1.0]hexano útiles como moduladores de los receptores D3 de dopamina
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
GB0507602D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507601D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
DE602006017543D1 (de) * 2005-06-14 2010-11-25 Glaxo Group Ltd Neue verbindungen
EP1915146A4 (en) 2005-07-27 2010-06-02 Dov Pharmaceutical Inc NOVEL 1-ARYL-3-AZABICYCLO [3.1.0] HEXANEES. PREPARATION AND USE FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
GB0517193D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use
GB0517187D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517191D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517175D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
WO2007113260A1 (en) * 2006-04-03 2007-10-11 Glaxo Group Limited Azabicyclo [3. 1. o] hexyl derivatives as modulators of dopamine d3 receptors
US8163927B2 (en) * 2006-04-03 2012-04-24 Glaxo Group Limited Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
BR112012000657A2 (pt) 2009-06-26 2016-11-16 Panacea Biotec Ltd novos azabicilohexanos
WO2019146740A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
CN113956157B (zh) * 2021-11-18 2024-05-03 西安都创医药科技有限公司 一种合成2-甲酰基-1-环丙烷甲酸乙酯的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
AR022229A1 (es) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
WO2004031181A1 (en) * 2002-10-07 2004-04-15 Glaxo Group Limited Sulfonamide derivatives as antipsychotic agents
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
ES2380990T3 (es) * 2004-02-23 2012-05-22 Glaxo Group Limited Derivados de azabiciclo[3.1.0]hexano útiles como moduladores de los receptores D3 de dopamina
GB0507601D0 (en) 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507602D0 (en) 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
DE602006017543D1 (de) * 2005-06-14 2010-11-25 Glaxo Group Ltd Neue verbindungen
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
GB0517187D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517193D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use
GB0517175D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517191D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
EP2007750B1 (en) 2006-04-03 2013-08-21 Glaxo Group Limited Azabicyclo [3. 1. 0] hexyl derivatives as modulators of dopamine d3 receptors
GB0616574D0 (en) 2006-08-21 2006-09-27 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
US20090221593A1 (en) 2009-09-03
EP1919908A1 (en) 2008-05-14
EP1919908B1 (en) 2010-11-10
DE602006018152D1 (de) 2010-12-23
JP2009504791A (ja) 2009-02-05
WO2007022933A1 (en) 2007-03-01
ATE487715T1 (de) 2010-11-15
US7799815B2 (en) 2010-09-21

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